Acne.org Products
4 hours ago, goblue1996 said:Here's a link I found that talks about elastagen briefly that I don't think lehran posted before. It just talks about the results of the acne scar trials they ran very briefly:"New topline data was presented on the use of TE-HA, the hydrogel containing recombinant tropoelastin, gained as part of Allergan's acquisition of Elastagen, for the treatment of adult patients with acne scars. At 6 months, 21 of 27 (78%) patients reported improvements in acne scar appearance. TE-HA also demonstrated significant reduction in acne scar depth and volume compared to the control group"
Doesn't really state how significant the improvement was and it's a small sample size obviously, but still seems like reason for some optimism and I'm not sure there's a current treatment out there that can say that over 70% of patients have improvement.
Sounds good, I managed to find percentages of improvement for stretch marks but not for acne. The problem imo is that they still need to work on box and icepic scars, which is probably why the product doesn't automatically works for all types of acne so far. The good point though, is that they mention significant reduction so far, which is good.
Bad News for Elastagen/Allergan (Tropoelastin)...
I recently had a discussion with a reputable Dermatologist that focuses on cosmetics who has a good track record with his commentary on upcoming products. I asked himabout Elastagen (Tropoelastin) and unfortunately it probably doesn't look like its going to be a product that can deliver the results we would hope for. He said its likely going to be of most benefit to promote faster healing and improved healing that would normally require grafts especially for burns and other trauma wounds. As a cosmetic approach Tropoelastin is being mentioned alongside Allergan's other popular injectable Juvederm which is a temporary filler. Tropoelastin injections issaid to add volume to voids in the skin much like Juvederm but that will not regenerate the texture, color and tone of scars. For this reason I also believe it probably falls behind Sunogel and Microcoring in terms of genuine scarless healing potential treatments.
Sadly this sort of narrative about Elastagen falls into line with Recell and PolarityTe. They are not failed products necessarily but they didn't have the reach many had hoped for. Im aware Recell repairs the epidermis where Tropoelastin is said to repair deeper in the Dermis to help lessen scarring. People with scars want complete skin regeneration.
My hope is that Sunogel, Microcoring and maybe Tropoelastincan work in collaboration to achieve scarless healing or close to it rather than hope just one of them can be the miracle home run.
Stay home and Stay safe everyone!
16 hours ago, goblue1996 said:Here's a link I found that talks about elastagen briefly that I don't think lehran posted before. It just talks about the results of the acne scar trials they ran very briefly:"New topline data was presented on the use of TE-HA, the hydrogel containing recombinant tropoelastin, gained as part of Allergan's acquisition of Elastagen, for the treatment of adult patients with acne scars. At 6 months, 21 of 27 (78%) patients reported improvements in acne scar appearance. TE-HA also demonstrated significant reduction in acne scar depth and volume compared to the control group"
Doesn't really state how significant the improvement was and it's a small sample size obviously, but still seems like reason for some optimism and I'm not sure there's a current treatment out there that can say that over 70% of patients have improvement.
This was something I posted way back.
2 hours ago, Sniffy said:Bad News for Elastagen/Allergan (Tropoelastin)...
I recently had a discussion with a reputable Dermatologist that focuses on cosmetics who has a good track record with his commentary on upcoming products. I asked himabout Elastagen (Tropoelastin) and unfortunately it probably doesn't look like its going to be a product that can deliver the results we would hope for. He said its likely going to be of most benefit to promote faster healing and improved healing that would normally require grafts especially for burns and other trauma wounds. As a cosmetic approach Tropoelastin is being mentioned alongside Allergan's other popular injectable Juvederm which is a temporary filler. Tropoelastin injections issaid to add volume to voids in the skin much like Juvederm but that will not regenerate the texture, color and tone of scars. For this reason I also believe it probably falls behind Sunogel and Microcoring in terms of genuine scarless healing potential treatments.
Sadly this sort of narrative about Elastagen falls into line with Recell and PolarityTe. They are not failed products necessarily but they didn't have the reach many had hoped for. Im aware Recell repairs the epidermis where Tropoelastin is said to repair deeper in the Dermis to help lessen scarring. People with scars want complete skin regeneration.
My hope is that Sunogel, Microcoring and maybe Tropoelastincan work in collaboration to achieve scarless healing or close to it rather than hope just one of them can be the miracle home run.
Stay home and Stay safe everyone!
Nothing new here pal. Just re-read the conversations that occured the last 10 pages: Elastagen is merely mentioned as the solution that will fix stretch marks, not hypertrophic scars. I asked my own dermatologist here in Berlin, and he told me that their tropoelastin-based solution is going to be revolutionary to striae distensae/striae gradivarium and stretch marks in general...not so much for the rest.
In fact, you mentioned something that's very accurate: "Tropoelastin injections issaid to add volume to voids in the skin much like Juvederm but that will not regenerate the texture, color and tone of scars"'.
Their tropoelastin-based product won't be able to do anything at first against raised scars, what it will do is fill areas devoid of skin with new skin thanks to the creation of elastin fibers.
It is, before ANYTHING else, a super promising product for getting rid of the appearance of stretch marks, as people like lehran said in the past, and that, in itself, is very, VERY big.
When it comes to serious scars, I also don't think Elastagen is going to bring a proper solution to people's worries.
TLDR: elastagen is going to be great for stretch marks, not scars. And yeah that kinda sucks for a lot of people but what are ya gonna do.
2 hours ago, Sniffy said:Sadly this sort of narrative about Elastagen falls into line with Recell and PolarityTe. They are not failed products necessarily but they didn't have the reach many had hoped for.
Wow, this forum is active tonight.
The big difference between polaritye and elastagen is that one is still looking for funds and losing credibility by the day, while the other one was acquired for hundreds of millions of dollars by allergan, which was also acquired by one of the top 3 pharmaceutical companies in the world recently. Elastagen proved that tropoelastin can bring groundbreaking promise to fixing several skin issues, polarityte didn't.
However I, myself, have been reminding others on a constant basis that Elastagen is just not the solution for serious forms of scarring which forms excess skin above the skin level, at least right now. Basically it's like what @Valkyros said: filling up a zone devoid of healthy skin is one thing, remodeling big raised scars is another. Tropoelastin could be a solution for that in the future, but we don't know how it's really gonna work.
Tropoelastin is the logical solution for stretch marks as it activates the assembling of what wasn't there in the first place: elastin fibers. Therefore I can only agree with you about the rest: this isn't the solution for scars, at least not now.
Thank you for your input btw
19 hours ago, lehran said:Wow, this forum is active tonight.
The big difference between polaritye and elastagen is that one is still looking for funds and losing credibility by the day, while the other one was acquired for hundreds of millions of dollars by allergan, which was also acquired by one of the top 3 pharmaceutical companies in the world recently. Elastagen proved that tropoelastin can bring groundbreaking promise to fixing several skin issues, polarityte didn't.
However I, myself, have been reminding others on a constant basis that Elastagen is just not the solution for serious forms of scarring which forms excess skin above the skin level, at least right now. Basically it's like what @Valkyros said: filling up a zone devoid of healthy skin is one thing, remodeling big raised scars is another. Tropoelastin could be a solution for that in the future, but we don't know how it's really gonna work.
Tropoelastin is the logical solution for stretch marks as it activates the assembling of what wasn't there in the first place: elastin fibers. Therefore I can only agree with you about the rest: this isn't the solution for scars, at least not now.
Thank you for your input btw
I've got several stretchmarks on my back, buttocks, 1 stretching down my knee, inner and outer thighs. They are not noticeable except under certain lighting. More than 90% of us have these especially on the butt. For a guy, I don't see why you should be alarmed about them. I don't believe you will be flaunting your behind in a bikini anytime soon unless off course you are a girl and you absolutely believe that looks are everything.
Young girls will do anything to hide these using cosmetic products or surgery. Reality is that more than 95% of the world's most famous models have them too. What makes us human is our imperfections afterall. You can consider them normal and part of life.Now, if your stretchmarksare quite large, prominent and purple/red, than I can understand your predicament.
For my case, what really bugs me is the multiple little slightly raised white and yellowish scars that formed after years of severe acne. These cover most of my upper arms, back and shoulders. Add to these, a few pockmarks which look great under different angles. My back looks as if small amounts of acid were thrown my wayandburned me on small patches of my skin.It looks lovely. Fortunately, my face was spared. I have seen horrific facial acne scarring and luckily mine areminor imperfections.
To be honest, I have rarely seen people with substantial acne scarring as displayed by some userson this forum.Most people have a few pimples which heal without leaving a trace. Something, everyone will outgrow at a given time.
Imagine having a swollen red face oozing with pus for most of your teenage years into early adulthood. Once all this clears, you have facial pits to present to the outside world. Not to mention, patches of scarred skin throughout your body because of boils. Therefore, if tropoelastin can't help acne scarred individuals, I don't see why it needs to be discussed. Although, Allergan had published papers which stated otherwise. I posted this several years back and it was reposted again by another user. The paper does mention considerable improvements in acne scarring.
However, many products out there claimed to have achieved the holy grail of skin regeneration. None have succeeded to this day. Hopefully, tropoelastin is not another failure.
5 hours ago, MyBeautifulScars said:Now, if your stretchmarksare quite large, prominent and purple/red, than I can understand your predicament.
they're normal stretch marks, a few mms large and a few mms long, white and silvery old ones (slightly purple) but they're placed on most of my joins and I am still self conscious about them for sure. I understand what you say though, it's not the biggest problem in the world for sure.
Can also scarless healing be achieved without making an incision ? i have a notch on my eyelid ... it's little and no one notices ... however it bothers the hell out of me .... would be great if we could just take a pill and no more scars .... to dream a dream.
23 hours ago, Scarcure said:Can also scarless healing be achieved without making an incision ? i have a notch on my eyelid ... it's little and no one notices ... however it bothers the hell out of me .... would be great if we could just take a pill and no more scars .... to dream a dream.
All of the teams that claimed that they achived scarless healing said that in order to regenerate skin you have excise whole scar tissue so if scarless healing comes they will need excise every scar in order to regenerate. It might be possible to change scar tissue into healtht tissue but its probably will take even more time
15 hours ago, AlexZ77 said:All of the teams that claimed that they achived scarless healing said that in order to regenerate skin you have excise whole scar tissue so if scarless healing comes they will need excise every scar in order to regenerate. It might be possible to change scar tissue into healtht tissue but its probably will take even more time
Well i mean , anything can make an incision .... even a sharpened paper clip lol .... so if something is small enough and precise enough even your eyeball can be incised and the regenerative gel applied and can achieve scarfree healing ... it's a question of time when we can regenerate fully and perfectly , not if .... years ago we couldn't imagine stem cells proliferated creating new organs to transplant .... and it's now something that happens ... science is a beautiful thing.
11 hours ago, Scarcure said:Well i mean , anything can make an incision .... even a sharpened paper clip lol .... so if something is small enough and precise enough even your eyeball can be incised and the regenerative gel applied and can achieve scarfree healing ... it's a question of time when we can regenerate fully and perfectly , not if .... years ago we couldn't imagine stem cells proliferated creating new organs to transplant .... and it's now something that happens ... science is a beautiful thing.
The really lucky generation is the one being born right now: imagine all they're going to have access when they're super young too: longevity escape velocity, scarless healing, yada yada
On 4/23/2020 at 11:44 PM, Scarcure said:Can also scarless healing be achieved without making an incision ? i have a notch on my eyelid ... it's little and no one notices ... however it bothers the hell out of me .... would be great if we could just take a pill and no more scars .... to dream a dream.
Closest thing to that is the idea of an enzyme that dissolves scar tissue. I assume it's applied topically. If I remember correctly the Birch biomed people who work(ed) on FS2 also spoke of this.
6 hours ago, Lapis lazuli said:Closest thing to that is the idea of an enzyme that dissolves scar tissue. I assume it's applied topically. If I remember correctly the Birch biomed people who work(ed) on FS2 also spoke of this.
Could it be possible to apply to eyelid margins ?.
https://www.x-mol.com/paper/1254921341779206144
"this is the first time scarless skin regeneration with hair follicles based on silk material systems is reported."
another good news
6 hours ago, De Rerum Natura said:https://www.x-mol.com/paper/1254921341779206144
"this is the first time scarless skin regeneration with hair follicles based on silk material systems is reported."another good news
Thanks for posting. Thank goodness that people smarterthan me are working on stuff like this lol. It seems like using hydrogels after excising scar tissue would be the easiest way to solve scarring, but obviously it's pretty complicated. Here's my favorite part of that paper: "To the best our knowledge, it is the first time scarless wound healing similar to normal dermis has been achieved using SFbased biomaterials." This is only in rat studies so it has a way to go to being used in humans, but cool anyway.
12 hours ago, De Rerum Natura said:https://www.x-mol.com/paper/1254921341779206144
"this is the first time scarless skin regeneration with hair follicles based on silk material systems is reported."another good news
This is great news, more and more proof that hydrogels can solve scarring but I dont understand one thing why dont they rush those products to market?! Solving scarring can made bilionsof profit so why do just test it on animals and we never hear again
Scar tissue is too strong and hard to get through, i think the main goal should be a product that could dissolve only scar tissue in the skin, followed by a well developed hydrogel.
I think wound healing sector shouldve have more attention from the scientific community, sometimes it seems that only few are working out on it
1 hour ago, De Rerum Natura said:Scar tissue is too strong and hard to get through, i think the main goal should be a product that could dissolve only scar tissue in the skin, followed by a well developed hydrogel.
I think wound healing sector shouldve have more attention from the scientific community, sometimes it seems that only few are working out on it
I would like this , like a gel that dissolves scar tissue , because i have an eyelid indent ( on the eyelid margin ) it isn't noticeable to anyone i talk to , my mother can't see anything ... but it's still bothersome.
14 hours ago, AlexZ77 said:This is great news, more and more proof that hydrogels can solve scarring but I dont understand one thing why dont they rush those products to market?! Solving scarring can made bilionsof profit so why do just test it on animals and we never hear again
Unfortunately that's how medical research goes. You can't really rush stuff to market when it takes years of animal studies and then years of human trials to prove something is both safe and effective for us.
Its because even thothere is anything out there that can bring scar free healing, i doubt it can "change" a scar tissue back to a normal skin, u will need to excise/remove the damagedtissue completely leaving a deep hole that hopefully will be scarless fullfiled by a hydrogel or anything that could change our regeneration mechanism, so, another thing that comes to mind is, why so many protocols/treatments/studies are always trying to focus in "improve' scar tissue instead of erasing it completely and discover new methods to change the regeneration process after we removed all the scarred area? After several reports already showing that scarless healing already has ben shown in several reportsbut not only that, scarless healing isactually aprocess that happens in fetus, what companies are doing still focusing in creams, lasers or whatever bullshit that clearly will not work
Doesnt sound too archaic that we are still hurting, piercing, burning, using useless creams in order to improve something that we know will never be completely out until we literally remove the entire damaged tissue and replace somehow with "good one" or create the right envinroment to scarless healing take place
Doesnt it sound so clear? Why we still see so many bullshit in 2020? I cant understand
13 hours ago, De Rerum Natura said:Its because even thothere is anything out there that can bring scar free healing, i doubt it can "change" a scar tissue back to a normal skin, u will need to excise/remove the damagedtissue completely leaving a deep hole that hopefully will be scarless fullfiled by a hydrogel or anything that could change our regeneration mechanism, so, another thing that comes to mind is, why so many protocols/treatments/studies are always trying to focus in "improve' scar tissue instead of erasing it completely and discover new methods to change the regeneration process after we removed all the scarred area? After several reports already showing that scarless healing already has ben shown in several reportsbut not only that, scarless healing isactually aprocess that happens in fetus, what companies are doing still focusing in creams, lasers or whatever bullshit that clearly will not work
Doesnt sound too archaic that we are still hurting, piercing, burning, using useless creams in order to improve something that we know will never be completely out until we literally remove the entire damaged tissue and replace somehow with "good one" or create the right envinroment to scarless healing take placeDoesnt it sound so clear? Why we still see so many bullshit in 2020? I cant understand
If scientists still can't regenerate human severed limbs, then we will never have scarless healing. A more robust immune system is believed to hinder regeneration. Mammals have evolved in such a way that infectious dwellers are dealt withfirst hand and scar tissue is the evolutionary responseto seal wounds effectively. It's a compromise of sorts. Researchers have figured out ways to change cells to perform other functions, however everything is in the experimental stage. What you have posted is nothing new.If you can manipulate the immune system, then you can start investigating a path to mammalian regeneration. The key is to perform commissioning work and making it all work together efficiently.
.... oh goody.