14 minutes ago, nikkigirl said:

15 hours ago, Acnesucksforgood said:

Again, testoreone does not cause acne. It is the bacteria p.acnes that causes it. Testoreone makes your oil glands produce more oil and the bacteria proliferates in it infecting your pores. Taking Spiro means that you block androgens like T. and your skin doesn't produce so much oil and keeps P.acnes at bay. Again stop blaming T. for your skin woes. Without T., men wouldn't be men. Women wouldn't be able to reproduce. T. is not so bad after all.

In the end, I feel you have a deep hatred of T. which represents anything manly. Spiro is something some men take to become effeminate into their transition to womanhood. Society is more accepting of this now but society cannot continue in this path of feminizing men. T does causes baldness in more than half of older men but it is something that is accepted. Baldness itself is not a disease but rather a sign of aging. There are cheap hair transplants that men can opt for now anyways. Many men are also lucky to keep their hair until they reach 90. You can't blame T. here either. You can say that some men have good hair genes.

Men have it way worse with acne than women do because of what I mentioned above in their teenage years. For most men, their acne tends to die down by their thirties. Women seem to get hit by acne more and more in their early twenties nowadays and lasts a lifetime. It is not T. that is causing this. It is stress, a high glycemic diet, allergies, other pathogenic organisms and staphylococcus infections. Also, older women tend to have hormone imbalances in their older years producing more Estrogen which causes breakouts around the mouth.

If anything blame P.acnes not T. The best thing to do would be to develop a medication specifically targeting P.acnes. P.acnes actually helps our skin but too much of it causes our body to attack it which results in inflammation and scarring once the pimples heal. Evolution has selected for scarring and not complete regeneration to close wounds fast to prevent infection.

So a medication to stop the proliferation of p.acnes and to keep pores unclogged without any side effects would be the best thing to do. Secondly, reprogramming scar tissue into normal tissue with hair follicles and the basket wave pattern would be a start. Researchers are working on this but a lot of work needs to be done before something good can be available on the market.

Then why are you here? If you are so manly just put up with your scars and acne.....if it bothers you.....it means you are sensitive..something a REAL man of your stature would never allow to happen.

This forum was not meant to attack other members. I called you out as to how T. does not cause acne but simply is one factor amongst many others which may lead to acne. I re-explained that acne is caused by P.acnes.

The scars don't bother me. I am close to my forties and I am not getting any younger. I signed up here to find something that works to stop my painful breakouts. The pain from the breakouts are what bothers me. I just wanted to call you out for the misinformation you spread about acne. Now, once more, stop spreading lies about T and acne.

22 minutes ago, nikkigirl said:

Then why are you here? If you are so manly just put up with your scars and acne.....if it bothers you.....it means you are sensitive..something a REAL man of your stature would never allow to happen. That is true......you can try to control your acne but if you shut off Testosterone..your skin will clear up....just suck it up...enjoy your pimples and scars and be a man. Then don't take it......it has help a lot of people out. It doesn't help the root problem which is hormones mainly testosterone but it is suppose to shrink oil glands.....doesn't work for everybody.

Again, testoreone is not the root problem of acne. It is p.acnes. It is a bacteria which infects your pores that get clogged by oil. P.acnes proliferates in that oil. Some people have extremely oily skin and don't have acne at all. Accutane causes a whole set of side effects. You need to inform people of the side effects before you claim it helps. If you block testoreone, you stop puberty and then you get boys who don't grow up to be men. Again, if you block testoreone you end up with effeminate boys. Maybe since you're a woman, blocking T. has its advantages for you. Men cannot block off T. as you claim. I suggest you do research to back up your claims. Blocking T. in women can also cause depression. But you can continue believing that T. is the cause of all your skin woes.

36 minutes ago, Acnesucksforgood said:

1 hour ago, nikkigirl said:

Then why are you here? If you are so manly just put up with your scars and acne.....if it bothers you.....it means you are sensitive..something a REAL man of your stature would never allow to happen. That is true......you can try to control your acne but if you shut off Testosterone..your skin will clear up....just suck it up...enjoy your pimples and scars and be a man. Then don't take it......it has help a lot of people out. It doesn't help the root problem which is hormones mainly testosterone but it is suppose to shrink oil glands.....doesn't work for everybody.

Again, testoreone is not the root problem of acne. It is p.acnes. It is a bacteria which infects your pores that get clogged by oil. P.acnes proliferates in that oil. Some people have extremely oily skin and don't have acne at all. Accutane causes a whole set of side effects. You need to inform people of the side effects before you claim it helps. If you block testoreone, you stop puberty and then you get boys who don't grow up to be men. Again, if you block testoreone you end up with effeminate boys. Maybe since you're a woman, blocking T. has its advantages for you. Men cannot block off T. as you claim. I suggest you do research to back up your claims. Blocking T. in women can also cause depression. But you can continue believing that T. is the cause of all your skin woes.

yeah I had testosterone blood test a month ago my test was in the sky 900mg/dl (200-1000) and I don't have acne at all just few pimples

Not that I've been an avid participant of this thread, but I thought this thread was all about SCARLESS HEALING. How did it suddenly morphed into a ground zero for empty chatter? If you wanna talk about testosterone or any other off-topic agendas, maybe you should create another thread?

Just my 2-cents.

18 hours ago, Sirius Lee said:

You might want to look again. My sources tell me hairs don't grow on scars. That's not to saythat hairfollicles from the normal skin adjacent to thescar tissue cannot penetrate and grow out through the scar. Yeah, that sounds loony but that's how the story goes.

Nope. Had my epidermis and a part of my dermis removed for a skin graft and i can assure you i need to shave that area of my leg still and it has no pigment.

This is what im saying, sources can be sources but doesnt explain anomalies (cant spell that) and as someone said scaring occurs when dermis is damaged and also ill add that those renewall cells at thr epidermal junction are damaged so how does a implanted hair lead for regeneration and authors to say hair follicles is what leads to scarless healing. It doesnt. I have proof on my a large part of my leg!

45 minutes ago, nikki_gargin said:

Nope. Had my epidermis and a part of my dermis removed for a skin graft and i can assure you i need to shave that area of my leg still and it has no pigment.

This is what im saying, sources can be sources but doesnt explain anomalies (cant spell that) and as someone said scaring occurs when dermis is damaged and also ill add that those renewall cells at thr epidermal junction are damaged so how does a implanted hair lead for regeneration and authors to say hair follicles is what leads to scarless healing. It doesnt. I have proof on my a large part of my leg!

The dermis is quite thick and the hair follicules lie deep in the dermis. If your hair follicles were not damaged when they removed your skin for a skin graft then they will continue to grow and penetrate the scar tissue above it that replaced your once normal skin. Our bodies can heal themselves in ways we can't imagine. I have facial atrophic scars from previous acne and facial hair grows from them. This makes my facial acne scars less serious than they seem. I also have scars on my knees from when I was a kid. They lack pigment as you said but hair grows on top hiding the scar.

Researchers found that when myofibroblasts which replace normal injured skin are turned into fat tissue or what we call adipose tissue, then the skin heals without scarring. The transformed adipose tissue tells hair to grow in the new scarless healed skin. This was a study that was released back in Jan 2017 and posted once more today on the forum. However, we haven't heard anything else since then.

1 hour ago, Acnesucksforgood said:

This was a study that was released back in Jan 2017 and posted once more today on the forum. However, we haven't heard anything else since then.

Oh, I'm sure there have been many subsequent studies based on that particular finding. For example, this one caught my fancy recently.

https://www.nature.com/articles/s41598-017-12919-x

Exosomes secreted by human adipose mesenchymal stem cells promote scarless cutaneous repair by regulating extracellular matrix remodelling

Scar formation is an intractable medical problem that appears after skin wounds have healed. Recent research has shown that exosomes secreted by human adipose mesenchymal stem cells (ASC-Exos) can benefit wound healing. To further explore the therapeutic potential of ASC-Exos, we investigated their effects on mitigating scar formation, and the underlying mechanisms of these effects. We found that intravenous injection of ASC-Exos decreased the size of scars and increased the ratio of collagen III to collagen I in murine incisional wounds. Exosome treatment also prevented the differentiation of fibroblasts into myofibroblasts and increased the ratio of transforming growth factor-3 (TGF-3) to TGF-1in vivo. Additionally, we found that ASC-Exos increased the matrix metalloproteinases-3 (MMP3) expression of skin dermal fibroblasts by activating the ERK/MAPK pathway, leading to a high ratio of MMP3 to tissue inhibitor of matrix metalloproteinases-1 (TIMP1), which is also beneficial for the remodelling of extracellular matrix (ECM). In conclusion, our results demonstrated that ASC-Exos promote ECM reconstruction in cutaneous wound repair by regulating the ratios of collagen type III: type I, TGF-3:TGF-1 and MMP3:TIMP1, and by regulating fibroblast differentiation to mitigate scar formation. Therefore, the application of ASC-Exos may be a novel therapeutic approach for scarless wound repair.

The following article was recently authored by Dr. Sun of Sunogel, dated 04/16/2018. Was this talked about here?

does nose skin also have epidermis..dermis and hypodermis ??????

searched internet but cant get a concrete answer

2 hours ago, Anish004 said:

does nose skin also have epidermis..dermis and hypodermis ??????

searched internet but cant get a concrete answer

Yes all parts of your skin are composed of three layers.

I know this is a bit irrelevant with scarless healing but since I only view this thread and people ask about acne stuff I would like to inform you that I just had a chat with a clinic in the UK where they are using sebacia gold partices to treat acne and they will propably have the treatment officialy launched in the UK during Autumn.Hopefully this is good news for people who are still acne sufferers and it could also be used cosmetically for people who suffer from large pores due to acne since the nanoparticles shrink the oilglands.Ag ain sorry for the parenthesis that I made which was irrelevant to the main topic of this thread.

37 minutes ago, Ps93 said:

I know this is a bit irrelevant with scarless healing but since I only view this thread and people ask about acne stuff I would like to inform you that I just had a chat with a clinic in the UK where they are using sebacia gold partices to treat acne and they will propably have the treatment officialy launched in the UK during Autumn.Hopefully this is good news for people who are still acne sufferers and it could also be used cosmetically for people who suffer from large pores due to acne since the nanoparticles shrink the oilglands.Ag ain sorry for the parenthesis that I made which was irrelevant to the main topic of this thread.

i suffer from scarred pores(they are not ice pick scars..as they are just 0.01 mm like very pin point)from comedonal acne
is it true news ????
bad thing is still i cant able to control my comedonal acne ..afte using AHA facewash
now i ordered a 2%salicylic acid gel..hope it works out

18 hours ago, Ps93 said:

I know this is a bit irrelevant with scarless healing but since I only view this thread and people ask about acne stuff 

And what should non-acne sufferers do that only view this thread for "scarless healing" and you know but you only view this thread... 

Efficiency of Adipose-Derived versus Bone Marrow-Derived Stem Cells in Modulation of Histopathological Changes and CD31 Immunoexpression during Wound Healing in Rats

Hashem HE* , Mobasher MOI, Mohamed MZ and Alkhodary AAM

Journal of Biochemistry & Cell Biology
Received date: April 04, 2018; Accepted date: April 17, 2018; Published date: April 25, 2018

polarityTe moved forward to OsteoTe ..meand thry have really got success in skinTe

1 hour ago, Anish004 said:

polarityTe moved forward to OsteoTe ..meand thry have really got success in skinTe

Yeah osteote showed to regenerate bone that's means the technology and the platform it self works to regenerate human tissue not only skin but bone the lgr6 just target the defect tissue and demands for regeneration it doesn't matter what tissue is

4 hours ago, Anish004 said:

polarityTe moved forward to OsteoTe ..meand thry have really got success in skinTe

The OsteoTE business makes no sense to me. First off, bones heal without any structural damage or scarring. When a bone brakes, it forms a callus then once it heals it is good as new. Sometimes, you get a small line on the bone from the original fracture but who cares about that. It can only be revealed in a X-ray.

What exactly is OsteoTE supposed to regenerate? Amputated bones from limb amputation?

Not all broken/fractures bones heal correctly. Some have complications, such as nonunion, where the bones don't reattach. Some bones also have inherent defects that are difficult to correct.

3 hours ago, Acnesucksforgood said:

The OsteoTE business makes no sense to me. First off, bones heal without any structural damage or scarring. When a bone brakes, it forms a callus then once it heals it is good as new. Sometimes, you get a small line on the bone from the original fracture but who cares about that. It can only be revealed in a X-ray.

What exactly is OsteoTE supposed to regenerate? Amputated bones from limb amputation?

im sorry but are you abit....narrow minded? Plenty of people with mucked up legs hips skulls joints spines even people with their jaws rotting that before 3d printing had a standard 'large' etc put in to replace it and spent a month in hospital and had to get physio to use it. With 3d print they can eat day 1! Acne does suck but common....think and learn outside of your own suffering! ...facial bone deformity???? The list is more extensive than proberly skin

I was thrilled to see a post about OsteoTE because im sure they wouldnt be publishing preclinicals if SkinTE was a flop ahh! How exciting.few more years minimum i reckon and some real regeneration medicine for skin will be here. Maybe it will never be 100% as our mums made us but 90...95% i can live with that. Im still not sure about SkinTE for acne and surgery scars (mines surgery) but as some have said a derivitive perhaps.#ifeelgoodvibes

2 hours ago, nikki_gargin said:

im sorry but are you abit....narrow minded? Plenty of people with mucked up legs hips skulls joints spines even people with their jaws rotting that before 3d printing had a standard 'large' etc put in to replace it and spent a month in hospital and had to get physio to use it. With 3d print they can eat day 1! Acne does suck but common....think and learn outside of your own suffering! ...facial bone deformity???? The list is more extensive than proberly skin

I was thrilled to see a post about OsteoTE because im sure they wouldnt be publishing preclinicals if SkinTE was a flop ahh! How exciting.few more years minimum i reckon and some real regeneration medicine for skin will be here. Maybe it will never be 100% as our mums made us but 90...95% i can live with that. Im still not sure about SkinTE for acne and surgery scars (mines surgery) but as some have said a derivitive perhaps.#ifeelgoodvibes

Thanks for clearing that out. So OsteoTE is meant to cure bone defects. Some people make out to be that OsteoTE is for cosmetic purposes.

I'd like to point out that most, if not all of PolarityTE's products and pipeline products are primarily for function first, and cosmetic second (if at all). It's only we here at acne.org who are concentrating on the cosmetic portion of their products. And if they are ever indicated to be useful for cosmetic stuff, it will be a secondary outcome.

10 hours ago, Acnesucksforgood said:

13 hours ago, nikki_gargin said:

im sorry but are you abit....narrow minded? Plenty of people with mucked up legs hips skulls joints spines even people with their jaws rotting that before 3d printing had a standard 'large' etc put in to replace it and spent a month in hospital and had to get physio to use it. With 3d print they can eat day 1! Acne does suck but common....think and learn outside of your own suffering! ...facial bone deformity???? The list is more extensive than proberly skin

I was thrilled to see a post about OsteoTE because im sure they wouldnt be publishing preclinicals if SkinTE was a flop ahh! How exciting.few more years minimum i reckon and some real regeneration medicine for skin will be here. Maybe it will never be 100% as our mums made us but 90...95% i can live with that. Im still not sure about SkinTE for acne and surgery scars (mines surgery) but as some have said a derivitive perhaps.#ifeelgoodvibes

Thanks for clearing that out. So OsteoTE is meant to cure bone defects. Some people make out to be that OsteoTE is for cosmetic purposes.

yeah they explain on their latest press release their intentions for OsteoTE.

Yes i agree. Its functional medicine company not cosmetic.

2 hours ago, Tano1 said:

This is definitely great news and we should note that today Polaritys stock has increased close to 17% but this might be mostly due to OsteoTe news.Everything shows that 2018 will be an interesting and hopeful year for us.I would also like to add another interesting scientific finding that shows that we are moving to the right direction towards skin regeneration. https://www.sciencedaily.com/releases/2018/04/180423110807.htm

Lol yes point taken. Dont get me wrong im hoping this is going to help me as well! I am just not planning on forking out until maybe 2020 at the earliest for scar revision as they do say 'explore' not 'roll out'. But, i do think it will happen.

Wish i invested when the market was down to $16 recently.