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I think Acell is a step ahead of Juvista, and more effective.
I hope so...but right now Juvista has more scientific evidence.
Renovo, is also traded publicly in the UK, like a serious drug company.
Unfortuntely, the kind of results they are getting seem only about 30-50% at best. So this type of "scarless healing" drugs has a long way to go.
Thay have a few products in trail, but nothing on the market as yet.
Does anyone know when Juvista is going to be released here in the US?
As far as the 30-50% results go, it was my understanding that this was the percentage from a recent study using only one application, and that they then discovered that it works better if it is applied twice within a 24 hour period, and that the poor results from this trial are what has held up its release here in America. Does anyone know if this is correct???
Well if you watch the video they say that the percent improvement was wrong b/c the scale they had developed was bad ...meaning that if the scar wasn't that bad in begin with the sensitivity of the scale was all off. They were seeing an improvement with there own eyes but couldn't understand why the scale results from the independents were lower than what they were observing. I know it sounds like "oh they didn't get the results they wanted so they had to come up with a scale so they would" but if you watch the video it explains it and it does make more sense the way they are going about it now. Honestly if it works a little that is enough for me ...it might make excisions worth trying. Think about it if you can reduce an excision scar with the stuff and then use other methods like fraxel etc to reduce the excison scar the results may be very dramatic.
Yes, I agree. I know from my own experience of getting a very deep scar excised last September that the resulting scar, without any other treatment, is very, very faint. On most days I have to really look for it. It was a dramatic improvement for me. I can imagine what the results would be if I had the excision scar blended in with a laser.
I think that Juvista could give a very dramatic improvement. I've also read that it can be injected into already existing scars.
I wonder how many other products are going to be coming out??? I think I read that Juvista is coming out in 2010? I had thought that it was ready to come out within the next year or so, though...
I wonder how many other products are going to be coming out??? I think I read that Juvista is coming out in 2010? I had thought that it was ready to come out within the next year or so, though...
From the Times of London
http://business.timesonline.co.uk/tol/busi...icle1960911.ece
"The drug, which is due to enter final-stage Phase III trials next year, is designed to be used after surgery, for burns victims, cosmetic surgery or for acne scars.
It could be launched in 2011, according to Mark Ferguson, Renovo‚„s chief executive officer."
Well at least it mentions Acne Scars! I don't think they can go any faster coming to market, as the chairman explained in his little presentation.
My only concern for the efficacy of ACell or any other ECM is that an individual undergoing treatment should be in great heath. Their bodies should respond normally to the triggers the medicine is pulling and they should be able to heal at a normal rate. For acne veterans with scarring, I'm dead set in thinking that the majority of us are still a mess inside and we need total inside makeovers before a drug like this is even utilizable. This is why I have been cleansing and testing out my healing mechanism to make sure that my skin will respond appropriately to this advanced device.
Still waiting to hear from a couple of MD's that I left messages for. I wish I had the money to schedule consultations with these people. I'm sure their time is valuable, but I wish they knew the potency of the message I have for them 
I know this article has been shown on here before, but I just want to re-link it:
http://stanmed.stanford.edu/2007fall/scar-wars.html
That article offers great hope to all of us that there actually people out there trying to help scar sufferers.
I know this article has been shown on here before, but I just want to re-link it:
http://stanmed.stanford.edu/2007fall/scar-wars.html
That article offers great hope to all of us that there actually people out there trying to help scar sufferers.
Hey, EXCELLENT article!!!! Thank you!!!!! 
🙂
I especially liked the part that said Dr. Gurtner predicts that new therapies to significantly reduce scarring are only a year or two away...
I didn't like the part where a mechanical aspect was thought to be the culprit to scarring. I think it would be really hard to recreate the suspended environment of the womb. So if this is the case our scarring would be very hard to treat.
However I do not believe it is the case for two reasons:
The growth factors in the fetal scarless healing and adult scar healing are different ...therefore it suggests the different levels in growth factors is the culprit.
adult skin grafted onto a fetus that is in the womb still scars (this suggests it is the growth factors and genetic profile inherent in the tissue, not the environment the tissue is in).
I would say that the reason that larger animals scar more easily than smaller animals may be due to reasons that larger animals might have to scar easier b/c it enhances there survival and replication and not because their wound sites are more mechanically stressed.
Nah, hopeseed, it's hard to disagree that the mechanical side of things is what contributes to scarring. This is based on scientific research. Look at the picture of my back and you'll notice that most of my scarring is on the shoulder blades, but as you get in towards the center it's not as bad. Think about the hot spots on the face, the temples, and the cheeks where smiles can cause it. Think about where most people don't get scars, the forehead, the nose, although some people scar here, it's not as common.
What's even neater is that my scars seem to fit a pattern consistent with the movement. In areas where I'm more likely to stretch out my skin from the normal position I seem to have more depressed or flat scars but places where I'm more likely to squeeze my skin together created more raised scars.
Perhaps excisions, followed by like an acell treatment, followed by being placed in suspended animation will equal scars be gone. haha.
I especially liked the part that said Dr. Gurtner predicts that new therapies to significantly reduce scarring are only a year or two away...
I didn't like the part where a mechanical aspect was thought to be the culprit to scarring. I think it would be really hard to recreate the suspended environment of the womb. So if this is the case our scarring would be very hard to treat.
However I do not believe it is the case for two reasons:
The growth factors in the fetal scarless healing and adult scar healing are different ...therefore it suggests the different levels in growth factors is the culprit.
adult skin grafted onto a fetus that is in the womb still scars (this suggests it is the growth factors and genetic profile inherent in the tissue, not the environment the tissue is in).
I would say that the reason that larger animals scar more easily than smaller animals may be due to reasons that larger animals might have to scar easier b/c it enhances there survival and replication and not because their wound sites are more mechanically stressed.
Ive heard from another article that the mechanical forces aspect do not affect scarless healing but rather the intrinsic properties of the fetal skin, so yeah we dont have to worry about going to space.
As far as I know he's using them exclusively for strip scars for hair FUE transplant patients. Do you have some additional info to indicate that he is using them for other types of scars Franklin?
Yes. I spoke with him today and he is using Acell on hypertrophic and keloid scars.
Nah, hopeseed, it's hard to disagree that the mechanical side of things is what contributes to scarring. This is based on scientific research. Look at the picture of my back and you'll notice that most of my scarring is on the shoulder blades, but as you get in towards the center it's not as bad. Think about the hot spots on the face, the temples, and the cheeks where smiles can cause it. Think about where most people don't get scars, the forehead, the nose, although some people scar here, it's not as common.
What's even neater is that my scars seem to fit a pattern consistent with the movement. In areas where I'm more likely to stretch out my skin from the normal position I seem to have more depressed or flat scars but places where I'm more likely to squeeze my skin together created more raised scars.
Perhaps excisions, followed by like an acell treatment, followed by being placed in suspended animation will equal scars be gone. haha.
Well my disagreement is based on scientific research as well ...like I stated adult skin grafted to a fetus still scarred in the mechanical stress free environment of the womb.
I don't disagree that places where movement occurs on the body might scar easier ...its common sense if you keep on messing with a wound while its trying to heal it will scar. But I think this is more due to disruption to the healing process ...I don't think a persons size or weight or the force of gravity has much bearing ...if at all ... on scarring.
And we know that the growth factors involved in the fetal scar free response are different than the adult scarring response. To me that screams it is a tissue dependent growth factor thing...not a mechanical.
Also we know that DOT cells contribute to scarless healing and fetuses have a higher count.
and the big kicker is that if we put adult tissue in the fetal environment IT STILL SCARS...therefore pretty much ruling out the womb environment hypothesis.
Think about the hot spots on the face, the temples, and the cheeks where smiles can cause it. Think about where most people don't get scars, the forehead, the nose, although some people scar here, it's not as common.
Oh, and I would also argue that these "hot spots" are also places where acne usually occurs. I know in my case acne was concentrated on my cheeks...and that is where I scarred. I've noticed when people have a cluster of acne activity it usually occurs on the cheeks and the temples so another explanation that could be is that those area are more prone to ACNE and therefore more prone to SCARS.
Think about the hot spots on the face, the temples, and the cheeks where smiles can cause it. Think about where most people don't get scars, the forehead, the nose, although some people scar here, it's not as common.
Oh, and I would also argue that these "hot spots" are also places where acne usually occurs. I know in my case acne was concentrated on my cheeks...and that is where I scarred. I've noticed when people have a cluster of acne activity it usually occurs on the cheeks and the temples so another explanation that could be is that those area are more prone to ACNE and therefore more prone to SCARS.
I beg to differ. I have had clusters of acne al over my face, and there are definitely areas more prone to scarring than others. I have had ridiculous breakouts in some areas, and slight ones in others, and I have seen the subtly broken out areas scar while the severe areas remain fine when breakouts subside. I think it can vary person to person, BUT I also think different areas have different chances of scarring.
As far as I know he's using them exclusively for strip scars for hair FUE transplant patients. Do you have some additional info to indicate that he is using them for other types of scars Franklin?
Yes. I spoke with him today and he is using Acell on hypertrophic and keloid scars.
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WELL WHAT DID HE SAY?! lol. Or does he not have results yet? =/
bets....how many years till we have something that will dramaticly improve scarring? 100 years.never.....or a few months.really this is all talk and no results.
I have to agree, us sufferers need to start seeing results and not hear excuses.
Then i ask, what are YOU personally doing to find answers? I see three types in this thread. Those who watch and follow as the thread progresses, not really saying much (people like me I guess). Those who are making an effort, making calls and trying to figure it out (hoursafter). And finally, the people who just complain, say it'll never work and call this thread heresay...yet seemingly do nothing to aid it's progression. If you guys wanna complain about not seeing results, or how this is not gonna work (without even knowing much about the product) then by all means please do! As this forum DOES facilitate the creation of new threads. But please keep your negative comments, which are unfounded and bring us no closer to a resolution, out of a thread based on TRYING to gain answers.
I have personally put hours into researching ECM, how it acts on the biological functions in response to a wound, and just the overall science behind scars as well. And from what I've read, if this product is able to do what it says it can do (which seems quite logical), then I believe it will benefit us in our quest for clearer, smoother skin in a great way. I am by no means claiming it as a "savior," I am simply saying that from what I have read, this could be a great advancement. BUT, we wont know until we have results, and your foundationless assumptions do nothing to aid in gaining them.
Think about the hot spots on the face, the temples, and the cheeks where smiles can cause it. Think about where most people don't get scars, the forehead, the nose, although some people scar here, it's not as common.
Oh, and I would also argue that these "hot spots" are also places where acne usually occurs. I know in my case acne was concentrated on my cheeks...and that is where I scarred. I've noticed when people have a cluster of acne activity it usually occurs on the cheeks and the temples so another explanation that could be is that those area are more prone to ACNE and therefore more prone to SCARS.
I beg to differ. I have had clusters of acne al over my face, and there are definitely areas more prone to scarring than others. I have had ridiculous breakouts in some areas, and slight ones in others, and I have seen the subtly broken out areas scar while the severe areas remain fine when breakouts subside. I think it can vary person to person, BUT I also think different areas have different chances of scarring.
As far as I know he's using them exclusively for strip scars for hair FUE transplant patients. Do you have some additional info to indicate that he is using them for other types of scars Franklin?
Yes. I spoke with him today and he is using Acell on hypertrophic and keloid scars.
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WELL WHAT DID HE SAY?! lol. Or does he not have results yet? =/
If you had it all over your face then it might be hard to tell where you had it slightly more. I've noticed people tend to have acne concentrate on their cheeks and temples...and they also seem to have there scarring there.
If you had it all over your face then it might be hard to tell where you had it slightly more. I've noticed people tend to have acne concentrate on their cheeks and temples...and they also seem to have there scarring there.
actually in all honesty, I can remember where I had it worse. Along my jawline, around my chin, and the area below my lips i had bad cysts. I have gotten them in other areas, but as serious as they were they never seemed to scar along THAT particular area. Then along my cheeks I would get scars that I didn't even know the origin of because I didn't think i had anything bad enough to scar in that area lol. It's really frustrating. Any I get around my cheeks and nose scare me cuz I am afraid they will scar. The temple is another area that was plagued with cysts yet saw no scarring... idk it's weird, but I can definitely tell there are areas that scar more easily than others
WELL WHAT DID HE SAY?! lol. Or does he not have results yet? =/
He just started using it. He said that it will take several months to possibly see results but was hesitant to give any definitive timelines.
The point of my post was that if someone here has hypertrophic or keloid scars and lives relatively close, then we could have regular updates from a patient perspective.