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14 hours ago, FromScarredtoFree said:I spoke to Dr. Sun and he was very nice and friendly. He told me he plans to include scarring in the clinical trials. Whether that means he will create a scar in a patient like some clinical trials do or allow people with preexisting scars to join is unknown at this point however. He also talked to me about the burn scars on his arms and how he understands the pain we go through which I didn't expect. I think for someone to go through the effort to cure scarring they have to understand what we go through because it seems like people with cancer or Aids have it worse. Also some unrelated good new that I found is while approval rates for drugs is very low (14%) approval rates for devices is much higher (60-90%) depending on what sort of Device it is classified. Sunogel isn't a life or death device (except maybe in burn victims) nor it is a permanent implant so it's likely it will be a Category II device putting it at a high chance of success if it shows efficacy. We should all endeavor to support Dr Sun as he seems to be the closest this form has ever gotten to an answer. Another interesting thing to note is that Dr. Sun put the whole recipe of his hydrogel in his last paper. To all the super desperate people, you can always make the hydrogel yourself and let us know how it works. XD
Skinte has fallen into even deeper problems it seems as one of their officials was caught doing shady business in other companies. Also Mark Cuban from shark tank admitted he's selling short on it which doesn't help their publicity. But they plan to release clinical results at some sort of a convention soon if anyone is still following them.
His recipe is viral and we havent seen it?
Can you post this recipe so we can see whats in it?
3 hours ago, Sniffy said:His recipe is viral and we havent seen it?Can you post this recipe so we can see whats in it?
1 hour ago, damnBOY said:I am studing chemical engeeniring and I will follow biotechonology in my 4 years of my studies now I am on the second year send me the f*cking recipe xd
Materials: Dextran (MW 40, 000), dibutyltin dilaurate (DBTDL) were purchased from Sinopharm Chemical Reagent Co.(China). 2Isocyanatoethyl acrylate and 2isocyanatoethyl methacrylate (IEM) were purchased from Tokyo Chemical Industry Co.(Tokyo, Japan). Allyl isocyanate were purchased from SigmaAldrich Chemical Co. (St. Louis, MO). Dimethyl sulfoxide (DMSO), 2bromoethylamine hydrobromide (BEAHB), 3chloropropylamine hydrochloride, triethylamine, and other chemicals were purchased from Shanghai Chemical Reagent Ltd. and used without any treatments. The photoinitiator 2hydroxy1[4(hydroxyethoxy)phenyl]2methyl1propanone was obtained from Ciba Specialty Chemicals Co. (Tarrytown, NY). Dulbecco's modified Eagle's medium (DMEM), fetal bovine serum (FBS), MTT, (3(4,5dimethylthiazol2yl)5(3carboxymethoxyphenyl)2(4sulfophenyl)2Htetrazolium) (MTS), and phosphate buffered saline (PBS) were purchased from Invitrogen (Carlsbad, CA). Male 8 week old 129S1/SvImJ mice were obtained from Slac Laboratory Animal Company and 3 month Bahamas mini pigs from Strong Century Minipigs Breeding Base (China).
Bioabsorbable DextranDerived Macromers: The synthesis of dextran macromers involved two steps, as shown in Figure2. Dextranisocyanatoethyl methacrylate (DexIEM) hydrogels will be prepared similar to as previously reported.39Dextran was dried in an oven for 45 min at 60 C before reaction. Dextran will first react with IEM to form DexIEM in the presence of DBTDL catalyst. At room temperature (25 C), dry dextran (e.g., 9.0 g) will be dissolved in anhydrous DMSO (70 mL) under dry nitrogen gas. DBTDL catalyst (1.4 mL) will be injected into the solution at room temperature and then IM (1.4 mL) was added dropwise. The reaction mixture will be stirred at room temperature (22 C) for 12 h. The resulting macomer will be precipitated in cold excess isopropanol. The product will be further purified by dissolution and precipitation in DMSO and isopropanol, respectively. This resulting DexIEM will be dried overnight at 37 C under vacuum.
To increase the biocompatibility of the macromer, free amine group will be incorporated to the DexIEM macomer. Our prior study demonstrated that the incorporation of amine groups into dextran gives rise to hydrogels with better biocompatible and release properties.46Briefly, dry DexIEM (3.0 g) will be dissolved in anhydrous DMSO (30 mL) under dry nitrogen gas. Triethylamine (5.6 mL) will be injected into the above solution. BEAHB (3.75 g) will be dissolved in DMSO (10 mL) and then added to the above solution dropwise. This reaction solution was stirred at 50 C for 8 h. The reaction mixture will then be filtered to remove the precipitated Et3NH4Br. The resulting dextranisocyanatoethyl methacrylateethylamine (DexIEME) will be obtained by precipitating the filtered solution into excess cold isopropyl alcohol. The product was further purified at least three times by dissolution and precipitation with DMSO and cold isopropyl alcohol, respectively. DexIEME will then be dried at 37 C under vacuum overnight. The resulting DexIEME will be then dialyzed (MWCO: 1000 Da) against distilled water for 3 d and lyophilized for an additional 3 d.
Characterization: The dextran and its derived macromers will be characterized for their chemical structure by FTIR and1H NMR. For FTIR characterization, all samples were dried in a vacuum oven for at least 24 h and then compressed into pellets with KBr powder (1/10, w/w) for FTIR characterization (Nicolet Magna 560, Madison, SI). For1H NMR characterization, samples were dissolved in deuterated DMSO (DMSOd6) at a concentration of 25% (w/v) and their spectra were recorded on a Varian INOVA 400 MHz spectrometer (Palo Alto, CA). The DMSO peak at 2.50 ppm was used as the reference line.
30 minutes ago, FromScarredtoFree said:Materials: Dextran (MW 40, 000), dibutyltin dilaurate (DBTDL) were purchased from Sinopharm Chemical Reagent Co.(China). 2Isocyanatoethyl acrylate and 2isocyanatoethyl methacrylate (IEM) were purchased from Tokyo Chemical Industry Co.(Tokyo, Japan). Allyl isocyanate were purchased from SigmaAldrich Chemical Co. (St. Louis, MO). Dimethyl sulfoxide (DMSO), 2bromoethylamine hydrobromide (BEAHB), 3chloropropylamine hydrochloride, triethylamine, and other chemicals were purchased from Shanghai Chemical Reagent Ltd. and used without any treatments. The photoinitiator 2hydroxy1[4(hydroxyethoxy)phenyl]2methyl1propanone was obtained from Ciba Specialty Chemicals Co. (Tarrytown, NY). Dulbecco's modified Eagle's medium (DMEM), fetal bovine serum (FBS), MTT, (3(4,5dimethylthiazol2yl)5(3carboxymethoxyphenyl)2(4sulfophenyl)2Htetrazolium) (MTS), and phosphate buffered saline (PBS) were purchased from Invitrogen (Carlsbad, CA). Male 8 week old 129S1/SvImJ mice were obtained from Slac Laboratory Animal Company and 3 month Bahamas mini pigs from Strong Century Minipigs Breeding Base (China).
Bioabsorbable DextranDerived Macromers: The synthesis of dextran macromers involved two steps, as shown in Figure2. Dextranisocyanatoethyl methacrylate (DexIEM) hydrogels will be prepared similar to as previously reported.39Dextran was dried in an oven for 45 min at 60 C before reaction. Dextran will first react with IEM to form DexIEM in the presence of DBTDL catalyst. At room temperature (25 C), dry dextran (e.g., 9.0 g) will be dissolved in anhydrous DMSO (70 mL) under dry nitrogen gas. DBTDL catalyst (1.4 mL) will be injected into the solution at room temperature and then IM (1.4 mL) was added dropwise. The reaction mixture will be stirred at room temperature (22 C) for 12 h. The resulting macomer will be precipitated in cold excess isopropanol. The product will be further purified by dissolution and precipitation in DMSO and isopropanol, respectively. This resulting DexIEM will be dried overnight at 37 C under vacuum.
To increase the biocompatibility of the macromer, free amine group will be incorporated to the DexIEM macomer. Our prior study demonstrated that the incorporation of amine groups into dextran gives rise to hydrogels with better biocompatible and release properties.46Briefly, dry DexIEM (3.0 g) will be dissolved in anhydrous DMSO (30 mL) under dry nitrogen gas. Triethylamine (5.6 mL) will be injected into the above solution. BEAHB (3.75 g) will be dissolved in DMSO (10 mL) and then added to the above solution dropwise. This reaction solution was stirred at 50 C for 8 h. The reaction mixture will then be filtered to remove the precipitated Et3NH4Br. The resulting dextranisocyanatoethyl methacrylateethylamine (DexIEME) will be obtained by precipitating the filtered solution into excess cold isopropyl alcohol. The product was further purified at least three times by dissolution and precipitation with DMSO and cold isopropyl alcohol, respectively. DexIEME will then be dried at 37 C under vacuum overnight. The resulting DexIEME will be then dialyzed (MWCO: 1000 Da) against distilled water for 3 d and lyophilized for an additional 3 d.
Characterization: The dextran and its derived macromers will be characterized for their chemical structure by FTIR and1H NMR. For FTIR characterization, all samples were dried in a vacuum oven for at least 24 h and then compressed into pellets with KBr powder (1/10, w/w) for FTIR characterization (Nicolet Magna 560, Madison, SI). For1H NMR characterization, samples were dissolved in deuterated DMSO (DMSOd6) at a concentration of 25% (w/v) and their spectra were recorded on a Varian INOVA 400 MHz spectrometer (Palo Alto, CA). The DMSO peak at 2.50 ppm was used as the reference line.
I found it too thanks
3 hours ago, FromScarredtoFree said:Materials: Dextran (MW 40, 000), dibutyltin dilaurate (DBTDL) were purchased from Sinopharm Chemical Reagent Co.(China). 2Isocyanatoethyl acrylate and 2isocyanatoethyl methacrylate (IEM) were purchased from Tokyo Chemical Industry Co.(Tokyo, Japan). Allyl isocyanate were purchased from SigmaAldrich Chemical Co. (St. Louis, MO). Dimethyl sulfoxide (DMSO), 2bromoethylamine hydrobromide (BEAHB), 3chloropropylamine hydrochloride, triethylamine, and other chemicals were purchased from Shanghai Chemical Reagent Ltd. and used without any treatments. The photoinitiator 2hydroxy1[4(hydroxyethoxy)phenyl]2methyl1propanone was obtained from Ciba Specialty Chemicals Co. (Tarrytown, NY). Dulbecco's modified Eagle's medium (DMEM), fetal bovine serum (FBS), MTT, (3(4,5dimethylthiazol2yl)5(3carboxymethoxyphenyl)2(4sulfophenyl)2Htetrazolium) (MTS), and phosphate buffered saline (PBS) were purchased from Invitrogen (Carlsbad, CA). Male 8 week old 129S1/SvImJ mice were obtained from Slac Laboratory Animal Company and 3 month Bahamas mini pigs from Strong Century Minipigs Breeding Base (China).
Bioabsorbable DextranDerived Macromers: The synthesis of dextran macromers involved two steps, as shown in Figure2. Dextranisocyanatoethyl methacrylate (DexIEM) hydrogels will be prepared similar to as previously reported.39Dextran was dried in an oven for 45 min at 60 C before reaction. Dextran will first react with IEM to form DexIEM in the presence of DBTDL catalyst. At room temperature (25 C), dry dextran (e.g., 9.0 g) will be dissolved in anhydrous DMSO (70 mL) under dry nitrogen gas. DBTDL catalyst (1.4 mL) will be injected into the solution at room temperature and then IM (1.4 mL) was added dropwise. The reaction mixture will be stirred at room temperature (22 C) for 12 h. The resulting macomer will be precipitated in cold excess isopropanol. The product will be further purified by dissolution and precipitation in DMSO and isopropanol, respectively. This resulting DexIEM will be dried overnight at 37 C under vacuum.
To increase the biocompatibility of the macromer, free amine group will be incorporated to the DexIEM macomer. Our prior study demonstrated that the incorporation of amine groups into dextran gives rise to hydrogels with better biocompatible and release properties.46Briefly, dry DexIEM (3.0 g) will be dissolved in anhydrous DMSO (30 mL) under dry nitrogen gas. Triethylamine (5.6 mL) will be injected into the above solution. BEAHB (3.75 g) will be dissolved in DMSO (10 mL) and then added to the above solution dropwise. This reaction solution was stirred at 50 C for 8 h. The reaction mixture will then be filtered to remove the precipitated Et3NH4Br. The resulting dextranisocyanatoethyl methacrylateethylamine (DexIEME) will be obtained by precipitating the filtered solution into excess cold isopropyl alcohol. The product was further purified at least three times by dissolution and precipitation with DMSO and cold isopropyl alcohol, respectively. DexIEME will then be dried at 37 C under vacuum overnight. The resulting DexIEME will be then dialyzed (MWCO: 1000 Da) against distilled water for 3 d and lyophilized for an additional 3 d.
Characterization: The dextran and its derived macromers will be characterized for their chemical structure by FTIR and1H NMR. For FTIR characterization, all samples were dried in a vacuum oven for at least 24 h and then compressed into pellets with KBr powder (1/10, w/w) for FTIR characterization (Nicolet Magna 560, Madison, SI). For1H NMR characterization, samples were dissolved in deuterated DMSO (DMSOd6) at a concentration of 25% (w/v) and their spectra were recorded on a Varian INOVA 400 MHz spectrometer (Palo Alto, CA). The DMSO peak at 2.50 ppm was used as the reference line.
Umm...Where can I get the ingredients and rent a lab? I'll start working on it....
36 minutes ago, nikki_gargin said:are people seriously going to try and make it? Lol
We don't even know if it truly works. I am sure the makers, Dr. Sun, are probably pursuing a patent if it truly works. Anyone trying to make this hydrogel at home may be risking copyright infringement.
2 hours ago, MyBeautifulScars said:3 hours ago, nikki_gargin said:are people seriously going to try and make it? Lol
We don't even know if it truly works. I am sure the makers, Dr. Sun, are probably pursuing a patent if it truly works. Anyone trying to make this hydrogel at home may be risking copyright infringement.
Dr Sun actually was awarded a patent in 2017 for Hydrogel. A lot of people speculate that the delay between discovery and marketing was caused by the different researchers fighting over a patent. However, making it isn't illegal. A patent makes it illegal to sell his product on your own. I think it would be really stupid to make it at this point bc we don't even know if it works on humans, but if someone is suicidal over their scars I guess making a hydrogel is an improvement over committing suicide. It's not even illegal to buy the chemicals he used.
7 hours ago, surgical scar said:LOL it's called PR news
A lot of PR gibberish, you bet!!! I would like to see some results instead on patients.
Please nobody try making sunogel at home and applying it. You're not surgeons and you messing yourself up could set sunogel back and ruin scarless healing for everyone by means of sheer stupidity.
Thank you guys for being so active on this forum. I always come here when im depressed again due to new scars. The people on here sharing the same problems as me and still being positive is the best therapy i can get.
Also i can always get the latest updates on scarless healing on here.
Thx guys, keep it going. This forum really means alot to me.
On 9/19/2018 at 9:34 PM, nikki_gargin said:I think polarity are going to wait for a year post application of skinte to share real reults. The leg wound pic says midstage healing. Also I heard some good news. I cant say much more than that. Only that my source is reliable.
is it austin?
19 hours ago, FastMedia said:On 20/09/2018 at 4:34 AM, nikki_gargin said:I think polarity are going to wait for a year post application of skinte to share real reults. The leg wound pic says midstage healing. Also I heard some good news. I cant say much more than that. Only that my source is reliable.
is it austin?
I wont discuss who or what exactly was said as I want to keep them anonymous. But it wasnt, no.
The only thing I wanted share is some positivity as I know some people want to hear the hope,m
On 20/09/2018 at 1:34 PM, nikki_gargin said:I think polarity are going to wait for a year post application of skinte to share real reults. The leg wound pic says midstage healing. Also I heard some good news. I cant say much more than that. Only that my source is reliable.
Good news regarding Polarityte?
yes i saw that. I was looking at the slides again and it did dawn on me that Polarity are bringing out a adiposeTE (fat) at some point. Which means Skinte doesnt regenerate fat at all. So patients having skinte on basically muscle will look very different than what we desire as fat also gives a lot of appearence to the quality of the skin. Its odd because a third degree burn includes fat but I believe skinte only generates dermis epidermis and appendages.
Anyone remember the demo of them doing a pinch test on skinte to show pliability? I would bet money that patient has hardly any fat underneath that patch from the burn. Thats why it looks weird and see through.
But then hypodermics is where the adipose is so its actually very confusing.
I would use skinte for my surgical scar to improve pliability and then get it micropigmented to make it look more normal.
also. Scars take up to 2 years to fully mature. We cant expact full regeneration in 6 months. I think they themselves mentioned a year to see its full potential.
also they have said they have a 5 year plan to bring it to EU and Asia.
29 minutes ago, nikki_gargin said:yes i saw that. I was looking at the slides again and it did dawn on me that Polarity are bringing out a adiposeTE (fat) at some point. Which means Skinte doesnt regenerate fat at all. So patients having skinte on basically muscle will look very different than what we desire as fat also gives a lot of appearence to the quality of the skin. Its odd because a third degree burn includes fat but I believe skinte only generates dermis epidermis and appendages.
Anyone remember the demo of them doing a pinch test on skinte to show pliability? I would bet money that patient has hardly any fat underneath that patch from the burn. Thats why it looks weird and see through.
But then hypodermics is where the adipose is so its actually very confusing.
I would use skinte for my surgical scar to improve pliability and then get it micropigmented to make it look more normal.
also. Scars take up to 2 years to fully mature. We cant expact full regeneration in 6 months. I think they themselves mentioned a year to see its full potential.
also they have said they have a 5 year plan to bring it to EU and Asia.
Well I guess we'll see. In theory healthy skin is supposed to have fat intertwined in it (Costarelis). While Skinte does not have the best track record for delivering, they're sticking to their scarless healing promise and I can't imagine them lying at this point lest they want to be humiliated in front of all these plastic surgeons.
52 minutes ago, FromScarredtoFree said:Well I guess we'll see. In theory healthy skin is supposed to have fat intertwined in it (Costarelis). While Skinte does not have the best track record for delivering, they're sticking to their scarless healing promise and I can't imagine them lying at this point lest they want to be humiliated in front of all these plastic surgeons.
No they havent disappeared in disgrace have they. So not all is lost yet.
I think acne scars are alot harder because they are all so different and i would say the majority is not full thickness. Where skinte relies on a full thickness sample to allow for regeneration. Would be abit messy.they do advertise its applicable for surgery scars so i guess thats the difference x
18 minutes ago, nikki_gargin said:I think acne scars are alot harder because they are all so different and i would say the majority is not full thickness. Where skinte relies on a full thickness sample to allow for regeneration. Would be abit messy.they do advertise its applicable for surgery scars so i guess thats the difference x
do you think they will cut all your face and apply a gel
skinTE on top of it? it looks scary who whould gonna do this ? by the way skinTE doesn't even promote scarless healing it shows efficancy to close wounds and replace split thickness skin grafts for severe burns that's what skinTE is about or you know something about skinTE I don't know explain please ... also don t forget skinTE needs a biopsy of full thickness skin with fat and this create a new scar and the doctor will close it with stiches
6 minutes ago, damnBOY said: