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13 hours ago, ladanse said:Hello! I hope it's all right to join this community and especially this conversation even through I do not suffer from acne scars myself. I still do have acne even as I am reaching middle age, but I am lucky not to have permanent damage. I initially found this forum as I was looking for feedback concerning a particular dermatologist specializing in scar treatment as I am having issues with another type of scar. I have been following the conversation regarding the research conducted by Stanford University on scarless healing and I enjoy reading your thoughts on its potential. While different sources published since late April usually repeat the same story, I have found some additional information in which Dr Michael Longaker mentions the following:
"Dr. Longaker said he hoped to get permission from the Food and Drug Administration by the end of the year to test the Safety and effectiveness of the drug in babies with cleft lip and palate.
For Dr. Longaker, speed is essential if the treatment works and is safe. I don't want this to be a 10-year trip, he says.
Stanford has filed for patents for the use of verteporfin in scar formation."
Link: https://www.hebergementwebs.com/health/imagine-scarless-surgery
I have looked for the project focusing on the use of verteporfin in cleft lip surgeries and have found the project on a list of funded projects for 2021 here https://doctrc.org/itp-portfolio/
and here https://c-doctor.org/research/
If the research team is thinking on moving on with the use of verteporfin on children and especially in facial surgeries, I hope that the potential of the use verteporfin in human scarless healing has somehow already been proven and that studies have perhaps already moved on from pigs. Although children heal much better than adults, this is a very sensitive surgery on a very visible part of the body and it somehow makes the whole idea even more promising. I am keeping my fingers crossed for everyone suffering from different forms of scars as this may truly be a remarkable discovery. Thank you all for posting your thoughts!
where did you read that they applied to fda?
What really bothers me is, that they achieved complete regeneration in mice, including hair follicles, sweat glands, basically, totally normal skin but in case of pigs which are similar to us in terms of flesh it says that - "pigs, whose skin is closest to that of humans. With these new subjects, the surgeons made an incision as wide as an inch and five inches long. When they sutured the cut and injected the verteporfin around the edge, there was much less scarring."
From complete regeneration to "much less scarring". 
34 minutes ago, giddy said:Maybe they just had the wrong amount the first time they tried it inpigs.
Hope is eternal on this forum
2 hours ago, ladanse said:Exactly. And the New York Times article mentioned "dramatically less scarring" in pigs.
"The study involved mice, but the researchers, Dr. Michael Longaker, Stanfords vice chair of surgery, and Geoffrey Gurtner, Stanfords vice president of surgery for innovation, have now moved on to pigs, whose skin is closest to that of humans. With these new subjects, the surgeons made an incision as wide as a thumb and five inches long. When they sutured the cut and injected Verteporfin around the edge, there was dramatically less scarring."
https://www.nytimes.com/2021/04/22/health/surgery-scar.html
I guess we just have to wait and see. Personally, I would be fine with skin that looked abnormal only under some kind of a microscope or under this algorithm that the research team used in order to find the difference between normal skin and regenerated one. But others, e.g. hair transplant community, would of course benefit from complete regeneration. Let's wait and hope.
Me too, as long as it looks normal, I think I'll be fine, I don't really care how it looks on a microscopic level.
But again, by "less scarring" reported in pigs its most likely that the scarring is visible to the eye.
5 hours ago, Miro said:50 years
Rofl.
I think aside fromhope,pessimism is also eternal in this forum lol.
Anyways, elastagen is like.. its not gonna get rid of scar tissue.. whateves, I dont wanna get into that lol.
On the verteporfin side of things, there were some research articlespublished looking into why verteporfin works, but other than thatits really the hair loss community that is jumping on the verteporfinbandwagon.. (more so than the downers on this thread lol). Some guy put a YouTube video, with sizable enough following, and there are other platforms with that discussion.
4 hours ago, Scars4Life said:Rofl.
I think aside fromhope,pessimism is also eternal in this forum lol.
Anyways, elastagen is like.. its not gonna get rid of scar tissue.. whateves, I dont wanna get into that lol.
On the verteporfin side of things, there were some research articlespublished looking into why verteporfin works, but other than thatits really the hair loss community that is jumping on the verteporfinbandwagon.. (more so than the downers on this thread lol). Some guy put a YouTube video, with sizable enough following, and there are other platforms with that discussion.
Yes but apart from optimism , pesimism on this forum is based on experience , hope is just hope
For those who havent heard the interview with Michael Longaker in April:
https://www.google.no/amp/s/news.wosu.org/show/all-sides-with-ann-fisher/2021-04-28/wellness-wednesday-healing-without-scarring%3f_amp=true
The interview starts around the middle of the episode
Meet Ellacor, The New, Scar-Free Treatment That Improves Wrinkles And Loose Skin.Neera Nathan, MD
Contributor
ForbesWomen
Im a dermatologist who writes about skin care and womens health.
Ellacor was recently cleared by the FDA to treat[+]
GETTY
Think that going under the knife is the only way to treat loose, aging skin?
Think again.
Heres howellacor,the new FDA-cleared system, creates small holes in the skin to tighten and improve deep facial lines sansscalpel.
Skin aging is a normal process.
As we age, collagen, which is a key protein that helps skin appear firm and youthful,reduces by more than 50% and decreases in quality, contributing to the appearance of wrinkles. Unfortunately, skin aging is inevitable, althoughsun-exposed skin tends to age faster. It is important to note that aging is more than skin deep; the appearance of an aged face is also due to changes that occur in the fat, muscles, and bones.
Removing tiny cores of skin can lead to scar-free skin tightening.
Anytime the skin is cut or injured, the wound healing process is triggered. This involves multiplication of cells, called fibroblasts, that produce collagen, as well as special types of fibroblasts, called myofibroblasts, that contract to help wounds close.
Ellacor intentionally creates wounds byremoving thousands of very small cores of skinin a pattern that leaves some intervening skin intact. The wound healing process is stimulated from removal of these micro-cores, which results in collagen production and contraction that tightens skin. The cores are full-thickness, meaning that they penetrate both layers of the skin (epidermis and dermis), but are small enough in diameter (less than 0.5 millimeters) that they do not create visible scars and close almost immediately post-procedure. In an animal study, this micro-coring technique nearly doubled skin thickness compared to untreated skin, and alsodemonstrated tissue remodeling that may correlate to skin tightening.
Unlike lasers, ellacor does not use energy or heat, and also produces less inflammation; therefore, it does not carry the same risk of unintentional burns or prolonged downtime. Unlike a rhytidectomy, or facelift, there is no associated visible (or microscopic) scarring, or need for general anesthesia.
ellacor Micro-Coring Technology showed promise in clinical trials.
In clinical studies, ellacor was well-tolerated, an entire facial treatment took less than 30 minutes, and the post-procedure recovery time was short (~3-4 days). Thousands of micro-cores were removed each session,which could equate to about 5-10% of treated skin,resulting in a tightening effect that opposes the skins natural tendency to sag downward. Ellacor was associated with high patient satisfaction and data from two pooled trials showed that more than 90% of treated patients had an objective improvement in their skin appearance at 3-6 months post-treatment.
There are other treatment options, too, for sagging or wrinkled skin.
Ellacor appears to be a promising, heat-free, minimally invasive treatment for facial wrinkles and loose skin. It is expected to become commercially available in early 2022. Larger studies in diverse patient populations will be helpful to confirm the promising data from early trials.
There are other non-surgical treatments that are currently used to improve the appearance of aging skin. These include energy-based devices that use radiofrequency, ultrasound, or fractional lasers. Of these, treatments that break the skin barrier (i.e. create a wound or puncture) aremore likely to tightenthan their non-invasive counterparts.
A facelift is a surgical treatment that is usually performed in an operating room to substantially lift skin, as well as deeper structures, like the fat or muscles. It is important to note that these deeper layers are not treated by ellacor or other energy-based devices that target the skin alone.
Hello, all! I'm not sure if this has been posted before but has anyone heard about ScarlessWorld Project? It's European funded project with a budget of about 2 million euros.
https://cordis.europa.eu/project/id/819933
https://cordis.europa.eu/project/id/819933/reporting (These are their current reports)
The end date for this project is 31st March 2024.
Good times ahead, I hope.
11 minutes ago, nikkigirl said:This thread has been going on for years without nothing really new that actually works for scars. The original poster prolly isn't even around anymore!
Nothing so far, sure. Nothing in the near future either. But it doesn't mean scars will remain untreated forever.
4 hours ago, nikkigirl said:This thread has been going on for years without nothing really new that actually works for scars. The original poster prolly isn't even around anymore!
I still check in once in a while.
science has made very good progress on how healing works. it will not be surprising if we have a treatment for complete skin regeneration in the near future. be positive!