Acne.org Products
1 hour ago, gantz said:this is what micro coring does (in its concept).
Micro coring only removes a small area though. Removing out a wide area of scarred tissue and promoting new healing is something I trust Elastagen more with. There are proof of concept videos showing elastagen sealing an open wound within a minute. If Elastagen works, it's success may depend on the delivery method. Without creating a new wound, Elastagen could be inserted into a rolling scar. That would reduce volume loss, but I doubt it would remove the existing scar tissue. Maybe the existing scar won't be noticeable so it won't matter. The most promising application of Elastagen would be removing the existing scar tissue, creating a new wound, and then applying Elastagen. I'm not sure that sort of process is ready yet.
Some posters disagree with me but I'll continue doubting micro coring unless it is shown to be practical for large scars. Micro coring only removes a narrow area of skin. It seems like something that would work best on ice pick scars. I doubt it will ever be a great option for wider scars, since it would require many sessions. For those scars, you'd probably be better off opting for subcision. Of course, none of us really know for sure. My entire post is full of speculation. We'll have to see
2 hours ago, Scarcure said:What both of you are forgetting is scarless healing isn't just a cosmetic problem , this is far more important than any of you give credit , there are many people that have severe 3rd degree burns and live in agony every day of their lives , even a 6 year old child , can you imagine the hell theses poor people go though.
This is a huge incentive for these scientists to be the very first man in history to discover a way to completely regenerate scarred skin to its original state of pure perfect skin , this person will be famous all over the world , receive a awards , noble peace prizes etc.
So anyone that gives all this baloney of 50 to 60 years isn't thinking in a wider context of how important all this research is and the incentive these great minds have.
There are far more important things In the world then this , trust me
13 minutes ago, Miro said:There are far more important things In the world then this , trust me
So their are more important issues than victim of acid attacks and children that have burns that severely imper their movement . yes Covid is a issues , but also health is , and skin is a major concern.
8 hours ago, Scarcure said:So their are more important issues than victim of acid attacks and children that have burns that severely imper their movement . yes Covid is a issues , but also health is , and skin is a major concern.
Milions of people dying every week from cancer and AIDS etc, people are on wheelchairs, they have missing limbs etc, acne scarring is not really a big world problemjust because its problem here on this forum for few hundreds people it doesnt mean world gives a f...
On 8/17/2020 at 9:20 PM, Scarcure said:So their are more important issues than victim of acid attacks and children that have burns that severely imper their movement . yes Covid is a issues , but also health is , and skin is a major concern.
Yes scarring is awful, you're preaching to the choir. I have a horrible burn scar on my face.Just because people feel sorry for me doesn't mean they can pull the solution to scarless healing out of a magic hat.
Finding a scarless healing solution or being able to disguise a scar so you become essentially scar free is currently immensely difficult. However, we will make great strides in the next two decades at making small- medium scars virtually invisible. Large burns scars, diabetic ulcers, and total regeneration? Much further away.
https://www.scientistlive.com/content/fighting-world-without-scars
Yeah , you can argue that , but what about the baldness community ? they're still scientists researching baldness cures and are succeeding , the level of importance is in accordance to how much funding is being poured into it .... but lets be honest , people are always going to be concerned with how people look and not to mention the importance of skin itself being the largest organ of the human body ....
Lots of wishful thinking in this thread. I kinda share lehran's opinion about this,. I'm glad that we're apparently getting a real working treatment for stretch marks thanks to elastagen but if it doesn't work, we''ll just need to wait for something else and that's about it! Same attitude should be applied for scars imo
28 minutes ago, voulzeyes said:Lots of wishful thinking in this thread. I kinda share lehran's opinion about this,. I'm glad that we're apparently getting a real working treatment for stretch marks thanks to elastagen but if it doesn't work, we''ll just need to wait for something else and that's about it! Same attitude should be applied for scars imo
If at least it even leaves skin color of stretch marks, but fill voids (thats imo more disturbing than color, cuz if skin shrinks it looks meh), it would be soooo cool. And thats main idea behind elastagen. Honestly, i think that slin color for such treatment is a problem because of pigmentation etc that tropoelastin probably cant bring back
Well no one's posted about FS2 for awhile, so here's an update. From what I can see is that they're in the middle of a Phase 2 clinical trial. The trial will wrap up in March 2021
Clinical Safety and Scar Prevention Study of a Topical Antifibrotic Compound FS2. (FS2)
The study will investigate the safety and effectiveness of daily post surgical scar management, using a moisture-balancing base product containing different amounts of a novel (NCE) antifibrogenic compound FS2, a natural metabolite of the kynurenine pathway. Results of recent peer-reviewed, pre-clinical evidence warrant further investigation to validate therapeutic scar preventive efficacy of topically administered/delivered FS2. There are no known safety concerns with current product formulations. Recent Phase I clinical safety and tolerability data further support continuation of the research proposed in this study.
Phase 1 report - https://pubmed.ncbi.nlm.nih.gov/29421218/
"Scarring is a consequence of biological tissue repair following trauma. Currently, there are no generally agreed ways to prevent scarring. Recently, kynurenic acid has shown to be a potent modulator of extracellular matrix deposition and remodeling. Kynurenic acid can reduce matrix deposition and other fundamental characteristics of fibrosis in vitro and in vivo. Specifically, kynurenic acid has shown to increase matrix metalloproteinase-1 activity and subsequently reduce collagen deposition in a rabbit ear scar model. In the present study kynurenic acid cream in different concentrations was topically applied on healthy skin on volunteers to assess skin reactions and skin sensitivity in both acute and chronic application settings. Skin reactions were assessed, and concentrations for kynurenic acid were assessed both form serum and urine. Results showed to acute or delayed skin reactions. Kynurenic acid was not detectable in blood at any time point, and only trace elements of kynurenic acid were found in urine. This study supports safety and tolerability of topically administered FS2 when using a liposomal, compounding base carrier."
On 8/18/2020 at 6:12 AM, Miro said:Milions of people dying every week from cancer and AIDS etc, people are on wheelchairs, they have missing limbs etc, acne scarring is not really a big world problemjust because its problem here on this forum for few hundreds people it doesnt mean world gives a f...
Missing limbs is also another issue that is associated with a lack of regeneration abilities of humans , and yes even scientists are working on that , if they're working on that what makes you think it's not going to be possible for skin to be easier to finally get right ?.
1 hour ago, BeneficialCell said:Well no one's posted about FS2 for awhile, so here's an update. From what I can see is that they're in the middle of a Phase 2 clinical trial. The trial will wrap up in March 2021
Clinical Safety and Scar Prevention Study of a Topical Antifibrotic Compound FS2. (FS2)
The study will investigate the safety and effectiveness of daily post surgical scar management, using a moisture-balancing base product containing different amounts of a novel (NCE) antifibrogenic compound FS2, a natural metabolite of the kynurenine pathway. Results of recent peer-reviewed, pre-clinical evidence warrant further investigation to validate therapeutic scar preventive efficacy of topically administered/delivered FS2. There are no known safety concerns with current product formulations. Recent Phase I clinical safety and tolerability data further support continuation of the research proposed in this study.
Phase 1 report - https://pubmed.ncbi.nlm.nih.gov/29421218/
"Scarring is a consequence of biological tissue repair following trauma. Currently, there are no generally agreed ways to prevent scarring. Recently, kynurenic acid has shown to be a potent modulator of extracellular matrix deposition and remodeling. Kynurenic acid can reduce matrix deposition and other fundamental characteristics of fibrosis in vitro and in vivo. Specifically, kynurenic acid has shown to increase matrix metalloproteinase-1 activity and subsequently reduce collagen deposition in a rabbit ear scar model. In the present study kynurenic acid cream in different concentrations was topically applied on healthy skin on volunteers to assess skin reactions and skin sensitivity in both acute and chronic application settings. Skin reactions were assessed, and concentrations for kynurenic acid were assessed both form serum and urine. Results showed to acute or delayed skin reactions. Kynurenic acid was not detectable in blood at any time point, and only trace elements of kynurenic acid were found in urine. This study supports safety and tolerability of topically administered FS2 when using a liposomal, compounding base carrier."
Sounds promising , see , we shouldn't be so pessimistic.
1 hour ago, Scarcure said:Missing limbs is also another issue that is associated with a lack of regeneration abilities of humans , and yes even scientists are working on that , if they're working on that what makes you think it's not going to be possible for skin to be easier to finally get right ?.
Because of thing called market, investment, return of investmetn etc
54 minutes ago, Scarcure said:Sounds promising , see , we shouldn't be so pessimistic.
Science today is really developing faster and faster. Despite the fact that there are not so many outstanding discoveries yet, one must understand that the challenges have become stronger. And don't overstate your expectations.
9 hours ago, Miro said:Because of thing called market, investment, return of investmetn etc
An improved procedure to reduce scars, wrinkles, and stretch marks would generate lots of revenue. Skincare isn't the most pressing issue in the world, but it's a growing industry for a reason. The caveat? Innovation takes time. Cancer still takes many lives
6 hours ago, Skin Pessimist said:An improved procedure to reduce scars, wrinkles, and stretch marks would generate lots of revenue. Skincare isn't the most pressing issue in the world, but it's a growing industry for a reason. The caveat? Innovation takes time. Cancer still takes many lives
I think this procedure will also be available soon. Just wait
11 hours ago, Skin Pessimist said:An improved procedure to reduce scars, wrinkles, and stretch marks would generate lots of revenue. Skincare isn't the most pressing issue in the world, but it's a growing industry for a reason. The caveat? Innovation takes time. Cancer still takes many lives
Cancer is unfortunately part of how mammals evolved , you can prevent it , but it could never go away , scarring is also the case , however the complete regeneration of skin is far more attainable and realistic , also you are aware skin cancer can be cause because of skin scarring because of the lack of skin integrity and how the skin is weaker and can't protect itself from the sun as well as unscarred healthy skin.