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19 hours ago, NagarNikku_ said:Where did you read about them using it like a gel? Everywhere ive seen they say they injected it on the edges of the wound.
This news piece published in a stanford student run newspaper says that they mixed it with gel. Some articles I've read say verteporfin was "applied", some say "injected"
1 hour ago, Violet_daisy said:
This news piece published in a stanford student run newspaper says that they mixed it with gel. Some articles I've read say verteporfin was "applied", some say "injected"
Interesting. I wonder if applying or injecting can have different outcomes.
Thank you for linking the source.
This seems promising, it solved a third degree burn with minimum scar tissue, a third degree burn goes deeper than the dermis.
It has been previously used for acne as well, and this mentions about skin regeneration and minimising scarring as well.
This is from folliclethought.com which has to do with verteporfin
2 hours ago, gueste said:This is from folliclethought.com which has to do with verteporfin
Big update!! Thank you for this.
4 hours ago, gueste said:This is from folliclethought.com which has to do with verteporfin
Like I said before, the hair loss community is more on top of this than we are lol. The term ˜reduced scarring™ is most likely used for liability purposes, they can™t call it scarless healing.. that would be promising too much lol.
On a side note, a few people now have personally asked me when I thought scarless healing would come, I™ll just give my two cents here..
Around 10 years ago I put a timeline of around 35 years, and proceeded to stop visiting these forums. My biggest issue was that the approach of just looking at the skin was incorrect, because you™re only studying scarring in skin and mostly ignoring the way other organs scar. To truly achieve scarless healing you would need to understand the entire underlying mechanism of healing. And the only research that I thought was truly working on that was limb regeneration.
So I gave up. Told myself scarless skin healing will be discovered in the process of trying to achieve limb regeneration, there was no reason to stress anymore.
But with the recent events in place, verteporfin could prove me wrong.
But if it doesn™t work out, I™ll go back to my original timeline, within 25 years. Personally I think Dr. Michael Levin™s work is totally mind blowing and can potentially achieve something bigger than even limb regeneration, the mad Russian. You should look into him. https://www.newyorker.com/magazine/2021/05/10/persuading-the-body-to-regenerate-its-limbs
13 hours ago, gueste said:This is from folliclethought.com which has to do with verteporfin
So it will take about 2 years to start human trials?
Wonder if someone will try it off label if pig studies goes well¦
5 hours ago, giddy said:So it will take about 2 yearsto start human trials?
Wonder if someone will try it off label if pig studies goes well
Theres defo ppl out there that would try it. Everyone that has acne scars especially severe ones cant wait to get their hands on some verteporfin. The thing is they need to do it properly.
I want to try it on myself, but I'm scared of it
7 hours ago, Diamond9199 said:I want to try it on myself, but I'm scared of it
I suggest waiting for pig results before though.
5 hours ago, Iker99 said:and it will be replaced with what ?
I think verteporfin would be used and skin would be regenerated in about a month?
As far as existing scars and verteporfin goes, Ireally dont see much reason why it wouldnt work.
Wounds treated with verteporfin heals without scars. Thats the statement right? So just create a wound.
How to create a wound?
Well yeah you could just excise the scar,stitch together, and add verteporfin,but thats kinda lame.
Sunogel had a bunch of illustrationson how you cut off the existing scar and deploy hydrogel, and bam scarless healing. You can do the same thing except you would add verteporfin.
Another approach of wounding is to use dermabrasion. Just as a dentist chips away at the infected tooth,you can do the same with skin, and then apply verteporfin.Leave some ointment on top and you should have a decently looking healthy patch.
You can come up with a bunch of different waysto wound the skin and trigger regeneration. But all of this hinges on verteporfin actually working as we expect it to lol, so I try not dwell on what approach would be ideal to treat existing scars, were not there yet.
9 minutes ago, Scars4Life said:I mean it™s right on their front page.
Nevermind. I thought the procedure was described to effectively remove small scattered scars, like acne scars for regeneration.
What exactly do you think is the procedure going on in the above image that can accurately remove the scar tissue deep inside the dermis and let it regenerate? I'm not sure.
On 9/4/2021 at 6:19 PM, NagarNikku_ said:
I think verteporfin would be used and skin would be regenerated in about a month?
Im sorry but medicine doesnt work like that, removing one single not big scar maybe , but not zones with scarring like many people have on cheeks for example, u have to remove a lot of tissue, u need to replace it with something.
11 hours ago, Iker99 said:Im sorry but medicine doesnt work like that, removing one single not big scar maybe , but not zones with scarring like many people have on cheeks for example, u have to remove a lot of tissue, u need to replace it with something.
So you're talking about surgically removing the entire cheek, the entire area where there's scattered scars?
13 hours ago, NagarNikku_ said:So you're talking about surgically removing the entire cheek, the entire area where there's scattered scars?
No, im talking about the fact, that this method cannot help people with wide spread acne scars for example on the cheeks, cause there would be too much tissue removed, it cant be done.
2 hours ago, Iker99 said:No, im talking about the fact, that this method cannot help people with wide spread acne scars for example on the cheeks, cause there would be too much tissue removed, it cant be done.
I think theres a general consensus in the field that if any method claiming to regenerate skin doesnt involve theremoval of the damaged skin, then regeneration will not be achieved. Which also happens to beone of theskepticisms around elastagen.
The only method for scarless healing in this scenario would be for scarred skin to undergo a metamorphosisto normal skin. But nosuch method exists and its probably a harder problem to tackle than scarless healing. (Though there is a paper published that Iodine can regenerate scarsin this fashion back to normal, it wasnt a very rigorous study though)
Now when excising the scar, if closingthe wound is required for verteporfin to work then that would be dumb, we can pretty much do that right now so verteporfin would be kinda useless. From the published paper, the mice grew full set of hair in the excisedarea, vs the mouse that developed a scar instead. The excised area was replaced with normal skin, so its not like the surface area of available skin has decreased.
If you buy that, then you do have anoption ofcontinuous spot treatments. In theory if you got your scar from acne.. then we can assume that each acne event produced an individual scar. For some that could be a lot of events, butyou couldtackle each one in reverse order of occurrencelol. Most of us have very defining scar features, which even morning swelling wont cover, I think getting rid of some of thosespots on the first runwould lift our spiritsquite a bit. Then we can move on to tackling less severe spots.
https://www.nature.com/articles/s41467-021-25410-z
Longaker's Lab published the result of pig studies by FAKI inhibition.
Please know that Verteporfin is used for YAK inhibition, and it's results aren't out yet. However, FAKI inhibition was undertaken by Gurtner, one of the member involved in the previous mice study in April.
I wonder if FAKI inhibition and YAK inhibition will produce different results.
This wasn't a complete regeneration, but still an incredible amount of scarring was prevented. Let me know what you all think
29 minutes ago, Yeeeeaaaaaaahhhhhhhh said:Okay that is actually amazing. Its not reallyscarless but itregrew hairfollicles and sweatglands on a pig. it's basically nothing compared to the scarring on the pigs without it
It isn't a complete regeneration, sure. But yes, there's a massive difference with/without it. It should only get better from here I believe.
12 hours ago, NagarNikku_ said:https://www.nature.com/articles/s41467-021-25410-z
Longaker's Lab published the result of pig studies by FAKI inhibition.
Please know that Verteporfin is used for YAK inhibition, and it's results aren't out yet. However, FAKI inhibition was undertaken by Gurtner, one of the member involved in the previous mice study in April.
I wonder if FAKI inhibition and YAK inhibition will produce different results.
This wasn't a complete regeneration, but still an incredible amount of scarring was prevented. Let me know what you all think
here's why I didn't see the word verteporfin.if it's verteporfin