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Tons of people have stretch marks. Most people in fact. And even though they're not considered as scars since they're more like zones where elastin fibers couldn't grow rather than skin lesions, the fact that we're going to be able to treat them is a really big thing imo.
I don't know, I took a look at conversations from months ago in this thread, and tons of people are talking about stretch marks too.
Also, isn't elastagen very promising for scars as well?
20 hours ago, user99 said:Stretch marks are scars!!!!
so we need information about ALL TREATMENTS AND NEWS!!! included elastagen
They're not though. Just like Valkyros said, they're zones devoid of elastin fibers. It's also why they're not something as problematic as scars (they don't hurt, and you don't feel them).
17 hours ago, Scarcure said:But everyone has them .... facial scarring is vastly more important to cure than damn stretch marks.
That's your opinion, and a lot of people would disagree, trust me. Some of us have lots of stretch marks, and although you're absolutely right when you say that almost everyone has them, it's still something that can cause a lot of distress. They day we really get something out for striae (let's hope it's elastagen), it's going to be at least as big as the day botox was out. Probably much more than that in fact.
So yeah, everyone has something they want to get fixed, fon't start saying fixing scars is more important than "damn" stretch marks.
8 hours ago, lehran said:They're not though. Just like Valkyros said, they're zones devoid of elastin fibers. It's also why they're not something as problematic as scars (they don't hurt, and you don't feel them).
That's your opinion, and a lot of people would disagree, trust me. Some of us have lots of stretch marks, and although you're absolutely right when you say that almost everyone has them, it's still something that can cause a lot of distress. They day we really get something out for striae (let's hope it's elastagen), it's going to be at least as big as the day botox was out. Probably much more than that in fact.
So yeah, everyone has something they want to get fixed, fon't start saying fixing scars is more important than "damn" stretch marks.
Are you fucking kidding me ? people that suffer severe burns from acid attacks , scarring from accidents , destroys lives and the integrity of movement , burns reaching all the way into the hypodermis , and you get distressed over stretch marks ? ... this has to be a joke.
People end up dying because of these acid attacks and severe scarring from burns ... scarless healing can give them their lives back , their dignity and health , but of course stretch marks right ?.
2 hours ago, Scarcure said:Are you fucking kidding me ? people that suffer severe burns from acid attacks , scarring from accidents , destroys lives and the integrity of movement , burns reaching all the way into the hypodermis , and you get distressed over stretch marks ? ... this has to be a joke.
People end up dying because of these acid attacks and severe scarring from burns ... scarless healing can give them their lives back , their dignity and health , but of course stretch marks right ?.
Thank you, I'm well aware of the effects of severe scars following a big accident. Of course it's important, and of course it will be life changing once a proper treatment is out there. What I'm saying is that there's an incredibly big amount of people who will pay to get rid of their stretch marks. Like you said most people get them, and even if a tiny percentage of these people are seriously suffering from their presence, it's still big. Even if 5% of the people who have stretch marks would want to do something about them, that's still hundreds of millions of people on a regular basis, since stretch marks are a "natural occurence".
Just look at how many followers a guy like rodolfo torres, who does stretch marks tattoos, gets just because he's known for that. Now imagine what will happen when the first treatment for stretch marks is finally available?
All I'm saying is that it would be a big change for hundreds of millions of people, and of course it would be insanely profitable (which is why elastagen focused on stretch marks before scars in general).
It doesn't really matter though: things are changing very quickly, so scars will get their treatment in the future as well. Just be patient
On 2/19/2020 at 5:40 PM, nikki_gargin said:Tropoelastin looks amazing. Another missing link in the puzzle. Im not sure if it would work for me but still good product.
i have had fat grafting recently and it has worked amazing for me for comfort and softness of scar but the elasticity is still yet to be seen. A scar revision and tropoelastin injectable for me could be enough actually for full function again. Also elasticity helps reduce tension which in itself improves scars.
We have technology now that improve the collagen composition eg type 3 to type 1 through lasers, needling etc its just you cant bring back any of the other missing bits. Elasticity is what causes most of the superficial problems like contracture and just the odd way the skin looks. Also the cause of disability as well. Dermal substitutes have elastic fibres in them I believe though? I know it reduces contracture big time.
(living with a burn injury not acne scars)
5 hours ago, nikki_gargin said:Dermal substitutes have elastic fibres in them I believe though? I know it reduces contracture big time.
Pretty much yes, like you said elasticity is what allows tissue to keep its original form, and the loss of elastine is what cause skin damage (scarring, stretch marks, spots, injuries...)
I believe the main issue so far, when it comes to the available dermal substitutes, is their inability to replicate the most basic functions of the skin tissue. So it doesn't work as a skin replacement entity should.
Imo, tropoelastin is going to be a big game changer in the future, especially for people who have big painful scars or severe tissue damage.
There's some discussion about elastagen going on on quora if you guys are interested: https://qr.ae/TjDbJf
The waiting is still killing me, day after day after day, I really hope we will get scarless healing within next 5-10 years...
10 hours ago, AlexZ77 said:The waiting is still killing me, day after day after day, I really hope we will get scarless healing within next 5-10 years...
Is it physically painful in your case? Because if it's not about the aesthethics, I completely understand where you're coming from. Having to deal with pain on a daily basis because of scars really is a problem.
If it's just about looks, then it's purely about accepting you how you are at the moment. I have lots of stretch marks from puberty, and although it's something that seriously annoys me, and that prevents me from showing skin in several situations, at least women don't seem to care at all about it, so it's not the end of the world.
But yeah, if it's a problem in terms of "not being able to move, or having to deal with pain", then I can for sure understand how annoying it must be to wait.
On 2/23/2020 at 7:20 PM, lehran said:Pretty much yes, like you said elasticity is what allows tissue to keep its original form, and the loss of elastine is what cause skin damage (scarring, stretch marks, spots, injuries...)
I believe the main issue so far, when it comes to the available dermal substitutes, is their inability to replicate the most basic functions of the skin tissue. So it doesn't work as a skin replacement entity should.
Imo, tropoelastin is going to be a big game changer in the future, especially for people who have big painful scars or severe tissue damage.
Did I read you have trauma scars as well? One of mine is over an area which needs to stretch in multiple directions of motion, neck directly under the chin about an inch underneath, stretching round about 180 circumference of my upper neck. I can feel it is elasticity missing. I think you know these things with these injurys because you feel it rather than reading about it. Micro needling has been great for improving softness of the collagen. Fat grafting same thing, collagen remodelling with improved pliability. But no change at all in elasticity.
i feel very excited about this just so I can move properly and feel comfortable! Also I think it will sort some deformity i have. Keep us all updated please.
12 hours ago, Valkyros said:Is it physically painful in your case? Because if it's not about the aesthethics, I completely understand where you're coming from. Having to deal with pain on a daily basis because of scars really is a problem.
If it's just about looks, then it's purely about accepting you how you are at the moment. I have lots of stretch marks from puberty, and although it's something that seriously annoys me, and that prevents me from showing skin in several situations, at least women don't seem to care at all about it, so it's not the end of the world.
But yeah, if it's a problem in terms of "not being able to move, or having to deal with pain", then I can for sure understand how annoying it must be to wait.
Its only aboutaesthethics actually.
Those acne scars on my temples are really making me sad some days, like eveything in my life is going great, going to a great uni, i dohaveagf that i love, just got a brand new lexus ISfrom parents but I feel like doesnt matter what I have and do I just cant be 100% happy couse of those scars and this is the only place where I can tell the truth couse the people from my life would call me crazy and wouldnt understand how those scars are making me feel. I also spend a small fortune on treating them (got overall 7 co2 fractional laser with prp.. for what a 30-40% improvement). ...If my doc didnt put on me clonozepanum i would hang myself a long time ago, so I really need a assurance that scarless healing will be possible by 2030
10 hours ago, AlexZ77 said:Its only aboutaesthethics actually.
Those acne scars on my temples are really making me sad some days, like eveything in my life is going great, going to a great uni, i dohaveagf that i love, just got a brand new lexus ISfrom parents but I feel like doesnt matter what I have and do I just cant be 100% happy couse of those scars and this is the only place where I can tell the truth couse the people from my life would call me crazy and wouldnt understand how those scars are making me feel. I also spend a small fortune on treating them (got overall 7 co2 fractional laser with prp.. for what a 30-40% improvement). ...If my doc didnt put on me clonozepanum i would hang myself a long time ago, so I really need a assurance that scarless healing will be possible by 2030
It's basically exactly the same for me, but it's about my stretch marks. They're not particularly huge, they're your usual stretch marks, but I have them on all my joints since puberty. Women don't seem to care about them at all, in fact none ever mentioned them, but it's still a big problem for me.
I don't have acne scars, no scars at all in general, but the fact that I have lots of stretch marks as a man (and I was never big) is something that is depressing, for sure.
7 hours ago, Valkyros said:It's basically exactly the same for me, but it's about my stretch marks. They're not particularly huge, they're your usual stretch marks, but I have them on all my joints since puberty. Women don't seem to care about them at all, in fact none ever mentioned them, but it's still a big problem for me.
I don't have acne scars, no scars at all in general, but the fact that I have lots of stretch marks as a man (and I was never big) is something that is depressing, for sure.
Have you tried micropigmentation? Because you have normal epidermis this should hide them nicely?
18 hours ago, nikki_gargin said:Have you tried micropigmentation? Because you have normal epidermis this should hide them nicely?
Nah, I'm not going to do that. First, putting pigments on stretch marks is not a good idea in general, in the long-term, and it doesn't really address the problem that much, imo.
I might have considered it if no good option was in sight, but with elastagen having developed a proper product for filling the void of stretch marks with synthethic skin, I can wait a few years honestly.
You guys shoulnd't even bother with micropigmentation if you have scars or stretch marks, just don't. Sure, it might (keyword here: might) help make them less noticeable, but it's not gonna change their shape or anything.
The truth is that it could go super wrong as well: you could get additional scarring if it's done wrong, infections, the ink might not blend in well at all and so on...just not worth the risk at all.
And honestly why bother at all? When it comes to scars/burns/acne scars/stretch marks, we're going to have amazing options in the near future. Only a couple years left now, it's just around the corner (at least for elastagen).
I dont know how much more waiting i can take , i got a margin from dry eye .... looks like someone cut my eyelid
I have been battling scars since 18 years old , am going to be 31 in under 3 weeks .... am so depressed my eyes are red from crying , i tried suicide 3 to 4 times because of the scars on my face .... Am weak in this respect , you have to admire the people that are victim of burns and they try to get on.
There's a 6 year old child that was burned from a house fire ..... it breaks my heart seeing her .... but with my depression , ocd , and lack of friends coping is all i can do.
i meditate every morning , i train , i eat right , i try to look at the bright side , but i just see myself 6 feet under ... if i was never cursed with the acne in the first place all this would be prevented.
I hope this decade is it .... because this isn't right for anyone to go though , not just acne scars , but any scarring.
8 hours ago, Scarcure said:I dont know how much more waiting i can take , i got a margin from dry eye .... looks like someone cut my eyelid
I have been battling scars since 18 years old , am going to be 31 in under 3 weeks .... am so depressed my eyes are red from crying , i tried suicide 3 to 4 times because of the scars on my face .... Am weak in this respect , you have to admire the people that are victim of burns and they try to get on.
There's a 6 year old child that was burned from a house fire ..... it breaks my heart seeing her .... but with my depression , ocd , and lack of friends coping is all i can do.
i meditate every morning , i train , i eat right , i try to look at the bright side , but i just see myself 6 feet under ... if i was never cursed with the acne in the first place all this would be prevented.
I hope this decade is it .... because this isn't right for anyone to go though , not just acne scars , but any scarring.
You sound quite familiar of someone I know. Where are you located?
15 hours ago, Valkyros said:Nah, I'm not going to do that. First, putting pigments on stretch marks is not a good idea in general, in the long-term, and it doesn't really address the problem that much, imo.
I might have considered it if no good option was in sight, but with elastagen having developed a proper product for filling the void of stretch marks with synthethic skin, I can wait a few years honestly.
I am still quite eerieabout introducing something synthetic inside the largest organ of my body:
1)firstly on the bed of an open wound and 2)secondly leavingit inside theskin as the wound contracts.
I wonder if this product gets eventually absorbed by the body and wether it has carcinogenic or other health effects in the longrun. Is this manufactured thin layer free of all contaminents that may be life-threatening? What happens if the wound gets infected afterthe material gets placed?
SkinTE is complete hogwash for scars. They cut pieces of skin, make a paste and put it on the wound. Congratulations, now you have 2 scars instead of 1. The only discipline it can be useful for is possibly burns. Those stem cells in that paste may minimize scarring to a certain degree. If anyone goes back a few pages onthis thread, patient pictures under clinical trials usingthe revolutionary SkinTE technology have been posted. It is not scar-free, scarless or complete regeneration as you may wish to call it. Is the scarring minimized? Yes to some degree. Moving along.
There were a few topicals that I had discussed under clinical trials a few years back. I had really high hopes particularly on BirchBiomed's FS2. Unfortunately, we haven't heard anything from themafter they commenced their second clinical trial stage, which was about 2 years ago. I no longer feel enthusiastic that they will ever release anything to market in the foreseeable future.
Another offshoot was OLX101. This startup apparently discovered a way of transforming RNAreverting existing scars to normal skin and preventing new ones from forming. Quite innovative, their methodology involves gene sequencing and scars dissapear with a simple injection. Unfortunately, as many other proponents, they vanish several years later after initially releasing forward looking statements.
For scarless healing to be achieved, I have realized it can only happen under the following circumstance. Let me elaborate further. I personally believe scar reduction or formation will and must be achieved through a topical or injectable plasma like material. Our bodies have evolved to close wounds as quickly as possible to stop infectious agents from spreading. Mammalian evolution came with a major stepback : no complete regeneration in order to reduce microbial disease. A small write-off you may say but in a society were beauty standards are constitantly pushed to new limits, I can understand why everybody is ashamed of their scars, acne and stretch marks.
Let's think for a moment. Messing around with an existing wound is strictly not recommended by all physicians. Best remedy is to wash withwater and let heal. Obviously, when the gap is clearly life-threatening, surgeons will use sutures or own skin grafts to assist the healing process. Constant monitoring is then providedto eliminate contamination for several days to even years. This is why SkinTE poses several serious risks. No credible physician will leave, for example, a 0.5cm wide open wound exposed to apply some magic paste and hope for regeneration. The product is suggested to some patients and a signed waiver is usually requested. Nothing is set in stone yet for SkinTE.Their recent struggles make me question their credibility as a whole.
3 hours ago, MyBeautifulScars said:You sound quite familiar of someone I know. Where are you located?
I am still quite eerieabout introducing something synthetic inside the largest organ of my body:
1)firstly on the bed of an open wound and 2)secondly leavingit inside theskin as the wound contracts.
I wonder if this product gets eventually absorbed by the body and wether it has carcinogenic or other health effects in the longrun. Is this manufactured thin layer free of all contaminents that may be life-threatening? What happens if the wound gets infected afterthe material gets placed?
SkinTE is complete hogwash for scars. They cut pieces of skin, make a paste and put it on the wound. Congratulations, now you have 2 scars instead of 1. The only discipline it can be useful for is possibly burns. Those stem cells in that paste may minimize scarring to a certain degree. If anyone goes back a few pages onthis thread, patient pictures under clinical trials usingthe revolutionary SkinTE technology have been posted. It is not scar-free, scarless or complete regeneration as you may wish to call it. Is the scarring minimized? Yes to some degree. Moving along.
There were a few topicals that I had discussed under clinical trials a few years back. I had really high hopes particularly on BirchBiomed's FS2. Unfortunately, we haven't heard anything from themafter they commenced their second clinical trial stage, which was about 2 years ago. I no longer feel enthusiastic that they will ever release anything to market in the foreseeable future.
Another offshoot was OLX101. This startup apparently discovered a way of transforming RNAreverting existing scars to normal skin and preventing new ones from forming. Quite innovative, their methodology involves gene sequencing and scars dissapear with a simple injection. Unfortunately, as many other proponents, they vanish several years later after initially releasing forward looking statements.
For scarless healing to be achieved, I have realized it can only happen under the following circumstance. Let me elaborate further. I personally believe scar reduction or formation will and must be achieved through a topical or injectable plasma like material. Our bodies have evolved to close wounds as quickly as possible to stop infectious agents from spreading. Mammalian evolution came with a major stepback : no complete regeneration in order to reduce microbial disease. A small write-off you may say but in a society were beauty standards are constitantly pushed to new limits, I can understand why everybody is ashamed of their scars, acne and stretch marks.
Let's think for a moment. Messing around with an existing wound is strictly not recommended by all physicians. Best remedy is to wash withwater and let heal. Obviously, when the gap is clearly life-threatening, surgeons will use sutures or own skin grafts to assist the healing process. Constant monitoring is then providedto eliminate contamination for several days to even years. This is why SkinTE poses several serious risks. No credible physician will leave, for example, a 0.5cm wide open wound exposed to apply some magic paste and hope for regeneration. The product is suggested to some patients and a signed waiver is usually requested. Nothing is set in stone yet for SkinTE.Their recent struggles make me question their credibility as a whole.
Am located in the UK.
7 hours ago, MyBeautifulScars said:I am still quite eerieabout introducing something synthetic inside the largest organ of my body:
1)firstly on the bed of an open wound and 2)secondly leavingit inside theskin as the wound contracts.
I wonder if this product gets eventually absorbed by the body and wether it has carcinogenic or other health effects in the longrun. Is this manufactured thin layer free of all contaminents that may be life-threatening? What happens if the wound gets infected afterthe material gets placed?
SkinTE is complete hogwash for scars. They cut pieces of skin, make a paste and put it on the wound. Congratulations, now you have 2 scars instead of 1. The only discipline it can be useful for is possibly burns. Those stem cells in that paste may minimize scarring to a certain degree. If anyone goes back a few pages onthis thread, patient pictures under clinical trials usingthe revolutionary SkinTE technology have been posted. It is not scar-free, scarless or complete regeneration as you may wish to call it. Is the scarring minimized? Yes to some degree. Moving along.
There were a few topicals that I had discussed under clinical trials a few years back. I had really high hopes particularly on BirchBiomed's FS2. Unfortunately, we haven't heard anything from themafter they commenced their second clinical trial stage, which was about 2 years ago. I no longer feel enthusiastic that they will ever release anything to market in the foreseeable future.
Another offshoot was OLX101. This startup apparently discovered a way of transforming RNAreverting existing scars to normal skin and preventing new ones from forming. Quite innovative, their methodology involves gene sequencing and scars dissapear with a simple injection. Unfortunately, as many other proponents, they vanish several years later after initially releasing forward looking statements.
For scarless healing to be achieved, I have realized it can only happen under the following circumstance. Let me elaborate further. I personally believe scar reduction or formation will and must be achieved through a topical or injectable plasma like material. Our bodies have evolved to close wounds as quickly as possible to stop infectious agents from spreading. Mammalian evolution came with a major stepback : no complete regeneration in order to reduce microbial disease. A small write-off you may say but in a society were beauty standards are constitantly pushed to new limits, I can understand why everybody is ashamed of their scars, acne and stretch marks.
Let's think for a moment. Messing around with an existing wound is strictly not recommended by all physicians. Best remedy is to wash withwater and let heal. Obviously, when the gap is clearly life-threatening, surgeons will use sutures or own skin grafts to assist the healing process. Constant monitoring is then providedto eliminate contamination for several days to even years. This is why SkinTE poses several serious risks. No credible physician will leave, for example, a 0.5cm wide open wound exposed to apply some magic paste and hope for regeneration. The product is suggested to some patients and a signed waiver is usually requested. Nothing is set in stone yet for SkinTE.Their recent struggles make me question their credibility as a whole.
Tons of interesting things were mentioned here, let's see:
I/ About elastagen: it's an interesting thought. And you're quite right when you say that infections could always happen if it's not done right. However, that's only when we're talking about open wounds. When it comes to stuff like stretch marks (which is what is going to interest most people), it's a non-issue imo. If I can get something like a 90% reduction, I'm more than willing to do it, it's going to be way too much of a life change for. Also, I looked into it: there's no way that this will be absorbed by the body, as clinical trials proved that the body is tricked into thinking that it's the original skin = 0 compatibility issues (and ofc, it reproduces every function of the skin, as mentioned here ( https://go8.edu.au/wp-content/uploads/2019/04/Allies-In-Excellence.pdf)
II/About SkinTE: you're dead on man. SkinTE is not going to do jack shit for scars, acne scars, atrophic scars, hypertrophic scars, yada yada...I asked several surgeons/dermatologists, and it's a clear difference when compared to how lauded elastagen's product is right now.
III/Do take a look at what direct biologics is doing with exoflo (since you mentioned birchbiomed and OLX): my surgeon tells me it's very promising for scars and stretch marks.
I'm probably starting to look like a fanboy since I'm always talking about elastagen, but it's just because I'm very careful, probably like you are, with these things: who are the investors, what is the medical team like, how popular is it, what were the clinical trials like, are the big dogs from the pharmaceutical industries interested and so on...
So far, when it comes to tissue regeneration/skin replacement/scar healing, I haven't seen any clinical trial company been bought for hundreds of millions of dollars by a big company except elastagen, so, although I do keep the other names in mind, my bet is on that one for now. Now when it comes to 100% scar healing we're not quite ther yet, but something which will make an extremely big difference (90% reduction, which is what their trials show so far) is more than enough for small scars/skin lesions, as that will allow us to show our skin without feeling bad about it.
I honestly don't get why people act like any human creation is bad for your health. Just because something isn't organic/"natural" doesn't mean it is bad for you. Natural products aren't the solution to our problems. In fact, many natural substances and remedies are complete hogwash without any sort of scientific evidence. There are some exceptions of course, but you get the gist.
Something penetrating the dermis isn't necessarily a bad thing. These sort of products go through clinical testing to ensure their safety. If a new innovation removes or lessens acne scars without severe consequences, then it's something many of us will be excited about. Are scars the worst issue in the world? No. There are many people dealing with much worse things. That doesn't change the reality that human appearance impacts people's perception of you, social outcomes, self esteem, and even quality of life.