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18 hours ago, AlexaderZ77 said:There is a lotof treatments that can improve scars rn, but cure is not that far away probably 10 or 20 years at most. Still I would bet that by 2030 there will be already a cure
Current methods are mediocre at best. Treatments cost thousands of dollars and require multiple procedures. All that for 40 or 50% improvement if you're incredibly lucky.
On 1/4/2019 at 6:39 PM, MyBeautifulScars said:Yeah, but a scar is not a disease,remember that. You keep thinking that scarring is a disease. It's a way for the body to repair itself, nature has decided sobut not all organisms heal this way. Mammals have limited regenerative capacity, so blame your genes not the scientists who spend days in labs discovering the mechanisms behind life.There is no cure to find for scarring as it is not a disease. You can say that scarring affects people emotionally and this can lead to mental illness. If we didn't scar however, our wounds would never close and we would probably die by hemorrhage or infection.
I believe that research is going on behind closed doors. Many diseases can be cured but unfortunately certain individuals (religious groups, the incredibly wealthy, big companies, politicians, doctors, etc.) don't want these new therapiesto be accessible to the general populace. If you still can't cure acne in 2019 and can't regenerate limbs, how do you expect them tofind a way to eliminate scarring? I truly believe that the only way scarring can ever be addressedis if one day they figure outto regenerate limbs. This is truly the key to regeneration and scarless healing. Scar tissue blocks off regeneration.
Mammals are complex organisms with several cells working together. Smaller less primitive organisms are capable of regeneration. Mammals can regenerate, the key is to reactivate that capability which evolution switched off.
Why would religious groups not want solutions to acne scarring? I don't see the motive.
22 minutes ago, Skin Pessimist said:Current methods are mediocre at best. Treatments cost thousands of dollars and require multiple procedures. All that for 40 or 50% improvement if you're incredibly lucky.
Why would religious groups not want solutions to acne scarring? I don't see the motive.
Right. There isn't even a mediocre method. Allnon-surgical current "methods" made zero improvement for my scar. Lasers makeZero difference.
40-50% improvement? Please...I haven't even heard their marketerstry to sellanything close to that
3 hours ago, Skin Pessimist said:Why would religious groups not want solutions to acne scarring? I don't see the motive.
You need to understand that it has nothing to do with scarring per say but it goes deeper than that.
What is morally acceptable forscience to do or not do when it comes to changing human DNA, gene manipulation or stem cell research.Many politiciansin western countries have passed legislation that don't allowresearchers from doing much.
Religious leaders will often speak out about the implications of cloningand stem cell research. It's another debate on ethics and morals. People are frightened of the unknown.
8 hours ago, MyBeautifulScars said:You need to understand that it has nothing to do with scarring per say but it goes deeper than that.
What is morally acceptable forscience to do or not do when it comes to changing human DNA, gene manipulation or stem cell research.Many politiciansin western countries have passed legislation that don't allowresearchers from doing much.
Religious leaders will often speak out about the implications of cloningand stem cell research. It's another debate on ethics and morals. People are frightened of the unknown.
Gotcha. Thanks for clarifying
We need to remeber that not every country has those legislations. Japan is huge on research,dna therapy, gene editing and their FDA process takes a lot shorter and is supported by gov. You can look up guys like Dr Tsuji whose doing amazing thighs there in Japan and is supported by gov at the same time.
Its quite possible that cure for scarring wont come from USA rather asian coutries.
1 hour ago, AlexaderZ77 said:We need to remeber that not every country has those legislations. Japan is huge on research,dna therapy, gene editing and their FDA process takes a lot shorter and is supported by gov. You can look up guys like Dr Tsuji whose doing amazing thighs there in Japan and is supported by gov at the same time.
Its quite possible that cure for scarring wont come from USA rather asian coutries.
There are many things happening all over the world. Experimental and regenerative medicine is at our doorstep. Many new treatments are in clinical trials currently and can be game changers. However, it takes a long time for new drugs or therapies to be approved. Also, if there is profits to be made, nobody will block these things forever.
The next decade will be interesting. Twenty years ago, we still had cassette radios and pagers. Face and hand transplants were impossible.
Currently, scarring is a billion dollar industry that will expand no doubt.People are increasingly becomingself aware of their body. Nowadays, looks are everything. Do any of you expect for a miracle solution to make scars or stretchmarks vanish overnight? There is still millions to be made in promising minimal improvement for scarring.The solution (I repeat solution as scarring is not a disease, no cure to be found) will surely take a little longer.
In any case, severe forms of acne do result in disfigurement wether severe or minor. I was lucky enough to avoid severe facial disfigurement but my back and upper arms look like I was severely burned. I can hide my back thankfully but how many out there wake up to aface everyday coveredwith deepcraters. It is a minor inconvenience for most guys but I can't imagine how devastatingit must be for a young girl looking at her skin. Nobody wants thatand this is why facial acne scars are by far the worst thing to have for any young person.
Addressing cystic acne and developing new treatments should be a top priority in this modern age.However, this industry itself is a million dollar business where many professionals will promise false hope to young people who have tobattlethis stupid skin affliction.
Accutane is the only thing available and this drug comes with a wide range of side effects.When it comes to acne scarring, some dermatologists have developed techniques to improve those pits but it is a costly endeavour. Lasers, subcision, microneedling and peels are performed but they don't do much for most people.
I think within this year we will know a lot about possible cure for scarring. Just hoping Sunogel and FS2 will be succesful
It's amazing as how many posters here still think that scarring is a disease. Don't expect a "cure" for something that is not a disease.
Scarring is completely natural, part of the healing process for many living organisms.
We can expect solutions to eliminate or fade dcarsin the next decades hopefully.
Dont get us wrong we know that scarring is natural and not a disease. By cure wemean a solution that could eliminate scarring even though its mostly a cosmetic problem
12 hours ago, AlexaderZ77 said:Dont get us wrong we know that scarring is natural and not a disease. By cure wemean a solution that could eliminate scarring even though its mostly a cosmetic problem
The semantics are unimportant. Acne scarring is an issue we all want to improve or eliminate. That's the bottom line
Rewatched birchbiomed on YouTube talking about fs2..... and semantics are interesting. They dont claim full regeneration, but they say prevents scars in new wounds.....
now apart from epidermis, dermis..eg.normal tissue,or scar tissue, whats the alternative? There actually isnt one unless its a scab for life lol
fs2therefore must promote normal tissue generation rather than scaring. Maybe it can never be perfect like it never happened, egunder a microscope or perfect pigment, texture etc. Sohence they cant say scarless.
learning more about how the creator got inspired to create the drug, which was through fetus regeneration capacity, then I think they have cracked it as good as the human body can do.
9 minutes ago, nikki_gargin said:Rewatched birchbiomed on YouTube talking about fs2..... and semantics are interesting. They dont claim full regeneration, but they say prevents scars in new wounds.....
Regeneration means creating something out of nothing or another type of cell. Scar prevention means blocking the process of scar formation during the healing of skin which is more realistic and likely that will succeed now...
Regeneration just sounds exciting as a slogan
18 minutes ago, nikki_gargin said:Rewatched birchbiomed on YouTube talking about fs2..... and semantics are interesting. They dont claim full regeneration, but they say prevents scars in new wounds.....
now apart from epidermis, dermis..eg.normal tissue,or scar tissue, whats the alternative? There actually isnt one unless its a scab for life lol
fs2therefore must promote normal tissue generation rather than scaring. Maybe it can never be perfect like it never happened, egunder a microscope or perfect pigment, texture etc. Sohence they cant say scarless.
learning more about how the creator got inspired to create the drug, which was through fetus regeneration capacity, then I think they have cracked it as good as the human body can do.
FS2 as I stated before contains kynurenine, a natural occurring metabolite found in living organisms.A metabolite is normally a byproduct of an amino acid,in this case tryptophan. Amino acids are important as they play an important role in protein synthesis.
Kynurenine is also important because it regulates the immune system and also dilates blood vessels during inflammation. So its essential to wound healing. Too much kynurenine suggests however increased risk of mental illness and cardiovascular disease.
It was found that this metaboliteprevents and breaks down scar tissue during experimental research when applied topically. BirchBioMed never claimed regenaration. How kynurenine breaks down scar tissue remains a mystery as surely BirchBiomed has patented their discovery. Scar tissue either way is just mis-aligned collagen bundleswhich replaceold tissue after an injury. This is also called fibrosis as fibroblasts laydown collagen hastily to repair the damage. Almost all human organs go through fibrosis when damagedand it is believed that this phenomenon blocks off regeneration. It's a trade off that nature decided to implement and switch off regeneration in complex organisms such as mammals.
The issue is that our body is not capable of re-aligning the new collagen into the basket weave pattern. Nowadays, seeing that people have become quite self aware of their image, scars are not pleasant and a serious issue for most of us who have to deal with cystic acne and its embarrassing scarring.
In scar tissue, pores are not regenerated and as a consequence neither do hair follicles. Skin also lacks the ability to produce pigment. This results in hypertrophic scars or fine line scars for most people after several years. In acne or infectious pore diseases,the underlying fat tissue is lost and not replaced, resulting in a dent at the healed area. Others are not so lucky and the fibroblasts go out of control producing masses ofcollagen. These scars are known as keloids which are benign tumours of collagen. Recent research suggests that fat tissue is essential to skin regeneration. The trick is to regenerate pores and hair follicles.
I personally believe that FS2 is mostly targeting hypertrophic/keloid scars and not atrophic scars, the dents left behind chicken pox or acne per say. I also believe they are playing with words. They claim theirproduct prevents scarring in new wounds but I believe the healing outcome is an invisible looking flat scar if anything. It's a start and can help many people. I rather have a fine line flat scar which lacks pigment rather than a dent or raised bundles of skin.
14 hours ago, surgical scar said:Regeneration means creating something out of nothing or another type of cell. Scar prevention means blocking the process of scar formation during the healing of skin which is more realistic and likely that will succeed now...
Regeneration just sounds exciting as a slogan
Yeah exactly what I was thinking. It will never be regeneration as that does imply creating what was lost again exactly. Which is impossible. A normal tissue replacement is more of suitable way to look at it.
If its flat, soft, pale and in a more basket weaved pattern then honestly it will most likely be invisable to others.
13 hours ago, MyBeautifulScars said:
I personally believe that FS2 is mostly targeting hypertrophic/keloid scars and not atrophic scars, the dents left behind chicken pox or acne per say. I also believe they are playing with words. They claim theirproduct prevents scarring in new wounds but I believe the healing outcome is an invisible looking flat scar if anything. It's a start and can help many people. I rather have a fine line flat scar which lacks pigment rather than a dent or raised bundles of skin.
If I breaks down the scar It has to go through replacing that scar with something. Newer better collagen. You mind find those dented scars do change and fill out if thats the case.
7 hours ago, nikki_gargin said:Yeah exactly what I was thinking. It will never be regeneration as that does imply creating what was lost again exactly. Which is impossible. A normal tissue replacement is more of suitable way to look at it.
If its flat, soft, pale and in a more basket weaved pattern then honestly it will most likely be invisable to others.
If I breaks down the scar It has to go through replacing that scar with something. Newer better collagen. You mind find those dented scars do change and fill out if thats the case.
I will look into that for you. When I have relative information, I will post it.
What about hyperpigmentation/hypopigmentaion?
I wonder if it could help renew normal pigmentation in PIH areas or loss of colour. If FS2 stops scarring forming will it allow normal skin to heal over and thus heal without hyperpigmentation.
Dr Sun told me WizGel hasnt been tested on models with hyperpigmentation but WizGel targets any abnormalities in the skin so should regenerate to its original state pre injury, acne, damage etc.
Looking forward to some answers in 2019
On 1/4/2019 at 7:44 PM, nikki_gargin said:I wanted to shout amen after I read this lol
scar cure involves molecular signaling manipulation to change how our DNA reacts to wound healing as such with fs2 and sunogel.The people finding these break throughs are geniuses.
There is some form of regeneration available to us now through re injury like with laser, dermabrasion, peels etc. Scars could remodel back to pretty normal tissue but the fibrosis left behind from wound closure also prevents further remodelling. Again fs2. I really think fs2 is going to be good enough scars and fs2 is really happening. Exciting.
What is FS2??
There is another emerging playerthat nobody has talked about, PXL01.
https://www.promorepharma.com/en/pxl01
They are currently in clinical trials. They have developed a peptide which aims to tackle scarring. They are primarily focused however on eliminating internal scarring aftertendon surgery for now.
On 1/14/2019 at 5:34 PM, MyBeautifulScars said:FS2 as I stated before contains kynurenine, a natural occurring metabolite found in living organisms.A metabolite is normally a byproduct of an amino acid,in this case tryptophan. Amino acids are important as they play an important role in protein synthesis.
Kynurenine is also important because it regulates the immune system and also dilates blood vessels during inflammation. So its essential to wound healing. Too much kynurenine suggests however increased risk of mental illness and cardiovascular disease.
It was found that this metaboliteprevents and breaks down scar tissue during experimental research when applied topically. BirchBioMed never claimed regenaration. How kynurenine breaks down scar tissue remains a mystery as surely BirchBiomed has patented their discovery. Scar tissue either way is just mis-aligned collagen bundleswhich replaceold tissue after an injury. This is also called fibrosis as fibroblasts laydown collagen hastily to repair the damage. Almost all human organs go through fibrosis when damagedand it is believed that this phenomenon blocks off regeneration. It's a trade off that nature decided to implement and switch off regeneration in complex organisms such as mammals.
The issue is that our body is not capable of re-aligning the new collagen into the basket weave pattern. Nowadays, seeing that people have become quite self aware of their image, scars are not pleasant and a serious issue for most of us who have to deal with cystic acne and its embarrassing scarring.
In scar tissue, pores are not regenerated and as a consequence neither do hair follicles. Skin also lacks the ability to produce pigment. This results in hypertrophic scars or fine line scars for most people after several years. In acne or infectious pore diseases,the underlying fat tissue is lost and not replaced, resulting in a dent at the healed area. Others are not so lucky and the fibroblasts go out of control producing masses ofcollagen. These scars are known as keloids which are benign tumours of collagen. Recent research suggests that fat tissue is essential to skin regeneration. The trick is to regenerate pores and hair follicles.
I personally believe that FS2 is mostly targeting hypertrophic/keloid scars and not atrophic scars, the dents left behind chicken pox or acne per say. I also believe they are playing with words. They claim theirproduct prevents scarring in new wounds but I believe the healing outcome is an invisible looking flat scar if anything. It's a start and can help many people. I rather have a fine line flat scar which lacks pigment rather than a dent or raised bundles of skin.
So you think pore and hair follicle regeneration is the key to reducing acne scarring?
On 1/16/2019 at 6:16 AM, Sniffy said:What about hyperpigmentation/hypopigmentaion?
I wonder if it could help renew normal pigmentation in PIH areas or loss of colour. If FS2 stops scarring forming will it allow normal skin to heal over and thus heal without hyperpigmentation.
Dr Sun told me WizGel hasnt been tested on models with hyperpigmentation but WizGel targets any abnormalities in the skin so should regenerate to its original state pre injury, acne, damage etc.
Looking forward to some answers in 2019
WizGel....lol What do they do pee and make it into a gel? I am still waiting. Looks of talk and no action.
3 hours ago, Skin Pessimist said:So you think pore and hair follicle regeneration is the key to reducing acne scarring?
Scarring in general. Pores and hair follicles release BMPs which are essential for adipose tissue, fatty tissue. With acne or atrophic scarring, there is an absence of fat tissue resultingin skin indentations.
51 minutes ago, nikkigirl said:WizGel....lol What do they do pee and make it into a gel? I am still waiting. Looks of talk and no action.
I agree, this stuff doesn't seem legit and does nothing on existing scars anyways.
Well when you guysbuild your own company and find a literal holy grail of medicine you can complain about Dr. Sun. I'm sure if he wanted to he could easily become a Beverly Hills dermatologist and charge people 2000 for a Fraxel treatment but he's trying to make improvements to medicine. Lots of people are working very hard to solve issues like scarring but unfortunately the FDAdiscourages innovation and research and makes it difficult and expensive to solve medicalproblems. I'm sure Dr. Sun's product isn't perfect but his pictures of the rat and pig were some of the closest things I've seen to scarless healing.