To be honest, russian science ismuch less developed than in the US. They spend pennies from the budget on the development of science. Don't expect anything from them

On 8/9/2020 at 2:40 PM, Scarlessfuture said:

Allah will get you nothing my dear if you don't work for it.

Sunogel is still going on

1 minute ago, skinregenerator said:

Sunogel is still going on

how do you know? Did they fail?

3 hours ago, Armanilko said:

Yep, def gonna take a long time in their case.

From all I've gathered, seems like the most difficult scars to treat by far are indeed keloid scars and hypertrophic scars, as you can't just fix them by using a skin implant or anything, like elastagen would with tropoelastin.

Absolutely. Hypertrophic scars and atrophic scars pose a very different problem: you need to fill in the void left by atrophic scars (I.E what elastagen will do with its tropoelastin-based product) while you need to find a way to remove the excess skin caused by excessively raised scars while also giving back the original looking aspect of the skin.

We had tons of conversations about it, and basically some people asked Tony Weiss ( https://en.wikipedia.org/wiki/Anthony_S._Weiss) about it: apparently they're also working on hypertrophic ones, but it's gonna take several more years than stretch marks and acne scars to fix (which is why, I suppose, the science papers that will be released at the end of the year will only mention stretch marks and acne scars).

tldr: nothing really changed since the last few months we talked. Elastagen brings a real fix to stretch marks, atrophic scars and several forms of acne scars, but as for the more serious forms of scarring it's going to take longer before we see something appear it would seem.

Just now, lehran said:

We had tons of conversations about it, and basically some people asked Tony Weiss ( https://en.wikipedia.org/wiki/Anthony_S._Weiss) about it: apparently they're also working on hypertrophic ones, but it's gonna take several more years than stretch marks and acne scars to fix (which is why, I suppose, the science papers that will be released at the end of the year will only mention stretch marks and acne scars).

 

Yeah, that part makes a lot of sense. Allergan only releases scientific drafts (proof of concept + results and safety of the procedure) right before they release a new product. Which means that the results are definitely good enough in their eyes, and that they're preparing to launch either next year or the year after 2021 (so either 2021-2022)

8 hours ago, Scarlessfuture said:

When will you ever grow up... I wonder. Did you ever realize you are 31 years old?

I have read about this and scientists in the US have also found ways to regenerate scar tissue into healthy looking skin with full appendages. Look up Cotsarelis.

Unfortunately, most of these studies stay on the shelves in university libraries for years. The funding is either not there or the conditions to get results are impossible to achieve.

There are more important things that scientists are working on such as finding a Covid19 vaccine or HIV cure. This is why a good treatment for scarring is still far away. There are clinical trials that need to be done and those take an awfully long time.

Someone has mentioned subcision and TCA peels. It seems these are the preferred acne scar treatments at that moment and some get excellent results.

Yeah , and how many times have i told you stop responding ...., you are aware you can block me right ?

10 minutes ago, Scarcure said:

Yeah , and how many times have i told you stop responding ...., you are aware you can block me right ?

I don't block people. You are just an overgrown baby.I pity you.

15 minutes ago, Scarlessfuture said:

I don't block people. You are just an overgrown baby.I pity you.

So you just carry on ? who's the real arsehole in all of this ? .... and calling someone with depression( which is clear by my writing ) a baby is pretty shitty of you .... you really are something else .... be careful who you talk to as they may be suicidal and at the end of their rope .... oh and cry me a river .... you are clearly a decent and empathetic person.

oh my, this topic never changes. Chill guys.

21 minutes ago, Candy Says said:

oh my, this topic never changes. Chill guys.

I apologies..but today has been an incredibly trying day.

1 hour ago, Scarcure said:

So you just carry on ? who's the real arsehole in all of this ? .... and calling someone with depression( which is clear by my writing ) a baby is pretty shitty of you .... you really are something else .... be careful who you talk to as they may be suicidal and at the end of their rope .... oh and cry me a river .... you are clearly a decent and empathetic person.

You need help!!! You forgot your meds.

At some point one of you two has to stop replying to or mentioning the other. If not, the arguments will just continue

9 hours ago, Armanilko said:

Yeah, that part makes a lot of sense. Allergan only releases scientific drafts (proof of concept + results and safety of the procedure) right before they release a new product. Which means that the results are definitely good enough in their eyes, and that they're preparing to launch either next year or the year after 2021 (so either 2021-2022)

Did you ask someone related to elastagenspecifically about the appearance of the treated area? Maybe you already answered, but I didn't notice (sorryif so)

1 hour ago, gantz said:

Did you ask someone related to elastagenspecifically about the appearance of the treated area? Maybe you already answered, but I didn't notice (sorryif so)

Well also i d be interested how this is supposed to work, i mean technicly, do they remove scared area and they replace it with synthetic skin ? Or is it supposed to be some kind of filler ?

The product that Allergan is bringing out is an injectable. If you look at the patent, it will be a series of injections spaced a few weeks/months apart.

13 minutes ago, Miro said:

Well also i d be interested how this is supposed to work, i mean technicly, do they remove scared area and they replace it with synthetic skin ? Or is it supposed to be some kind of filler ?

probably grows new skin

47 minutes ago, Didikaxonim said:

probably grows new skin

This sounds highly unlikely to me

if micro coring gives good results, the allergen will try to market its product faster

10 minutes ago, Miro said:

This sounds highly unlikely to me

anything can happen in life

3 hours ago, Miro said:

This sounds highly unlikely to me

4 hours ago, Didikaxonim said:

probably grows new skin

Elastogen is a synthetic product made from organic elements allowing for elasticin to regeneration. All connective tissue has elasticin including blood vessels, tendons and ligaments. What does this protein do.....? Well, it allows the skin to return to it's normal position when stretched.

The idea behind Elastogen is that it will promote elasticin, laying down new layers of collagen which will improve healing time and scar appearance. Research suggests that scar tissue lacks elasticin blocking off regeneration.

@Miro@BeneficialCell@gantz

(I'm pinging the three of you since you asked a similar question, and @Armanilko PM'd me, asking me to answer the "how does it work" question in details)

I'm simply repeting what I've mentioned before:

ELAPR002 (elastagen's product 002) is not a surgical tool in the sense that it's not a heavy surgical intervention, and it's not really a filler, as dermal fillers are temporary: it's a skin implant (which is exactly what they call it https://www.hra.nhs.uk/planning-and-improving-research/application-summaries/research-summaries/elapr002-implant-safety-and-efficacy-v1/)

Elastin has never been synthethized before: it's an essential component of the skin (with collagen) that the body just can't reproduce after it's been lost, and it's how the skin manages to stretch so much. So basically Elastagen is the only company in the world who has access to elastin production (which kinda explains why allergan got them for hundreds of millions of dollars).

You kinda have to see their tropelastin-based product as a "liquid implant" that serves to fill void-like lesions, which is exactly why it's ideal for atrophic scars (stretch marks for example). That's also why they mention stuff like depression volume reduction: the new healthy skin fills atrophic lesions up to a certain percentage, so it's not tightening it or anything, it's literally using an implant to replace the void with healthy skin which can grow hair follicles, sweat yada yada yada...

Some of you might have heard of METRO () well that's the same idea.

I agree with what Armanilko said also: if they're ready to publish scientific papers to show us the results, it means they're happy with it, so the next months are going to be seriously interesting (I personally can't wait for that).

One thing that is important to note though, is that these drafts will ONLY be about stretch marks and acne scars. Why? Because they're, by nature, atrophic scars, lesions, "void". That's what the product can fix.

I have no idea when they'll create a product to fix hypertrophic scars and keloid scars (aka the most severe scarring most of the time), but they said they intended to do so, although it would tak more research as you can't really use a "filling implant" to fix a raised scar. Makes sense, doesn't it?

So yeah, when it comes to elastagen's product: don't see it as a filler. It's an implant, a dermis-repairing implant, and if you want to get rid of stretch marks or acne scars, you should be very excited overall.

nb: @Scarlessfuture I think elastagen nicknamed the regeneration process "elastatherapy" btw. Google it they mention some interesting things about it.

@lehranMy dermatologist told me that elastagen could very well be a revolution for striae distensae too, and I have lots of them everywhere unfortunately, so I'm really hopeful. Fingers crossed. Thank you for the explanation in any case, although I've been following discussions here for a couple months

well thats pretty interesting give the science behind it is very solid

could be a resolution for those with striae and atrophic scars

hope wont take another ten years

How much do you think this could cost if successful ?

@De Rerum Natura@Scarcure

-As far as striae distensae (stretch marks) go, I think we're indeed about to see the first real working treatment come out, which is honestly about time. When it comes to atrophic scars in general it's also a breakthrough for sure, but It's going to depend on the type of scarring, as scars are often very different compared to each other (even amongst the same type of scars, aka atrophic in this case). This should definitely make a lot of noise if the results from the drafts are there (which I believe they are, based on the questions several of us have been asking to their staff, and the answers we got too).

-No idea how much it's gonna cost: prob very expensive at first (thousands of dollars imo) as it will be a new biotech product, and then cheaper very quickly. Might also depend on the type of treatment: striae distensae affect 70-80% of people (although to very varying degrees), so the cheaper it is, the more accessible it will be, and that's honestly what you want to achieve.

70-80% improvement range regard stretch marks in MY opinion is something that can be considered a solution already, specially if it comes to resolve the major problem with striae which is the depression/elasticity of the skin

the rest can be adressed with lasers or even tattoing over it if it comes to texture/color