Acne.org Products
there are already two drugs which prevent scar formation to some extent
such as
5-fluorouracil
mitomycin-c
2 minutes ago, AI3forever said:This looks great. The margin is smaller than I expected. As you can see on the picture it is barely visible. In fact that natural creases on the skin looks deeper than the margin.
time will tell ..until full trials results dont come out we cant be happy or sad with these polarityTe Results..hope full human trials results look better
8 hours ago, AcneScarsbegone said:I see that the young boy with the rare skin disease does have a lot of scarring as you mentioned. So, it was a false lead but at least the boy was cured from all those blisters.They should really make the distinction between keloids and hypertrophic scarring. Keloids are scars or collagen buildup that keeps on growing extending beyond the original wound site. Thus, it's a tumour of some sorts. A small cut can therefore become a larger scar extending beyond the cut and destroying healthy undamaged skin in the process. Only a few people are susceptible to them. It's a exaggerated healing response.
Hypertrophic scars do not extend beyond the original wound site. Most surgical incisions result in hypertrophic scarring. They become less visible with time.
Doing a full thickness excision and applying SkinTE on it is pretty risky. There's already a pretty big chunk cut out of the boy's back. No sensible doctor would allow for full thickness excisions at this time. Even with split thickness, SkinTE does not look that great at this point. If it looks like that on split thickness, I can't imagine what it would look like on full thickness.
As with many new inventions or discoveries, funding is always needed. With Sunogel, if the funding is not there, I believe the technology will stall and never make it on the market unless a company buys it off. I believe the creators of Sunogel are trying to make it big however the asking price may not be good presently. We also have very limited data as with SkinTE to claim Sunogel regenerates skin. With SkinTE, the money is there from the creators themselves. No company will buy off a technology without having concrete results that something is proven to work.
As for now, SkinTE seems to be the front runner in the field but I'm not impressed by the results shown in that presentation. We can wait a little longer and wait for the final results in a few months. I don't believe this product is intended for other types of accidental scars or acne scars right now.
As clearly stated, it's more targeted for burn victims giving them back some appendages like hair follicules, natural pigmentation and sweat glands, giving them a sense of normality. I am sure, the creators behind SkinTE will hit the cosmetic market. Right now, everything is experimental. Will take a few years, that's for sure before they really develop something that fully regenerates skin. As for now, we must be patient.
Even with regular skin grafts, a full-thickness excision yields better cosmetic results than a split-thickness one. The reason is simplea split-thickness graft leaves behind the underlying fibrotic tissues (as is the case of the young boy treated with SkinTE and clearly stated in the presentation) whereas a full-thickness excision and graft wipes the slate clean. F
Any kind of excision of an already healed graft (for better or worse) is a substantial risk, but full-thickness ones obviously carry more. As I wrote before, the parents probably didn't want to risk a full-thickness excision on an unproven technology and for PolarityTE all they need to do in order to be profitable for the burn market is be better than split-thickness grafts. They do that, and they're already a success.
I would guess that some of the other patients treated thus far did get full-thickness excisions, but only on ones where it wasn't a large area (like the young boy' chest) I hope so anyway, because I don't see SkinTE getting total regeneration with appendages otherwise even if it propagates into existing scar tissue to a degree.
What's perplexing to me if this is the case than what was the point ?
This child clearly has scarring that even effects the hypodermis , this obviously being the case why on Earth would Plority only do a split thickness excision , an excision which could potentially be deep enough for acne scars and laser damage to get complete regeneration due that type of damage only effects the dermis , which if the dermis of anyone's skin is damaged they scar , but not in the case of deep 3rd degree wounds , which this poor child has , doesn't make any sense at all because the under lyingly damaged tissue is still there , but I guess this isn't at this current time for cosmetic purposes but for physiological.
Yes Im a little confused why they only did split thickness. Im scratching my head for many reasons. Just do a small piece and full thickness, white skin please, before photos, with adjacent skin normal appearing. This is such a poor example, I know its only 6 weeks and its bad scarring but i hope next images coming through are easier to judge.
They never showed anything like this in pig tests like partially removing scarred skin so perhaps they are being extra careful with human patients. Pig results still stand as very impressive. The doctor for this boy did say they were using this as an unknown and had back up plans if it didnt heal well hence being cautious.
Contracture is the key for acne scar sufferes here. If it can significantly reduce contraction then this could well be better suited for acne scars who knows. These burns scars have very poor texture/colour skin.
Again, I think it's two reasons:
1. Split-thickness skin grafts are the standard for burns. SkinTE is successful for the burn market if it merely is better than this standard. And really, as long as the paste gets the skin to grow back and cover the site of injury, it's almost impossible for it not to be better because of one huge advantagethe skin biopsy to make the past is so much smaller than the area of skin that needs to be grafted using a split-thickness graft.
2. Dr. Mundinger and the child's parents likely didn't want to attempt a full-thickness excision while using an untested product. If it turned out SkinTE was a complete failure, that child was in far more trouble if they'd excised down to the muscle.
A third reason is that this is a clinical trial. The way almost all clinical trials work is to show efficacy against a standard (this is tied into reason 1). It could be that the specific parameters of the trial are such that they need to test against the standard in order to gain approval for SkinTE's use indications.
I of course don't know any of this for certain, but this is a logical conclusion to draw considering PolarityTE in almost every forward-facing statement talks about how the split-thickness skin graft is a 3,000 year old surgery that needs to be replaced.
I still like to think focusing on one small acne scar with this product will benefit. They still noted scar reduction and contraction prevention even if they left all that scar tissue under his new skinte graft.
As for propagation with this boy into scar tissue it was never going to penetrate all the way through his dermis and into hypoderdermis lets be honest. It still may propagate scsr tissue but not to that extent i wouldnt think.
Im just focusing on signs of scar reduction and contraction prevention. If you pick one small acne scar and needle the shit out of it and break it up again under skin deeper with subcision then apply skinte on surface and injected into skin also then you would hope that spot doesnt contract again under skin and it plumps up skin to normal contour.
The more you look at it and understand its only split thickness yet still you can see it looks smoother than surrounding old contracted graft scars. And in some areas the margin has almost completely dissapeared, its the different colours forming that are probably throwing most people off I dunno. The darker areas i believe are smooth with lighter areas that havent repigmented yet. Its just so bloody difficult to see because black skin is prone to hyperpigmention colour changes. All that said its only 6 weeks and this boy had issues with old grafts developing keloids and contraction over 2 years hence why they are using Skinte to prevent that even if from just split thickness.
By the way, I emailed PolarityTE about using it to treat acne scars and this was their response, pretty ambiguous. I think they are being careful with their words.
"We are very sorry to hear about the difficulties you have endured in the past and continue to endure today due to scarring.
SkinTE is a human cellular and tissue-based product derived from a patients skin and is intended to repair, reconstruct, replace, or supplement that patients skin tissue/integument. Whether an individual patients particular condition may be appropriate for treatment with SkinTE is a medical decision to be determinedin consultation with a licensed and trained physician. For additional information about SkinTE, please refer to our website:www.PolarityTE.com.
Thank you for your inquiry and we will continue to update the public as further developments become available as it relates to SkinTE and other PolarityTE products and technology."
By the way it looks polarity is definitely not scarless treatment , also margins is evident although this wound didnt heal completely, you can tell , its most likely an improvement, the healing time also can tell you how bad the scar is , fast complete healing therefore less scarring, as the company states you can alreadY make your hypothesis
5 minutes ago, onelane21 said:By the way it looks polarity is definitely not scarless treatment , also margins is evident although this wound didnt heal completely, you can tell , its most likely an improvement, the healing time also can tell you how bad the scar is , fast complete healing therefore less scarring, as the company states you can alreadY make your hypothesis
You're basing this off results that are only six weeks old on a split-thickness excision. You can't say definite about anything at this point.
In pigs the majority of healing took place over 4-5 months but it remodeled and changed over an entire year. Obviously, 6 weeks does not equal either of those timeframes.
I don't think it will get complete regeneration for a split-thickness excision (full-thickness however, I will hold them to their established burden and statements), but none of us can make any definitive statements about anything at this point.
The Margin only stands out because of the colour difference with the black skin. If it were all white skin i dont think you would see this margin hardly tbh. The Margin is already starting to fill in with pigment in some areas for this boy. I cant see any obvious contraction either. Seems to blend from one side to other well so far after 6 weeks.
theoretically it's even simpler to regenerate an acne scar in comparison to a burn wound
is not hard to imagine they excising the existing scar then what would naturally happen is the acne scar would turn into a line scar that should not be hard to regenerate scarlessly with skinTE
32 minutes ago, rudy1986 said:What do you mean ? You seems to always start a fight in this thread? With that aggresive terms coming out from you is really pissing me off.. please dont come back. You bring nothing but misery in this thread
I'm not sure who you are referring to, but you should understand we are all entitled to our own opinion. Some people are skeptical and who can blame them, with all the empty promises being advertised by money hungry doctors looking to take advantage of people who are feeling vulnerable.
I am looking forward to the release of the full results, it could potentially be a very interesting development in scar revision practice.
5 hours ago, rudy1986 said:What do you mean ? You seems to always start a fight in this thread? With that aggresive terms coming out from you is really pissing me off.. please dont come back. You bring nothing but misery in this thread
Do you have schizophrenia? I didn't say anything rude or offensive. Stop getting hystericalover everything. If you have anything against me then PM me. But right now there's no moreirrelevant post than yours.
That research with 10-years-old boy is not what we're waiting for. In that test they used a different technique. They applied SkinTE on underlying fibrotic scar tissue if I got it right. This approach won't regenerate hair follicles, sebaceous glands, sweat glands, fat and so on.In the porcine model research they did full-thickness excision and got the perfect result. "SkinTE looks like skin", "SkinTE functions like skin ", "SkinTE molecularly acts like skin". We should wait for another research or some of us could contact PolarityTE for details.
15 hours ago, rudy1986 said:16 hours ago, RickeyDog1989 said:The picture of the arm on one of the slides seems to be a full-thickness excision. If it is a photo of someone using SkinTE, we can expect to see something about full-thickness application in the future.
Which arm?
The one on the top right corner in one of the slides on PolarityTE's website.
5 hours ago, JackDoe said:Do you have schizophrenia? I didn't say anything rude or offensive. Stop getting hystericalover everything. If you have anything against me then PM me. But right now there's no moreirrelevant post than yours.That research with 10-years-old boy is not what we're waiting for. In that test they used a different technique. They applied SkinTE on underlying fibrotic scar tissue if I got it right. This approach won't regenerate hair follicles, sebaceous glands, sweat glands, fat and so on.In the porcine model research they did full-thickness excision and got the perfect result. "SkinTE looks like skin", "SkinTE functions like skin ", "SkinTE molecularly acts like skin". We should wait for another research or some of us could contact PolarityTE for details.
Hey relax im not talking about you.. you and i are in a cool terms
I dont think people understand what a STSG is. It contains a small section of dermis and full epidermis. Its used in deep 2nd and 3rd degree burns. If this person had their STSG removed then it will leave a full thickness injury. FTSG relates to what was donated not what is treated as you can use both fof full thickness injury. Burns is alot to do with function. Even if it doesnt look perfect then fully functioning skin wouldbe a success.
3 hours ago, nikki_gargin said:I dont think people understand what a STSG is. It contains a small section of dermis and full epidermis. Its used in deep 2nd and 3rd degree burns. If this person had their STSG removed then it will leave a full thickness injury. FTSG relates to what was donated not what is treated as you can use both fof full thickness injury. Burns is alot to do with function. Even if it doesnt look perfect then fully functioning skin wouldbe a success.
If they had the split thickness graft removed, then I would think it would be a split thickness excision IF only the graft was removed though. It wasnt specified whether it was a split or full thickness excision so it could still be a FTSG. The confusion is in the wording where they stated that they excised the previous split thickness graft that the boy had from the current standard of treatment. The biopsy will always be full thickness, but the treated area can be either STSG or FTSG. I think people are getting caught up in the fact that there was underlying scar tissue left after the excision so its automatically assumed that its a split-thickness excision. What needs to be taken into account as well is that a full thickness excision in medical terms is considered the excision of the entirety of the dermal and epidermal layer, but does not constitute all 3 layers so the hypodermis doesnt have to be excised at all to still be considered a FTSG.
There can still be underlying scar tissue in a fractional part of the hypodermis that they decided not to excise due to risk factors, parents consent, trial settings or because they wanted to test for propagation that was claimed to occur in scar tissue. I agree with everything except Im not following your comment in why a split thickness excision would be considered a full thickness injury if half of the dermis was left untouched. Keeping in mind that it couldve been a full thickness excision still of course, but was only stated to us as the STSG being removed so the depth of excision is actually not known. I believe golf panther has e-mailed them about it so maybe theyll respond with a straight-forward answer. Regardless there was an exponential amount of improvement between weeks 4 and 6 so thats very good considering its just a 2 week gap between the amount of healing that occurred within that time frame.