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[Sticky] Scarless Healing

 
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41
(@gueste)

Posted : 08/29/2021 4:45 pm

1 hour ago, Miro said:

can please someone explain how this is supposed to help people with acne scarring ?

Im guessing excision of the scar, then inject verteporfin into the edges of the wound?

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(@violet_daisy)

Posted : 08/29/2021 11:06 pm

8 hours ago, Miro said:

can please someone explain how this is supposed to help people with acne scarring

They'll figure out a treatment protocol but i personally thinkthat microcoring+verteporfin can work well together for striae and acne scars(if verteporfin works).I'm holding off being too excited aboutthis treatment until pig study results are published.

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116
(@niketgandhir)

Posted : 08/30/2021 1:36 am

2 hours ago, Violet_daisy said:

They'll figure out a treatment protocol but i personally thinkthat microcoring+verteporfin can work well together for striae and acne scars(if verteporfin works).I'm holding off being too excited aboutthis treatment until pig study results are published.

I think the wounds would be too microscopic for verteporfin to be injected in its edges.

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(@ivvan)

Posted : 08/30/2021 11:35 am

Why would microcoring even need verteporfin, microcoring should work very good on its own.

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(@violet_daisy)

Posted : 08/31/2021 9:45 am

On 8/30/2021 at 12:06 PM, NagarNikku_ said:

I think the wounds would be too microscopic for verteporfin to be injected in its edges.

They applied verteporfin mixed in gel base to wound in the research. Ithink it can work like how microneedling+ prp treatment works. Dab some gel onto micro cored skin and let it heal for a month and as wound will close, it won't just close but it will heal. The wounds in microcoring close by shrinking and not actually healing (thats what those pictures they published shows). But its just an idea based on a few facts that I gathered about microcoring and verteporfin. I may be completely wrong.

Also, since skin regenration can't happen in natural conditions, micro coring can't actually heal skin on its own. That's why they are advertising their products for wrinkles and haven't said enough about acne scars and stretch marks for last couple of years.I guess it sort of removes some excess skin and gives a feel of tightening and that's all.

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(@niketgandhir)

Posted : 08/31/2021 5:09 pm

7 hours ago, Violet_daisy said:

They applied verteporfin mixed in gel base to wound in the research. Ithink it can work like how microneedling+ prp treatment works. Dab some gel onto micro cored skin and let it heal for a month and as wound will close, it won't just close but it will heal. The wounds in microcoring close by shrinking and not actually healing (thats what those pictures they published shows). But its just an idea based on a few facts that I gathered about microcoring and verteporfin. I may be completely wrong.

Also, since skin regenration can't happen in natural conditions, micro coring can't actually heal skin on its own. That's why they are advertising their products for wrinkles and haven't said enough about acne scars and stretch marks for last couple of years.I guess it sort of removes some excess skin and gives a feel of tightening and that's all.

Where did you read about them using it like a gel? Everywhere ive seen they say they injected it on the edges of the wound.

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(@violet_daisy)

Posted : 09/01/2021 1:00 pm

19 hours ago, NagarNikku_ said:

Where did you read about them using it like a gel? Everywhere ive seen they say they injected it on the edges of the wound.

https://www.stanforddaily.com/2021/05/27/in-groundbreaking-discovery-stanford-researchers-identify-drug-that-could-prevent-scarring/

 

This news piece published in a stanford student run newspaper says that they mixed it with gel. Some articles I've read say verteporfin was "applied", some say "injected"

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116
(@niketgandhir)

Posted : 09/01/2021 2:28 pm

1 hour ago, Violet_daisy said:

https://www.stanforddaily.com/2021/05/27/in-groundbreaking-discovery-stanford-researchers-identify-drug-that-could-prevent-scarring/

 

This news piece published in a stanford student run newspaper says that they mixed it with gel. Some articles I've read say verteporfin was "applied", some say "injected"

Interesting. I wonder if applying or injecting can have different outcomes.

Thank you for linking the source.

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(@giddy)

Posted : 09/01/2021 3:03 pm

A comment onthe Longaker finding:

https://www.nature.com/articles/s41392-021-00738-6

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116
(@niketgandhir)

Posted : 09/01/2021 3:58 pm

https://www.prdistribution.com/news/burn-injury-healed-with-complete-skin-regrowth-in-only-6-days-using-new-stem-cell-drug/1836901

This seems promising, it solved a third degree burn with minimum scar tissue, a third degree burn goes deeper than the dermis.

https://www.biospace.com/article/releases/viaderma-lead-product-tetrastem-shows-promise-in-treating-acne-/

It has been previously used for acne as well, and this mentions about skin regeneration and minimising scarring as well.

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(@gueste)

Posted : 09/02/2021 6:43 pm

This is from folliclethought.com which has to do with verteporfin

Screen Shot 2021-09-02 at 4.41.02 PM.png

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(@niketgandhir)

Posted : 09/02/2021 8:57 pm

2 hours ago, gueste said:

This is from folliclethought.com which has to do with verteporfin

Screen Shot 2021-09-02 at 4.41.02 PM.png

Big update!! Thank you for this.

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(@scars4life)

Posted : 09/02/2021 11:48 pm

4 hours ago, gueste said:

This is from folliclethought.com which has to do with verteporfin

Screen Shot 2021-09-02 at 4.41.02 PM.png

Like I said before, the hair loss community is more on top of this than we are lol. The term ˜reduced scarring™ is most likely used for liability purposes, they can™t call it scarless healing.. that would be promising too much lol.

On a side note, a few people now have personally asked me when I thought scarless healing would come, I™ll just give my two cents here..

Around 10 years ago I put a timeline of around 35 years, and proceeded to stop visiting these forums. My biggest issue was that the approach of just looking at the skin was incorrect, because you™re only studying scarring in skin and mostly ignoring the way other organs scar. To truly achieve scarless healing you would need to understand the entire underlying mechanism of healing. And the only research that I thought was truly working on that was limb regeneration.

So I gave up. Told myself scarless skin healing will be discovered in the process of trying to achieve limb regeneration, there was no reason to stress anymore.

But with the recent events in place, verteporfin could prove me wrong.

But if it doesn™t work out, I™ll go back to my original timeline, within 25 years. Personally I think Dr. Michael Levin™s work is totally mind blowing and can potentially achieve something bigger than even limb regeneration, the mad Russian. You should look into him.  https://www.newyorker.com/magazine/2021/05/10/persuading-the-body-to-regenerate-its-limbs

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(@giddy)

Posted : 09/03/2021 8:24 am

13 hours ago, gueste said:

This is from folliclethought.com which has to do with verteporfin

Screen Shot 2021-09-02 at 4.41.02 PM.png

So it will take about 2 years to start human trials? 

Wonder if someone will try it off label if pig studies goes well¦

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(@mimiytrewq)

Posted : 09/03/2021 2:16 pm

5 hours ago, giddy said:

So it will take about 2 yearsto start human trials?

Wonder if someone will try it off label if pig studies goes well

Theres defo ppl out there that would try it. Everyone that has acne scars especially severe ones cant wait to get their hands on some verteporfin. The thing is they need to do it properly.

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(@diamond9199)

Posted : 09/04/2021 4:02 am

I want to try it on myself, but I'm scared of it

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(@ikermourinho99)

Posted : 09/04/2021 5:40 am

On 8/1/2021 at 1:01 PM, Sniffy said:

Scar tissue has to be removed

and it will be replaced with what ?

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(@niketgandhir)

Posted : 09/04/2021 11:19 am

7 hours ago, Diamond9199 said:

I want to try it on myself, but I'm scared of it

I suggest waiting for pig results before though.

5 hours ago, Iker99 said:

and it will be replaced with what ?

I think verteporfin would be used and skin would be regenerated in about a month?

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(@niketgandhir)

Posted : 09/04/2021 5:36 pm

https://www.liebertpub.com/doi/abs/10.1089/wound.2021.0040

Published by Longaker's Lab.

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54
(@scars4life)

Posted : 09/04/2021 5:51 pm

As far as existing scars and verteporfin goes, Ireally dont see much reason why it wouldnt work.

Wounds treated with verteporfin heals without scars. Thats the statement right? So just create a wound.

How to create a wound?

Well yeah you could just excise the scar,stitch together, and add verteporfin,but thats kinda lame.

Sunogel had a bunch of illustrationson how you cut off the existing scar and deploy hydrogel, and bam scarless healing. You can do the same thing except you would add verteporfin.

Another approach of wounding is to use dermabrasion. Just as a dentist chips away at the infected tooth,you can do the same with skin, and then apply verteporfin.Leave some ointment on top and you should have a decently looking healthy patch.

You can come up with a bunch of different waysto wound the skin and trigger regeneration. But all of this hinges on verteporfin actually working as we expect it to lol, so I try not dwell on what approach would be ideal to treat existing scars, were not there yet.

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(@niketgandhir)

Posted : 09/04/2021 7:14 pm

1 hour ago, Scars4Life said:

Sunogel had a bunch of illustrationson how you cut off the existing scar and deploy hydrogel, and bam scarless healing. You can do the same thing except you would add verteporfin.

Can you please source the illustration? I'm curious. Thanks.

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(@scars4life)

Posted : 09/04/2021 8:47 pm

1 hour ago, NagarNikku_ said:

Can you please source the illustration? I'm curious. Thanks.

I mean it™s right on their front page.

image.jpeg.e991eef21a5ca1869fffd59b6065f58e.jpeg

 

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116
(@niketgandhir)

Posted : 09/04/2021 8:58 pm

9 minutes ago, Scars4Life said:

I mean it™s right on their front page.

image.jpeg.e991eef21a5ca1869fffd59b6065f58e.jpeg

 

Nevermind. I thought the procedure was described to effectively remove small scattered scars, like acne scars for regeneration.

What exactly do you think is the procedure going on in the above image that can accurately remove the scar tissue deep inside the dermis and let it regenerate? I'm not sure.

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(@ikermourinho99)

Posted : 09/05/2021 11:23 am

On 9/4/2021 at 6:19 PM, NagarNikku_ said:

 

I think verteporfin would be used and skin would be regenerated in about a month?

Im sorry but medicine doesnt work like that, removing one single not big scar maybe , but not zones with scarring like many people have on cheeks for example, u have to remove a lot of tissue, u need to replace it with something.

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(@niketgandhir)

Posted : 09/05/2021 10:35 pm

11 hours ago, Iker99 said:

Im sorry but medicine doesnt work like that, removing one single not big scar maybe , but not zones with scarring like many people have on cheeks for example, u have to remove a lot of tissue, u need to replace it with something.

So you're talking about surgically removing the entire cheek, the entire area where there's scattered scars?

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