Acne.org Products
8 hours ago, Scarcure said:So their are more important issues than victim of acid attacks and children that have burns that severely imper their movement . yes Covid is a issues , but also health is , and skin is a major concern.
Milions of people dying every week from cancer and AIDS etc, people are on wheelchairs, they have missing limbs etc, acne scarring is not really a big world problemjust because its problem here on this forum for few hundreds people it doesnt mean world gives a f...
On 8/17/2020 at 9:20 PM, Scarcure said:So their are more important issues than victim of acid attacks and children that have burns that severely imper their movement . yes Covid is a issues , but also health is , and skin is a major concern.
Yes scarring is awful, you're preaching to the choir. I have a horrible burn scar on my face.Just because people feel sorry for me doesn't mean they can pull the solution to scarless healing out of a magic hat.
Finding a scarless healing solution or being able to disguise a scar so you become essentially scar free is currently immensely difficult. However, we will make great strides in the next two decades at making small- medium scars virtually invisible. Large burns scars, diabetic ulcers, and total regeneration? Much further away.
https://www.scientistlive.com/content/fighting-world-without-scars
Yeah , you can argue that , but what about the baldness community ? they're still scientists researching baldness cures and are succeeding , the level of importance is in accordance to how much funding is being poured into it .... but lets be honest , people are always going to be concerned with how people look and not to mention the importance of skin itself being the largest organ of the human body ....
Lots of wishful thinking in this thread. I kinda share lehran's opinion about this,. I'm glad that we're apparently getting a real working treatment for stretch marks thanks to elastagen but if it doesn't work, we''ll just need to wait for something else and that's about it! Same attitude should be applied for scars imo
28 minutes ago, voulzeyes said:Lots of wishful thinking in this thread. I kinda share lehran's opinion about this,. I'm glad that we're apparently getting a real working treatment for stretch marks thanks to elastagen but if it doesn't work, we''ll just need to wait for something else and that's about it! Same attitude should be applied for scars imo
If at least it even leaves skin color of stretch marks, but fill voids (thats imo more disturbing than color, cuz if skin shrinks it looks meh), it would be soooo cool. And thats main idea behind elastagen. Honestly, i think that slin color for such treatment is a problem because of pigmentation etc that tropoelastin probably cant bring back
Well no one's posted about FS2 for awhile, so here's an update. From what I can see is that they're in the middle of a Phase 2 clinical trial. The trial will wrap up in March 2021
Clinical Safety and Scar Prevention Study of a Topical Antifibrotic Compound FS2. (FS2)
The study will investigate the safety and effectiveness of daily post surgical scar management, using a moisture-balancing base product containing different amounts of a novel (NCE) antifibrogenic compound FS2, a natural metabolite of the kynurenine pathway. Results of recent peer-reviewed, pre-clinical evidence warrant further investigation to validate therapeutic scar preventive efficacy of topically administered/delivered FS2. There are no known safety concerns with current product formulations. Recent Phase I clinical safety and tolerability data further support continuation of the research proposed in this study.
Phase 1 report - https://pubmed.ncbi.nlm.nih.gov/29421218/
"Scarring is a consequence of biological tissue repair following trauma. Currently, there are no generally agreed ways to prevent scarring. Recently, kynurenic acid has shown to be a potent modulator of extracellular matrix deposition and remodeling. Kynurenic acid can reduce matrix deposition and other fundamental characteristics of fibrosis in vitro and in vivo. Specifically, kynurenic acid has shown to increase matrix metalloproteinase-1 activity and subsequently reduce collagen deposition in a rabbit ear scar model. In the present study kynurenic acid cream in different concentrations was topically applied on healthy skin on volunteers to assess skin reactions and skin sensitivity in both acute and chronic application settings. Skin reactions were assessed, and concentrations for kynurenic acid were assessed both form serum and urine. Results showed to acute or delayed skin reactions. Kynurenic acid was not detectable in blood at any time point, and only trace elements of kynurenic acid were found in urine. This study supports safety and tolerability of topically administered FS2 when using a liposomal, compounding base carrier."
On 8/18/2020 at 6:12 AM, Miro said:Milions of people dying every week from cancer and AIDS etc, people are on wheelchairs, they have missing limbs etc, acne scarring is not really a big world problemjust because its problem here on this forum for few hundreds people it doesnt mean world gives a f...
Missing limbs is also another issue that is associated with a lack of regeneration abilities of humans , and yes even scientists are working on that , if they're working on that what makes you think it's not going to be possible for skin to be easier to finally get right ?.
1 hour ago, BeneficialCell said:Well no one's posted about FS2 for awhile, so here's an update. From what I can see is that they're in the middle of a Phase 2 clinical trial. The trial will wrap up in March 2021
Clinical Safety and Scar Prevention Study of a Topical Antifibrotic Compound FS2. (FS2)
The study will investigate the safety and effectiveness of daily post surgical scar management, using a moisture-balancing base product containing different amounts of a novel (NCE) antifibrogenic compound FS2, a natural metabolite of the kynurenine pathway. Results of recent peer-reviewed, pre-clinical evidence warrant further investigation to validate therapeutic scar preventive efficacy of topically administered/delivered FS2. There are no known safety concerns with current product formulations. Recent Phase I clinical safety and tolerability data further support continuation of the research proposed in this study.
Phase 1 report - https://pubmed.ncbi.nlm.nih.gov/29421218/
"Scarring is a consequence of biological tissue repair following trauma. Currently, there are no generally agreed ways to prevent scarring. Recently, kynurenic acid has shown to be a potent modulator of extracellular matrix deposition and remodeling. Kynurenic acid can reduce matrix deposition and other fundamental characteristics of fibrosis in vitro and in vivo. Specifically, kynurenic acid has shown to increase matrix metalloproteinase-1 activity and subsequently reduce collagen deposition in a rabbit ear scar model. In the present study kynurenic acid cream in different concentrations was topically applied on healthy skin on volunteers to assess skin reactions and skin sensitivity in both acute and chronic application settings. Skin reactions were assessed, and concentrations for kynurenic acid were assessed both form serum and urine. Results showed to acute or delayed skin reactions. Kynurenic acid was not detectable in blood at any time point, and only trace elements of kynurenic acid were found in urine. This study supports safety and tolerability of topically administered FS2 when using a liposomal, compounding base carrier."
Sounds promising , see , we shouldn't be so pessimistic.
1 hour ago, Scarcure said:Missing limbs is also another issue that is associated with a lack of regeneration abilities of humans , and yes even scientists are working on that , if they're working on that what makes you think it's not going to be possible for skin to be easier to finally get right ?.
Because of thing called market, investment, return of investmetn etc
54 minutes ago, Scarcure said:Sounds promising , see , we shouldn't be so pessimistic.
Science today is really developing faster and faster. Despite the fact that there are not so many outstanding discoveries yet, one must understand that the challenges have become stronger. And don't overstate your expectations.
9 hours ago, Miro said:Because of thing called market, investment, return of investmetn etc
An improved procedure to reduce scars, wrinkles, and stretch marks would generate lots of revenue. Skincare isn't the most pressing issue in the world, but it's a growing industry for a reason. The caveat? Innovation takes time. Cancer still takes many lives
6 hours ago, Skin Pessimist said:An improved procedure to reduce scars, wrinkles, and stretch marks would generate lots of revenue. Skincare isn't the most pressing issue in the world, but it's a growing industry for a reason. The caveat? Innovation takes time. Cancer still takes many lives
I think this procedure will also be available soon. Just wait
11 hours ago, Skin Pessimist said:An improved procedure to reduce scars, wrinkles, and stretch marks would generate lots of revenue. Skincare isn't the most pressing issue in the world, but it's a growing industry for a reason. The caveat? Innovation takes time. Cancer still takes many lives
Cancer is unfortunately part of how mammals evolved , you can prevent it , but it could never go away , scarring is also the case , however the complete regeneration of skin is far more attainable and realistic , also you are aware skin cancer can be cause because of skin scarring because of the lack of skin integrity and how the skin is weaker and can't protect itself from the sun as well as unscarred healthy skin.
51 minutes ago, David4bay said:Does anyone know if we will have consumer focused microcoring devices?
what doesit mean?Your own device?I saw a couple of pictures and it looks like the device is too bulky and suitable for various beauty salons. I think you probavly could buy it anyway, but price will he too high.The reason I doubt there is an affordable option for the general consumer is the need for a powerful compressor to suction the tissue.
1 hour ago, Scarcure said:Cancer is unfortunately part of how mammals evolved , you can prevent it , but it could never go away , scarring is also the case , however the complete regeneration of skin is far more attainable and realistic , also you are aware skin cancer can be cause because of skin scarring because of the lack of skin integrity and how the skin is weaker and can't protect itself from the sun as well as unscarred healthy skin.
however, breakthroughs in cancer therapy are much more significant. when it comes to skin, all we can do is use lasers / radio waves and other nonsense.there is some progress in this direction, growth factors, stem cells are being studied, research is being carried out, but nevertheless, there is still nothing applicable for people.While cancer is treated in many ways and in recent years new ones have emerged (gene therapy)
59 minutes ago, gantz said:what doesit mean?Your own device?I saw a couple of pictures and it looks like the device is too bulky and suitable for various beauty salons. I think you probavly could buy it anyway, but price will he too high.The reason I doubt there is an affordable option for the general consumer is the need for a powerful compressor to suction the tissue.
Thanks for the reply, I saw some shots of their device also and it truly does look bulky. With demand I assumed you might see smaller variations of the device tailored to certain skin conditions and was wondering if anyone knew if they had already accounted for this.
Best to leave it to skilled operators when it's out though, one might see some beauty craze fanatics attempt self treatments videos when it does become released and that idea led to my question.
Fingers crossed and expectations in check.
21 minutes ago, David4bay said:Thanks for the reply, I saw some shots of their device also and it truly does look bulky. With demand I assumed you might see smaller variations of the device tailored to certain skin conditions and was wondering if anyone knew if they had already accounted for this.
Best to leave it to skilled operators when it's out though, one might see some beauty craze fanatics attempt self treatments videos when it does become released and that idea led to my question.
Fingers crossed and expectations in check.
I also was thinking about self treatment by this device.I wish that at some point it would become real
16 hours ago, Skin Pessimist said:An improved procedure to reduce scars, wrinkles, and stretch marks would generate lots of revenue. Skincare isn't the most pressing issue in the world, but it's a growing industry for a reason.
Skincare yes, wrinkles yes of course, thats why we have lasers and Microneedling RF etc, there are all made for skin rejuvenzation,
to make you look younger after series of treatments, to clear skin of signs of aging like sunspots, sun damage etc. Thats where money are , people want this treatments, everyone wants to look young or younger.
All those devices are not made for acne scars.
Stretch marks ? Yes that is something that a lot of people have and nothing is working for those nowadays really, thats something what is worth investing in.
Scars and mainly acne scarring ? Not so much, thats why theres no device made specialy for acne scarring or for scars.
Treatments that are herespecialy for acne scars are : subcision and TCA cross, thats all. All other procedures and energy devices can also work for acne scarring, but they also dont have to.
Thats why many people are dissapointed by lasers and M RF when it comes to serious acne scars . Thats why all specialists in acne scars revision will tell you improvement is possible up to 50 %, mostly 30-40 % and thatis if u heal good and you re not unlucky enough to have side effects .
Today I was in shopping centre - out of 100 people that I met or saw, i was the only one that had acne scars ( i am not talking about some superficial nonsense , but at least medium deep acne scarring ). Its simply not very common to have "real" acne scars, its not worth investing in.
If i undesrtood it correctly this new treatment we re here talking about is focused on tissue regeneration and probably should work for stretch marks and maybe scars or acne scars, no one would start to do this and invest in it cause of acne scarring revision.
6 minutes ago, Miro said:Skincare yes, wrinkles yes of course, thats why we have lasers and Microneedling RF etc, there are all made for skin rejuvenzation,
to make you look younger after series of treatments, to clear skin of signs of aging like sunspots, sun damage etc. Thats where money are , people want this treatments, everyone wants to look young or younger.
All those devices are not made for acne scars.
Stretch marks ? Yes that is something that a lot of people have and nothing is working for those nowadays really, thats something what is worth investing in.
Scars and mainly acne scarring ? Not so much, thats why theres no device made specialy for acne scarring or for scars.
Treatments that are herespecialy for acne scars are : subcision and TCA cross, thats all. All other procedures and energy devices can also work for acne scarring, but they also dont have to.
Thats why many people are dissapointed by lasers and M RF when it comes to serious acne scars . Thats why all specialists in acne scars revision will tell you improvement is possible up to 50 %, mostly 30-40 % and thatis if u heal good and you re not unlucky enough to have side effects .
Today I was in shopping centre - out of 100 people that I met or saw, i was the only one that had acne scars ( i am not talking about some superficial nonsense , but at least medium deep acne scarring ). Its simply not very common to have "real" acne scars, its not worth investing in.
If i undesrtood it correctly this new treatment we re here talking about is focused on tissue regeneration and probably should work for stretch marks and maybe scars or acne scars, no one would start to do this and invest in it cause of acne scarring revision.
gotta agree with this statement. Research investments are made because they can bring value to the table later on (duh). Stretch marks occur in 80% of people, and like Miro said there's no treatment so far. An effective treatment at filling these lesions with healthy looking skin again would bring tremendous profit. There's a reason why you already have something like 10-15 treatments out there for striae although not a single one really works (which is kinda revealing in a way). Acne scars ain't super scarce or anything for sure, but it's nowhere near as common as stretch marks.