Acne.org Products
This seems interesting
https://www.uml.edu/News/stories/2018/Gulden-tissue-research.aspx
On 01/03/2018 at 6:00 PM, Rez77 said:ARE YOU PEOPLE CRAZY!!!!?????? YEAH I GUESS SO AND SO AM I FOR EVEN ENTERTAINING ALL THIS BS BS BS BS BS BS
WHAT ARE YOU GOING TO DO? EXCISE MY WHOLE FACE LIKE FACE OFF AND THEN HAVE A PASTE APPLIED TO MY SKINLESS ANATOMICALLY EXPOSED FACE SO I"M LIKE A ZOMBIE IN A HORROR MOVIE. GIVE ME A BREAK. THAT"S NOT HOW IT WORKS AND NO ONE IS GOING TO DO THIS.
YOU GUYS ARE LEGIT ALL INSANE EVEN ENTERTAINING THIS BS. I'm OUT.
A very high degree of critical thinking skills on display here.
I am not a medical student, but I do have a four year degree. I'm clearly no match for you when it comes to Skin TE analysis. You even managed to include the word 'zombie' in your analysis. God bless you Rez.
2 hours ago, ScarRight said:11 hours ago, SimpleMutton said:Will we have this product available for treating acne scars by the end of this year?
That would be pushing it, even if it is a roaring success. They would need to implement a cosmetic application, assuming they are not going to do deep excisions for acne scars.
I think the cosmetic application is for the face
My scars problem is 90% on the back and I wouldn't mind to have deep excision on my back (provided skinte can regenerate the skin fully)
But yeah I probably wouldn't do it on the face
one thing is clear that polarityTe has achieved same scarless healing in humans as they did in pig..as there some last news releases states..the question is now to see
to what % it regenerate skin is it 100% regeneration like normal skin.
or less than 100% close to normal skin.
how they use it
the price...etc
hope we all get these answer soon
https://www.sec.gov/Archives/edgar/data/1076682/000149315218003132/ex99-1.htm
It looks like there's some pictures from human patients in here.
1 hour ago, ObservantJeep said:https://www.sec.gov/Archives/edgar/data/1076682/000149315218003132/ex99-1.htmIt looks like there's some pictures from human patients in here.
Yup, pictures of the child that was mentioned in the reports.
What is remarkable is that the photo is of a child with black skin, which has a greater propensity for scarring.
If indeed this works on black skin, then it's a game changer indeed!! (I'm black with keloid scars from surgery and absolutely nothing has worked for me!)
You know what? This looks fucking amazing. I'll say this, if they can pull of the skin and osteo products and find some derivatives that could be used for cosmetic applications (which they will) this will be FUCKING AMAZING. It may not be available now, or even for a few years. But it will be a reality. And just for that I'm thankful and look forward to the future. Honestly guys, I think its 5-10 years away for use. Part of my rational there is that even with the skinTE they say everywhere that its "through the technology we are developing or proposing etc.." I think their 2017-2018 rollout date is just for pre-clinical tests. I don't think they mean it is necessarily clinically available. Unless someone phones them and finds out where/when they can get it now (it is afterall well into 2018), I think that's just a ruse to keep investors happy.
2 hours ago, Rez77 said:You know what? This looks fucking amazing. I'll say this, if they can pull of the skin and osteo products and find some derivatives that could be used for cosmetic applications (which they will) this will be FUCKING AMAZING. It may not be available now, or even for a few years. But it will be a reality. And just for that I'm thankful and look forward to the future. Honestly guys, I think its 5-10 years away for use. Part of my rational there is that even with the skinTE they say everywhere that its "through the technology we are developing or proposing etc.." I think their 2017-2018 rollout date is just for pre-clinical tests. I don't think they mean it is necessarily clinically available. Unless someone phones them and finds out where/when they can get it now (it is afterall well into 2018), I think that's just a ruse to keep investors happy.
man i dont say when it will be available for cosmetic use but for burn patients its going to available this year
Rez77, preclinical tests are those done on animals, not humans. This is a clinical trial being done for post-market approval of SkinTE.
Their timelines have been adhered to 100% up to this point. If that holds, SkinTE as is will be available for commercial use the second half of this year.
In terms of derivatives coming 5-10 years... there is no way that PolarityTE will wait that long. If SkinTE works on burns like it did in pigs, someone would figure out a way to copy their formula, alter it slightly to avoid patent issues and beat them to the punch. PolarityTE will have an imperative to do this first to save the bulk of their potential business.
I'm curious to know if any patient has been treated for full-thickness excision and eagerly awaiting final results to see how well SkinTE propagated into the existing scar tissue of the young boy since that was a split-thickness excision.
The case of the 10-year-old is of interest to those who have shallow scarring. They did not excise his scars their full depth (possibly for damage control, in case SkinTE did not work as planned, among other possible reasons), but enough to counteract scar contraction, as was mentioned in the presentation. We are able to see how SkinTE works on the relatively outer layers of the skin. What I'm getting from the limited information is that the areas where SkinTE was applied healed as expected, without much scarring (or possibly any, from a cosmetic perspective). Of course the scar wasn't excised fully, so the irregularities in the skin texture probably stem from the scar tissue beneath the depth of excision. But down to the depth of skin treated, it seems like the skin has healed as we hoped.
Judging from the picture, at 6 six weeks, it looks like a bad scrape that is healing but the margins at the edge of the wound are extensively visible. Naturally, wounds heal by contraction so SkinTE seems to stop contraction. The skin starts healing from the inside and healing propagates outwards.
The body's natural wound contraction tendancy and SkinTE seem to make a pretty visible wound edge which is probably composed of scar tissue. There may be need of improvement here in the future. The edge doesn't look smooth at all. Natural pigmentation is coming back inside the wound which suggests regeneration is reoccurring because scar tissue has no melanin producing cells or there is not too much scar tissue buildup.
At six weeks however, it doesn't look good at all. Most scrapes don't scar and melanin does return progressively.
Also, I don't understand the focus on creating an OsteoTE regeneation product. Bones heal without scarring. There is a callus that is formed but it eventually disappears. Removed rib cage bones regenerate on their own to begin with. Sometimes, bones heal in a crooked mannerso OsteoTE may be of help here.
14 minutes ago, AcneScarsbegone said:Judging from the picture, at 6 six weeks, it looks like a bad scrape that is healing but the margins at the edge of the wound are extensively visible. Naturally, wounds heal by contraction so SkinTE seems to stop contraction. The skin starts healing from the inside and healing propagates outwards.
The body's natural wound contraction tendancy and SkinTE seem to make a pretty visible wound edge which is probably composed of scar tissue. There may be need of improvement here in the future. The edge doesn't look smooth at all. Natural pigmentation is coming back inside the wound which suggests regeneration is reoccurring because scar tissue has no melanin producing cells or there is not too much scar tissue buildup.
At six weeks however, it doesn't look good at all. Most scrapes don't scar and melanin does return progressively.
Also, I don't understand the focus on creating an OsteoTE regeneation product. Bones heal without scarring. There is a callus that is formed but it eventually disappears. Removed rib cage bones regenerate on their own to begin with. Sometimes, bones heal in a crooked mannerso OsteoTE may be of help here.
This isn't the final product , i'd like to think it's still in the healing phase .... remember 3 months is when you get the final result of this skinte product .... so 6 more weeks and we can really judge fully without reservations.
7 hours ago, rudy1986 said:What i dont get is why didnt they excise full thickness skin? For testing purposes?
seems they only trying to get rid of keloid scars and improve colour by excision of epidermis and top part of dermis. Its hard to see whats going on because he has black skin and no before photo to compare with. Maybe his age and the unknown of product made them tread more cautious doing split thickness only.
I think we should all be cautious. This may indeed work and be a better option than Fraxel or any other existing scar treatment, but it may not deliver perfect results for everyone. Results will probably vary from patient to patient, with things such as the patient's healing abilities and adherence to aftercare, just a couple of factors influencing the final result.
This probably will not deliver 100%. Some people will find that very hard to accept. Even if this delivers 80% improvement, some people will not be happy and will not accept the result.
I'm just throwing that out there. The full results will be presented as a company announcement in the near future. Even if they get a positive result, I'd still wait for some patient reviews before jumping in.
Well the results of the 10 year old boy is equal to shit. How can they even show bad results like that and keep adding those arrows to show the margin. Well f*ck the margin, look at the bad result.
I was very optimistic. And I know that they did not fully excised his skin but showing results like that on presentation slides is not really motivating but seems to be reality. Lets just hope that we can get rid of our scars. The pig results were way more impressive than this one. The sad thing is that it looks like the surrounding skin. Where is the clear improvement? Scar reduction??? Come on. They clearly said regeneration of full thickness skin.
Anyways... I know that we have to wait but this example is just really bad.
1 hour ago, ScarRight said:I think we should all be cautious. This may indeed work and be a better option than Fraxel or any other existing scar treatment, but it may not deliver perfect results for everyone. Results will probably vary from patient to patient, with things such as the patient's healing abilities and adherence to aftercare, just a couple of factors influencing the final result.
This probably will not deliver 100%. Some people will find that very hard to accept. Even if this delivers 80% improvement, some people will not be happy and will not accept the result.
I'm just throwing that out there. The full results will be presented as a company announcement in the near future. Even if they get a positive result, I'd still wait for some patient reviews before jumping in.
If a wound heals under 2 weeks, it doesn't scar. Most wounds under 2 mm heal within 2 weeks and regenerate. All other wounds leave a trace behind from the original injury. Will the wound shown on that picture look better a year from now, definitely. But, this doesn't look like full regeneration as the company had us to believe with pig skin.
Judging from the pic after six weeks, the wound is still healing, so I am not overly optimistic that the margin will look like normal healthy skin. It's hypertrophic scarring which some of you confuse for keloids but they are not the same thing.
This product maybe a better alternative to lasers. It looks to be better suited for burn scars which form thick hypertrophic scarring known as contracture scars. I don't believe it is well suited for acne scars or deep lacerations at this point.
I had read an article on this thread about a young Syrian boy who migrated to Germany with a rare skin disease. The skin would melt off causing him blisters and large open sores which would never heal. A researcher used stem cells to completely cure the boy. There was minimal scarring if none at all. I believe science knows how to eliminate scarring but practicioners don't feel like exploiting it right now. Current methods which provide some improvement seem to be more cost effective. Unfortunately, everyone is looking to make money out of others' misery.
I know the focus seems to be on SkinTE at the moment, so forgive me asking an unrelated question. But has anyone been in touch with Dr. Sun from Sunogel lately? Is there any indication as to when their product could be ready? I've been reading about the hydrogels since 2012. I don't understand why nothing has ever come to fruition. Especially since they are supposedly just devices and could be approved quickly. Are they even trying to do clinical trials or...?
4 hours ago, jac3 said:I know the focus seems to be on SkinTE at the moment, so forgive me asking an unrelated question. But has anyone been in touch with Dr. Sun from Sunogel lately? Is there any indication as to when their product could be ready? I've been reading about the hydrogels since 2012. I don't understand why nothing has ever come to fruition. Especially since they are supposedly just devices and could be approved quickly. Are they even trying to do clinical trials or...?
I spoke to Dr. Sun on the day before Christmas. At that time he was looking for funding to conduct clinical trials. The big issue for him is that he's not a businessman. He's clearly knowledgable about his product, but ostensibly I was calling as a potential investor and he did not sell me on the product. Basically he said that while he got complete regeneration in pigs you can't go "0-100" but rather you need to step up and optimize the product after initial testing.
That's all well and good, but he's just not someone that should be the person dealing with calls like that. He needs an advocate in my opinion that can deal with the business and logistics side so he can focus on the research. He needs money, and for that he needs a better pitch.
His technology is pretty remarkable (preclinical results anyway) so perhaps someone with deep pockets will invest in the trials on that power alone. I hope so, but I'm dubious about that becoming a reality.
6 hours ago, AcneScarsbegone said:If a wound heals under 2 weeks, it doesn't scar. Most wounds under 2 mm heal within 2 weeks and regenerate. All other wounds leave a trace behind from the original injury. Will the wound shown on that picture look better a year from now, definitely. But, this doesn't look like full regeneration as the company had us to believe with pig skin.Judging from the pic after six weeks, the wound is still healing, so I am not overly optimistic that the margin will look like normal healthy skin. It's hypertrophic scarring which some of you confuse for keloids but they are not the same thing.
This product maybe a better alternative to lasers. It looks to be better suited for burn scars which form thick hypertrophic scarring known as contracture scars. I don't believe it is well suited for acne scars or deep lacerations at this point.
I had read an article on this thread about a young Syrian boy who migrated to Germany with a rare skin disease. The skin would melt off causing him blisters and large open sores which would never heal. A researcher used stem cells to completely cure the boy. There was minimal scarring if none at all. I believe science knows how to eliminate scarring but practicioners don't feel like exploiting it right now. Current methods which provide some improvement seem to be more cost effective. Unfortunately, everyone is looking to make money out of others' misery.
People are calling the scarring keloids because that's what it's called in the presentation.
The important thing to remember is that this is asplit-thicknessskin graft. With the pigs PolarityTE excised down to the muscle and then applied SkinTE. With this boy, they excised the top two layers but left the underlying fibrotic tissue. Even with skin grafts the cosmetic appearance of a full-thickness graft is better than split. If SkinTE somehow managed to get complete regeneration in a split-thickness graft that would truly be remarkable, but if it can do what it did in pigs it'll likely need full-thickness excisions in humans as well.
In my opinion, the reasons this is a split-thickness excision are likely two-fold: 1. The parents of the child and the doctor might not have wanted to do a full-thickness excision while using an unknown product. Full-thickness grafts fail far more than split and young boy would have been in serious trouble had SkinTE failed (i.e. he's likely already had skin grafted from other parts of his body, making healthy tissue harder to come by). and 2. For SkinTE to be successful in the burn market (it's main aim out of the gate) all it needs to do is perform better than a split-thickness graftthe clinical standard of care.
In the case of the young Syrian boy, they biopsied cells and used a method that sounds similar to CRISPR to create new sheets of skin that were then grafted. He did not get full-thickness skin with his appendages and the sheets of skin were only the epidermis. It's amazing what they did for him but if you look at the paper you can see that he definitely has a lot of scarring, which is still obviously better than the blisters he had before:
1 hour ago, golfpanther said:I spoke to Dr. Sun on the day before Christmas. At that time he was looking for funding to conduct clinical trials. The big issue for him is that he's not a businessman. He's clearly knowledgable about his product, but ostensibly I was calling as a potential investor and he did not sell me on the product. Basically he said that while he got complete regeneration in pigs you can't go "0-100" but rather you need to step up and optimize the product after initial testing.That's all well and good, but he's just not someone that should be the person dealing with calls like that. He needs an advocate in my opinion that can deal with the business and logistics side so he can focus on the research. He needs money, and for that he needs a better pitch.
His technology is pretty remarkable (preclinical results anyway) so perhaps someone with deep pockets will invest in the trials on that power alone. I hope so, but I'm dubious about that becoming a reality.
People are calling the scarring keloids because that's what it's called in the presentation.
The important thing to remember is that this is asplit-thicknessskin graft. With the pigs PolarityTE excised down to the muscle and then applied SkinTE. With this boy, they excised the top two layers but left the underlying fibrotic tissue. Even with skin grafts the cosmetic appearance of a full-thickness graft is better than split. If SkinTE somehow managed to get complete regeneration in a split-thickness graft that would truly be remarkable, but if it can do what it did in pigs it'll likely need full-thickness excisions in humans as well.
In my opinion, the reasons this is a split-thickness excision are likely two-fold: 1. The parents of the child and the doctor might not have wanted to do a full-thickness excision while using an unknown product. Full-thickness grafts fail far more than split and young boy would have been in serious trouble had SkinTE failed (i.e. he's likely already had skin grafted from other parts of his body, making healthy tissue harder to come by). and 2. For SkinTE to be successful in the burn market (it's main aim out of the gate) all it needs to do is perform better than a split-thickness graftthe clinical standard of care.
In the case of the young Syrian boy, they biopsied cells and used a method that sounds similar to CRISPR to create new sheets of skin that were then grafted. He did not get full-thickness skin with his appendages and the sheets of skin were only the epidermis. It's amazing what they did for him but if you look at the paper you can see that he definitely has a lot of scarring, which is still obviously better than the blisters he had before:
I see that the young boy with the rare skin disease does have a lot of scarring as you mentioned. So, it was a false lead but at least the boy was cured from all those blisters.
They should really make the distinction between keloids and hypertrophic scarring. Keloids are scars or collagen buildup that keeps on growing extending beyond the original wound site. Thus, it's a tumour of some sorts. A small cut can therefore become a larger scar extending beyond the cut and destroying healthy undamaged skin in the process. Only a few people are susceptible to them. It's a exaggerated healing response.
Hypertrophic scars do not extend beyond the original wound site. Most surgical incisions result in hypertrophic scarring. They become less visible with time.
Doing a full thickness excision and applying SkinTE on it is pretty risky. There's already a pretty big chunk cut out of the boy's back. No sensible doctor would allow for full thickness excisions at this time. Even with split thickness, SkinTE does not look that great at this point. If it looks like that on split thickness, I can't imagine what it would look like on full thickness.
As with many new inventions or discoveries, funding is always needed. With Sunogel, if the funding is not there, I believe the technology will stall and never make it on the market unless a company buys it off. I believe the creators of Sunogel are trying to make it big however the asking price may not be good presently. We also have very limited data as with SkinTE to claim Sunogel regenerates skin. With SkinTE, the money is there from the creators themselves. No company will buy off a technology without having concrete results that something is proven to work.
As for now, SkinTE seems to be the front runner in the field but I'm not impressed by the results shown in that presentation. We can wait a little longer and wait for the final results in a few months. I don't believe this product is intended for other types of accidental scars or acne scars right now.
As clearly stated, it's more targeted for burn victims giving them back some appendages like hair follicules, natural pigmentation and sweat glands, giving them a sense of normality. I am sure, the creators behind SkinTE will hit the cosmetic market. Right now, everything is experimental. Will take a few years, that's for sure before they really develop something that fully regenerates skin. As for now, we must be patient.
Unfortunately, I feel having something like skin TE for cosmetic treatment is quite a while away. Skin TE, as others have already mentioned, will most likely be effective for burn patients, as that was what the product was originally intended to treat.
There rarely ever is a miracle cure in cosmetic medicine. How many times over the years have we heard about a groundbreaking new treatment that doesn't deliver on the hype? More than once!