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The Wound care market is huge and the potential is being recognised. Research teams coming from every angle now to crack that elusive scarring problem millions suffer. Its a very interesting time the next couple years.
FS2 showing promise at preventing scar tissue. I hope FS2 offers genuine results and a go to cream that becomes a household name for preventing everyday wounds from forming into scars.
They still are using very different wording to Polarityte. Take it as it comes i suppose they dont want to be using terms like regeneration or scarless healing right now. They are focusing on stopping scar tissue forming at all from fresh wounds and to lessen existing scars with just cream application and they did say it doesnt hinder healing with fresh wounds so in that sense it is allowing normal skin to heal and appear as normal skin again. I just havent seen enough pre clinical results for FS2 to get too excited.
2 hours ago, Sniffy said:The Wound care market is huge and the potential is being recognised. Research teams coming from every angle now to crack that elusive scarring problem millions suffer. Its a very interesting time the next couple years.
FS2 showing promise at preventing scar tissue. I hope FS2 offers genuine results and a go to cream that becomes a household name for preventing everyday wounds from forming into scars.
They still are using very different wording to Polarityte. Take it as it comes i suppose they dont want to be using terms like regeneration or scarless healing right now. They are focusing on stopping scar tissue forming at all from fresh wounds and to lessen existing scars with just cream application and they did say it doesnt hinder healing with fresh wounds so in that sense it is allowing normal skin to heal and appear as normal skin again. I just havent seen enough pre clinical results for FS2 to get too excited.
There isn't one human being out there that doesn't have a scar somewhere on their body. Scars for most people tend to fade with time and are almost invisible unless you take a magnifying glass. Some people however have genetic predispositions that make them incredibly visible, ugly and very thick.
Others have to go through years of viral or microbial infections. The wounds heal with scarring forming pits, raised skin, uneven texture or depressions. Acne, chicken pox and folliculitis are very common skin conditions that heal with extensive scarring for some individuals. There are other not so common skin conditions that also do this too.
Our bodies can heal without scarring however evolution switched this off for all mammals. It's a fast and easy repair preventing further infection. However, scarring is not ideal and creates more problems than anything. Scarring is also thought of preventing regeneration of limbs.
The medical community used to not give too much importance to scars and thought of them as a blessing. The body can close or repair wounds naturally, so its easy for them to operate on individuals.
Since the mid 1900s, body image become increasingly important however. Nowadays, it has reached unprecedented levels. Females must look perfect. There is a whole market out there generating billions on beauty products. For many, scars are imperfections and will go to great extent to cover them up. Cosmetic surgery has also reached unprecedented levels. Males also feel the pressure to look their best. Transgenderism is also a new reality. Tons of money are thrown away by women to improve the appearance of stretchmarks.
It was a matter of time before researchers would try to find a way to promote scarless wound healing than scarring. Many people have extensive scarring which cannot be addressed by any of the traditional cosmetic procedures or make up. Scars not only look ugly but they can also hinder movement in some cases and cause so many other problems.
Burn victims are quite impacted. Also, other human organs heal with scarring resulting in decreased organ function and possible failure again. This is why finding a functional solution to scarring has become more important than ever.
By the way, interesting read:
https://thirdage.com/being-older-helps-skin-heal-with-less-scarring/
Scientists found that older people tend to scar less because they have less of SDF1.
I thought older people would scar easier but seems like its the other way around.
10 hours ago, AI3forever said:By the way, interesting read:
https://thirdage.com/being-older-helps-skin-heal-with-less-scarring/Scientists found that older people tend to scar less because they have less of SDF1.
I thought older people would scar easier but seems like its the other way around.
At least we can feel better about getting old while we're waiting to do a scar revision some day... 
On Ž12Ž/Ž10Ž/Ž2018 at 9:21 AM, surgical scar said:At least we can feel better about getting old while we're waiting to do a scar revision some day...
good luck 
17 hours ago, nikki_gargin said:Hey does anyone know when Dr Sun wants to start clinical trials? Surely he can get funding through John Hopkins? Where I believe he works? Really hoping fs2 and or Sunogel are good to go within 3 years.
preclinical end 3Q 2019
3 hours ago, damnBOY said:good luck
Ok so human clinical trials won™t happen till at least 2020 then.
i read also that birchbiomed have a partnership with a cosmetics company already in anticipation of bringing topical fs2 to market asap. Pretty good step in the right direction
4 hours ago, Binga said:
They are one of the original start-ups that began work on developing an anti-scarring hydrogel. Both Dr. Sun and the people behind Gemstone collaborated together in the past. Their initial products failed to address scarring. Dr. Sun then decided to go his separate way and founded Sunogel with his own hydrogel. Gemstone was pretty quiet until now and many on here thought the company was pretty much done. We can consider them now as an offshoot of Sunogel. They are now developing patches that close wounds that mimic human skin in an effort to reduce scarring.
Gemstone was founded before Sunogel; it is not an offshoot. Dr. Sharon Gerecht and Dr. Sun worked together at Johns Hopkins while Dr. Sun was a resident there and they came up with the hydrogel that originally obtained complete regeneration in mice.
After that, Dr. Sun's residency ended and he went to work for Columbia for a while before founding Sunogel. His product, while it's a hydrogel, is not the same as the one developed at Johns Hopkins. I asked him about this in my phone conversation and he had independent research done to illustrate how his hydrogel was novel and wouldn't have IP issues with Gemstone's products. Hence, he can get a patent to protect his product and not have to worry about it conflicting with Gemstone or JHU.
In vivo reprogramming of wound-resident cells generates skin epithelial tissue
https://www.nature.com/articles/s41586-018-0477-4
5 minutes ago, jobslhw said:In vivo reprogramming of wound-resident cells generates skin epithelial tissue
14 hours ago, jobslhw said:In vivo reprogramming of wound-resident cells generates skin epithelial tissue
https://www.nature.com/articles/s41586-018-0477-4
This looks like Skinte technology but without the platform. A epithelial substitute?
Great finds everyone!
It's important to note that all of these involve manipulation of cells and/or pathways so they'd face a strenuous process for approval and testing.
Nevertheless, good news for us that so many researchers are actively trying so many different ways to figure this out.
9 hours ago, Anish004 said:skinte will publisb result on 3 -4 nov
if they r confident of publishing then maybe there will be some good news ?????
I don't think their confidence (at least outwardly) has wavered, but that means little to us.
If they show completely regeneration with a matching aesthetic outcome, we'll be happy. If not, we won't be for our purposes. It's that simple.
Polarity has published 5 case studies on their websites:
https://www.polarityte.com/products/skinTE-providers
You can download the 5 PDFs if anyone wishes too. Judging from the results, there is definately scarring. I cannot truly say the results are better than having a skin graft. They have also posted pictures of skin grafts as well for comparisons.
I don't believe SkinTE can help us acne scar sufferers or people with minor scars resulting from cuts or scrapes. No doctor will excise skin without a reason. Skin excision was performed in the past by plastic surgeons but most surgeons are moving away from the practise as fillers and subcision are more effective.
5 hours ago, MyBeautifulScars said:Polarity has published 5 case studies on their websites:
https://www.polarityte.com/products/skinTE-providers
You can download the 5 PDFs if anyone wishes too. Judging from the results, there is definately scarring. I cannot truly say the results are better than having a skin graft. They have also posted pictures of skin grafts as well for comparisons.
I don't believe SkinTE can help us acne scar sufferers or people with minor scars resulting from cuts or scrapes. No doctor will excise skin without a reason. Skin excision was performed in the past by plastic surgeons but most surgeons are moving away from the practise as fillers and subcision are more effective.
they are creating a derivative product for acne scars which could be a filler
On 11/11/2018 at 3:18 PM, Binga said:On 11/11/2018 at 9:59 AM, MyBeautifulScars said:Polarity has published 5 case studies on their websites:
https://www.polarityte.com/products/skinTE-providers
You can download the 5 PDFs if anyone wishes too. Judging from the results, there is definately scarring. I cannot truly say the results are better than having a skin graft. They have also posted pictures of skin grafts as well for comparisons.
I don't believe SkinTE can help us acne scar sufferers or people with minor scars resulting from cuts or scrapes. No doctor will excise skin without a reason. Skin excision was performed in the past by plastic surgeons but most surgeons are moving away from the practise as fillers and subcision are more effective.
they are creating a derivative product for acne scars which could be a filler
LOL still the imaginary filler...
I'll go back to hibernation
https://phys.org/news/2018-11-skin-gel-wounds-scar.html
any member already heard of this
Sericin hydrogel?
3 hours ago, De Rerum Natura said:https://phys.org/news/2018-11-skin-gel-wounds-scar.html
any member already heard of this
Sericin hydrogel?
Sounds like Sunogel honestly, another hydrogel which is set to be in clinical trials next year, developed by Dr. Sun.
We may potentially have another hydrogel coming soon. Great find.
Hi Everyone,
I just wanted to post an update. I have been in contact with Guoming Sun of Sunogel via LinkedIn and said that they are the process of moving the product into clinical trials in 3Q 2019 which some of you I presume already know. He said that it is being classified as a medical device and will be testing it as a medical advice (there was some talk on here before that he wanted to do clinical trials like it would be a drug). After this I asked him a general timeline of when he could for see this being out (if successful) and he said on average when in clinical it takes about 3 years for FDA approval. We are looking at 2021-2022 if it works...