Acne.org Products
Happy new year I wish all of us to get rid of acne scars and stretch marks in 2021 with the help of micro-coring
Guys after abbvie acquired Elastagen, we didn't even heard of it . Is it coming to the market or not
On 1/3/2021 at 9:19 AM, Anushkaaa said:Guys after abbvie acquired Elastagen, we didn't even heard of it . Is it coming to the market or not
food for thought, how tropoelastin, aninjectablematerial, will remove scars, stretch marks, acne scars without removing the flawfirst, even if it has regenerative capacity, the first thing you have to do is to remove the scar tissue..
On 1/4/2021 at 8:52 PM, damnBOY said:food for thought, how tropoelastin, aninjectablematerial, will remove scars, stretch marks, acne scars without removing the flawfirst, even if it has regenerative capacity, the first thing you have to do is to remove the scar tissue..
The thing with stretchmarks is , that unlike other scars, it's just areas where the dermis has cracked up. There is no point in removing the scar tissue here because technically there is no tissue here. Why elastagen was making news is because their products will fill these empty tissue spaces with their material via elastogenesis.second thing ,when a scar is formed , if the area is large u cannot remove the entire tissue. Microcoring can definitely help in removing them , but we cant effectively get rid of stretch marks thru it as it's going to remove healthy tissue beneath it as well everytime we go for scar tissue removal. The only thing that works here is regeneration ( which is not possible as for now) and according to people elastagen which will give us back the elastin fibres that cannot be generated back by lasers.
BTW my main question was , do u have any update regarding the tropoelastin injections? I don't see it in abbvies pipeline. I mailed abbvie and they said , it's a product under Allergan and I should contact Allergan. But Allergan doesn't respond.
I sent a mail to Rob Daniels about the JDD online article since many people here would like to see how good this thing would be on stretch marks, and he was kind enough to give me an answer. I'm sure he wouldn't mind as it's not anything secret or anything, so I'll share that with you guys:
Me:
"Dear ///
I do wonder, however, if the public will have an opportunity to see a "before/after" set of pictures, which would show exactly how efficient this product is when it comes to repariring/fixing skin affected by stretch marks? I've read a very interesting discussion on the acne.org forum, about elastagen, and it seems that many people were wondering the same thing?
Many thanks for the enquiry, and I appreciate your comments on the JDD article.
Your question is of course very relevant and were aware lots of people have the same interest.
The JDD paper is the first of a series of planned publications on the Elastagen product this one focussed on preclinical studies on the properties / mechanisms of action of the product.
There will shortly be a clinical opinion paper on the importance of elastin to the skin, this should be published in a couple of months. This will be followed later this year with two publications of the clinical data from our stretch mark and acne scar studies. These latter two papers will indeed include before/after photographs and clinical safety and efficacy data so please keep a look out for these!
I hope youre keeping well and thanks again for your interest.
Best regards,
Rob"
TLDR: we'll get before/after picture comparisons this year.
On 1/10/2021 at 3:34 PM, Anushka a said:The thing with stretchmarks is , that unlike other scars, it's just areas where the dermis has cracked up. There is no point in removing the scar tissue here because technically there is no tissue here. Why elastagen was making news is because their products will fill these empty tissue spaces with their material via elastogenesis.second thing ,when a scar is
, if the area is large u cannot remove the entire tissue. Microcoring can definitely help in removing them , but we cant effectively get rid of stretch marks thru it as it's going to remove healthy tissue beneath it as well everytime we go for scar tissue removal. The only thing that works here is regeneration ( which is not possible as for now) and according to people elastagen which will give us back the elastin fibres that cannot be generated back by lasers.
BTW my main question was , do u have any update regarding the tropoelastin injections? I don't see it in abbvies pipeline. I mailed abbvie and they said , it's a product under Allergan and I should contact Allergan. But Allergan doesn't respond.
unfortunately is not that simple strech marks has dermis, but its structure is different from normal skin , its not scar tissue but is similar to it, collagen is oriented in one direction (third pic)
15 hours ago, damnBOY said:unfortunately is not that simplestrech marks has dermis, butits structure is different from normal skin , its not scar tissue but is similar to it, collagen is oriented in one direction (third pic)
yeah.I did not understand why it is impossible to remove the skin on the stretch marks
What worries me most is doesmicro-coring device has special attachments for point work with the skin.I do not think that what was on the video is suitable for stretch marks, rather for big areas such face
With what I understand from the process the larger the area of skin treated the greater skin tightening you can have, so it may not matter you're hitting normal skin as it'll remove whatever you're looking to remove by shrinking the whole area, so surface level scars and stretch marks recede(or are removed) with each treatment.
On 20/01/2021 at 1:56 AM, David4bay said:With what I understand from the process the larger the area of skin treated the greater skin tightening you can have, so it may not matter you're hitting normal skin as it'll remove whatever you're looking to remove by shrinking the whole area, so surface level scars and stretch marks recede(or are removed) with each treatment.
Recros medica claim Microcoring will remove a tattoo in 4-5 treatments spaced 1 month apart.
Im interested in getting Microcoring when its available for scars. Im not sure about scarring at the Sub cutaneous layer, as in will healthy dermis that is closing in over the top of the damaged deeper layers. Or will it be able to core deep enough that it wont matter. I think I read somewhere it can core 6mm deep.
6 hours ago, Sniffy said:Recros medica claim Microcoring will remove a tattoo in 4-5 treatments spaced 1 month apart.
Im interested in getting Microcoring when its available for scars. Im not sure about scarring at the Sub cutaneous layer, as in will healthy dermis that is closing in over the top of the damaged deeper layers. Or will it be able to core deep enough that it wont matter. I think I read somewhere it can core 6mm deep.
With the way I see it you're getting reduction of scar tissue(damaged skin) and also skin tightening that will be helpful to even out the skin. If the scar doesn't involve too much fat loss you may end up with slightly less of a depression in that area. Other treatments like microneedling may also help lift up the area more(who knows if the two micro procedures will be the key to lift skin totally over time) That's for acne scarring.
Fractional injury of skin actually replaces a part of scarred skin with healthy skin, it's just that the dermis has lost the info(genetically speaking) in the area to make normal skin through it's ECM so the scar will still print out scar tissue like a plank of wood to cover a hole in a cement. But when the scarred skin itself is removed fractionally and the injury is small enough it heals by contracting without scars. Reducing the scar over time.
For regular injury scars like mine, it's flat, I have normal sensation there and can see sebaceous filaments dotting the scarred skin(with pores) so the scar is surface level(got it from a water burn), microcoring should be able to get rid of the area over time. Nose scarring may be another different issue as the nose is not really skin but cartilage. When it's out we'll see how the device will be used on all areas of skin going forward. Keloid scars are a danger zone as they are recurrent and spread easily if re-injured. Hopefully it comes out this year and is both cheap enough and easy enough to do without problems.
2 hours ago, ParisN said:I've received an email response (I have been added to their mailing list to receive date of release) doesn't seem too far away actually!
Cytrellis?
Theyreplied me today saying they will update as soon as they can. I guess they are just waiting for FDA to make a move now
3 hours ago, Sniffy said:Cytrellis?
Theyreplied me today saying they will update as soon as they can. I guess they are just waiting for FDA to make a move now
Yes from Cytrellis! I agree it's probably the FDA approvals which have been probably further delayed by COVID ... I wonder how much itwill influence scar treatment!
On 2/1/2021 at 11:51 AM, gantz said:Do they have a mailing list? How to subscribe to it?
Yes they can add you to their mailing list, email [email protected]
Hi Guys,
So according to this youtube video, Lifesprout went into clinical trials starting Q4 of 2020 and Q1 of 2021, however I wasn't able to find any public clinical trials for them on clinicaltrials.gov.When do they plan on coming to market? Are they in fact in clincial trials?
23 hours ago, yepitsmewee said:Hi Guys,
So according to this youtube video, Lifesprout went into clinical trials starting Q4 of 2020 and Q1 of 2021, however I wasn't able to find any public clinical trials for them on clinicaltrials.gov.When do they plan on coming to market? Are they in fact in clincial trials?
Hey, Ive contacted their team to find out. I will let you know if they respond.
Thank you @ParisN. I have contacted them several time and have not heard back.
In addition, do you guys know when Tempo Theraputics is going to start clinical trials for their MAP gel? I just read that they are taking the 510k route through the FDA and their product is a hydrogel that gets rid of scar tissue on new wounds.
I know it sucks,but, things seem to moving at a quicker pace than 4/5 years ago.
I have a good feeling about micro-coringreplacing a lot of the functions/ improving on the functions of laser/ surgical excision. It might not be an immediate magic solution but I think it will give people a lot of hope. It's a Rox Anderson/ MGH inventionand they've got a proven track record of their ideas gettingto market. Cryolipolysis being one of the most recent ones.
"Dr. Anderson, recognized for his research, has advanced the basic knowledge of human skin photobiology, drug photosensitization mechanisms, tissue optics and laser-tissue interactions. He conceived and developed many of the non-scarring laser treatments now widely used in medical care. These include treatments for birthmarks, microvascular and pigmented lesions, tattoos and permanent hair removal.Notably, Dr. Anderson coinvented the fractional laser treatment, which is useful for improving burn scars, and recently invented and developed new devices for wound grafting without scarring."
I think they said they'd sent the final application off to the FDA in October 2020. On the FDA website they said verdicts can take 8 months. So we'll know by summerif they were successful or failed.