Acne.org Products
11 minutes ago, lehran said:A big update about how good polarityTE could be on stretch marks, after a discussion I had with a certified plastic surgeon (who's on the advisory boards of several start up companies or clinical trial companies). I didn't include his name, as I'm sure he would rather stay anonymous, and I don't want people to harass him with questions or anything of the sort...I mean, it's hard enough to get proper answers from surgeons or professionals involved in the tissue regeneration industry, so I thought I might just try to respect the anonymity of the people I had a conversation with, so far.
Here's our conversation:
-Me: " Dear ..., I thank you in advance for taking some time to answer my question, as Im sure that youre very busy. Ive heard a lot about polarityTE's and Elastagen's products recently, and their potential applications to several skin problems. I also read one of your comments on website "X" and I thought it was a very interesting one. My question is about stretch marks: which one of these companies, in your opinion, seem to have the best potential for treating this particular skin issue (basically, If I understood well, its about skin regeneration (polarityte) vs elastogenesis via the use of tropoelastin (elastagen))? Would you say a real treatment for stretch marks is going to be available in the very near future, or would it be wiser to manage my expectations? Again, thanks a lot for your time,
-Him: " Striae, or stretch marks, are tears in the dermis while the epidermis remains intact. SkinTE is a topical treatment and therefore would not work. I think actual tissue regeneration will be necessary to heal striae. A company called Direct Biologics makes a product called ExoFlo, which shows promising results upon injecting."
A lot of people have been talking about skinTE for stretch marks here months ago, so I thought it was important to just say it: this one won't work at all for stretch marks (kinda thought that was the case).
It's not very surprising: skin implant or tissue regeneration for striae distensae has to happen in the dermis, which is exactly what elastagen is about (read page 18 again to see what I mean https://go8.edu.au/wp-content/uploads/2019/04/Allies-In-Excellence.pdf)
Now the good news, is that he mentioned another company which shows "promising results upon injecting", called Direct Biologics (which work is based on exosomes).
I'll try to see if he knows anything about Elastagen and how it became famous because of its potential in treating stretch marks and acne scars (but he might simply not know about it, lots of clinical trial companies out there fellas), and I'll get back to you if I get an answer.
See you soon fellas
Wow, thanks for the update mate, yeah this is big. So basically it's either Elastagen of Direct Bilogics huh, interesting.
I'm kinda disappointed though, I heard so many people talk about skinTE for stretch marks, guess it just shows how you need to check things properly beforehand :s
Another update guys, this time about elastagen:
Still conversing with the same person:
-Me: "Thank you for answering so quickly, I appreciate it. I'll take a look at Direct Biologics then, it does sound interesting. Have you had the chance to work with the Elastagen team, or have you heard about them in general? I first heard about tropoelastin when a dermatologist pointed me to an article about them (page 18: https://go8.edu.au/wp-content/uploads/2019/04/Allies-In-Excellence.pdf ). Obviously, we'll have to wait and see, but it does sound promising as well. "
-Him: " I have heard of it and it sounds very promising but more research is definitely necessary. Ill keep you posted if I hear anything"
That's all I got folks. So for those who want to get rid of stretch marks one day (most people get them, so I suppose that a lot of you guys are concerned), it's either elastagen or Direct Biologics apparently.
Tropoelastin looks amazing. Another missing link in the puzzle. Im not sure if it would work for me but still good product.
i have had fat grafting recently and it has worked amazing for me for comfort and softness of scar but the elasticity is still yet to be seen. A scar revision and tropoelastin injectable for me could be enough actually for full function again. Also elasticity helps reduce tension which in itself improves scars.
2 hours ago, nikki_gargin said:Tropoelastin looks amazing. Another missing link in the puzzle. Im not sure if it would work for me but still good product.
i have had fat grafting recently and it has worked amazing for me for comfort and softness of scar but the elasticity is still yet to be seen. A scar revision and tropoelastin injectable for me could be enough actually for full function again. Also elasticity helps reduce tension which in itself improves scars.
I'd say it's probably a great indication for you yes
Why are we talking about stretch marks ?
this for scarless healing of facial scarring.
Ye thisis all great news but this thread is about scarless healing aka perfect skin regeneration, so lets keep it about that
Most people here and me will be only satisfied with 100% improvement
Tons of people have stretch marks. Most people in fact. And even though they're not considered as scars since they're more like zones where elastin fibers couldn't grow rather than skin lesions, the fact that we're going to be able to treat them is a really big thing imo.
I don't know, I took a look at conversations from months ago in this thread, and tons of people are talking about stretch marks too.
Also, isn't elastagen very promising for scars as well?
20 hours ago, user99 said:Stretch marks are scars!!!!
so we need information about ALL TREATMENTS AND NEWS!!! included elastagen
They're not though. Just like Valkyros said, they're zones devoid of elastin fibers. It's also why they're not something as problematic as scars (they don't hurt, and you don't feel them).
17 hours ago, Scarcure said:But everyone has them .... facial scarring is vastly more important to cure than damn stretch marks.
That's your opinion, and a lot of people would disagree, trust me. Some of us have lots of stretch marks, and although you're absolutely right when you say that almost everyone has them, it's still something that can cause a lot of distress. They day we really get something out for striae (let's hope it's elastagen), it's going to be at least as big as the day botox was out. Probably much more than that in fact.
So yeah, everyone has something they want to get fixed, fon't start saying fixing scars is more important than "damn" stretch marks.
8 hours ago, lehran said:They're not though. Just like Valkyros said, they're zones devoid of elastin fibers. It's also why they're not something as problematic as scars (they don't hurt, and you don't feel them).
That's your opinion, and a lot of people would disagree, trust me. Some of us have lots of stretch marks, and although you're absolutely right when you say that almost everyone has them, it's still something that can cause a lot of distress. They day we really get something out for striae (let's hope it's elastagen), it's going to be at least as big as the day botox was out. Probably much more than that in fact.
So yeah, everyone has something they want to get fixed, fon't start saying fixing scars is more important than "damn" stretch marks.
Are you fucking kidding me ? people that suffer severe burns from acid attacks , scarring from accidents , destroys lives and the integrity of movement , burns reaching all the way into the hypodermis , and you get distressed over stretch marks ? ... this has to be a joke.
People end up dying because of these acid attacks and severe scarring from burns ... scarless healing can give them their lives back , their dignity and health , but of course stretch marks right ?.
2 hours ago, Scarcure said:Are you fucking kidding me ? people that suffer severe burns from acid attacks , scarring from accidents , destroys lives and the integrity of movement , burns reaching all the way into the hypodermis , and you get distressed over stretch marks ? ... this has to be a joke.
People end up dying because of these acid attacks and severe scarring from burns ... scarless healing can give them their lives back , their dignity and health , but of course stretch marks right ?.
Thank you, I'm well aware of the effects of severe scars following a big accident. Of course it's important, and of course it will be life changing once a proper treatment is out there. What I'm saying is that there's an incredibly big amount of people who will pay to get rid of their stretch marks. Like you said most people get them, and even if a tiny percentage of these people are seriously suffering from their presence, it's still big. Even if 5% of the people who have stretch marks would want to do something about them, that's still hundreds of millions of people on a regular basis, since stretch marks are a "natural occurence".
Just look at how many followers a guy like rodolfo torres, who does stretch marks tattoos, gets just because he's known for that. Now imagine what will happen when the first treatment for stretch marks is finally available?
All I'm saying is that it would be a big change for hundreds of millions of people, and of course it would be insanely profitable (which is why elastagen focused on stretch marks before scars in general).
It doesn't really matter though: things are changing very quickly, so scars will get their treatment in the future as well. Just be patient
On 2/19/2020 at 5:40 PM, nikki_gargin said:Tropoelastin looks amazing. Another missing link in the puzzle. Im not sure if it would work for me but still good product.
i have had fat grafting recently and it has worked amazing for me for comfort and softness of scar but the elasticity is still yet to be seen. A scar revision and tropoelastin injectable for me could be enough actually for full function again. Also elasticity helps reduce tension which in itself improves scars.
We have technology now that improve the collagen composition eg type 3 to type 1 through lasers, needling etc its just you cant bring back any of the other missing bits. Elasticity is what causes most of the superficial problems like contracture and just the odd way the skin looks. Also the cause of disability as well. Dermal substitutes have elastic fibres in them I believe though? I know it reduces contracture big time.
(living with a burn injury not acne scars)
5 hours ago, nikki_gargin said:Dermal substitutes have elastic fibres in them I believe though? I know it reduces contracture big time.
Pretty much yes, like you said elasticity is what allows tissue to keep its original form, and the loss of elastine is what cause skin damage (scarring, stretch marks, spots, injuries...)
I believe the main issue so far, when it comes to the available dermal substitutes, is their inability to replicate the most basic functions of the skin tissue. So it doesn't work as a skin replacement entity should.
Imo, tropoelastin is going to be a big game changer in the future, especially for people who have big painful scars or severe tissue damage.
There's some discussion about elastagen going on on quora if you guys are interested: https://qr.ae/TjDbJf
The waiting is still killing me, day after day after day, I really hope we will get scarless healing within next 5-10 years...
10 hours ago, AlexZ77 said:The waiting is still killing me, day after day after day, I really hope we will get scarless healing within next 5-10 years...
Is it physically painful in your case? Because if it's not about the aesthethics, I completely understand where you're coming from. Having to deal with pain on a daily basis because of scars really is a problem.
If it's just about looks, then it's purely about accepting you how you are at the moment. I have lots of stretch marks from puberty, and although it's something that seriously annoys me, and that prevents me from showing skin in several situations, at least women don't seem to care at all about it, so it's not the end of the world.
But yeah, if it's a problem in terms of "not being able to move, or having to deal with pain", then I can for sure understand how annoying it must be to wait.
On 2/23/2020 at 7:20 PM, lehran said:Pretty much yes, like you said elasticity is what allows tissue to keep its original form, and the loss of elastine is what cause skin damage (scarring, stretch marks, spots, injuries...)
I believe the main issue so far, when it comes to the available dermal substitutes, is their inability to replicate the most basic functions of the skin tissue. So it doesn't work as a skin replacement entity should.
Imo, tropoelastin is going to be a big game changer in the future, especially for people who have big painful scars or severe tissue damage.
Did I read you have trauma scars as well? One of mine is over an area which needs to stretch in multiple directions of motion, neck directly under the chin about an inch underneath, stretching round about 180 circumference of my upper neck. I can feel it is elasticity missing. I think you know these things with these injurys because you feel it rather than reading about it. Micro needling has been great for improving softness of the collagen. Fat grafting same thing, collagen remodelling with improved pliability. But no change at all in elasticity.
i feel very excited about this just so I can move properly and feel comfortable! Also I think it will sort some deformity i have. Keep us all updated please.
12 hours ago, Valkyros said:Is it physically painful in your case? Because if it's not about the aesthethics, I completely understand where you're coming from. Having to deal with pain on a daily basis because of scars really is a problem.
If it's just about looks, then it's purely about accepting you how you are at the moment. I have lots of stretch marks from puberty, and although it's something that seriously annoys me, and that prevents me from showing skin in several situations, at least women don't seem to care at all about it, so it's not the end of the world.
But yeah, if it's a problem in terms of "not being able to move, or having to deal with pain", then I can for sure understand how annoying it must be to wait.
Its only aboutaesthethics actually.
Those acne scars on my temples are really making me sad some days, like eveything in my life is going great, going to a great uni, i dohaveagf that i love, just got a brand new lexus ISfrom parents but I feel like doesnt matter what I have and do I just cant be 100% happy couse of those scars and this is the only place where I can tell the truth couse the people from my life would call me crazy and wouldnt understand how those scars are making me feel. I also spend a small fortune on treating them (got overall 7 co2 fractional laser with prp.. for what a 30-40% improvement). ...If my doc didnt put on me clonozepanum i would hang myself a long time ago, so I really need a assurance that scarless healing will be possible by 2030
10 hours ago, AlexZ77 said:Its only aboutaesthethics actually.
Those acne scars on my temples are really making me sad some days, like eveything in my life is going great, going to a great uni, i dohaveagf that i love, just got a brand new lexus ISfrom parents but I feel like doesnt matter what I have and do I just cant be 100% happy couse of those scars and this is the only place where I can tell the truth couse the people from my life would call me crazy and wouldnt understand how those scars are making me feel. I also spend a small fortune on treating them (got overall 7 co2 fractional laser with prp.. for what a 30-40% improvement). ...If my doc didnt put on me clonozepanum i would hang myself a long time ago, so I really need a assurance that scarless healing will be possible by 2030
It's basically exactly the same for me, but it's about my stretch marks. They're not particularly huge, they're your usual stretch marks, but I have them on all my joints since puberty. Women don't seem to care about them at all, in fact none ever mentioned them, but it's still a big problem for me.
I don't have acne scars, no scars at all in general, but the fact that I have lots of stretch marks as a man (and I was never big) is something that is depressing, for sure.
7 hours ago, Valkyros said:It's basically exactly the same for me, but it's about my stretch marks. They're not particularly huge, they're your usual stretch marks, but I have them on all my joints since puberty. Women don't seem to care about them at all, in fact none ever mentioned them, but it's still a big problem for me.
I don't have acne scars, no scars at all in general, but the fact that I have lots of stretch marks as a man (and I was never big) is something that is depressing, for sure.
Have you tried micropigmentation? Because you have normal epidermis this should hide them nicely?
18 hours ago, nikki_gargin said:Have you tried micropigmentation? Because you have normal epidermis this should hide them nicely?
Nah, I'm not going to do that. First, putting pigments on stretch marks is not a good idea in general, in the long-term, and it doesn't really address the problem that much, imo.
I might have considered it if no good option was in sight, but with elastagen having developed a proper product for filling the void of stretch marks with synthethic skin, I can wait a few years honestly.
You guys shoulnd't even bother with micropigmentation if you have scars or stretch marks, just don't. Sure, it might (keyword here: might) help make them less noticeable, but it's not gonna change their shape or anything.
The truth is that it could go super wrong as well: you could get additional scarring if it's done wrong, infections, the ink might not blend in well at all and so on...just not worth the risk at all.
And honestly why bother at all? When it comes to scars/burns/acne scars/stretch marks, we're going to have amazing options in the near future. Only a couple years left now, it's just around the corner (at least for elastagen).