Acne.org Products
2 hours ago, SimpleMutton said:Let's be honest, there will be no cure at least for 10 years.
I decided to tattoo over my scars in my back and hide them that way.Every product in development is either still in clinical trials (and take years) or plainly doesn't work for acne scars.
Good luck everybody
Good idea. I'm thinking of doing the same. Getting tattoos on my back and shoulders to cover all those little nasty white scars. However, with time the tattoo will fade and the scars will become more prominent as we age, regardless. So, there's no way really to hide the scars. Also, scar tissue doesn't absorb ink that well. So, I guess for the short term getting tattoos would hide at least most of the scars.
With time, the scars get better but that's what severe acne leaves behind. People, especially many parents don't seem to think of the potential disfigurement to the skin it may cause.
Prevention is the best way to avoid the scarring. As a teenager, your parents might tell you it's just a phase. Accutane has too many side effects. Girls can take birth control but as soon as they stop it, severe acne manifests itself.
The best way to deal with acne is finding a functional cure. It is also in development and can take years. I guess, as a teenager if you have severe acne, you might as well accept the permanent skin scarring or take the Accutane route exposing yourself to other potential side effects to minimize future scarring. For most however Accutane gives them back their life.
I have my back and shoulders covered with these strange white wrinkly looking slightly raised scars that resemble little whiteheads. I also have a few on my jawline, thigh and upper arms. Some are large but most are small. They look better or worse as light conditions change. My face has a few ice pick scars as well.
I am an acne sufferer for close to 25 years. My skin condition has improved and the old scars are less noticeable. New pimples don't leave scars and resolve in about a few weeks with redness gone within a month. I never took Accutane and never went for any scar treatment but my skin condition has caused me great despair and limited me from doing fun activities as a young adult.
My skin is clear now and its the best it's ever been but the scars are a constant reminder of the my acne battle.
FS2 looks promising but let's hope it doesn't fail like Juvista.
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So this doesn't go completely along with this topic, but in a way it does. I suffer from acne scars like many of you do. I consider mine severe. They have ruined my life in many ways. They have caused me to have problems in my relationship as well as every other area of my life. I think one of the only things that makes me feel better is when I see others with acne scars too. It makes me feel like I'm not going through this battle alone. Out of curiosity , how many acne.org members would move to a place where others have scarring and acne? I'm talking about a community where a majority of the people have acne and scars . We could all be friends in real life and hang out and stuff. We could be there to support each other and cry together if we need to. I know the social isolation acne scars cause. Message me if you're interested. I know I would try to move in a heart beat if I could surround myself with other people that look like me. Also , message me if you'd like to have a friend. I'm looking for friends right now. I've been very suicidal lately over my scars. I definitely need friends. I think living in a community together could help a lot of us from feeling alone.
A few things:
I have talked to someone who had 3rd and 4th degree burns and was part of the US recell trial. The results have been pretty amazing aesthetically. Really amazing color, much better than having grafts everywhere. We all know that recell is not amazing for acne scars but it seems to be great for burns and chronic wounds. I also reached out to Sunogel. Funding seems to be the biggest hurdle and I don't think he has the best means to generate funding. I recommended crowdfunding and he seemed interested. I think we all need to try and help him with this. As it stands, he has one of the only studies I can think of that was used on pre existing scars where positive results were achieved. Everyone else is focused on wounds healing and not regenerating tissue from scarred areas. If any of you work in finance or have experience with crowdfunding we should come up with a plan to help fund a study.
1 hour ago, FastMedia said:A few things:
I have talked to someone who had 3rd and 4th degree burns and was part of the US recell trial. The results have been pretty amazing aesthetically. Really amazing color, much better than having grafts everywhere. We all know that recell is not amazing for acne scars but it seems to be great for burns and chronic wounds. I also reached out to Sunogel. Funding seems to be the biggest hurdle and I don't think he has the best means to generate funding. I recommended crowdfunding and he seemed interested. I think we all need to try and help him with this. As it stands, he has one of the only studies I can think of that was used on pre existing scars where positive results were achieved. Everyone else is focused on wounds healing and not regenerating tissue from scarred areas. If any of you work in finance or have experience with crowdfunding we should come up with a plan to help fund a study.
Is there any estimate as to when Recell would be available to the general public?
1 hour ago, mjg713 said:3 hours ago, FastMedia said:A few things:
I have talked to someone who had 3rd and 4th degree burns and was part of the US recell trial. The results have been pretty amazing aesthetically. Really amazing color, much better than having grafts everywhere. We all know that recell is not amazing for acne scars but it seems to be great for burns and chronic wounds. I also reached out to Sunogel. Funding seems to be the biggest hurdle and I don't think he has the best means to generate funding. I recommended crowdfunding and he seemed interested. I think we all need to try and help him with this. As it stands, he has one of the only studies I can think of that was used on pre existing scars where positive results were achieved. Everyone else is focused on wounds healing and not regenerating tissue from scarred areas. If any of you work in finance or have experience with crowdfunding we should come up with a plan to help fund a study.
Is there any estimate as to when Recell would be available to the general public?
It won't be for scars, at least not yet. It has only gained approval for burns in the United States.
In other new I talked to someone close to Austin. They seem pleased with SkinTe and she said scarring is very minimal and that he is only 3 months out from receiving skinte, so there is still quite some time before we see the final outcome, but right now the are is just a bit pinker but not super noticeable. Also, I saw pics of the lady who had grafting in combination with recell (she was cool enough to share pics). Pretty damn impressive. You lot would probably still complain but it is pretty impressive how well they healed. In early pics the legs were very dark and looked scarred but after time the color toned down drastically.
https://bioinformant.com/aegle-therapeutics/?utm_source=newsletter&utm_campaign=72818
Aegle therapeutics uses stem cells to heal wounds, mesenchymal I believe. Early studies indicate ver minimal to no scars. They just secured FDA approval for phase 1 of clinical trials. Edit, just read. I might be wrong about the stem cells. I think they use something similar idk.
sad days aren't fading
each day seems like a deduction of life days
remembering old days ..when everything was perfect gives goosebumps
these arent goingto fade..until someone take this scar thing more seriously ..feel it in him and do something which never had done before...i.e.., complete skin regenration
Never have faith in a company that is just keep talking without providing evidence.
The sunogay is just talking and polarityte did not show the desired results for us. I dont say its not working but we can forget their claim of scarless healing and they absolutely advertise it like it. They know exactly what they say. For burn patients its perfrct4and obviously better than the current methode of skin grafts.
For acne scar sufferers it looks really bad. Its a cospiracy. Hair loss and acne scar research dont progress. The only thing jn which both are perfect is different lighting settings and fooling people with pictures showing 0.00001 % improvement.
Sosad...
33 minutes ago, FreddiHendersson said:@Anish004Are you kidding me?! Where are your SCARS? Live your life, Bro
https://www.acne.org/messageboard/topic/377442-clogged-pores-help-please/
Anish004 has been a regular here claiming that he has the most absolute severe acne scarring and the worse possible acne.
You'll find many trolls, others here with low self esteem or serious mental health. All you can do is offer advice and try to help.
I don't believe Anish has severe acne or acne scarring for that matter. All I see is some blackheads that can easily be cleared with some over the counter creams or by a dermatologist. There may be 1 or 2 ice pick scars but those are nothing really to cry over.
12 minutes ago, MyBeautifulScars said:Anish004 has been a regular here claiming that he has the most absolute severe acne scarring and the worse possible acne.You'll find many trolls, others here with low self esteem or serious mental health. All you can do is offer advice and try to help.
I don't believe Anish has severe acne or acne scarring for that matter. All I see is some blackheads that can easily be cleared with some over the counter creams or by a dermatologist. There may be 1 or 2 ice pick scars but those are nothing really to cry over.
who are you to judge how severe my scars are ???come meet me.. i will show u my scars
i dont have any blackheads..i have many moles on face..i dont have ice picks but circular pox scars...AMVC scar and extra stretched pores
this is the reason why i left this thread times ago and join more fine persons on group messages and they are much better than immature people on this thread who just came months ago on this thread and started judging others....there are some peoples who are on this thread and forum for more than 10 years and you guys just keep talkinf about % improvement ...oh i forgot go get fraxel for your % improvement...and dont judge my scars....i dont like them and they appear disfiguring to me thats why i am here.....
1 hour ago, FreddiHendersson said:@Anish004Are you kidding me?! Where are your SCARS? Live your life, Bro
https://www.acne.org/messageboard/topic/377442-clogged-pores-help-please/
cant u see thats very good lighting and i have mainly scars on my nose
and my cheek scars only appear in index lighting and this pic is in full lighting
39 minutes ago, Anish004 said:who are you to judge how severe my scars are ???come meet me.. i will show u my scarsi dont have any blackheads..i have many moles on face..i dont have ice picks but circular pox scars...AMVC scar and extra stretched pores
this is the reason why i left this thread times ago and join more fine persons on group messages and they are much better than immature people on this thread who just came months ago on this thread and started judging others....there are some peoples who are on this thread and forum for more than 10 years and you guys just keep talkinf about % improvement ...oh i forgot go get fraxel for your % improvement...and dont judge my scars....i dont like them and they appear disfiguring to me thats why i am here..... cant u see thats very good lighting and i have mainly scars on my nose
and my cheek scars only appear in index lighting and this pic is in full lighting
Moles are normal. Everyone has them. You should see a dermatologist to verify if they are malignant before they become bigger.You can also remove or fade them but you need money as this is cosmetic and not life threatening.
You have at most 1 or 2 ice pick scars which as you said are from chicken pox. Everybody has a chicken pox scar somewhere on their body. These atrophic scars are easy to treat with permanent or temporary fillers and even subcision. You do not get 100% improvement but you can get as much as 90%.
Some people have enlarged pores. This is just genetics. Get over it. It's not disfiguring. It's like having freckles.
AMVC is rare random scarring and not caused by acne or any other skin condition. In fact, it's not scarring at all because there's no fibrosis going on. It seems it's a genetic disorder affecting skin elastin of the face. It is similar to anetoderma which occurs on the body. Even if someone finds a way to regenerate skin, your issue has to do with skin elastin not scar tissue.
Some people develop another type of acne scarring known as follicular macular or perifollicular elastolysis on the body after severe acne. Again, elastic fibers are affected but you also have fibrosis going on.
You have very minimal scarring. Go enjoy life.
I will second the sentiments about mental health here. I understand, it's easy to see all of our rejections and failings coming from our scars but it's not the case for the majority of us. Some of you need some perspective. Go out, live life or try live life. There are things to do and enjoy, don't let scars keep you from living.
This thread is 80% scar-ridden people talking about their personal issues, stemming from mental health disorders caused by scars and insecurity. 15% about bashing and doubting existing companies attempting to solve scarless healing. And lastly, 5% productive information regarding new advances in scarless healing.
Wish the moderators would step in as this is a fairly important forum topic on the internet, and is a top search result on Google for scarless healing. In the past I used to come here for valuable insight, but now it's just overwhelmingly toxictoo bad.
20 hours ago, Delto said:Wish the moderators would step in as this is a fairly important forum topic on the internet, and is a top search result on Google for scarless healing. In the past I used to come here for valuable insight, but now it's just overwhelmingly toxictoo bad.
This thread has been going for eleven years. They "stepped in" once in the past where it was temporarily closed. I don't think they'll do that again as there's no real point. I also don't think they'll lock it permanently.
Here are the pictures of Sunogel trial on animal models. This seems to be the only tease they have to offer so far. Wish they gave us some updates about what theyre up to. Their Facebook and website has been stagnant
http://www.sunogel.com/technology
1 hour ago, Lapis lazuli said:This thread has been going for eleven years. They "stepped in" once in the past where it was temporarily closed. I don't think they'll do that again as there's no real point. I also don't think they'll lock it permanently.
The moderator I've talked to has repeatedly said she/he is the only active volunteer moderator and is tired of getting reports about this threadand does not want to waste more moderation resources on this thread and she/he does not even follow this thread so we're better off if they don't even bother since they're clueless about the topic and discussions and sources of tantrums here. Forget about real moderation. This is an open thread for desperate trolls and shills.
9 minutes ago, surgical scar said:Forget about real moderation. This is an open thread for desperate trolls and shills.
lmao
This Post is Locked Temporarily Until Senior Mod's Make a Determination of the Above Complaints.
- We have reminded (several times prior) those who post here to use the report flag ( to the right of every post) for any issues. Also to hover over the screen name and select "ignore user" if you do not wish to follow someone'sposts.
This all could have been solved by simply ignoringposts that don't interest you. We realize everyone is ""dealing"" with different personal issues and individualized areas of concern to their interest. This is a public space it is up to you to maintain the topic your interested in. You find this in any public forum, differences of opinion and content. Some of the recent posts are taking a more personal tone than staying on topic or being useful to the goal of scarless healing.
Please do not engage or troll other member's it's pointless to the overall good and idea of "scar less" healing.
So lets get back on topic. Researchers have found the gene responsible for scar formation in Poland. Take it for what's worth.
16 hours ago, MyBeautifulScars said:So lets get back on topic. Researchers have found the gene responsible for scar formation in Poland. Take it for what's worth.
wow gene manipulation during healing is their proposal? Thats amazing.
A new drug is currently undergoing trials in both UK and South Korea. It's called OLX101 and apparently it works by inhibiting genes associated with scarring. Also the discovery of the FOXN1 gene that MyBeautifulScars mentioned looks very promising. In theory with one of these methods we could excise our scars and then prevent the scarring from ever occurring. Also, the same researches that discovered the FOXN1 gene found that when the gene is switched off not only does scarring not happen but the skins natural structures, such as hair and sebum glands are also regenerated.
I think we are getting closer to scarless healing more so then ever. I think within 5-10 years there will be a real solution as opposed to the bandage solutions used now.
Good post, MyBeautifulScars. I'm happy to see research is still ongoing into gene manipulation as a means for scar free healing.
I'm a little bit skeptical though because there has been a long line of research of this type that hasn't really panned out.
For example, this paper about osteopontin from 2008:
https://www.sciencedaily.com/releases/2008/01/080121080355.htm
And then there have been numerous published articles about WNT signal pathways as a means for scar free healing.
Now, it may be that manipulating both could yield the desired outcome. That would be great!
But the problem is two-fold. One, trials and tests for this kind of thing would take a long time. I'm not talking 3-5 years or even 8-10. The paper about osteopontin is already 10 years old and no movement has really taken place. Even if it made it to trials you're looking at the full 3-4 phase variety.
And the reason for that is the second problem in my opinion, which are very real safety concerns. If memory serves, the WNT pathway also helps regulate cell growth. Turning it off could lead to proliferation of a vast amount of cells quite rapidly that might help with wound healing at the time, but could lead to cancer later.
Here's another article about research being done into wound healing by studying oral injuries:
Basically, they found that eight genes were more active in oral wound healing and that by increasing the production of transcription factor SOX2 they were able to improve skin wound healing in mice. But again, this gets into gene manipulation, so anything like this is a long ways off. 
The WNT pathway is completely different than the FOXN1 Gene. The WNT pathway is located on the 12th Chromosome while the FOXN1 Gene is located on the 17th. Additionally, the FOXN1 Gene is has two functions, scarring and T cell production in the thymus. The WNT pathway has many more functions and messing with it can cause carcinogenic consequences. While gene therapy is a difficult thing to accomplish, there are ways to temporarily inhibit a gene during wound healing. I believe this is what OLX is trying to accomplish.
Wound healing is complex and still not well understood. What we do know is that scar tissue is the normal outcome of a healed wound. Once the dermis is injured, the new healed skin will not be the same as to pre-injury.
Issue is that fibroblasts tend to fill in the gap in order to close the wound. The faster the wound is healed, the less scar tissue is formed. Once the skin is injured, fibroblast cells begin laying down collagen in a different direction. A scab is formed to protect the wound. Fibroblast cells are few in numbers generally awating for an injury to happen in order to begin repair.
Too much collagen leads to thick scars known as hypertrophic scars. Almost everyone will get this type of scar if the wound is large enough. The fibroblasts turn into granulation tissue over time which fill up the wound. Scar tissue is basically matured granulation tissue lacking hair follicles, melanocytes and sweat glands. If the wound is small, fibroblasts tend to die out and white cells eliminate them by phagocytocis. The regenerated skin would look exactly the same as to pre-injury. Essentially, it seems the body cannot eliminate all these fibroblasts if the wound is large enough. Over time however, the scar might become smaller or significantly fade as the body attempts to reorganize the collagen by eliminating all these fibroblasts.
For some people, the fibroblasts multiply exceptionally resulting in excess scar tissue. This is considered abnormal healing and a disease. These scars are known as keloids. Some doctors consider keloids as tumors as they multiply abnormally just like cancer cells.
Too little collagen results in atrophic scars. These regularly develop after moderate or severe acne or othe skin diseases. They result in skin depressions.
Modern medicine has developed some methods to elevate the skin depressions by injecting collagen or promoting new collagen by re-injuring the skin. The outcome of the procedures depends on each individual.
Thick scars are injected with steroids which seem to flatten them or laser therapy can burn off some of the repaired excess skin resulting in a flatter smoother scar. However, thick scars tend to regenerate into even thicker layers if they are touched.
Researchers already know that the FOXN1 gene is involved in keratin expression and regulates wound healing. What the researchers found accordingly to the article is that there is higher activity of FOXN1 in healing wounds. Inhibiting the gene might prevent scars altogether. My assumption would be that FOXN1 regulates fibroblasts. More fibroblasts means more scar tissue. Less fibroblasts means less scar tissue. However, our skin heals with the aid of these cells which produce collagen in order to help close wounds. Manipulating FOXN1 might tamper the body's natural healing ability.
Cotsarelis and Plikus found a way to turn fibroblasts into fat tissue or adipose tissue which seemed to signal skin regeneration of hair follicles and sweat glands. The research was published on Jan 2017. There's nothing new to report from them ever since. They had intentions to launch clinical trials but over a year has passed and they seem to be quite silent ever since about their findings. I believe they truly hold the answer to scarless wound healing.
A cream or drug that helps turn existing scar tissue into normal looking skin again is the way to go.
WNT signal pathways control cell growth. Tampering with WNT signal pathways leads to uncontrollable cell progression or proliferation resulting in cell overgrowth and higher chancesof abnormal cell growth resulting in cancer.
With all the research going on right now in an attempt to eliminate scarring, we can only hope most that the products being currently tested do not fail like Juvista.
22 hours ago, FromScarredtoFree said:The WNT pathway is completely different than the FOXN1 Gene. The WNT pathway is located on the 12th Chromosome while the FOXN1 Gene is located on the 17th. Additionally, the FOXN1 Gene is has two functions, scarring and T cell production in the thymus. The WNT pathway has many more functions and messing with it can cause carcinogenic consequences. While gene therapy is a difficult thing to accomplish, there are ways to temporarily inhibit a gene during wound healing. I believe this is what OLX is trying to accomplish.
I'm not saying that FOXN1 and WNT are the same pathway, rather that at least in the US they will be regulated the same. As it stands now in regards to gene manipulation, the FDA will require a full 3-4 phase clinical trial, regardless of which chromosome we're talking about. Perhaps the FDA will one day ease up on this type of regulation, as they already did for regenerative medicine last year.
But the reason is simple. After the 10-15 years it takes to finish a full 3-4 phase clinical trial it's a much safer bet that harmful side effects will not occur. I don't know enough about FOXN1 to say what could go wrong, but in reality neither do the researchers working on it until it's been tested thoroughly for efficacy and safety. It's pretty unchartered territory.
I hope something regarding gene manipulation as a means for scar free healing comes to fruition soon, or at least gets going on trials. The time it takes for this type of research is depressing.