Acne.org Products
Ok back to discussion....
"In preclinical models of full-thickness swine burns and wounds, we observed that SkinTE generated healing with reduced scarring, hair follicle growth, complete wound coverage, and the progressive regeneration of all skin layers including epidermis, dermis and hypodermal566666r layers. We believe swine models of burns and wounds are predictive of results found in humans due to the similarities between swine and human skin. We have included images below of the SkinTE-generated swine wound healing we observed."
I think these statements hold some value as with a previous statement from a Doctor using Skinte who noted progressive dynamic healing in a patient. Wound coverage is fast yes but Time is neededfor skin layers to regenerate. Correct me if im wrong, SkinTe goes to work early in healing stages by preventing contraction/scar tissue to a degree and then progressive regeneration slowly takes place with complex skin layers laid down.
1 hour ago, rudy1986 said:Anyone knows how long it was required to regenerate full thickness in porcine model?
Not sure...was it about 3 or 4 months? From the fully excised wound i think.
Note they are saying this hand at 7 weeks is in early stage healing. I would have thought 6-10 weeks would be mid stage
I managed to come across this the day it was circulating around news media last month. I'll decide to share here with a small summary and give you all some sources to check out so you can draw your own thoughts.
Since late March, Scientists have discovered a new organ they are calling theInterstitiumwhich consists of a fluid based layer residing under the Epidermis, included in the skin's Dermis. But not only there, it resides within ALL connective tissues throughout the body so yes many of your body parts such as your lungs, stomach, etc... Scientists always knew the fluid was there, but thought it to be just a wall of collagen bundles and since they used traditional means to clean tissue (slicing it and adding chemicals to drain its fluids) it was missed.
They believe this will help explain the spread of cancer, but not just that; it will help explain inflammation andscarring of connective tissueand yes they directly state fibrosis in case anyone is wondering.
https://www.livescience.com/62128-interstitium-organ.html
https://www.cnn.com/2018/03/27/health/new-organ-interstitium-study/index.html
Here is an abstract for those of you who love to read:
https://www.nature.com/articles/s41598-018-23062-6
In the Abstract is good information about how it pertains to the Dermis and Keloid Scars are mentioned as well. Scar formation and Wound healing are also mentioned.
In Interstitial lining cells, they observed what's called CD34 which is a positive form of fibroblast (because there's good and bad types) that could play a crucial role in wound healing and scar formation.
At the very least, we've just taken another step forward to scar free healing.
1 hour ago, nikki_gargin said:Not liking Polarity's stock games as off late....seems abit like crowd funding??? Im not to hot on stocks and shares so what do you guys think?
Also i think renovacell is a different company to recell. We only have recell here in the UK.
I think pretty much all the investors expected them to do the public stock offering. PolarityTE is cash-strapped so if they have any hope of long-term success they needed to increase their liquidity in order to continue their research and grow their business. It could be a sign of something more nefarious, but to me it's as simple as them needing money.
Also, it's not like crowd funding because in that scenario people are just giving money, not investing. If PolarityTE's products pan out then those investors stand to make money as well.
If memory serves, Recell was the original one to use the technology. Renovacare then innovated it and launched as a company. Since then there has been a lot of legal back and forth over Renovacare's patents and earlier this year they won a victory when a judge (here in America) threw out Recell's case.
New products coming from korea.
6 minutes ago, skinregenerator said:8 hours ago, rudy1986 said:Anyone knows how long it was required to regenerate full thickness in porcine model?
Couple of weeks
That isn't accurate. Even if you look at the current presentation the earliest timeline for porcine models presented in their data is 50-54 days and that's not when it achieved complete regeneration.
12 hours ago, creativeusername1234 said:Can anyone give an update about sunogel? I looks promising but it got so little attention, it seems that its not that great after all.
I don't know. I would love to know this. They have recently updated their team on the sunogel website. Like I've always been saying, I would participate in trials if given the opportunity.
Side note; but it's nice to see how many users comment on this thread now. Back in 2013 when I joined, days would pass without anyone commenting.
6 hours ago, Binga said:New products coming from korea.
I know this is the Scarless Healing thread, but I'd also like to see a thread for new technologies in the pipeline that aren't necessarily "scarless", but represent an improvement in acne scar revision. Any papers, new techniques, new devices, discoveries, which people can actually get in the very near future -- it's difficult to sift through the net for new information when 90% of what you can find are glam mags talking about hyperpigmentation.
If anyone has a pet pig that has scars and is self concious tell that little Piggy he need not worry anymore for their days of misery are behind them. I hope I can say the same for you Homo Sapiens one day soon....
There has been enough breakthroughs in last couple years to suggest we are close and wont be waiting no 50 years as some say.
SkinTe we are still holding our breath but the wounds they are treating atm are not helping our cause much, more time is needed to properly guage.
Sunogel has very impressive pre-clinical results in pigs and was chosen to be one of 7 finalist at the Hello Tomorrow convention in Paris from 3000 Applicants and narrowed down to 500 from that to be chosen. So its not like they are being scoffed at or brushed under the carpet with their claims to skin regeneration. Some more air time is what they need to generate the kind of momentum we have see with PolarityTe $$$...
7 hours ago, Raster said:I know this is the Scarless Healing thread, but I'd also like to see a thread for new technologies in the pipeline that aren't necessarily "scarless", but represent an improvement in acne scar revision. Any papers, new techniques, new devices, discoveries, which people can actually get in the very near future -- it's difficult to sift through the net for new information when 90% of what you can find are glam mags talking about hyperpigmentation.
Elastagen got purchased by Allergan the makers of Botox. They are in the process of coming up with a new dermal filler Rejuvacross which I am pretty hopeful will take care most of our problems.
I think in terms of time for reaults there will be a difference between a clean sterile wound in a lab eg the pig vs a trauma patient eg surrounding tissue impact and the immune reaction and such on.
Epidermal regeneration is the bugger. Thatnice weave basket once taken for granted. Hmmm. But it is looking very hopeful as all these companies in different countries are trying different techniques.
I want to know what the hell the British are doing do contribute!? We normally win at everything...haha..
21 hours ago, nikki_gargin said:Not liking Polarity's stock games as off late....seems abit like crowd funding??? Im not to hot on stocks and shares so what do you guys think?
Also i think renovacell is a different company to recell. We only have recell here in the UK.
recell is total scam.
1 hour ago, nikki_gargin said:I think in terms of time for reaults there will be a difference between a clean sterile wound in a lab eg the pig vs a trauma patient eg surrounding tissue impact and the immune reaction and such on.
Epidermal regeneration is the bugger. Thatnice weave basket once taken for granted. Hmmm. But it is looking very hopeful as all these companies in different countries are trying different techniques.
I want to know what the hell the British are doing do contribute!? We normally win at everything...haha..
not at football
16 hours ago, CollegeKidd said:I don't know. I would love to know this. They have recently updated their team on the sunogel website. Like I've always been saying, I would participate in trials if given the opportunity.Side note; but it's nice to see how many users comment on this thread now. Back in 2013 when I joined, days would pass without anyone commenting.
Just try contacting Dr. Sun. He's very responsive, or at least was in the past. I got a call with him after a brief delay.
12 hours ago, creativeusername1234 said:14 hours ago, nikki_gargin said:I think in terms of time for reaults there will be a difference between a clean sterile wound in a lab eg the pig vs a trauma patient eg surrounding tissue impact and the immune reaction and such on.
Epidermal regeneration is the bugger. Thatnice weave basket once taken for granted. Hmmm. But it is looking very hopeful as all these companies in different countries are trying different techniques.
I want to know what the hell the British are doing do contribute!? We normally win at everything...haha..
not at football
oach! Lol....we will get the cup again!!
10 hours ago, golfpanther said:Just try contacting Dr. Sun. He's very responsive, or at least was in the past. I got a call with him after a brief delay.
I've already reached out to him a number of times in the past.... I don't want to be annoying or seem obsessive. But the truth is, I'm so desperate for Sunogel. It sounds so much more ideal to me than the Polarity procedure. I'm so tired of waiting, my whole life has been on hold for so long now.
2 hours ago, CollegeKidd said:12 hours ago, golfpanther said:Just try contacting Dr. Sun. He's very responsive, or at least was in the past. I got a call with him after a brief delay.I've already reached out to him a number of times in the past.... I don't want to be annoying or seem obsessive. But the truth is, I'm so desperate for Sunogel. It sounds so much more ideal to me than the Polarity procedure. I'm so tired of waiting, my whole life has been on hold for so long now.
Kidnap Guoming Sun in the dead of the night and have him lead you to the jello.....get a scoop full for me to.
I Would Choose SkinTE Every Time, says Patient Treated with PolarityTEs New Skin Regeneration Product
APRIL 18, 2018
SALT LAKE CITY, April 18, 2018 (GLOBE NEWSWIRE) -- PolarityTE, Inc. (NASDAQ:COOL) today announced continued success with SkinTE during its limited-market release across a variety of conditions, including burns, wounds, surgical reconstruction and the replacement of skin grafts.
We at PolarityTE are incredibly excited to see the success of SkinTE throughout such a wide spectrum of patients in such a short period of time. We expect to receive additional clinical results through multiple channels, such as case studies, peer-reviewed publications and a PolarityTE hosted Key Opinion Leader (KOL) Summit to learn more about SkinTE in clinical practice from early adopters. In the end, however, the most important outcome is the impact on the patients life, said Dr. Denver Lough, CEO of PolarityTE.
Among the outcomes observed are a SkinTE case involving a patient who suffered from a large chronic leg wound for multiple years. Prior failed treatment attempts included not only other wound care products, but also two failed skin grafts. Skin grafts have traditionally been considered the clinical standard of care in covering both small and large wounds.
Devon, who was treated with SkinTE, commented: After a motorcycle accident a few years ago, I was treated for several injuries; however, wounds on my leg were persistent and after trying a few different options for treatment, nothing was working. We eventually tried two skin grafts, which took many months for any healing, and each time we removed those bandages, about 75 percent of the graft came off with the bandage. These non-healing wounds were limiting my ability to do physical therapy and fully recover because the wounds would bleed through the bandages. Then, a few weeks ago, I was treated with a new product SkinTE and it has already provided nearly full coverage of the wounds and healing is a lot better than it was with the other stuff we tried. My leg feels as close to normal skin as I can imagine, and there is even some hair growth. If I had to choose between SkinTE and another skin graft, I would choose SkinTE every time because it is actually working, and you dont have a huge area of healthy skin removed that also then needs to heal, like with traditional skin grafts.
Dr. Mark S. Granick, MD, Professor and Chief of Plastic Surgery at Rutgers New Jersey Medical School and an early adopter of SkinTE commented on his experience with the product: I recently used SkinTE on a patient with a significantly sized leg wound which was the result of a traumatic skin avulsion. A hyper-granulating wound had persisted for more than two years despite treatments with currently available options, including split thickness skin grafts. The wound was painful, and long-term dressing care was insufficient for returning this otherwise healthy 39-year-old to his pre-injury function level.
Dr. Granick continued, Ultimately, the best thing for this patient, and generally any patient who is suffering with wounds, is to replace his own skin. SkinTE seems to be providing that. Thus far in the healing process, SkinTE has resulted in what appears to be full-thickness, pigmented skin regeneration. Certainly, in this case, SkinTE provided superior results with a quicker and less invasive procedure. I look forward to continuing to evaluate the potential and capabilities of this exciting and ground-breaking product.
Nothing speaks more highly of the products success than a patient testimonial, said Dr. Ned Swanson, Chief Operating Officer of PolarityTE. Dr. Swanson continued, The remainder of 2018 will be dedicated to building robust clinical packages across all wound types in concert with this first phase rollout, and we look forward to sharing additional information about these exciting outcomes.
What do you guys make of this Statement just released by PolarityTe?
Is it a desperation move or are they just re-affirming everyone they have something special?
This Doctor is saying it has regenrated full thickness pigmented skin... Big call!....or do you think they are being tricky with words meaning its regenerated skin yes but not necessarily scar free skin.
Remembering the statement release about the 10 year old boy before we seen photos of the boys healing. That Doctor just mentioned that the product had "quicky regenerated skin" which was pretty vague because we later found out the boy still had fibrotic scar tissue all under his SkinTe graft and that the "regenerated skin" was not what we were hoping. This New Jerseydoctor has said it looks like "full thicknessregeneration" so far in his patients healing.
This Devon patient said he only had SkinTe a few weeks ago for a wound deep enough it required skin grafts and already has hair regrowth!! ...but he did say it feels like normal skin (not looks like) worth noting. But I suppose hair regrowth is a sign of scar free skin so it should look like native appearing skin also.
SkinTe at least heals very fast from reports for some and this is the first we have heard of full thickness skin regeneration. There is hope at least for us....
First phase roll out 2018? More hospitals added I guess and then 2019 is full scale nation wide roll out from previous statements from Swanson.
15 minutes ago, Sniffy said:What do you guys make of this Statement just released by PolarityTe?
Is it a desperation move or are they just re-affirming everyone they have something special?
This Doctor is saying it has regenrated full thickness pigmented skin. Big call!
lets see lets see
