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https://www.zmescience.com/science/scientists-heal-wounds-without-scar-tissue/
Ive seen countless drugs and research studies through the yearscoming and going, but nothing has given me renewed hope anywhere near to the extend thatthis finding does.
Everything seems to point to that this is the miracle curethat weve all been waiting for. The issue was identified and directly tackled, and the results are shocking by any metric I canconceive,not to mention that theyrecycledan existingFDAapproved and stress tested drug.
Theyre not teasing us with anything, its not a multi million dollar venture ready to sell us the next product iteration in scar revision, this is the rawest form of a biological discovery, and validatedthrough the use of existing materials.
Is everyone just sleeping, whats with thelack of enthusiasm?
If Im being overly optimistic or am missing somethingplease keep me honest.
On 5/3/2021 at 2:08 AM, Scars4Life said:https://www.zmescience.com/science/scientists-heal-wounds-without-scar-tissue/
Ive seen countless drugs and research studies through the yearscoming and going, but nothing has given me renewed hope anywhere near to the extend thatthis finding does.
Everything seems to point to that this is the miracle curethat weve all been waiting for. The issue was identified and directly tackled, and the results are shocking by any metric I canconceive,not to mention that theyrecycledan existingFDAapproved and stress tested drug.
Theyre not teasing us with anything, its not a multi million dollar venture ready to sell us the next product iteration in scar revision, this is the rawest form of a biological discovery, and validatedthrough the use of existing materials.
Is everyone just sleeping, whats with thelack of enthusiasm?
If Im being overly optimistic or am missing somethingplease keep me honest.
Probably because several users here were so crushed by past expectations thateven if this is the real cure it will take a while for us to process and came back to earth.
I try to hold my expectations aways, even tho its real, and it works, the real question is; How WE can benefit from it?
Alot of treatments, alot of devices, alot of promises, always in the grudge of FDA taking YEARS to approval.. Its always about further studies, trials,etc etc etc..
Part of this forum session is literally cursed and depressed for so many years that we arent able anymore to hype and deposit further expectations.. We had enough disappoitment through all these years...
Only if i can imagine myself scar-free.. Looking in the mirror, and knowing that im free from it.. It will be the day ill collapse in tears of true relief and happiness.Like liftingthe weight ofan entire multiverse of suffering from my shoulders.
Old users and even new users here are so discouraged and traumatized that even if this is really THE BOMB it will take a while for us to process.
Its always about FDA and human trials, plus, we are in a middle of a pandemic. Everything seems to be slower now.
This drug seems to be administrated for decades with safety, why the need to queue its efficacy for so much time?
28 minutes ago, De Rerum Natura said:Probably because several users here were so crushed by past expectations thateven if this is the real cure it will take a while for us to process and came back to earth.
I try to hold my expectations aways, even tho its real, and it works, the real question is; How WE can benefit from it?
Alot of treatments, alot of devices, alot of promises, always in the grudge of FDA taking YEARS to approval.. Its always about further studies, trials,etc etc etc..
Part of this forum session is literally cursed and depressed for so many years that we arent able anymore to hype and deposit further expectations.. We had enough disappoitment through all these years...Only if i can imagine myself scar-free.. Looking in the mirror, and knowing that im free from it.. It will be the day ill collapse in tears of true relief and happiness.Like liftingthe weight ofan entire multiverse of suffering from my shoulders.
Old users and even new users here are so discouraged and traumatized that even if this is really THE BOMB it will take a while for us to process.
Its always about FDA and human trials, plus, we are in a middle of a pandemic. Everything seems to be slower now.
This drug seems to be administrated for decades with safety, why the need to queue its efficacy for so much time?
I strongly sympathize with this sentiment.
If you were to look at any of my past postings I am one ofthe first to tell everyone to please stop doing deep dive research into these topics and live life. But I did say to do the occasional glancing around to see what's new.. and this is definitely new.
I don't think I've ever posted any excitement about any treatment on this forum, everything up until this point, elastagen, microcoring etc.. (dont even get me started with fraxel), I've criticized as not tackling the root cause, they were simply a corrective response. Which is not the case with this approach.
Now I'll grant this. It worked on Mice. Will it work on humans? It's possible that it won't.
But if it doesn't.. that will reveal that there is a big fundamental difference between the skin of a mouse and that of humans. It'll be a pretty big blow too, as that finding itself can put breaks on future developments.
In the meantime they're moving to testing it on larger animals, aka pigs, which have a much closer skin structure to ours. Will take a couple months probably, past the summer, then based on those results they'll push for human trials, which does as of now look like it could take off by end of the year. This is medicine, so all precautions have to be taken, even if the drug appears to be safe.
Also, since this is an existing drug already being used for years without any major side effects, it doesn't stop any other scientist or foreign entitiesfrom replicating the tests that were conducted. This was a scientific discovery into the mechanisms of scar formation, not a development of a proprietary treatment, there's no patent on injecting a readily available drug wherever you feel like it, in theory if you're bold enough and have the know how, you can try it yourself.
If validated by other entities, treatments may be available in other parts of the world way before the FDA has anything to say about it.
I understand the skepticism, I am one of the worst skeptics, but through all the years of experience in this field I also recognize when something completely radical and so simplistic is presented that it just shakes my foundation.
Scars are caused by mechanical tension, and when that tension is removed there is no scar, is such an insane statement that it just must be true, or else it was simply an accident and the mice they were testing on were genetically engineered, or someone swapped them lol.
2 hours ago, Scars4Life said:
I strongly sympathize with this sentiment.
If you were to look at any of my past postings I am one ofthe first to tell everyone to please stop doing deep dive research into these topics and live life. But I did say to do the occasional glancing around to see what's new.. and this is definitely new.
I don't think I've ever posted any excitement about any treatment on this forum, everything up until this point, elastagen, microcoring etc.. (dont even get me started with fraxel), I've criticized as not tackling the root cause, they were simply a corrective response. Which is not the case with this approach.
Now I'll grant this. It worked on Mice. Will it work on humans? It's possible that it won't.
But if it doesn't.. that will reveal that there is a big fundamental difference between the skin of a mouse and that of humans. It'll be a pretty big blow too, as that finding itself can put breaks on future developments.
In the meantime they're moving to testing it on larger animals, aka pigs, which have a much closer skin structure to ours. Will take a couple months probably, past the summer, then based on those results they'll push for human trials, which does as of now look like it could take off by end of the year. This is medicine, so all precautions have to be taken, even if the drug appears to be safe.
Also, since this is an existing drug already being used for years without any major side effects, it doesn't stop any other scientist or foreign entitiesfrom replicating the tests that were conducted. This was a scientific discovery into the mechanisms of scar formation, not a development of a proprietary treatment, there's no patent on injecting a readily available drug wherever you feel like it, in theory if you're bold enough and have the know how, you can try it yourself.
If validated by other entities, treatments may be available in other parts of the world way before the FDA has anything to say about it.
I understand the skepticism, I am one of the worst skeptics, but through all the years of experience in this field I also recognize when something completely radical and so simplistic is presented that it just shakes my foundation.
Scars are caused by mechanical tension, and when that tension is removed there is no scar, is such an insane statement that it just must be true, or else it was simply an accident and the mice they were testing on were genetically engineered, or someone swapped them lol.
This can take years , and it sounds too goodto be true frankly , dont expect some results from this in5-10 years from now , i remember when there was first word out bout full ablation CO2 lasers , miracle , life changer , and it sounded promising , science behind it sounds reasonable , wellrest is history
If this drug really works we will know by anecdotal evidence way before any possible study or trial
Alot of guinea pig guys would test it on themselves and create their own protocols way before any conclusion taken by studies...
(Me included)
The real question is, taken it orally would prevent the formation of fibrotic tissue? How exact they conducted this on the rats?
If we were in 2013-2015when this forum was extremly active ppl would be sending e-mails and already trying to understand if this is real or not, unfortunately, this forum section is dead for a while now..
38 minutes ago, De Rerum Natura said:If this drug really works we will know by anecdotal evidence way before any possible study or trial
Alot of guinea pig guys would test it on themselves and create their own protocols way before any conclusion taken by studies...
(Me included)
The real question is, taken it orally would prevent the formation of fibrotic tissue? How exact they conducted this on the rats?If we were in 2013 - 2015 when this forum was extremly active ppl would be sending e-mails and already trying to understand if this is real or not, unfortunately, this forum section is dead for a while now..
"A 20-year-old drug, verteporfin, already on the market as an intravenous treatment for macular degeneration, can prevent scarring if it is injected at the edge of a wound."
There you go..
Now I don't advocate anyone to do this, and it doesn't really specify whether it was done once, daily, or weekly, so definitely hold out.
I know that there are some retards in these forums talking about using sandpaper, so I feel like some one is potentially desperate/crazy enough to try it.
And yes back in the day we used to have members who were connected to different people within the field and could get some quick feedback. If I was younger with a lot of free time I would probably try to get some answers, but I no longer have that drive, nor do I feel like I can influence anything. But it would be nice to know more about this.
20 minutes ago, Scars4Life said:
"A 20-year-old drug, verteporfin, already on the market as an intravenous treatment for macular degeneration, can prevent scarring if it is injected at the edge of a wound."
There you go..
Now I don't advocate anyone to do this, and it doesn't really specify whether it was done once, daily, or weekly, so definitely hold out.
I know that there are some retards in these forums talking about using sandpaper, so I feel like some one is potentially desperate/crazy enough to try it.
And yes back in the day we used to have members who were connected to different people within the field and could get some quick feedback. If I was younger with a lot of free time I would probably try to get some answers, but I no longer have that drive, nor do I feel like I can influence anything. But it would be nice to know more about this.
Like u said previously, even tho it doesnt work on humans, these results, even in mice, are absurd.
Scientists have been trying to replicate and grow hair on mice for decades from now. This rat just regenerated a skin with full functionality and hair follicles, thats remarkable even for a animal study
Heres the research paper.
https://drive.google.com/file/d/148KushWO1rAZj_zixgkhiabyBMPascAi/view?usp=drivesdk
10 hours ago, Scars4Life said:Heres the research paper.
https://drive.google.com/file/d/148KushWO1rAZj_zixgkhiabyBMPascAi/view?usp=drivesdk
Thanks for providing the research
Another problem related to this drug is that it seem to be EXTREMLY expensive.
https://www.drugs.com/price-guide/visudyne
15mg shot of verteporfin is 1800USD
1 hour ago, De Rerum Natura said:Thanks for providing the research
Another problem related to this drug is that it seem to be EXTREMLY expensive.
https://www.drugs.com/price-guide/visudyne
15mg shot of verteporfin is 1800USD
Well, according to that isotretinoin cost $360, Verteporfin is expensive, but can be obtanaided for the third part of this outside USA.
https://en.wikipedia.org/wiki/Verteporfin#Potential_against_scarring
Wikipedia has updated its article on verteporfin
"Potential against scarring
Verteporfin is mentioned as a marketed drug having effects sought during current research into elimination of scarring in the skin tissue healing process among humans".
It would be very good to have more information about this drug
It has so much potential and yet still looks so underground
An interesting past couple of weeks.
Mayo Clinic preclinical discovery triggers wound healing, skin regeneration Mayo Clinic News Network
Research paper
Now this one seems to be a bit more.. iffy.
But it does say it restored normal skin architecture with all the bells and whistles, (hair, sweat glands etc), and looks like it was achieved in more than one kind of animal. It also looks like they are ready to start clinical trials.
It does appears that it's their own product though, but it doesn't seem to be something as overly complicated as elastagen for example.
Anyways, what do you think..
18 hours ago, Scars4Life said:An interesting past couple of weeks.
Mayo Clinic preclinical discovery triggers wound healing, skin regeneration Mayo Clinic News Network
Research paper
Now this one seems to be a bit more.. iffy.
But it does say it restored normal skin architecture with all the bells and whistles, (hair, sweat glands etc), and looks like it was achieved in more than one kind of animal. It also looks like they are ready to start clinical trials.
It does appears that it's their own product though, but it doesn't seem to be something as overly complicated as elastagen for example.
Anyways, what do you think..
This study looks way more technical and harder to understand than the other
nonetheless.. All of this came just in april this year.. Im very sad that the hype is gone and this forum looks so dead
Im a lurker since 2011 when i started to develop acne in my late teens..
Created my account in 2012.. This section was so alive for so much time.. There are literally no other discussion forum about scars that im aware of I would love to hear more expertise opinions here and more discussion, specially now that we had so many good news with potential solutions
On 5/5/2021 at 4:58 AM, De Rerum Natura said:Thanks for providing the research
Another problem related to this drug is that it seem to be EXTREMLY expensive.
https://www.drugs.com/price-guide/visudyne
15mg shot of verteporfin is 1800USD
Well, not really. If you consider that scar sufferers spend, on average, $10,000 for various useless treatments that deliver mediocre result, this might be a real bargain. At least, you have a real shot here (if proven to be as effective as touted).
1 hour ago, Sirius Lee said:Well, not really. If you consider that scar sufferers spend, on average, $10,000 for various useless treatments that deliver mediocre result, this might be a real bargain. At least, you have a real shot here (if proven to be as effective as touted).
It is a tad expensive but luckily money is not an issue for me.
Honestly if there™s a barn owner here, I™ll sponsor a dosage of this drug if you can inject it into your pig..
8 hours ago, nikkigirl said:Maybe you all can go through life wearing a mask due to covid or pretend to be a masked singer and go around town masked.Problem solved!
I can understand that u might have lost your hope on future treatments and think that what we are discussing here are awaste of time.But this topic is exactly to debate about scarless healing you believing it or not, it being a reality or not.Whats the point to make this kind of post? What does this add to the topic? I dont expect a reasonable answer, nor i will feed any possible troll purpose arguing witha potential answer.Iwill just ask to respect the theme of the topic.And if you dont have literally nothing to add, and specially if you just have things to subtract, dont leave it here, please. This topic has lost enoughcredibility due to posts like this.
This New York Times article about the Stanford researchis interesting.
https://www.nytimes.com/2021/04/22/health/surgery-scar.html
Especially the statements at the end where he talks aboutthe fate ofexisting scars.
Alsoanotherdoctorsdoubt that other doctors will even wait for FDA approval to use it.
I dont think weve ever had anything so within reach.. provided that it works of course.
Dr. Longaker remembers the moment. Holy guacamole, he said. The healed wounds looked just like normal skin. They were the same under the microscope. They grew hair. They had oil glands.
His imagination soared. He might be able to prevent scars with a few quick injections of verteporfin. And there was no reason to think he couldnt go even farther. A patient who had a disabling and disfiguring scar could go to a surgeon who could dab the scar with lidocaine to numb the skin, cut open the scar, inject verteporfin around the edges, and close the wound. Would it reheal without the scar?
That could change their lives, Dr. Longaker said.
Dr. Spector said he doubted all doctors would wait until F.D.A. approval if early clinical data supported the laboratory studies. Some are sure to jump ahead and try it because there is nothing now to stop scarring.
Dr. Longaker hopes doctors hold off. Clinical trials must come first, he stressed, and safety must be assured.
I get it, he said. No one is more excited than me.
To be honest, he added, Ive been waiting for 34 years. I would love to use it. This is a big deal. But that doesnt mean we shortcut the process.
6 hours ago, De Rerum Natura said:I can understand that u might have lost your hope on future treatments and think that what we are discussing here are awaste of time.But this topic is exactly to debate about scarless healing you believing it or not, it being a reality or not.Whats the point to make this kind of post? What does this add to the topic? I dont expect a reasonable answer, nor i will feed any possible troll purpose arguing witha potential answer.Iwill just ask to respect the theme of the topic.And if you dont have literally nothing to add, and specially if you just have things to subtract, dont leave it here, please. This topic has lost enoughcredibility due to posts like this.
You know and i know...nothing new has been done in years for scarless healing.I have not seen anything in the news for years to help acne scars. Somebody will gladly take your money....i know...they stole 35k from me. Keep dreaming.......i speak the truth and have been here for years. You want to hold on to the dream that you can do something about scars but after you keep chasing that dream...and it never happens....your life will be over.
On 5/8/2021 at 3:16 PM, Scars4Life said:This New York Times article about the Stanford researchis interesting.
https://www.nytimes.com/2021/04/22/health/surgery-scar.html
Especially the statements at the end where he talks aboutthe fate ofexisting scars.
Alsoanotherdoctorsdoubt that other doctors will even wait for FDA approval to use it.I dont think weve ever had anything so within reach.. provided that it works of course.
Dr. Longaker remembers the moment. Holy guacamole, he said. The healed wounds looked just like normal skin. They were the same under the microscope. They grew hair. They had oil glands.
His imagination soared. He might be able to prevent scars with a few quick injections of verteporfin. And there was no reason to think he couldnt go even farther. A patient who had a disabling and disfiguring scar could go to a surgeon who could dab the scar with lidocaine to numb the skin, cut open the scar, inject verteporfin around the edges, and close the wound. Would it reheal without the scar?
That could change their lives, Dr. Longaker said.
Dr. Spector said he doubted all doctors would wait until F.D.A. approval if early clinical data supported the laboratory studies. Some are sure to jump ahead and try it because there is nothing now to stop scarring.
Dr. Longaker hopes doctors hold off. Clinical trials must come first, he stressed, and safety must be assured.
I get it, he said. No one is more excited than me.
To be honest, he added, Ive been waiting for 34 years. I would love to use it. This is a big deal. But that doesnt mean we shortcut the process.
Its Impressive and if anyone would truly grasp how big this news is then its gonna be Dr. Longaker seeing he has dedicated nearly 4 decades to scarring.
I read another article with comments from an outside Dr who said he had goosebumps reading over the findings.
Whether it works on us like it does for mice we just need to wait and see. It feels like its on a knifes edge tbh but its a huge win for us that the drug already exists and we can skip all the FDA crap.
This forum has become so skeptical and depressing over the years some people just wont even accept this news, they need to see the before and after of a real person that clinches the deal probably. I can understand that given so many let downs.
On 5/8/2021 at 9:09 PM, nikkigirl said:You know and i know...nothing new has been done in years for scarless healing.I have not seen anything in the news for years to help acne scars. Somebody will gladly take your money....i know...they stole 35k from me. Keep dreaming.......i speak the truth and have been here for years. You want to hold on to the dream that you can do something about scars but after you keep chasing that dream...and it never happens....your life will be over.
So whatdo you make of this recent news?..you were optimistic 6 months ago if I remember right.