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Of course PolarityTE will push for cosmetic applications for SkinTE if they take over the burn market. The answer is simple: money. Every person on the planet has a scar they'd rather not have so it's a no-brainer.
Again, on my call with them they mentioned their plans for the cosmetic market (e.g. injectables, an over the counter offering etc.), which you can all look back at if you're so inclined.
The price jump today is undoubtedly as a result of the conference and the OsteoTE data. Also, they closed their public offering of stock since they met their 32 million dollar goal for R&D. Investors were likely very keen on both accounts, but nothing new about SkinTE as far as I know.
On 5/2/2018 at 3:52 PM, Ps93 said:This is definitely great news and we should note that today Polaritys stock has increased close to 17% but this might be mostly due to OsteoTe news.Everything shows that 2018 will be an interesting and hopeful year for us.I would also like to add another interesting scientific finding that shows that we are moving to the right direction towards skin regeneration. https://www.sciencedaily.com/releases/2018/04/180423110807.htm
Its great news, but its also old news. Theyve claimed that since the site was first launched.
Thats a great find on the amphibians regeneration system. My guess is that this indicates a biopsy still if it involves pre-existing epithelial cells. They proliferate but since it was not some type of de-differentiation, then youd probably have to trigger already healthy cells to proliferate and with a chain reaction with them discovering its a several step process that includes another set of cells. All of these studies done on regeneration such as with frogs and the Mexican salamander involve wounding of already healthy tissue. I would think that reverting scar tissue without having to excise the scar itself would require them to revert fibroblasts into an embryonic state almost like a re-do that quickly matures, but youd still need to figure out how and where to signal them to produce skin if it doesnt do it naturally.
To do that in Vivo < (everything done as a part of the patient and in the patient themselves) as well would run a risk of Tumorigenesis which as anyone might guess is not good.
That would be pure opinion and speculation on my part though.
There are mesenchymal cells found in the skin that can be converted to another cell type which is being studied to see if they can convert it stably and effectively without producing tumors.
On 5/2/2018 at 4:13 PM, nikki_gargin said:I am just not planning on forking out until maybe 2020 at the earliest for scar revision as they do say 'explore' not 'roll out'.
Not a wrong assumption. It depends on their R&D, but it will definitely not be something we are getting in 2018. The bright side is that it will still involve their already trialing technology which is already approved for use in treatment. Funding and all of that will no longer be needed and any further trialing for cosmetic cases (if they even wanted trials for that) can be done much quicker since theyve already taken care of the most time consuming parts which is funding and the FDA.
It is the closest thing we have to a possible solution too so 2020 sounds better than never.
There is a new product in the market in asia called Rejuran. Its made from the DNA of Salmon skin , supposedly for its regenerative properties. More details below.
http://www.winterchee.com/blog/get-rid-of-acne-scars-with-rejuran-healer
http://www.mizuaesthetic.com/pn-rejuran-s-healer-acne-scar-treatment/
https://www.readysetbeauty.com/2017/10/22/i-tried-a-4500-skin-healing-treatment-ft-salmon-dna/
5 hours ago, Binga said:There is a new product in the market in asia called Rejuran. Its made from the DNA of Salmon skin , supposedly for its regenerative properties. More details below.
http://www.winterchee.com/blog/get-rid-of-acne-scars-with-rejuran-healer
http://www.mizuaesthetic.com/pn-rejuran-s-healer-acne-scar-treatment/
https://www.readysetbeauty.com/2017/10/22/i-tried-a-4500-skin-healing-treatment-ft-salmon-dna/
Any clinical study to back up their claims? If it sounds too good to be true, you know what you're supposed to do, right?
It's not really a "scarless" product. It's similar to a skin booster like the one Restylane offers.
On 5/4/2018 at 10:19 PM, Raster said:It's not really a "scarless" product. It's similar to a skin booster like the one Restylane offers.
Their previous product was a skin booster. Now they have a new product just for scars Rejuran S. It's not a scarless product but way better than other things on the market.
https://www.doctorxdentist.com/the-ultimate-rejuran-guide-in-singapore
if u really want to inject something into scar..inject insulin
(insulin promotes adipocytes and fat cells synthesis thats why many previous studies claimed complete disappearance of atrophic scars ..also some IGF are realted to this)
the same insulin which is used for diabetes
but only complication is this cause very low sugar to a non diabetic patient ..which may cause serious issue..even death ..thats why this is not used
7 hours ago, Anish004 said:if u really want to inject something into scar..inject insulin
(insulin promotes adipocytes and fat cells synthesis thats why many previous studies claimed complete disappearance of atrophic scars ..also some IGF are realted to this)
the same insulin which is used for diabetes
but only complication is this cause very low sugar to a non diabetic patient ..which may cause serious issue..even death ..thats why this is not used
Yes there are many published scientific articles that seem to suggest that insulin helps reduce scarring.
Not everyone has diabetes however. If insulin injections on scar tissue were beneficial, more plastic surgeons would offer such treatment. Right now, scar treatments involve lasers, peels, subcision, microneedling and fillers.
I should probably inject myself with insulin to make the dents on my face disappear as you suggest. Problem is, we need a prescription for insulin. I am pretty sure both of us are not diabetic.
2 hours ago, Acnesucksforgood said:Yes there are many published scientific articles that seem to suggest that insulin helps reduce scarring.Not everyone has diabetes however. If insulin injections on scar tissue were beneficial, more plastic surgeons would offer such treatment. Right now, scar treatments involve lasers, peels, subcision, microneedling and fillers.
I should probably inject myself with insulin to make the dents on my face disappear as you suggest. Problem is, we need a prescription for insulin. I am pretty sure both of us are not diabetic.
not only reduce but reduce to a extent where it is not so visble coz..insulin promotes adipocytes and fat sythesis
.you can read it in every biology book about insulin and fat synthesis
and surgeons ..haha if they statt doing this how they will suck thousands $ for lasers
also insulin to a non diabetic can cause serious issues....
in my family there are two diabetic persons i will try tubbing there insulin on my scar and see how it goes...i dont want to inject it currently..dont want to die foolishly
Interesting about the insulin. I hypothesis it may have something to do of mechanism of reducing glucose rather than the insulin per say. Its easy to see this ib everyday life with diabetes and chronic wounds that fail to heal at all responding the change in diet. Metformin i think was looked into for wound control? Ive read so much i cant remember.
Also the hybernating black bear that healed without a scar:
http://www.bbc.co.uk/nature/17404059
Now this must have been down to low blood glucose as the bear was on a ketogenic diet of its own fat stores. There is also stuff about metobolism and scar formation too.
Sometimes i think its amazing that we get new bodies every so many months/ years from renwal and then i think of the term'you wre what you eat' and think do i want to see the nikki who ate shite for a year, in a year. Or, ate real food with real cells...hmmm i can guess which me would look better.
insulin clearely synthesisAdipocytesand when u look back at costareils experimen about scarless healing he mentioned that
if scar have adipocytes myofibroblast turn into normal skin....
so thats how insulin reduces or prevent scars
it also eradicates formed scars...due to direct injecting in scar cause there adipocyte synthesis..
Salinomycin is a true anti scarring
it prevents myofibroblast formation and so scar
On 5/4/2018 at 9:58 PM, Sirius Lee said:Any clinical study to back up their claims? If it sounds too good to be true, you know what you're supposed to do, right?
Medical study on rejuran
Good find guys. I personally think having a meaningful debate based on clinical studies is more productive than banking all your hopes on the development of one or two companies' products.
Prrx1 Labels The Fibrogenic Fibroblast In The Ventral Dermis
A sub-population of fibroblasts, labeled by the embryonic expression of Prrx1, was the key contributor to connective tissue deposition during scar formation in the ventral dermis. This lineage increased as a proportion of total fibroblasts within the ventral dermis over the course of gestation, associated with the transition from scarless to scarring repair. Differential patterns of chromosomal accessibility further demonstrated the heterogeneic nature of fibroblasts. Ablation of PPFs resulted in diminished connective tissue deposition when examined after completion of wound healing (*p<0.05) without change in the tensile strength of the scar (p>0.05). PPF ablation prior to transplantation of melanoma tumor xenografts resulted in decreased tumor mass (*p<0.05). Analysis of collagen fiber characteristics demonstrated significant differences after PPF ablation versus control (*p<0.05).
Source: http://www.woundheal.org/meeting/Program/2018/G.08.cgi
From "30th Annual Meeting of the Wound Healing Society SAWCSpring/WHS Joint Meeting"
http://woundheal.org/meeting/multimedia/files/2018/WHS-Abstracts.pdf
On 8/5/2018 at 3:02 AM, Anish004 said:not only reduce but reduce to a extent where it is not so visble coz..insulin promotes adipocytes and fat sythesis
.you can read it in every biology book about insulin and fat synthesisand surgeons ..haha if they statt doing this how they will suck thousands $ for lasers
also insulin to a non diabetic can cause serious issues....in my family there are two diabetic persons i will try tubbing there insulin on my scar and see how it goes...i dont want to inject it currently..dont want to die foolishly
On 4/5/2018 at 11:09 PM, Binga said:
On 7/5/2018 at 4:37 PM, Anish004 said:NEWS FROM POLARITYTE: https://ir.polarityte.com/press-releases/detail/428
NEWS FROM POLARITYTE ABOUT MARKET RELEASE: https://ir.polarityte.com/press-releases/detail/428
Also interesting news from University of Toronto anout a portable 3d bioprinter for wounds: https://www.utoronto.ca/news/u-t-researchers-develop-portable-3d-skin-printer-repair-deep-wounds
1 hour ago, creativeusername1234 said:Anyone knows something about
StrataGraft?
This one looks very promising, if it does in fact work as promised.
There are currently two clinical studies of StrataGraft in progress: a Phase 2 trial thats expected to be completed by October 2018, and aPhase 3 trialthats projected to finish in late 2019.
A spokeswoman for Mallickrodt said last month that the company anticipates an FDA decision on StrataGraft by 2020.
Hey guys. Latest press release from polarity about hiring sales rep to promote skinte up the east coast of the USA for the purposes including scar reconstruction! They didnt say aiming at burns plastic surgeons either but just plastic surgeons. Waiting for pics now.. might need a ticket to NYC next year yay! Also stock is doing amazing. Look positive now actually...i lost faith for abit but i think we are really on the cusps now. Will look up stratagraft thanks fir the info x
2 hours ago, Sirius Lee said:This one looks very promising, if it does in fact work as promised.
There are currently two clinical studies of StrataGraft in progress: a Phase 2 trial thats expected to be completed by October 2018, and aPhase 3 trialthats projected to finish in late 2019.
A spokeswoman for Mallickrodt said last month that the company anticipates an FDA decision on StrataGraft by 2020.
sounds excellent! Only two things make me think this might not be suitable for non large skin defects: 1. It requires sutures or staples. So will heal via scaring around the margin.
2. Sounds like the next step in skin grafting that will need to mature on your body to live and grow meaning you will look like shit for awhile. Like bright red while red vessles do their thing. Polarity is alot more sorted to most our needs. No margin and is not a graft.
1 hour ago, nikki_gargin said:sounds excellent! Only two things make me think this might not be suitable for non large skin defects: 1. It requires sutures or staples. So will heal via scaring around the margin.
2. Sounds like the next step in skin grafting that will need to mature on your body to live and grow meaning you will look like shit for awhile. Like bright red while red vessles do their thing. Polarity is alot more sorted to most our needs. No margin and is not a graft.
When can we just wear a mask like Tom Cruise in Mission Impossible?? 
4 hours ago, Anish004 said:sorry.......to ask this but please let me ask
does anybody know any current method to remove moles without scarring ...because my mole is growing larger ....it looks ugly now
It seems you suffer from a condition known as body dysmorphic disorder. Sometimes your scars are not as bad as you make them out to be. Moles are not a serious problem unless it keeps growing. I would check your mole by a doctor to make sure you don't have melanoma, the beginning of skin cancer. Doctors don't like to touch moles unless for serious health reasons as I mentioned. Some doctors will remove them but you have to pay them and it will result in some sort of scarring nonetheless.
1 hour ago, Acnesucksforgood said:5 hours ago, Anish004 said:sorry.......to ask this but please let me ask
does anybody know any current method to remove moles without scarring ...because my mole is growing larger ....it looks ugly nowIt seems you suffer from a condition known as body dysmorphic disorder. Sometimes your scars are not as bad as you make them out to be. Moles are not a serious problem unless it keeps growing. I would check your mole by a doctor to make sure you don't have melanoma, the beginning of skin cancer. Doctors don't like to touch moles unless for serious health reasons as I mentioned. Some doctors will remove them but you have to pay them and it will result in some sort of scarring nonetheless.
when you come and look me closely..i am more than 1000000% sure you thank yourself that you are not at place of me..
i never said anyone anything while reading there sad story of skin...instead i took interest maybe i cam help someone...
My story ..now u listen and stay silence for lifetime...
1st.suffered from chickenpox and got 3 scars deep crater like on nose
mole occured on nose ..i tried to scratch those moles with blade ..leading to hypertrophic scarring and mole regrown on it..so my nose destroyed fully coz of pox scar hypertrophic scar and mole on it
2nd.suffered from AMVC Scarring(google it or search on this forum) spontaneous scarring occured in left side of face..and on same left side two moles from my childhood grown big in size
3rd.dont know the reason .buy my right cheek is covered up with closed comedones last year and still its occuring and giving me scarred pores
so thats it all
and from today if anyone skipped these
and told me that i am suffering from body dystrophy and blah blah...i will be sure he is a dumbass and same like me he also deserves a life like hell...and destryed skin..he deserves it
19 hours ago, Anish004 said:when you come and look me closely..i am more than 1000000% sure you thank yourself that you are not at place of me..i never said anyone anything while reading there sad story of skin...instead i took interest maybe i cam help someone...
My story ..now u listen and stay silence for lifetime...
1st.suffered from chickenpox and got 3 scars deep crater like on nose
mole occured on nose ..i tried to scratch those moles with blade ..leading to hypertrophic scarring and mole regrown on it..so my nose destroyed fully coz of pox scar hypertrophic scar and mole on it
2nd.suffered from AMVC Scarring(google it or search on this forum) spontaneous scarring occured in left side of face..and on same left side two moles from my childhood grown big in size
3rd.dont know the reason .buy my right cheek is covered up with closed comedones last year and still its occuring and giving me scarred pores
so thats it all
and from today if anyone skipped these
and told me that i am suffering from body dystrophy and blah blah...i will be sure he is a dumbass and same like me he also deserves a life like hell...and destryed skin..he deserves it
Ok this forum is not for you to attack other members. I understand you are dealing with allot but I believe I am far worse and so many others than you will ever be. Cursing and calling me names proves you are selfish and that you should seek help for your mental health.
Like you, I suffered from chicken pox as a youth. The disease left me scars including one on my neck, my stomach and my nose. I believe almost every human being has gotten chicken pox and has some sort of dent left behind from that virus. Pay attention closely and you will discover almost everyone has a chicken pox scar on their face. Stop putting yourself down about that.
Furthermore, moles are moles. There is nothing you can do about them. They are genetic and nothing you should worry about. Everyone has them. So move on. You should not touch moles because scarring occurs making your mole worse. Moles should only be a concern if they get bigger. At that point as I mentioned to you, that could be the beginning of skin cancer. Consulting a doctor to remove them to prevent further health concerns would be a good idea.
After my chicken pox, I developped staph MRSA which left me with more scarring on my back within a week. Then I got measles. This whole thing happened within a year. Also, I had multiple asthma attacks. I was also born with pectus excavatum. That's a serious condition where your sternum or chest bone grows inside your chest putting pressure on your heart. I had surgery as a teenager to push out my sternum as I would easily run out of breath. My asthma was also cured because my sternum was putting pressure on my lungs. How about getting a steel rod inserted inside you next to your heart? They had to open me up again to remove the rod. I have scars from my chest because of those surgeries alone. I also suffered a concussion as a youth due to an unrelated sports accident which opened up my head in half. I received 200 stitches and I am a proud owner of a hideous scar that runs down from my forehead to my neck.
As if I hadn't suffered enough, as a teenager I developped cystic acne on my face and acne conglobata on my back, shoulders, buttocks and thighs. My cystic acne lasted until my late twenties. It left me multiple scarred pores or ice pick scarring on my cheeks and forehead. My jawline has multiple white slightly raised scars which are called follicular macular atrophy or popular acne scars. My back is full of these white scars. As a teenager, I was involved in another accident which left me with multiple deep wounds. They healed quite nicely but left me scars.
I am into my late thirties and still breakout on my back. Time to time, I will breakout on my face. The pimples take months to heal often leaving more scars. Not to mention, I suffer from psoriasis, exczema and hidredinitis superitiva. How about sitting all day on massive butt boils that keep oozing blood and filling up again. My groin keeps oozing pus.
I avoid shaving because my face gets infected by staph leading to folliculitis and massive boils that hurt. My neckline has scars from the same folliculitis causing massive infections inside my hair. The only good thing I could at least say is that I am not bald yet.
You need to grow up. Nobody cares about your blackheads or scars. Rare are those who have perfect skin. Never ever say you have it way worse than me. Never!!!
Now let's get back on topic.