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2 hours ago, Diamond9199 said:Great
how much longer should we wait? when can we see the results of Elastagen and Vertoporfin
Tests on rats took around 90 days to regenerate the skin with all appendages, and they apparently already moved on to pigs, it will probably take more time on pigs because pig skin is probably different and more complex than rats, specially if it works partially..
Damn.. I would love to recieve more Verteporfin news..
3 minutes ago, De Rerum Natura said:Tests on rats took around 90 days to regenerate the skin with all appendages, and they apparently already moved on to pigs, it will probably took more time on pigs because pig skin is probably different and more complex than rats, specially if it works partially..
Damn.. I would love to recieve more Verteporfin news..
How can we get information from Michael Longaker? If we ask him about vertoporfin, will he answer?
31 minutes ago, Diamond9199 said:How can we get information from Michael Longaker? If we ask him about vertoporfin, will he answer?
I have no idea.. If you manage to get in contact with him through e-mail, he will probably answer.
I bet another surgeons and docs are already trying to use Verteporfin off-label at this very moment, but its too early to attest any efficacy, even if docs are using it offlabel by now
Yeah there isnt much news, but thatspartially because there were so many articles about regeneration and premature assumptions that not manycomprehend just how different this is.
Anyways its only been a month since the news broke out. So..pigs maybe I would say end of summer for any research to be published. If that comes out positive enough.. that would be insane.
You can always email his Stanford address. Dont know if hell entertain you though.
22 hours ago, De Rerum Natura said:I have no idea.. If you manage to get in contact with him through e-mail, he will probably answer.
I bet another surgeons and docs are already trying to use Verteporfin off-label at this very moment, but its too early to attest any efficacy, even if docs are using it offlabel by now
What about micro coring? Is there any news about it?
21 hours ago, Scars4Life said:Yeah there isnt much news, but thatspartially because there were so many articles about regeneration and premature assumptions that not manycomprehend just how different this is.
Anyways its only been a month since the news broke out. So..pigs maybe I would say end of summer for any research to be published. If that comes out positive enough.. that would be insane.
You can always email his Stanford address. Dont know if hell entertain you though.
vertoporfin.is this drug sold in pharmacies and can it be used?
Here's an interesting find ;
https://sec.report/Document/0001193125-20-314600/
"Directional Skin Tightening RoboCor Tighten skin through dermal micro-coring and directional compression during healing Remove up to 15% of skin in an area through excising hundreds of <1mm diameter dermal cores Apply compression during healing Results: Directional skin tightening without scarring Non-surgical skin tightening of 10-15% per treatment Initial target indications: upper arm lift, necklift, facelift, scars, stretchmarks, cellulite Anticipate ability to offer upgrade for each different indication at minimal COGS increase Consumable for each procedure"
5 hours ago, David4bay said:Here's an interesting find ;
https://sec.report/Document/0001193125-20-314600/
"Directional Skin Tightening RoboCor Tighten skin through dermal micro-coring and directional compression during healing Remove up to 15% of skin in an area through excising hundreds of <1mm diameter dermal cores Apply compression during healing Results: Directional skin tightening without scarring Non-surgical skin tightening of 10-15% per treatment Initial target indications: upper arm lift, necklift, facelift, scars, stretchmarks, cellulite Anticipate ability to offer upgrade for each different indication at minimal COGS increase Consumable for each procedure"
Lets see before after
48 minutes ago, Miro said:Lets see before after
I'd like to see myself but I doubt all these companies would go all in on the tech if it doesn't work. The paper I showed here that talked about reducing fibrosis after each treatment was okay for me though. I'm only waiting for the release as I'm personallyconvinced it'll work for my type of scarring.
20 minutes ago, David4bay said:I'd like to see myself but I doubt all these companies would go all in on the tech if it doesn't work. The paper I showed here that talked about reducing fibrosis after each treatment was okay for me though. I'm only waiting for the release as I'm personallyconvinced it'll work for my type of scarring.
Lets hope you re right but we all know how they promise and how they deliver , i remember when first full ablation laser CO2 were coming in 90 s , they promised miracles , all scars gone , rest is history
3 hours ago, Scarcure said:
Another technology "avaiable" but 5 years awaysometimes i feel that we are retreating instead of progressing in terms of regulations.
6 minutes ago, De Rerum Natura said:Another technology "avaiable" but 5 years awaysometimes i feel that we are retreating instead of progressing in terms of regulations.
I feel that also , but logically it would seem that skin regeneration will occur within 10 to 15 years .... that's how i feel.
Instead of regenerating new skin ......have a camera map you skin and find every pore on the scarring area and then print out a thin mask that you apply over the scarring area so the pores can breathe. It might work on woman but guys with facial hair might create a problem.It would be challenging but it would be better than trying to regenerate new skin which never be done.Our bodies evolved over millions of years and changing the way our bodies evolved in a matter of years may never happen.
On 6/2/2021 at 10:16 PM, nikkigirl said:Instead of regenerating new skin ......have a camera map you skin and find every pore on the scarring area and then print out a thin mask that you apply over the scarring area so the pores can breathe. It might work on woman but guys with facial hair might create a problem.It would be challenging but it would be better than trying to regenerate new skin which never be done.Our bodies evolved over millions of years and changing the way our bodies evolved in a matter of years may never happen.
I'm not sure it's wise to "print" skin on a scar, there's a reason you debride scarred skin before a skin transplant. You always need a fresh wound bed.
And the because the body has evolved one way doesn't mean it can't be coerced to negate a biological endpoint, take the mRNA vaccines, they trick your body to produce the spiked proteins of covid-how much so can't they map the different cell environments and cell type interactions to tailor a process that guides skin to regenerate. Take axolotls and other regenerative amphibians, their mature cells revert back to stem cells at the point of injury and regrow back into the original organ. Funny enough some scientists say even if we get to complete regeneration it would be very energy intensive to grow back an arm and will take 20 years atleast(not bad in my view than having no arm regenerate), a face, chest , etc would probably take a few months or weeks. I'm not hopeful for a regenerative procedure outside of 300 years into the future to be realistic. I hope I'm wrong but that's what I think. And then micro-coring can only help for leveled or not too deep scars in my opinion but time will tell as a lot of companies are creating their own techniques(recross, cytrellis,sperry-bio,Venus etc). Live your best lives guys, everyone is dealt a bad hand at some point.
Just to clarify one thing about Verteporfin
WHS - Transgenic Inhibition Of Engrailed-1 Results In Endogenous Postnatal Skin Regeneration
"CONCLUSIONS:Together, these data support that verteporfin promotes wound regeneration specifically through its effects on fibroblast YAP signaling. Furthermore, they suggest thatEn-1is a mechanoresponsive master regulator of fibroblast activation; accordingly, ablation ofEn-1signaling, either indirectly (YAP inhibition) or directly (DT ablation), is sufficient to trigger true wound regeneration. Our findings have translational implications as they suggest that mammalian regenerative potential might be regained in postnatal life if the dominant, mechanically-driven propensity for fibrosis can be averted."
Verteporfin wasnt used by accident, they already knew it was a YAP, EN1 inhibitor
There is a list of several other drugs that can inhibit YAP. Why nobody is talking about this?
DT ablation mentioned on the text is Diphteria Toxin and can also trigger scarless wound bed
12 minutes ago, De Rerum Natura said:Just to clarify one thing about Verteporfin
WHS - Transgenic Inhibition Of Engrailed-1 Results In Endogenous Postnatal Skin Regeneration
"CONCLUSIONS:Together, these data support that verteporfin promotes wound regeneration specifically through its effects on fibroblast YAP signaling. Furthermore, they suggest thatEn-1is a mechanoresponsive master regulator of fibroblast activation; accordingly, ablation ofEn-1signaling, either indirectly (YAP inhibition) or directly (DT ablation), is sufficient to trigger true wound regeneration. Our findings have translational implications as they suggest that mammalian regenerative potential might be regained in postnatal life if the dominant, mechanically-driven propensity for fibrosis can be averted."
Verteporfin wasnt used by accident, they already knew it was a YAP, EN1 inhibitor
There is a list of several other drugs that can inhibit YAP. Why nobody is talking about this?
DT ablation mentioned on the text is Diphteria Toxin and can also trigger scarless wound bed
Yeah I was reading more and more about this stuff. Havent had time to post anything, but it is seriously frustrating to see the lack of coverage and enthusiasm.
The discovery that Longaker and his team made really wasnt about verteporfin, it was aboutYAP and Engrailed-1, andtheres papers dating back a few years. From what I remember they already had mice that were bred with inhibited YAP and produced regeneration, the trick was finding a wayto deliver those results to a normal mouse.
Verteporfin was just one drug they chose to validatetheir findings, thats the accident portion of the story, they couldve went with any other drug. Nowit looks like theyre validating that just about any drug with those inhibiting propertieswill do.
The point is this is like stupid mind-blowingnews regarding mammalianregeneration. But.. nobody cares.
Waiting for pig results.
9 hours ago, De Rerum Natura said:Just to clarify one thing about Verteporfin
WHS - Transgenic Inhibition Of Engrailed-1 Results In Endogenous Postnatal Skin Regeneration
"CONCLUSIONS:Together, these data support that verteporfin promotes wound regeneration specifically through its effects on fibroblast YAP signaling. Furthermore, they suggest thatEn-1is a mechanoresponsive master regulator of fibroblast activation; accordingly, ablation ofEn-1signaling, either indirectly (YAP inhibition) or directly (DT ablation), is sufficient to trigger true wound regeneration. Our findings have translational implications as they suggest that mammalian regenerative potential might be regained in postnatal life if the dominant, mechanically-driven propensity for fibrosis can be averted."
Verteporfin wasnt used by accident, they already knew it was a YAP, EN1 inhibitor
There is a list of several other drugs that can inhibit YAP. Why nobody is talking about this?
DT ablation mentioned on the text is Diphteria Toxin and can also trigger scarless wound bed
What do you mean by DT ablation mate ?
13 hours ago, Scars4Life said:Yeah I was reading more and more about this stuff. Havent had time to post anything, but it is seriously frustrating to see the lack of coverage and enthusiasm.
People saw so many disapointment within years , that are just cautious. I am following this and i wonder how it turns out, but i keep my expectations low.
Winlevi, or clascoterone cream 1%, is a new acne-fighting topical medication that was FDA-approved in August 2020 for use in 2021 for the treatment of acne vulgaris. ... "The generic name is clascoterone and it is offered as a cream that inhibits the effects of hormones on oil production and inflammation.
Are there any treatmentsthat existcurrently that can get at least close to no visible scars? Like even if the scar tissue is still slightly there underneath the surface, is it possible to make the scars basically not visible to the human eye so the skin just looks normal? I just read a study someone posted on here talking about patients who went from having moderate scarring to no scars at all and some who just ended up with flat red marks aka PIE,and the improvement held up even a year after treatment.I havent started getting treatments yet, but Im about to with Dr. Rullan.
21 hours ago, Ziggystardust72 said:Are there any treatmentsthat existcurrently that can get at least close to no visible scars? Like even if the scar tissue is still slightly there underneath the surface, is it possible to make the scars basically not visible to the human eye so the skin just looks normal? I just read a study someone posted on here talking about patients who went from having moderate scarring to no scars at all and some who just ended up with flat red marks aka PIE,and the improvement held up even a year after treatment.I havent started getting treatments yet, but Im about to with Dr. Rullan.
What treatment are you getting with Dr. Rullan?
31 minutes ago, Scarfreelap said:What treatment are you getting with Dr. Rullan?
I havent set up the appointment yet but when I had the consultation he recommended the combinationtreatment with subcision, cross, erbium, and v-beam. Im honestly kinda apprehensive about getting all of these harsh treatments in one go bc I have extremely sensitive reactive rosacea skin, but they said it would be fine. Have you had treatment with Rullan?
1 hour ago, Ziggystardust72 said:I havent set up the appointment yet but when I had the consultation he recommended the combinationtreatment with subcision, cross, erbium, and v-beam. Im honestly kinda apprehensive about getting all of these harsh treatments in one go bc I have extremely sensitive reactive rosacea skin, but they said it would be fine. Have you had treatment with Rullan?
Ak ok! No I haven't... Unfortunately, I don't have any experience with any of those treatments.
On 5/17/2021 at 10:10 AM, Scarcure said:I wonder if this drugVerteporfin can be used on the eyelids , i have terrible skin texture on my eyelids due to dermatitis
I've had good success with 70% DMSO cream for dermatitis on the eyelid. 4days of application and it was 100% goneand hasn't come back - this was after 6 months of trying every topical anti fungal/anti bacterial cream I could find.