Acne.org Products
Take it for what is worth. This is FS2 applied on a rabbit with a scar.
https://www.folliclethought.com/birch-biomed-therapies-for-scarring-alopecia-areata/
7 minutes ago, MyBeautifulScars said:Take it for what is worth. This is FS2 applied on a rabbit with a scar.
https://www.folliclethought.com/birch-biomed-therapies-for-scarring-alopecia-areata/
As much as I'd personally like to get excited about FS2, those results don't inspire much confidence.
Percentage improvements are such a finicky thing. 90%, 40%... at the end of the day you still have a scar without regenerated skin and appendages. Since this is a board about scarless healing, I think that's what we all want from any product that comes out.
24 minutes ago, golfpanther said:As much as I'd personally like to get excited about FS2, those results don't inspire much confidence.Percentage improvements are such a finicky thing. 90%, 40%... at the end of the day you still have a scar without regenerated skin and appendages. Since this is a board about scarless healing, I think that's what we all want from any product that comes out.
I believe many of us here as long as we can get 90% improvement on our acne scars will be happy. It's not scarless healing but it's a start. Let's hope this doesn't fail like all the other products they came out with.
2 hours ago, HandyDonjon said:FS2 may cause potentially reduced scar formation in animal experiments.
Reduces collagen deposition. Also in human experiments?
We don't know yet. That is why clinical trials are being done. Phase 1 saw reduction in scarring in mammals on existing scars. Phase 2 will now test if 40 or up to 90% scarring is reduced in humans. Issue is that clinical trials take very long.
1 hour ago, Albaneso said:What is happening with SkinTE can anyone tell me??
Hard to fill you in when I don't know when you dropped off but here goes...
1. They presented twice in June, on the 7th and 25th. They presented new slides and in the latter had an accompanying webcast. The images are up on their site. Mixed views from the people on this board in terms of results but go take a look and decide for yourself. Ultimately they aren't final healing results so it's hard to tell what it will yield aesthetically at this time. PolarityTE does claim that it is regenerating all layers of skin with appendages.
2. Citron Research (founded by short seller Andrew Left) published a report calling PolarityTE a fraud. This was based mostly on their patent application receiving a non-final and then final rejection for one of their applications (PolarityTE claims to have several). Here's that report:
PolarityTE responded to the report, calling it misleading:
Here's an article by a patent lawyer that claims Citron's report is false:
Make of that what you will. I personally don't care (I only care about results), but I do find it odd that a short seller, and therefore someone with an active interest in making a stock's price tumble, published a report on June 25th, the same day as PolarityTE's second event in June.
3. Since then they added Peter Cohen to their board of directors.
That's about all that's happened in the last month or so.
15 hours ago, MyBeautifulScars said:18 hours ago, HandyDonjon said:FS2 may cause potentially reduced scar formation in animal experiments.
Reduces collagen deposition. Also in human experiments?We don't know yet. That is why clinical trials are being done. Phase 1 saw reduction in scarring in mammals on existing scars. Phase 2 will now test if 40 or up to 90% scarring is reduced in humans. Issue is that clinical trials take very long.
the picture looks like it really calms hypertrophic scars which is easier to hide and for no one to notice. A nice reasonable start.
better concentrate on sunogel and Microcoring ....thay are devices and very fast for approval
15 hours ago, Anish004 said:better concentrate on sunogel and Microcoring ....thay are devices and very fast for approval
Sunogel is taking long as well. All these so called scarless healing technologies are far away, not for the immediate future. SkinTE is just a big fail in my books regardless of what some people think on here. Since the whole report came out that they can be a scam and their patent was rejected, they have become relatively silent.
Might as well, make the best of our present situation. One day, it might be possible to make our acne scarring vanish. Also, I really hope they find a functional cure to acne and folliculitis.
https://clinicaltrials.gov/ct2/show/NCT03036306
There's also another product in development known as SCX-001. It is in phase 1 of clinical trials. It promises to reduce scarring by half. It is still not scarless healing but for acne scarred individual it is a step in the right direction.
On 7/15/2018 at 4:37 AM, MyBeautifulScars said:Sunogel is taking long as well. All these so called scarless healing technologies are far away, not for the immediate future. SkinTE is just a big fail in my books regardless of what some people think on here. Since the whole report came out that they can be a scam and their patent was rejected, they have become relatively silent.Might as well, make the best of our present situation. One day, it might be possible to make our acne scarring vanish. Also, I really hope they find a functional cure to acne and folliculitis.
Does anyone know why sunogel taking so long? They have been here since 2015, you would have thought they have a working product already.
8 hours ago, AI3forever said:On 7/14/2018 at 1:37 PM, MyBeautifulScars said:Sunogel is taking long as well. All these so called scarless healing technologies are far away, not for the immediate future. SkinTE is just a big fail in my books regardless of what some people think on here. Since the whole report came out that they can be a scam and their patent was rejected, they have become relatively silent.Might as well, make the best of our present situation. One day, it might be possible to make our acne scarring vanish. Also, I really hope they find a functional cure to acne and folliculitis.
Does anyone know why sunogel taking so long? They have been here since 2015, you would have thought they have a working product already.
When I talked to him in December he was looking for investors. He wants to go through the full clinical trials process, despite the hydrogel being considered a device. That takes a lot of money with nothing even close to a promise of a return from an investor. He's basically between a rock and a hard place with this approach.
I get his reasoninghe wants to prove efficacy and safety and earn FDA approval (which is different than being registered, like SkinTE) before a market launch. But it doesn't exactly have investors beating down your door so he's probably relying a lot on grants.
Well, I guess the forum has become silent over the past few days. No news from SkinTE. I looked at Polarity's stock and it has taken quite a plunge which suggests that it may be a huge failure.
I would like to give an update on different anti scarring drugs, creams or devices currently in development to prevent or eliminate scarring.
These products are as follows:
1) FS2
FS2 is currently in phase 2 clinical trials. Mind you almost 50% of all experimental drugs fail at this stage. FS2 is licensed to the University of British Columbia in Canada.
It apparently has the power to eliminate scarring in fresh wounds and improve the appearance of existing scar tissue. It also prevents type 1 diabetes also known as juvenile diabetes. Phase 2 of the clinical trials will help drug developers determine if it improves from 40 to 90% existing scar tissue.
If successful, it can take long for such a drug to be sold.
Initially, they had created another anti scarring drug known as Fibrostop. It passed phase 1 clinical trials but ultimately failed.
2) SCX-001
ScarX Therapeutics is developing a anti scarring cream known as SCX-001. They are currently in phase 1 clinical trials. Apparently, their product improves scars by up to 50%. They are based in Toronto, Canada. Their product is being developed from Nefopam. Nefopam is a painkiller currently prescribed.
https://clinicaltrials.gov/ct2/show/NCT03036306
3) Tropoelastin
Elastagen based in Sydney, Australia were behind developing a product known as tropoelastin. Elastin is a naturally protein found in the skin which gives skin its elastic nature. They were sold in February to a bigger company known as Allergan, a maker of Botox. Their product is designed to treat stretch marks and acne scars. Allergan has been quite silent about the product ever since they acquired it. There are clinical trials underway.
https://clinicaltrials.gov/ct2/show/NCT03056235
4) Sunogel
The developer seems to be lacking the funds to proceed in clinical trials. Sunogel has been discussed on this forum heavily. No need to provide further details.
) There is also research that was done which suggest some proteins or molecules help with reducing scarring.
1) Decorin
Researchers have found that Decorin, a human protein, reduces hypertrophic scarring if applied on fresh wounds.
2) TD139
Galecto Biotech seems to have developed a product to prevent lung scarring. If successful, it can possibly be used on skin scars.
3) Salbutamol
https://www2.le.ac.uk/offices/red/funding/case studies/wound-healing
C) Products currently available that may help with scar reduction.
1) Pirfenidone
D) Notable failures
1) Avotermin (Juvista)
Juvista failed in phase 3 clinical trials.
According to this research, inhibition of TGF-3 reduces scar formation in humans.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4292081/#!po=38.8158
In conclusion, we may have too wait a little longer to rid ourselves of acne scars.
1 hour ago, MyBeautifulScars said:1) FS2
FS2 is currently in phase 2 clinical trials. Mind you almost 50% of all experimental drugs fail at this stage. FS2 is licensed to the University of British Columbia in Canada.
It apparently has the power to eliminate scarring in fresh wounds and improve the appearance of existing scar tissue. It also prevents type 1 diabetes also known as juvenile diabetes. Phase 2 of the clinical trials will help drug developers determine if it improves from 40 to 90% existing scar tissue.
If successful, it can take long for such a drug to be sold.
Initially, they had created another anti scarring drug known as Fibrostop. It passed phase 1 clinical trials but ultimately failed.
Fibrostop failed? Well what hope is there then for FS2 if the basic principle has already proven to be ineffective?
Birch biomed's FS2
4 hours ago, mjg713 said:Any new information on the research done by Dr. Cotsarelis? Wasn't the method he discovered proven to be 100% effective in preventing scarring?
Unfortunately we don't know what's going on with Dr. Cotsarelis.
Seems to me that the medical community has more important things to find a cure for than finding something to minimize or prevent scarring. It's important to note that scarring is a normal healing process and not a disease. It will take time before something comes around that regenerates skin as it was before.
It sucks for us acne sufferers and acne scarred individuals who wished their skin was blemish and scar free.
I have been suffering from back, butt, face, thigh, upper arms and shoulder acne for many years. My skin has gotten better with time however I have a collection of acne scars covering different parts of my body especially tiny white slightly raised spots on my back, thigh, upper arms, shoulders and jawline. If I had a random spot here and there, it wouldn't be a big deal but I have collected a substantial amount of these throughout my cystic acne years.
I really hope FS2 doesn't fail as it seems to have taken the lead over all the others promising scarless healing in fresh wounds. Issue here is that it's a drug and can take time to see it ever being prescribed provided it doesn't fail.
news about polarityte:PolarityTE today announced an update on the Companys commercial progress. The Companys first product, SkinTE, has transitioned into Stage 2 of commercialization and has continued to be successful in regenerating autologous full-thickness skin in the treatment of complex wounds including acute and chronic wounds, traumatic and surgical defects, burn wound reconstruction and skin graft replacement. With continued growing physician, facility, and VAC committee purchase agreement approvals, the Company has begun generating revenues while improving the lives of patients. For more information:
20 minutes ago, royaume said:LoL now they stopped talking about scarless healing.
It's worth noting that they never claimed scarless healing because from their own findings it wasn't.
What preclinical studies showed was regeneration of all three layers of skin with appendages, but it had a margin. That margin is scar tissue and to their credit they never shied away from that.
The idea was that the margin would be so small as to be invisible to the naked eye, which I think would be just fine for us on here.
Now, none of the results they've presented thus far are aesthetically good enough for us. However, if SkinTE does indeed take over the skin graft market and shows the ability to regenerate full thickness skin with appendages that's great news, not just for burn patients and severe those suffering from severe trauma, but us as well.
Investors are squeamish in this market and for good reason. Its history is littered with scams, failures and incremental/percentage improvements. But if SkinTE does replace skin grafts as the standard of care I think more investors would start looking at skin regeneration products more seriously.
That would help Sunogel tremendously and of course it would help PolarityTE work on derivatives and optimization.
There is a LOT of conflicting ideas about whether or not PolarityTE is legit, a fraud or somewhere in between. Honestly, most, if not all, of it is motivated by investors wanting to drive up or down the price. On the shorts side you have articles oscillating from questioning the tech altogether to now questioning whether or not it meets the requirements of the 361 regulatory pathway and if JHU or Southern Illinois might actually own the product. On the long side you have articles talking about Ausome Weaver and the results it's obtained thus far.
A tangible bit of good news is that PolarityTE states in that press release that they will be presenting at the Annual Meeting of the American Society of Plastic Surgeons in September. Real clinical data that will cut through all this noise and let us see and hear what's actually going on.
To be honest you cannot trust anybody. Even the sunguy can immediately show us his incredible results. Over night he would have MANY investors but he cannot deliver, why? We dont need 1000 pages of data, we just need a clear before and after shot. Where is the problem with the sunguy? I bet there are many volunteers who would love to take part in his small trial.
Instead he shows us a ridicilous picture from his finger. I have cut my Finger at least 100 times and it always healed scarless so what is our sunguy trying to proove? That his small finger healed without scarring? Wow... He deserves the nobel prize for his observation.
