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https://link.springer.com/article/10.1007/s00441-021-03505-9
Can anyone help get the complete research paper?
So was sunogel just a sham? I've been reading the forum and seen that Dr.Sun claimed to have full regenerationin pigs and mice.He even had photo evidence right?However, there has never been any news on human trials. Is anyone in contact with him anymore? Also, wouldn't his hydrogel be making news everywhere if it did produce full regeneration as we've seen with verteporfin.Sunogel seemed to be a big achievement with no news coverage at all. Quite disappointing.
When will verteporfin be tested in children? It is written on the Internet that it will be until the end of 2021. I wonder how children's lips are treated with this drug? Or do they apply this drug to children lips after surgery?
44 minutes ago, gueste said:So was sunogel just a sham? I've been reading the forum and seen that Dr.Sun claimed to have full regenerationin pigs and mice.He even had photo evidence right?However, there has never been any news on human trials. Is anyone in contact with him anymore? Also, wouldn't his hydrogel be making news everywhere if it did produce full regeneration as we've seen with verteporfin.Sunogel seemed to be a big achievement with no news coverage at all. Quite disappointing.
I wrote to him today. well, he hasnt answered yet
22 hours ago, Miro said:Lets pray , but i doubt it , i think 30-40 years
so you'd better come back here in 30 or 40 years, otherwise you'll suffer while waiting for a treatment. For me, I think it will be soon, this is my opinion of course, but if I come here it's because I'm optimistic given the recent discoveries
1 hour ago, gueste said:So was sunogel just a sham? I've been reading the forum and seen that Dr.Sun claimed to have full regenerationin pigs and mice.He even had photo evidence right?However, there has never been any news on human trials. Is anyone in contact with him anymore? Also, wouldn't his hydrogel be making news everywhere if it did produce full regeneration as we've seen with verteporfin.Sunogel seemed to be a big achievement with no news coverage at all. Quite disappointing.
sunogel is not a sham, it is that with the epidemic crisis it has delayed the events.
4 hours ago, slave of jesus said:so you'd better come back here in 30 or 40 years, otherwise you'll suffer while waiting for a treatment. For me, I think it will be soon, this is my opinion of course, but if I come here it's because I'm optimistic given the recent discoveries
sunogel is not a sham, it is that with the epidemic crisis it has delayed the events.
I d better come here whenewer i want , yes lets stay optimistic , optimism and hope is eternal on this forum
Of course we should stay optimistic no matter what, what else can we do, get depressed and kill ourselves? Science is increasing exponentially, we know more about skin and scars than ever, there is a hope, a cure will come, and after it comes it will get better and better.
Guoming Song answered me. he said the sunogel had been postponed due to the pandemic. but he hopes that everything will be fine soon
19 minutes ago, Diamond9199 said:Guoming Song answered me. he said the sunogel had been postponed due to the pandemic. but he hopes that everything will be fine soon
Fucks sake.
What I find strange is Longaker said in the NyTimes article that they already had tested it on pigs and it caused dramatically less scarring. But he also says in other interviewsthat they moved on to the pigs, which will take 3-4 months. So what is the difference betweenthe first test that caused less scarring and what they are testing now?
Also, why would Lonaker suggest they might have a cure toscarringinNyTimes if he knew Verteporfin did not provide full regeneration in pigs?
7 hours ago, Ivvan said:Of course we should stay optimistic no matter what, what else can we do, get depressed and kill ourselves? Science is increasing exponentially, we know more about skin and scars than ever, there is a hope, a cure will come, and after it comes it will get better and better.
Lets stay realistic, no one should kill himself due to anything
2 hours ago, giddy said:What I find strange is Longaker said in the NyTimes article that they already had tested it on pigs and it caused dramatically less scarring. But he also says in other interviewsthat they moved on to the pigs, which will take 3-4 months. So what is the difference betweenthe first test that caused less scarring and what they are testing now?
They're probably trying to obtain complete regeneration in pigs. Maybe they need different dosage size etc.
1 hour ago, NagarNikku_ said:They're probably trying to obtain complete regeneration in pigs. Maybe they need different dosage size etc.
Yeah, I hope we will get som news by the end of september!
New article published by Michael Longaker regarding skin scarring.
https://onlinelibrary.wiley.com/doi/abs/10.1002/med.21853
16 hours ago, giddy said:What I find strange is Longaker said in the NyTimes article that they already had tested it on pigs and it caused dramatically less scarring. But he also says in other interviewsthat they moved on to the pigs, which will take 3-4 months. So what is the difference betweenthe first test that caused less scarring and what they are testing now?
I think that was a 2011 or 2015 study. The same team made a bandage to reduce tension and found that rodents have no scarring and pigs have "much less scarring" or "six times less scarring".
They haven't released the effect of verteporfin yet. Since its a drug that blocks the signalling altogether, that's why scientists are very hopeful that this will be it. I read an interview of another researcher who thinks that this discovery is huge.
Im not losing hope no matter what...
This is a research paper published by some chinese authors in July.
It covers everything regarding skin scarring, everything researchers know by far. YAP inhibition, mechanotransduction, WNT inhibition.
I honestly believe there are multiple pathways to achieve scarless regeneration.
https://www.mdpi.com/2218-273X/11/8/1095/htm
17 hours ago, Violet_daisy said:I think that was a 2011 or 2015 study. The same team made a bandage to reduce tension and found that rodents have no scarring and pigs have "much less scarring" or "six times less scarring".
They haven't released the effect of verteporfin yet. Since its a drug that blocks the signalling altogether, that's why scientists are very hopeful that this will be it. I read an interview of another researcher who thinks that this discovery is huge.
Im not losing hope no matter what...
can please someone explain how this is supposed to help people with acne scarring ?
8 hours ago, Miro said:can please someone explain how this is supposed to help people with acne scarring
They'll figure out a treatment protocol but i personally thinkthat microcoring+verteporfin can work well together for striae and acne scars(if verteporfin works).I'm holding off being too excited aboutthis treatment until pig study results are published.
2 hours ago, Violet_daisy said:They'll figure out a treatment protocol but i personally thinkthat microcoring+verteporfin can work well together for striae and acne scars(if verteporfin works).I'm holding off being too excited aboutthis treatment until pig study results are published.
I think the wounds would be too microscopic for verteporfin to be injected in its edges.
Why would microcoring even need verteporfin, microcoring should work very good on its own.
On 8/30/2021 at 12:06 PM, NagarNikku_ said:I think the wounds would be too microscopic for verteporfin to be injected in its edges.
They applied verteporfin mixed in gel base to wound in the research. Ithink it can work like how microneedling+ prp treatment works. Dab some gel onto micro cored skin and let it heal for a month and as wound will close, it won't just close but it will heal. The wounds in microcoring close by shrinking and not actually healing (thats what those pictures they published shows). But its just an idea based on a few facts that I gathered about microcoring and verteporfin. I may be completely wrong.
Also, since skin regenration can't happen in natural conditions, micro coring can't actually heal skin on its own. That's why they are advertising their products for wrinkles and haven't said enough about acne scars and stretch marks for last couple of years.I guess it sort of removes some excess skin and gives a feel of tightening and that's all.
7 hours ago, Violet_daisy said:They applied verteporfin mixed in gel base to wound in the research. Ithink it can work like how microneedling+ prp treatment works. Dab some gel onto micro cored skin and let it heal for a month and as wound will close, it won't just close but it will heal. The wounds in microcoring close by shrinking and not actually healing (thats what those pictures they published shows). But its just an idea based on a few facts that I gathered about microcoring and verteporfin. I may be completely wrong.
Also, since skin regenration can't happen in natural conditions, micro coring can't actually heal skin on its own. That's why they are advertising their products for wrinkles and haven't said enough about acne scars and stretch marks for last couple of years.I guess it sort of removes some excess skin and gives a feel of tightening and that's all.
Where did you read about them using it like a gel? Everywhere ive seen they say they injected it on the edges of the wound.