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43 minutes ago, damnBOY said:do you think they will cut all your face and apply a gel
skinTE on top of it? it looks scary who whould gonna do this ? by the way skinTE doesn't even promote scarless healing it shows efficancy to close wounds and replace split thickness skin grafts for severe burns that's what skinTE is about or you know something about skinTE I don't know explain please ... also don t forget skinTE needs a biopsy of full thickness skin with fat and this create a new scar and the doctor will close it with stiches
If you read what I said, I said I dont think skinte is applicable for acne scars because most acne scars arent full thickness. And like you said, no surgeon will cut out full thickness skin that isnt damaged.
surgical and burn scars are different and therefore improvement is possible with skinte. Scars dont have 3 layers. Just one block. So in that regard skinte is regeneration and cosmetically better than scar tissue. But proberly not cosmetically or functionally better than acne scars.
3 hours ago, nikki_gargin said:If you read what I said, I said I dont think skinte is applicable for acne scars because most acne scars arent full thickness. And like you said, no surgeon will cut out full thickness skin that isnt damaged.surgical and burn scars are different and therefore improvement is possible with skinte. Scars dont have 3 layers. Just one block. So in that regard skinte is regeneration and cosmetically better than scar tissue. But proberly not cosmetically or functionally better than acne scars.
Tell me more about AdiposeTE? You mentioned that fat is not regenerated. What are they planning to do about AdiposeTE?
8 minutes ago, nikki_gargin said:Says anyone with a stiff hypertrophic scar or a keloid mate.adipose they havent discussed much but if for fat grafting,
Um what? Anyone withstiff hypertrophic scar or a keloid has had skinte?
Another new discovery regarding scarless healing came out today by UPenn. The reason that older people tend not to scar is not because their skin is less elastic, but rather that they have less of a protein called SDF1. Doctors have found that inhibiting it in both rats and lab grown human skin has the effect of greatly reducing scar formation and promoting regeneration. In mice it appears that inhibiting or removing SDF1 causes regeneration with hair in mouse skin with ear piercings (Skin completely removed). Another good thing is that an SDF1 inhibitor already exists on the market and is FDA approved and they are planning clinical trials for scarring soon, so it could be on the market very soon. Another piece of the puzzle 
. It seems that the NIH is taking a keen interest in scar research as it funded this study along with the large grant it gave to UC Irvine. Hopefully if we keep throwing money at the problem it will go away soon.
It's important to keep in mind our skin is perfectly capable of regenerating itself. Evolution has switched this process off in exchange for quicker wound healing. We just need to find the right combination to turn regeneration back on.
https://www.cell.com/cell-reports/fulltext/S2211-1247(18)31340-8
I do not know if u guys believe in prayers. But I hope everyone will try to project a thought every night before going to bed that scarless healing would be a reality. Maybe our collective prayers will be answered if we focus hard enough. I've had unexpectedly good things happen by really wishing it hard enough by believing and somehow manifesting it to reality. All these may sound like pseudoscience, but really no harm trying it at these stage.
17 hours ago, surgical scar said:Um what? Anyone with stiff hypertrophic scar or a keloid has had skinte?
You know what I™m saying. Don™t twist it into a different point. I™m saying skinte skin would be better than Something stiff and bulky that moves against your body. You don™t have to have skinte on you or be a genius to work that one out. Do you know what a burn scar feels like to wear everyday?
12 hours ago, FromScarredtoFree said:Another new discovery regarding scarless healing came out today by UPenn. The reason that older people tend not to scar is not because their skin is less elastic, but rather that they have less of a protein called SDF1. Doctors have found that inhibiting it in both rats and lab grown human skin has the effect of greatly reducing scar formation and promoting regeneration. In mice it appears that inhibiting or removing SDF1 causes regeneration with hair in mouse skin with ear piercings (Skin completely removed). Another good thing is that an SDF1 inhibitor already exists on the market and is FDA approved and they are planning clinical trials for scarring soon, so it could be on the market very soon. Another piece of the puzzleIt's important to keep in mind our skin is perfectly capable of regenerating itself. Evolution has switched this process off in exchange for quicker wound healing. We just need to find the right combination to turn regeneration back on.
https://www.cell.com/cell-reports/fulltext/S2211-1247(18)31340-8
What SDF1 inhibitor is currently on the market?
3 hours ago, nikki_gargin said:You know what Im saying. Dont twist it into a different point. Im saying skinte skin would be better than Something stiff and bulky that moves against your body. You dont have to have skinte on you or be a genius to work that one out. Do you know what a burn scar feels like to wear everyday? What SDF1 inhibitor is currently on the market?
Plerixafor
38 minutes ago, nikki_gargin said:43 minutes ago, FromScarredtoFree said:Plerixafor
Do you think its worth a shot at healing a new injury? Lol
Well it wouldn't be easy to get it as a doctor has to prescribe it... and we aren't even sure if it works. It looks promising in rats and in theory it should work in human skin based upon their methodology.
5 hours ago, nikki_gargin said:You know what Im saying. Dont twist it into a different point. Im saying skinte skin would be better than Something stiff and bulky that moves against your body. You dont have to have skinte on you or be a genius to work that one out.
Not everyone is a genius like you. How would I know if skinte hasn't been tried for anyone with hypertrophic/keloid scar, especially that people prone to keloids tend to react badly to getting cut again.
Anyway, extreme scar overgrowth isn't the case of most people here.
20 hours ago, surgical scar said:Not everyone is a genius like you. How would I know if skinte hasn't been tried for anyone with hypertrophic/keloid scar, especially that people prone to keloids tend to react badly to getting cut again.
Anyway, extreme scar overgrowth isn't the case of most people here.
The guy who had a patch applied on his chest on the presentation slides says it was in replacement of a keloid scar. Im not a genius I just read my subject material.
anyways my original point was Polarity arent completely out of the game yet for scarless healing.
22 hours ago, FromScarredtoFree said:Well it wouldn't be easy to get it as a doctor has to prescribe it... and we aren't even sure if it works. It looks promising in rats and in theory it should work in human skin based upon their methodology.
Yeah self experimentation isnt a good idea it is lol
video from birchbiomed last week. They say they want to release fs2 in cream topical form maybe next year.
1 hour ago, mjg713 said:I thought Polarity was supposed to release their final results after this weekend after some sought of conference they had?
Yeah the results are probably pretty lousy. Someone mentioned that the skin regenerates with sweat glands and hair follicles but it is missing the fat layer underneath the skin.
6 hours ago, damnBOY said:On 01/10/2018 at 5:16 PM, nikki_gargin said:video from birchbiomed last week. They say they want to release fs2 in cream topical form maybe next year.
Fs2 never claimed scarless healing
They do claim scarless healing for fresh wounds. For existing scars, they claim reduction not total elimination. They are in phase 2 clinical trials to measure the degree of improvement on existing scars.
"Stops the formation of scars and breaks down pre-existing scars on the molecular lever. There is nothing on the market that can do that"..."We have reversed type I diabetes in combination with FS2"...
LOL at the ones that are waiting for Polarity's "scarless healing" while this triggers them
I got my eye on fs2. There is an autoimmune conpound to scarring as we know from other research about immunorepressants. Could get a very good improvement at least. Sunogel too. You can see in face transplants there scars heal very well. Because they on immunesupressant tablets.
Polarity I watched there latest webcast. Some look very good. Some not so much.maybe depends on injury. There was a large heel injury that looked very good at 12 weeks.
But burn scars looked 50/50
44 minutes ago, nikki_gargin said:I got my eye on fs2. There is an autoimmune conpound to scarring as we know from other research about immunorepressants. Could get a very good improvement at least. Sunogel too. You can see in face transplants there scars heal very well. Because they on immunesupressant tablets.
Polarity I watched there latest webcast. Some look very good. Some not so much.maybe depends on injury. There was a large heel injury that looked very good at 12 weeks.
But burn scars looked 50/50
I agree with this. Scarring seems to be heavily based on how your immune system chooses to respond to wounds and the subsequent inflammation. There was the recent study that found people who have a tendency to scar from acne have more T-Cells responding than people that don't. On the positive side I guess this implies that we have better a immune system than people without acne scars. In theory keloids should be the same as acne scars because they follow an almost identical process in wound healing but keloid scarring differs in that the fourth and final stage of scarring lasts longer. If FS2 stops scarring at step 2 or 3 of the 4 step scarring process, hopefully it will work for acne scars. At the very least we have both Sunogel and FS2 to look forward to in a year. If combined they can reduce scars by 70-80% or say they can turn atrophic scarring into flat scarring, I'm sure many of us will be happy.
Like I said earlier stem cells are unpredictable. Sometimes they become what we want, other times they don't. I think that's where the problem lies with Skinte.
If scars can be improved to be near enough invisible thats fine. Im sure we all have those somewhere already but never see it.
I think ink there is some thought that humans can regenerate but scar as a short cut. Maybe fs2 slows down scarring so much it allows for regeneration? Thats the vibe Im getting from their info.
In Quebec City, they are already developing similar technology to polarity to help burn victims. The article is in french though. Just saying that the people behind SkinTE are just trying to market an idea already in use by others. The researchers behind this work at a prestigious canadian university, Laval University.
The article says that for just under 2$ dollars, a doctor can take a skin biopsy out of normal skin (only few skin cells needed) and grow normal skin in a lab in just under a few days. The skin is then grafted on open wounds. The same skin can be glued also and the skin will regenerate.
Pictured on the left is a man who was burned on over 90% of his body with boiling water. The burn scars are not that noticeable.
Seems to me that canadian researchers are really ahead when it comes to scarless healing.