Acne.org Products
There is another emerging playerthat nobody has talked about, PXL01.
https://www.promorepharma.com/en/pxl01
They are currently in clinical trials. They have developed a peptide which aims to tackle scarring. They are primarily focused however on eliminating internal scarring aftertendon surgery for now.
On 1/14/2019 at 5:34 PM, MyBeautifulScars said:FS2 as I stated before contains kynurenine, a natural occurring metabolite found in living organisms.A metabolite is normally a byproduct of an amino acid,in this case tryptophan. Amino acids are important as they play an important role in protein synthesis.
Kynurenine is also important because it regulates the immune system and also dilates blood vessels during inflammation. So its essential to wound healing. Too much kynurenine suggests however increased risk of mental illness and cardiovascular disease.
It was found that this metaboliteprevents and breaks down scar tissue during experimental research when applied topically. BirchBioMed never claimed regenaration. How kynurenine breaks down scar tissue remains a mystery as surely BirchBiomed has patented their discovery. Scar tissue either way is just mis-aligned collagen bundleswhich replaceold tissue after an injury. This is also called fibrosis as fibroblasts laydown collagen hastily to repair the damage. Almost all human organs go through fibrosis when damagedand it is believed that this phenomenon blocks off regeneration. It's a trade off that nature decided to implement and switch off regeneration in complex organisms such as mammals.
The issue is that our body is not capable of re-aligning the new collagen into the basket weave pattern. Nowadays, seeing that people have become quite self aware of their image, scars are not pleasant and a serious issue for most of us who have to deal with cystic acne and its embarrassing scarring.
In scar tissue, pores are not regenerated and as a consequence neither do hair follicles. Skin also lacks the ability to produce pigment. This results in hypertrophic scars or fine line scars for most people after several years. In acne or infectious pore diseases,the underlying fat tissue is lost and not replaced, resulting in a dent at the healed area. Others are not so lucky and the fibroblasts go out of control producing masses ofcollagen. These scars are known as keloids which are benign tumours of collagen. Recent research suggests that fat tissue is essential to skin regeneration. The trick is to regenerate pores and hair follicles.
I personally believe that FS2 is mostly targeting hypertrophic/keloid scars and not atrophic scars, the dents left behind chicken pox or acne per say. I also believe they are playing with words. They claim theirproduct prevents scarring in new wounds but I believe the healing outcome is an invisible looking flat scar if anything. It's a start and can help many people. I rather have a fine line flat scar which lacks pigment rather than a dent or raised bundles of skin.
So you think pore and hair follicle regeneration is the key to reducing acne scarring?
On 1/16/2019 at 6:16 AM, Sniffy said:What about hyperpigmentation/hypopigmentaion?
I wonder if it could help renew normal pigmentation in PIH areas or loss of colour. If FS2 stops scarring forming will it allow normal skin to heal over and thus heal without hyperpigmentation.
Dr Sun told me WizGel hasnt been tested on models with hyperpigmentation but WizGel targets any abnormalities in the skin so should regenerate to its original state pre injury, acne, damage etc.
Looking forward to some answers in 2019
WizGel....lol What do they do pee and make it into a gel? I am still waiting. Looks of talk and no action.
3 hours ago, Skin Pessimist said:So you think pore and hair follicle regeneration is the key to reducing acne scarring?
Scarring in general. Pores and hair follicles release BMPs which are essential for adipose tissue, fatty tissue. With acne or atrophic scarring, there is an absence of fat tissue resultingin skin indentations.
51 minutes ago, nikkigirl said:WizGel....lol What do they do pee and make it into a gel? I am still waiting. Looks of talk and no action.
I agree, this stuff doesn't seem legit and does nothing on existing scars anyways.
Well when you guysbuild your own company and find a literal holy grail of medicine you can complain about Dr. Sun. I'm sure if he wanted to he could easily become a Beverly Hills dermatologist and charge people 2000 for a Fraxel treatment but he's trying to make improvements to medicine. Lots of people are working very hard to solve issues like scarring but unfortunately the FDAdiscourages innovation and research and makes it difficult and expensive to solve medicalproblems. I'm sure Dr. Sun's product isn't perfect but his pictures of the rat and pig were some of the closest things I've seen to scarless healing.
15 hours ago, FromScarredtoFree said:Well when you guysbuild your own company and find a literal holy grail of medicine you can complain about Dr. Sun. I'm sure if he wanted to he could easily become a Beverly Hills dermatologist and charge people 2000 for a Fraxel treatment but he's trying to make improvements to medicine. Lots of people are working very hard to solve issues like scarring but unfortunately the FDAdiscourages innovation and research and makes it difficult and expensive to solve medicalproblems. I'm sure Dr. Sun's product isn't perfect but his pictures of the rat and pig were some of the closest things I've seen to scarless healing.
Yeah we still haven't seen any trials and results from Sunogel to call it bullshit
Someone should start a petition on change.org or facebook's new petition feature for more research on acne and acne scarring. I tried once on here but only got 10 supporters. Need more funding for acne and acne scarring from the NIH, philanthropic foundations, universities, etc. Real research not just combining old creams to make new ones which is mostly done right now.
On 10/29/2018 at 1:01 AM, Binga said:
4 hours ago, KhakiSkewer said:On 10/29/2018 at 5:31 AM, Binga said:
all these researches should retire ..
tired of such articles ,fast wound healing was seen
complete regenration occured
all these are nonsense ....nothing gonna come
seen these type of news and articles from many years,nothing came
only option is to correct our scar is study become researches,research,find smthng that works,use it on ur own skin(no need of FDA for this)
10 hours ago, Anish004 said:all these researches should retire ..
tired of such articles ,fast wound healing was seen
complete regenration occured
all these are nonsense ....nothing gonna come
seen these type of news and articles from many years,nothing came
only option is to correct our scar is study become researches,research,find smthng that works,use it on ur own skin(no need of FDA for this)
1. It's not a science paper, it's just a journalist article that always exaggerates things.
2. Good luck with studying and becoming a researcher, our "only option" 
And finding on your own that "smth" ofc. Just do it!
13 hours ago, GeneTrouble said:1. It's not a science paper, it's just a journalist article that always exaggerates things.
2. Good luck with studying and becoming a researcher, our "only option"
thanx for trolling me and best of luck for ur scar solution by these statements "scarless healing was seen in mice etc and also fs2
good luck
https://www.eurekalert.org/pub_releases/2019-02/uoc--usr020719.php
Exciting news from Cotsarelis' team. Seems the research is advancing.
Its kind of sad there's been such little enthusiasm as of late on this thread.
Fuck I remember when this thread started 12 years ago and some people had some hope. Can't have much hope now that we got old.
Still there's stuff like this. Why isn't anyone talking about this:
https://science.howstuffworks.com/innovation/everyday-innovations/lab-grown-skin2.htm
Welcome back Rez.
Unfortunately, nobody cares enough about scars to do something about it. Most of us accept them and go on. Scientists have other priorities to tackle including finding functional cures to cancer, HIV and MS. I do believe we have the cures but it's all politics.
You have some research going on if you have followed the thread the last few months including but not limited to papers published by a team headed by Cotsarelis at UCI.It can take years however before any treatment comes out of this if anything really does. Cotsarelis has been promising a permanent solution to male alopecia and we are still light years away, I'm blessed at least with hair but acne really disfigured me.
You have few startups testing anti scarring drugs including FS2 and OLX101. They are in phase 2 of clinical trials so we are hoping they don't fail. People were once raving about Sunogel and Polarity but the enthusiasm has faded for these two. Dr. Sun doesn't seem to be moving forward with his hydrogel and Polarity is moving ahead by presenting itself as an alternative to skin grafts.
One day, scars will be historybut we will never probably see it in our lifetime. Make the best of what you have presently.
looks like scarless healing to me
https://www.linkedin.com/pulse/next-phase-treating-skin-laxity-coming-2019-marc-weiser/
2 hours ago, Binga said:looks like scarless healing to me
https://www.linkedin.com/pulse/next-phase-treating-skin-laxity-coming-2019-marc-weiser/
1.5mm diameter?? than how the hell it can heal scarlessly.
i am a supporter of microcoring but 1.5mm diameter is big for healing scarlessly
On 2/12/2019 at 5:48 PM, MyBeautifulScars said:Welcome back Rez.
Unfortunately, nobody cares enough about scars to do something about it. Most of us accept them and go on. Scientists have other priorities to tackle including finding functional cures to cancer, HIV and MS. I do believe we have the cures but it's all politics.
You have some research going on if you have followed the thread the last few months including but not limited to papers published by a team headed by Cotsarelis at UCI.It can take years however before any treatment comes out of this if anything really does. Cotsarelis has been promising a permanent solution to male alopecia and we are still light years away, I'm blessed at least with hair but acne really disfigured me.
You have few startups testing anti scarring drugs including FS2 and OLX101. They are in phase 2 of clinical trials so we are hoping they don't fail. People were once raving about Sunogel and Polarity but the enthusiasm has faded for these two. Dr. Sun doesn't seem to be moving forward with his hydrogel and Polarity is moving ahead by presenting itself as an alternative to skin grafts.
One day, scars will be historybut we will never probably see it in our lifetime. Make the best of what you have presently.
I dont think that much pessimism is necessary, itll probably another decade or two but Im sure well see something that will be good enough in our lifetime. I feel you have to take into account other areas of research when talking about any research at all because they all have the potential to speed up, or even acidentally find the solution to another problem.
https://gizmodo.com/complete-axolotl-genome-may-be-a-huge-step-toward-human-1832015926
Another step in the right direction. If only all the worlds top scarless healing researchers work together, we probably have a cure by now.
On 2/15/2019 at 10:30 AM, Beanbagdog said:I dont think that much pessimism is necessary, itll probably another decade or two but Im sure well see something that will be good enough in our lifetime. I feel you have to take into account other areas of research when talking about any research at all because they all have the potential to speed up, or even acidentally find the solution to another problem.
I really hopesomething comes out in a decade or two but I'll be in my 50s by then. Who cares about scars then.