Acne.org Products
16 minutes ago, damnBOY said:2 hours ago, rudy1986 said:Please read completely what i stated, i said that even though we are more shallow in depth, we have to eventually excise it to full thickness
No they don't have to excise full thickness they will excise only the defect read the conservation of Swanson with Tano
What page is that conversation on with Swanson?
I agree with what Tano was saying. I dont mind having something i can just put abit of makeup on and no one can notice it with a close to normal texture eg with pores. Perfect is never something healthy to aim for even if it maybe achievable which i do hope!
Does someone know if the hypodermis heals 100% after surgery? Every pic of scar healing phases where they have drawings of the 3 layers looks like the hypodermis goes back to normal.
Atm im looking a luminis ultrapulse for my scar but abit mmmm over the fact you basically get a 3rd degree burn from it. But does seem to improve texture and function.
3 hours ago, damnBOY said:5 hours ago, rudy1986 said:Please read completely what i stated, i said that even though we are more shallow in depth, we have to eventually excise it to full thickness
No they don't have to excise full thickness they will excise only the defect read the conservation of Swanson with Tano
I know man, i know, but unfortunately it is a no-no
The "far less scarring" part could mean a lot of things. For one, it's only been six weeks as of that post! Six weeks to get coverage, glands and hair follicles in a wound down to the bone.
Also, SkinTE was never scarless in the absolute sense of the term because of the margin. The margin, according to PolarityTE, is not visible to the naked eye but since it exists it can't claim to be completely scar free.
Remember that in the preclinical studies it took much longer than six weeks to get the final outcome, as the skin continued to heal and remodel, for the better, over an extended period of time. I'm not saying it will match that 100% in humans or this patient in particular, but at six weeks not even the pigs had results we'd all be happy with.
12 hours ago, Sniffy said:What page is that conversation on with Swanson?
The entire interview is still up in my past posts on my profile if you want to dig through there youll find it a lot easier.
Its true that a full excision wouldnt be necessary depending on the extent of the injury/scar. If only the upmost part of the dermis was damaged, then only part of the dermis could be excised and the rest left alone.
9 hours ago, nikki_gargin said:Does someone know if the hypodermis heals 100% after surgery? Every pic of scar healing phases where they have drawings of the 3 layers looks like the hypodermis goes back to normal.
Yes it does regenerate, but as to whether its 100%, probably not. I would think the margin extends all the way down to where the native skin and new skin meet as seen in pre-clinical images when looking at the inside of healed tissue. My opinion based on what Ive seen anyway.
It will indefinitely regenerate though as the CEO repeatedly has said and still continues to say that all 3 layers do regenerate. So you can establish that the people who had such deep injuries where even the hypodermis was obliterated still regenerated it and the other layers as well. As for the amount of improvement or a percentage estimate, wed have to wait until they publish the details from the trial results.
interesting article with Lough couple days ago. Here are some key points.
"He noted that the product also needs to be cost-efficient. While most skin substitutes are priced between $100 and $250 per square centimeter, PolarityTE sells its system for close to $50 per square centimeter, according to Lough"
"The company is also in talks with major biopharma companies, Lough said, to set up potential distribution deals nationally and internationally."
"Over the next year, PolarityTE plans to continue its limited release of SkinTE, as well as disclose data from its clinical work. Early data show great promise for the companys first commercial product, according to Lough, who described a case in which doctors used SkinTE to treat a 45-year-old patient who had burns permeating 75% of their body."
The patient was coding the night before the SkinTE product was put onto them, he said. Typically these patients, if they do live, theyre in the burn center for over a year. And the average cost for that type of burn care is usually $1.3 to $1.5 million, per the National Burn Repository data thats out there. Following application of the SkinTE product, the patient was ambulating, grew full-thickness skin and was discharged six weeks later.
2 hours ago, Sniffy said:https://www.drugdeliverybusiness.com/polarityte-aims-to-wage-war-on-skin-grafts-with-regenerative-tech/interesting article with Lough couple days ago. Here are some key points.
"He noted that the product also needs to be cost-efficient. While most skin substitutes are priced between $100 and $250 per square centimeter, PolarityTE sells its system for close to $50 per square centimeter, according to Lough"
"The company is also in talks with major biopharma companies, Lough said, to set up potential distribution deals nationally and internationally."
"Over the next year, PolarityTE plans to continue its limited release of SkinTE, as well as disclose data from its clinical work. Early data show great promise for the companys first commercial product, according to Lough, who described a case in which doctors used SkinTE to treat a 45-year-old patient who had burns permeating 75% of their body."
The patient was coding the night before the SkinTE product was put onto them, he said. Typically these patients, if they do live, theyre in the burn center for over a year. And the average cost for that type of burn care is usually $1.3 to $1.5 million, per the National Burn Repository data thats out there. Following application of the SkinTE product, the patient was ambulating, grew full-thickness skin and was discharged six weeks later.
$50 per cm square ????
i cant understand what that mean
previouslt they said a 2 cm skin graft converted to paste and then it can be applied to a large area
so that 50$ is the cost for a amount of paste which can cover 1 cm injured area ?
5 hours ago, Anish004 said:$50 per cm square ????i cant understand what that mean
previouslt they said a 2 cm skin graft converted to paste and then it can be applied to a large area
so that 50$ is the cost for a amount of paste which can cover 1 cm injured area ?
Yeh I guess so if you had 1 small acne scar its 1cm by 1cm so $50 but i doubt that would be the case for just 1 or 2 small scars. There will be a minimum processing fee i would think just to get the paste/jelly.
If SkinTe is a big success for smaller cosmetic purposes PolarityTe really need to be ready for the demand. Hopefully Skinte can be sent internationally for elective treatments also for people outside of America.
some time ago somebody said that healed area will take properties of donor area skin...so i guess for face we have to give a small piece of skin for face i think lower jawline..will be perfect ..and fhat donor area will also be covered by paste
stilll imagining these things ..hope it all come true soon
10 minutes ago, Anish004 said:some time ago somebody said that healed area will take properties of donor area skin...so i guess for face we have to give a small piece of skin for face i think lower jawline..will be perfect ..and fhat donor area will also be covered by paste
stilll imagining these things ..hope it all come true soon
No. Skinte biopsy can be taken from anywhere, preferably hidden places like groin and armpit. SkinTe applied to any wound on face or body grows skin that takes on the properties of the surrounding skin of where it grows.
3 hours ago, Sniffy said:No. Skinte biopsy can be taken from anywhere, preferably hidden places like groin and armpit. SkinTe applied to any wound on face or body grows skin that takes on the properties of the surrounding skin of where it grows.
hey Sniffy thats amazing. Did you get that info from Polarity website? Could you point me to where i can read more? X
I think it was me that said it would have properties of donor skin and i was looking at it as a cell for cell swap if you get me. If the jello is that smart to take on properties of other skin that is amazing! I cant wait ive got all my fingers crossed!
13 minutes ago, nikki_gargin said:hey Sniffy thats amazing. Did you get that info from Polarity website? Could you point me to where i can read more? XI think it was me that said it would have properties of donor skin and i was looking at it as a cell for cell swap if you get me. If the jello is that smart to take on properties of other skin that is amazing! I cant wait ive got all my fingers crossed!
Yea true because the skinTE is cells lgr6 cells which demands the serounding cells to go to the wound and form new tissue like the serounding tissue
10 minutes ago, SimpleMutton said:I hope by the end of the year we can use it for cosmetic purposes, even if it solves 80% of the problem I'd still consider it scarless healing
Will be supposedly by cutting our stomach and plant it on face...
i got an idea, why dont skinte take our kidney as donor, develop into paste and inject it to our skin?
i heard we can live with 1 kidney..
If this really works on acne scars, the demand will he incredibly high.
Cant wait to see the current result of the hand. The oicture was taken 7 weeks post applying skinte and the injury was very deep (bone). They already showed that they are able to regenerate skin and replace skin grafts but imagine that the hand picture is now evem better than the first picture! I cannot understand why some of you still think that the hand result was not good.... I MEAN this guy's bone is visible in the before pictures and you guys talk about bad results.
3 hours ago, royaume said:If this really works on acne scars, the demand will he incredibly high.
Cant wait to see the current result of the hand. The oicture was taken 7 weeks post applying skinte and the injury was very deep (bone). They already showed that they are able to regenerate skin and replace skin grafts but imagine that the hand picture is now evem better than the first picture! I cannot understand why some of you still think that the hand result was not good.... I MEAN this guy's bone is visible in the before pictures and you guys talk about bad results.
Yeah, I honestly don't get why people were down on the hand pic. And now we have the Facebook page where the patient's mother states he has full thickness skin with hair and sweat glands. Great results.
Still don't know when a cosmetic application will come but I can't imagine PolarityTE wouldn't be making that a priority. Way too much money.
On 18/05/2018 at 1:38 AM, Tano1 said:The entire interview is still up in my past posts on my profile if you want to dig through there you™ll find it a lot easier.It™s true that a full excision wouldn™t be necessary depending on the extent of the injury/scar. If only the upmost part of the dermis was damaged, then only part of the dermis could be excised and the rest left alone.
Yes it does regenerate, but as to whether it™s 100%, probably not. I would think the margin extends all the way down to where the native skin and new skin meet as seen in pre-clinical images when looking at the inside of healed tissue. My opinion based on what I™ve seen anyway.It will indefinitely regenerate though as the CEO repeatedly has said and still continues to say that all 3 layers do regenerate. So you can establish that the people who had such deep injuries where even the hypodermis was obliterated still regenerated it and the other layers as well. As for the amount of improvement or a percentage estimate, we™d have to wait until they publish the details from the trial results.
I meant after injury not after use of skinte. Or ia that what you meant as well? If you google scar and it has a diagram of healing it always shows scar tissue is dermis and epidermis with the hypodermis looking renewed. All im getting at is that if this is the case any scar correction with skinte wouldnt need a full excise of 3 layers. Just 2. Afterall, deep 2nd degree burns still require grafting but im sure they would not remove intact hypodermis to put on skinte as that wouldnt be ethical really. Which, im sure they must have a deep 2nd in their human trials. Interesting.
I am saving as we speak for the day to fly to USA from UK to have my scar removed. 2 years time i reckon. Just a feeling....or a wish 
On 5/21/2018 at 1:56 PM, nikki_gargin said:I meant after injury not after use of skinte. Or ia that what you meant as well? If you google scar and it has a diagram of healing it always shows scar tissue is dermis and epidermis with the hypodermis looking renewed.
Yes the images might be based off general scarring in which the dermis is the extent of the damage. Most scarring occurs in the dermis, but the damage can extend into the hypodermis in severe cases. So theyre likely just referring to the biggest part that scars in general which would be the dermis. You probably wont generally have things like acne scars, cuts and such extending past the dermis anyway.
They wont remove the hypodermis but if damage extended into it then they do have the option to according to what Swanson told me.
16 hours ago, Tano1 said:Yes the images might be based off general scarring in which the dermis is the extent of the damage. Most scarring occurs in the dermis, but the damage can extend into the hypodermis in severe cases. So theyre likely just referring to the biggest part that scars in general which would be the dermis. You probably wont generally have things like acne scars, cuts and such extending past the dermis anyway.They wont remove the hypodermis but if damage extended into it then they do have the option to according to what Swanson told me.
im interested for an insicion scar so would be all 3 layers effected for sure. I read somewhere the hypodermis does not renew as part of skin shedding renewal. I think this is done within the epidermal junction with the dermis if i read it right.
I try really hard not to get desperate but i feel the technology is so close thats its a realistic goal in the next 10 years. People can get their faces replaced now. I mean...imagine that idea 20 yea4s ago? ....sigh.
Tano, do you plan to speak with Swanson again?
On 22/05/2018 at 4:56 AM, nikki_gargin said:I am saving as we speak for the day to fly to USA from UK to have my scar removed. 2 years time i reckon. Just a feeling....or a wish
Hopefully you dont have to fly to America. They are in talks with major Biopharma companies now about possible distribution of Skinte Internationally which makes sense. At least for elective treatments like acne scars it makes sense to send them your biopsy and then have them send back your Skinte kit to country you live in. Any treating doctor can use the kit thats why they designed the real time app for doctors using Skinte.
Unless they are looking at labs to process skinte in other coutries or they will just process everything from Utah.
We're almost in June and still no announcement about possibilities of getting this treatment for patients with acne scars.
How much longer do we have to wait? My life is ruined if I can't fix my scars. So tired of waiting.
I hope we can get this done by the end of the year or fuck it....it also takes 6 months to regenerate the skin, it's not quick
1 hour ago, SimpleMutton said:We're almost in June and still no announcement about possibilities of getting this treatment for patients with acne scars.
How much longer do we have to wait? My life is ruined if I can't fix my scars. So tired of waiting.
I hope we can get this done by the end of the year or fuck it....it also takes 6 months to regenerate the skin, it's not quick
from my thinking it will not take that longer for non burn injury....hope so..
but still we are waiting for release of pics
2 hours ago, SimpleMutton said:We're almost in June and still no announcement about possibilities of getting this treatment for patients with acne scars.
How much longer do we have to wait? My life is ruined if I can't fix my scars. So tired of waiting.
I hope we can get this done by the end of the year or fuck it....it also takes 6 months to regenerate the skin, it's not quick
Lough said SkinTe will be available across the country within 12 months. If your desperate and cant wait for derivative product whenever that will be im sure you could find a plastic surgeon but whether they will excise on your face is another thing. Im sure when this becomes more widely available there will definately be people seeking treatment for acne scars and surgical scars through different methods ie; excision, needling, injection, subcision. No way id go ahead with excision unless i did a sample on scar on arm first and was satisfied even if more photos come through snd it looks good.
Remember these guys are burn surgeons primarily and their focus has been helping them first and fair enough.