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If the research on pigs comes positive for verteporfin I'm willing to cut my arm in 2 different places and see how different they heal with verteporfin and without, and if it works positively then this is earth shattering for me.
Me and NagarNikku_ would really appreciate if we could get everyone who is interested in this research project for a possible cure for acne scars, to contact the lead researchers and any other members involved in this project, regrding acne scarring. We would really appreciate it as the more emails they get flooding in regarding the issue we are all being handicapped by, the more they can take acne scarring seriously and help us to find a way out of this hell-hole. Thanks to everyone who has the time to participatein this mass emailing. Here is the lead researchers email:[email protected]
Hey guys,
Ive been on vacation for the past few weeks, I would recommend everyone first and foremost to try to enjoylife, regardless of whethera cure comes or not you will not recover these days of your life.
If you insist on crying and staying home, at least try to learn new skills, maybe a musicalinstrument or learn to code, so that youre enriching yourself in other ways.
Anyways, itlooks like theres a follow up publication to the Longaker led research. Ill try to get a hold of the full paper some time later, but it at least looks like theyre activelystudying the effects of verteporfin and what actually happens under the hood that leads to scarless healing vs regular wound healing. Not sure if theres any movement on pigs yet, well have to see.
Does anyone know how this would work for acne scars? How would they go about healing a whole area like the cheek, using this method if it works that is?
2 hours ago, Sniffy said:Scar tissue has to be removed
Obviously.
But what about the widespread scarring? How will it work for that?
Since this needs to get injected on the edges of the wound, would each scar would have to get manually excised and then verteporfin injected on the edges? Or is it possibly by ablative laser or just dermabrasion?
It can work perfectly for any standalone scar but what we have is scars scattered across the face and I'm not sure how this will work for that.
2 hours ago, NagarNikku_ said:Obviously.
But what about the widespread scarring? How will it work for that?
Since this needs to get injected on the edges of the wound, would each scar would have to get manually excised and then verteporfin injected on the edges? Or is it possibly by ablative laser or just dermabrasion?
It can work perfectly for any standalone scar but what we have is scars scattered across the face and I'm not sure how this will work for that.
Hopefully Microcoring can help as it would carry less risk however it could be to slow andthe hole size would be so small i dont know if Verteporfin would sit in suvh a tiny wound. Otherwise maybe punch excision but thats only if Verteporfin truly works the way they hope. Lasers wont do anything, you need a wound site.
32 minutes ago, Sniffy said:Hopefully Microcoring can help as it would carry less risk however it could be to slow andthe hole size would be so small i dont know if Verteporfin would sit in suvh a tiny wound. Otherwise maybe punch excision but thats only if Verteporfin truly works the way they hope. Lasers wont do anything, you need a wound site.
I don't think micro coring will cause enough deep trauma at the scar site for the body to re-heal itself with this new scar blocking mechanism?
I was thinking about punch excision too, but that's only good for individual scars? If someone has lots of small scattered scars across their face I don't know what can be done about that though.
I guess I should keep my expectations low until the research paper for pigs is published.
11 hours ago, NagarNikku_ said:I don't think micro coring will cause enough deep trauma at the scar site for the body to re-heal itself with this new scar blocking mechanism?
I was thinking about punch excision too, but that's only good for individual scars? If someone has lots of small scattered scars across their face I don't know what can be done about that though.
I guess I should keep my expectations low until the research paper for pigs is published.
If your scarring is minimal to moderate in patches I think Microcoring might genuinely help with enough sessions.It goes deep beyond the dermis so removal of scar tissue wont be an issue its just happening on a micro scale so its going to take time. We have seen before and afters on stretch marks after 1 or 2 treatments and it has reduced the amount of scarring so you can imagine getting 10+ sessions should be even more impressive. I dont know ifVerteporfin can infiltrate those tiny micro cores as they close up pretty fast also. Maybe it would I dunno
For more severe scarring i guess Verteporfin but you cant just remove largechunks of skin and apply Verteporfin, thats risky.It would be a slower process with punch excision/Microcoring. Recros may have larger gauge cores than Cytrellis also. Again we need to see the effectiveness of Verteporfin. Theydid say it dramatically reduced scarring in a pig model so thats a real positive. Even if it didnt remove 100% but even 80% or 90% is fantastic and it may only mean you need a 2nd or 3rd procedure but with a less invasive technique as the target area is less.
We know Verteporfin blocks those mechanical stress signals. Its already seen in elderly people who have loose skin, they barely scar.
3 hours ago, Sniffy said:If your scarring is minimal to moderate in patches I think Microcoring might genuinely help with enough sessions.It goes deep beyond the dermis so removal of scar tissue wont be an issue its just happening on a micro scale so its going to take time. We have seen before and afters on stretch marks after 1 or 2 treatments and it has reduced the amount of scarring so you can imagine getting 10+ sessions should be even more impressive. I dont know ifVerteporfin can infiltrate those tiny micro cores as they close up pretty fast also. Maybe it would I dunno
For more severe scarring i guess Verteporfin but you cant just remove largechunks of skin and apply Verteporfin, thats risky.It would be a slower process with punch excision/Microcoring. Recros may have larger gauge cores than Cytrellis also. Again we need to see the effectiveness of Verteporfin. Theydid say it dramatically reduced scarring in a pig model so thats a real positive. Even if it didnt remove 100% but even 80% or 90% is fantastic and it may only mean you need a 2nd or 3rd procedure but with a less invasive technique as the target area is less.
We know Verteporfin blocks those mechanical stress signals. Its already seen in elderly people who have loose skin, they barely scar.
I've had 8 sessions of MNRF. I have seen some improvement, but overhead lighting makes it looks like I have got nothing done at all. All the scars are there, just shallower.
Where did you obtain the information about the pig results? Is the research paper already out?
45 minutes ago, NagarNikku_ said:I've had 8 sessions of MNRF. I have seen some improvement, but overhead lighting makes it looks like I have got nothing done at all. All the scars are there, just shallower.
Where did you obtain the information about the pig results? Is the research paper already out?
It was mentioned briefly in an article that thry had tested it on a pig with a 5 inch wound they created
3 hours ago, Sniffy said:It was mentioned briefly in an article that thry had tested it on a pig with a 5 inch wound they created
I wonder when they'll release the actual research paper with before/after images and maybe some other treatment optimiziation to achieve scarless healing in pigs completely.
I'm hanging on a thread here with this.
Some news articles regarding scarless healing:
https://med.stanford.edu/news/all-news/2021/04/drug-enables-healing-without-scarring.html
https://www.statnews.com/2021/04/22/scientists-unlock-key-to-scar-free-skin-healing/
The technology is here, just that whether they need tofind an appropriate way to transition to using it
on humans.
1 hour ago, AI3forever said:Some news articles regarding scarless healing:
https://med.stanford.edu/news/all-news/2021/04/drug-enables-healing-without-scarring.html
https://www.statnews.com/2021/04/22/scientists-unlock-key-to-scar-free-skin-healing/
The technology is here, just that whether they need tofind an appropriate way to transition to using it
on humans.
I still dont understand how this will help people with acne scars
4 hours ago, AI3forever said:Some news articles regarding scarless healing:
https://med.stanford.edu/news/all-news/2021/04/drug-enables-healing-without-scarring.html
https://www.statnews.com/2021/04/22/scientists-unlock-key-to-scar-free-skin-healing/
The technology is here, just that whether they need tofind an appropriate way to transition to using it
on humans.
Yep this was posted a while ago, this is the closest we've ever been to a cure.
1 hour ago, Lbjtui said:Sorry if this has been asked before, but does anyone know what happened to sunogel? If you check their website right now, it still says its in preclinical trials. Or maybe they just havent updated it? Thank you in advance.
My personal opinion is , that it sounded too good to be true , the last update on site is 2 years ago
On 8/13/2021 at 8:55 AM, Lbjtui said:Sorry if this has been asked before, but does anyone know what happened to sunogel? If you check their website right now, it still says its in preclinical trials. Or maybe they just havent updated it? Thank you in advance.
There's a show about hairloss where people call in and share their stories and experienceswith treatments etc. and the presenter has said recently that he started that show in 1998 and since then all new ideas regarding treatments started out promising maybe but then they fizzled out i.e. the researchers/developersdidn't maintain momentum and nothing ever came to fruition.So he's kinda "cynical" now though he did speak of something that's in the pipelineand he's going to follow it because you never know.
People with hairloss get treatments which often cause scarring so scarless healing is also something of interest to them. People get disfigured through certain hairloss treatments. Or through hairloss treatments that fail.
He spoke of hair being able to be regenerated in mice and also in pigs, the latter being a recent development which is also what Sunogel has done. Maybe the treatment that the presenter spoke of is Sunogel though I doubt it. Whatever it is he says it's the most promising new idea he's seen to date and it will be spoken about in the fall I think at a conference. But like I said, he's become rather cynical about anythingcoming to fruition seing as since 1998 nothing ever really has.
I also wonder what happened to Sunogel. It's strange to me that their website is still up. Obviously a lot of work and thought has gone into that site which may indicate that they believed in their product at the time at least. Two years is a long time for there to not be any updates but if they've completely abandoned their work/project then why is that site still up? It's mystifying.
10 hours ago, Lapis lazuli said:There's a show about hairloss where people call in and share their stories and experienceswith treatments etc. and the presenter has said recently that he started that show in 1998 and since then all new ideas regarding treatments started out promising maybe but then they fizzled out i.e. the researchers/developersdidn't maintain momentum and nothing ever came to fruition.So he's kinda "cynical" now though he did speak of something that's in the pipelineand he's going to follow it because you never know.
People with hairloss get treatments which often cause scarring so scarless healing is also something of interest to them. People get disfigured through certain hairloss treatments. Or through hairloss treatments that fail.
He spoke of hair being able to be regenerated in mice and also in pigs, the latter being a recent development which is also what Sunogel has done. Maybe the treatment that the presenter spoke of is Sunogel though I doubt it. Whatever it is he says it's the most promising new idea he's seen to date and it will be spoken about in the fall I think at a conference. But like I said, he's become rather cynical about anythingcoming to fruition seing as since 1998 nothing ever really has.
I also wonder what happened to Sunogel. It's strange to me that their website is still up. Obviously a lot of work and thought has gone into that site which may indicate that they believed in their product at the time at least. Two years is a long time for there to not be any updates but if they've completely abandoned their work/project then why is that site still up? It's mystifying.
If verteporfin works I think it can be used for balding as well? Since new hair follicle is generated at the injected wound site?
3 hours ago, NagarNikku_ said:If verteporfin works I think it can be used for balding as well? Since new hair follicle is generated at the injected wound site?
I guess so.
Perhaps verteporfin is something that can help people but to be honest I think it (the solution) may very well not be in the future but in the present. It's an interesting thought, the idea that the solution is here already. That it's just being kept from us...
Recently I saw an interview with Fiona Wood who works with burn victims and she's been thinking about scarless healing for years she says and one thing she started wondering was about why dogs lick their wounds. This is the type of thing she says she thinks about when thinking about making progress. She wonders why it is that dogs lick their wounds. It just sounds kinda like she's starting way at the beginning while it's flipping 2021... There's so much research already been done and she goes for bike rides she says to think about how to achieve scarless healing and the type of thoughts she has are like the one about the dogs. That doesn't come across as very serious to me. Maybe she's just bullshitting us in order to keep her job or something. Lots of money to be made the way things are now. Sounds cynical maybe but coldness like that is sadly shown by a lot of people.
3 hours ago, Lapis lazuli said:I guess so.
Perhaps verteporfin is something that can help people but to be honest I think it (the solution) may very well not be in the future but in the present. It's an interesting thought, the idea that the solution is here already. That it's just being kept from us...
Recently I saw an interview with Fiona Wood who works with burn victims and she's been thinking about scarless healing for years she says and one thing she started wondering was about why dogs lick their wounds. This is the type of thing she says she thinks about when thinking about making progress. She wonders why it is that dogs lick their wounds. It just sounds kinda like she's starting way at the beginning while it's flipping 2021... There's so much research already been done and she goes for bike rides she says to think about how to achieve scarless healing and the type of thoughts she has are like the one about the dogs. That doesn't come across as very serious to me. Maybe she's just bullshitting us in order to keep her job or something. Lots of money to be made the way things are now. Sounds cynical maybe but coldness like that is sadly shown by a lot of people.
Probably. They're making billions every year off these shitty treatments that provide "improvements" in just angled lightings. The scar tissue is there, everything is still there.
But again, if scarless healing is already a reality (if you think so) then it would generate huge amount of revenue as well.