nb2: http://elastagen.com /" rel="external nofollow"> https://web.archive.org/web/20190423230745/http://elastagen.com/

That's the original website of elastagen, I'd encourage you guys to take a look at it, especially the graph down below

12 minutes ago, lehran said:

nb2: http://elastagen.com /" rel="external nofollow"> https://web.archive.org/web/20190423230745/http://elastagen.com/

 

That's the original website of elastagen, I'd encourage you guys to take a look at it, especially the graph down below

Thank you.

Rejuvecross - maybe? These slides are old.

1 hour ago, BeneficialCell said:

Rejuvecross - maybe? These slides are old.

oh nice, good find, mostly seems to be about acne scars in rejuvecross's case?

@lehranYes, the slides are from 2018 so I can't guarantee things won't have changed since then. In the 2023-25 column they talk about a regenerative body filler which maybe interesting. It might be Elatsagen or it might be Histogen (they recentlybought exclusive rights toHistogen's future intellectual property, which includes some fascinatingstuff.)

https://www.histogen.com/applications/matrix-regeneration/

1 hour ago, lehran said:

oh nice, good find, mostly seems to be about acne scars in rejuvecross's case?

Yes but this is all about situation when skin is intact on surface, its just missing volume underneath, but what about scarring when surface is damaged, thats the problem.

https://media.allergan.com/actavis/actavis/media/allergan-pdf-documents/labeling/strattice/str_ifu_121p0295i_t4.pdf

when elastagen is expected to hit the market

So , when does anyone think scarless healing , complete skin regeneration will occur ? i say this decade , at most 20 years ...

3 hours ago, Scarcure said:

So , when does anyone think scarless healing , complete skin regeneration will occur ? i say this decade , at most 20 years ...

The technology for nearly complete regeneration will likely come out soon. The problem for acne scars is that there isn't an open wound. The healing process has already played out. That makes it more difficult. I don't think there will be any procedure to completely remove acne scars within the next 10 years. If Elastagen works, it is initially being targeted for rolling scars and stretch marks. I'm not completely familiar with the approval process, but I'm guessing application towards boxcar and ice pick scars would require a new trial process

6 hours ago, Skin Pessimist said:

The technology for nearly complete regeneration will likely come out soon. The problem for acne scars is that there isn't an open wound. The healing process has already played out. That makes it more difficult. I don't think there will be any procedure to completely remove acne scars within the next 10 years. If Elastagen works, it is initially being targeted for rolling scars and stretch marks. I'm not completely familiar with the approval process, but I'm guessing application towards boxcar and ice pick scars would require a new trial process

Well it would stand to reason for the acne scar to regenerate is to create a wound on the damaged site , in other words cut out the acne scar and apply the regenerative gel or whatever the material would be , if Elastagen will work than the 80 to 90 percent improvement is pretty impressive.

6 hours ago, Skin Pessimist said:

The technology for nearly complete regeneration will likely come out soon. The problem for acne scars is that there isn't an open wound. The healing process has already played out. That makes it more difficult. I don't think there will be any procedure to completely remove acne scars within the next 10 years. If Elastagen works, it is initially being targeted for rolling scars and stretch marks. I'm not completely familiar with the approval process, but I'm guessing application towards boxcar and ice pick scars would require a new trial process

13 minutes ago, Scarcure said:

Well it would stand to reason for the acne scar to regenerate is to create a wound on the damaged site , in other words cut the acne scar and apply the regenerative gel or whatever the material would be , if Elastagen will work than the 80 to 90 percent improvement is pretty impressive.

@Scarcure I'm not sure it can work like that honestly, they'll have to figure out a way. But Skin Pessimist is right about elastagen: it's going to be aimed at stretch marks first and rolling scars (acne scars), but box scars and ice pick scars will need more work before fixing.

IIRC that's why many people were confused the last months about the application of tropoelastin for acne scars: it's not the same depending on the type of acne scar, meaning it will take more time for the aformentioned cases.

NB: in general, I remember them saying that more severe scarring might need more research, so it's quite likely that not all stretch marks, for example, will be treatable, if you get what I mean.

NB2: they WANT to fix hypetrophic scars as well, it's just gonna take more time as well, research-wise

7 minutes ago, lehran said:

 

 

@Scarcure I'm not sure it can work like that honestly, they'll have to figure out a way. But Skin Pessimist is right about elastagen: it's going to be aimed at stretch marks first and rolling scars (acne scars), but box scars and ice pick scars will need more work before fixing.

IIRC that's why many people were confused the last months about the application of tropoelastin for acne scars: it's not the same depending on the type of acne scar, meaning it will take more time for the aformentioned cases.

NB: in general, I remember them saying that more severe scarring might need more research, so it's quite likely that not all stretch marks, for example, will be treatable, if you get what I mean.

NB2: they WANT to fix hypetrophic scars as well, it's just gonna take more time as well, research-wise

Then how else could it possibly work ? if you can't make some kind of wound or incision on the damaged site then how else ? i really am confused here because what would the method be in order to regenerate the site to the original state of the skin to 80 to 90 percent in the first place ?.

I don't know how it will work for icepick scars/box scars, and I certainly don't know how it will work for hypertrophic scars. Just wait and see.

45 minutes ago, lehran said:

I don't know how it will work for icepick scars/box scars, and I certainly don't know how it will work for hypertrophic scars. Just wait and see.

One thing i do know , if we keep the faith we will see that complete skin regeneration will be a reality , science dictates this  

6 minutes ago, Scarcure said:

One thing i do know , if we keep the faith we will see that complete skin regeneration will be a reality , science dictates this  

You probably said that for the 100th time . Of course full scarless regeneration will happen at some point, but we don't know when. Could be a very long time before we completely get rid of any scarring process.

10 minutes ago, lehran said:

You probably said that for the 100th time . Of course full scarless regeneration will happen at some point, but we don't know when. Could be a very long time before we completely get rid of any scarring process.

50-60 years At least 

1 hour ago, Miro said:

50-60 years At least

I doubt that , if research is occurring now and we could potentially be getting a 80 to 90 percent reduction of scarring with Elastgen then it would stand to reason we be getting it sooner rather than later.

3 hours ago, Scarcure said:

I doubt that , if research is occurring now and we could potentially be getting a 80 to 90 percent reduction of scarring with Elastgen then it would stand to reason we be getting it sooner rather than later.

It is not regeneration. Anyway, doubt about 60 years too. But who knows...

ps

we even dont know how exactly treated stretch mark looks like. we cant be sure that it would be impressiveresult...

42 minutes ago, gantz said:

It is not regeneration. Anyway, doubt about 60 years too. But who knows...

 

ps

we even dont know how exactly treated stretch mark looks like. we cant be sure that it would be impressiveresult...

Pretty much. I'm eagerly waiting, but we just don't know exactly how good this is going to be visually. Let's wait and see.

I personally dont believe in this hype, but I hope i am wrong.

If theres any treatment that can reduce stretch marks 80% - 90% , then you got pretty much "cure" for acne scars too.

Stretchmarks are practicaly impossible to treat for medicine nowadays, theres literaly nothing that works on em, its very challenging skin condition, acne scars on the other hand can be treated and can be reduced 50% with combination of treatments and skilleddr.

I guess they ll come up with something that can reduce scars slightly better then treatments we have now and maybe with less possible side effects then laser etc.

If u want to get rid of scar, or correct it 90% which makes it practicaly invisible , u have to cut the scar tissue out and replace it with new skin / skin tissue and of course without forming new scar in healing process, that is just sci-fi nowadays

1 minute ago, Miro said:

I personally dont believe in this hype, but I hope i am wrong.

If theres any treatment that can reduce stretch marks 80% - 90% , then you got pretty much "cure" for acne scars too.

Stretchmarks are practicaly impossible to treat for medicine nowadays, theres literaly nothing that works on em, its very challenging skin condition, acne scars on the other hand can be treated and can be reduced 50% with combination of treatments and skilleddr.

I guess they ll come up with something that can reduce scars slightly better then treatments we have now and maybe with less possible side effects then laser etc.

If u want to get rid of scar, or correct it 90% which makes it practicaly invisible , u have to cut the scar tissue out and replace it with new skin / skin tissue and of course without forming new scar in healing process, that is just sci-fi nowadays

Again, just wait for the scientific papers coming this year, we'll see

Just now, lehran said:

Again, just wait for the scientific papers coming this year, we'll see

Of course we ll wait and see, but dont count on this too much, i have asked my good friend very skilled dr what he thinks about acne scarring and improvement from the treatments before i started my journey with acne scar revision.

He told me he was not dermatologist and that improvement is def. possible, but he also told me no to put my hopes too high.

He said tha as a doctor he sees only way to remove scar and that is cut it out , but then healing process createsanother scar , that can be even worse then before.

Medicine have to find the way how to remove scared skin, this meanscut scar tissue out, and replace it with new skin tissue without creating scar - scarless healing, this is nowaday just impossible, mark my words when u all be dissapointed by scientific papers this or next year.

Again I hope i am wrong.

Theres no true despair without false hope 🙂

5 minutes ago, Miro said:

Of course we ll wait and see, but dont count on this too much, i have asked my good friend very skilled dr what he thinks about acne scarring and improvement from the treatments before i started my journey with acne scar revision.

He told me he was not dermatologist and that improvement is def. possible, but he also told me no to put my hopes too high.

He said tha as a doctor he sees only way to remove scar and that is cut it out , but then healing process createsanother scar , that can be even worse then before.

Medicine have to find the way how to remove scared skin, this meanscut scar tissue out, and replace it with new skin tissue without creating scar - scarless healing, this is nowaday just impossible, mark my words when u all be dissapointed by scientific papers this or next year.

Again I hope i am wrong.

Theres no true despair without false hope 🙂

All I know is that Tony Weiss is known by top hardvard and stanford PHD holders in tissue engineering as one of the leading scientists in the world when it comes to tissue regeneration research (you can check it out ^^ ). if the man tells me he's very optimistic about stretch marks, I'd say it means they probably get promising results with their clinical trials so far.

I agree about one thing though, and it's something I kept saying myself, so I'm not arguing with what you said at all: managing your expectations is always the safest course of action, as you might end up being very disappointed afterwards, or even worse. Some people here have hoped so much and have been disappointed so much that it can be kind of devastating in some cases.

Tldr: I agree about managing our expectations, but I remain optimistic for striae (I don't know about acne scars, we'll see, I'll admit I'm only interested in their ability to treat stretch marks). If it doesn't end up being what we thought it would be? Well, it's not the end of the world, after all cosmetics are just cosmetics.

What both of you are forgetting is scarless healing isn't just a cosmetic problem , this is far more important than any of you give credit , there are many people that have severe 3rd degree burns and live in agony every day of their lives , even a 6 year old child , can you imagine the hell theses poor people go though.

This is a huge incentive for these scientists to be the very first man in history to discover a way to completely regenerate scarred skin to its original state of pure perfect skin , this person will be famous all over the world , receive a awards , noble peace prizes etc.

So anyone that gives all this baloney of 50 to 60 years isn't thinking in a wider context of how important all this research is and the incentive these great minds have.