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No way! All this speculation is getting out of hand. I don't care about "the margin" and I don't care about the timeline of 3 months.
Like okay, one side of my face, and I have thick skin, is full of deep rolling scars, icepick scars and some really deeply gouged boxcar scars. like i'd say a 3cm by 3 cm portion of my cheek. And because I'm aging the collagen and fat have gone down and made the depressions of these scars even worse.
So you're telling me I "EXCISE" a 9 cm area portion of my skin to full depth thickness. This is the first thing that is BS. No surgeon will do that --okay maybe you find someone trained in Skin TE who does and then what? They smear this past in this area. And you're telling me this will grow to new fresh skin? Will it be as "old" as the surrounding skin or will it be young new skin? What is guiding it to mold into the particular shape of my cheek? Like none of this sounds feasible or even possible and its certainly not explained by any of the questions and answers Tano very kindly posted. What guides the generation? What sort of skin is then created? And I mean how does one deal with the incredibly huge pain of this procedure and how does one live during those three months when the paste is somehow forming into new skin. I just don't understand how this would work to produce potentially new fresh skin. Maybe I'm not understanding something. I want to believe in this but it doesn't sound kosher to me unless I understand it more. If you were to tell me okay there could be some deriviative product that could be an injectable goo that forms into skin and you just inject that into your scars or something that makes more sense to me --it might make 60 percent improvement even. But something that would do the full deal who knows.
4 hours ago, Rez77 said:No way! All this speculation is getting out of hand. I don't care about "the margin" and I don't care about the timeline of 3 months.
Like okay, one side of my face, and I have thick skin, is full of deep rolling scars, icepick scars and some really deeply gouged boxcar scars. like i'd say a 3cm by 3 cm portion of my cheek. And because I'm aging the collagen and fat have gone down and made the depressions of these scars even worse.
So you're telling me I "EXCISE" a 9 cm area portion of my skin to full depth thickness. This is the first thing that is BS. No surgeon will do that --okay maybe you find someone trained in Skin TE who does and then what? They smear this past in this area. And you're telling me this will grow to new fresh skin? Will it be as "old" as the surrounding skin or will it be young new skin? What is guiding it to mold into the particular shape of my cheek? Like none of this sounds feasible or even possible and its certainly not explained by any of the questions and answers Tano very kindly posted. What guides the generation? What sort of skin is then created? And I mean how does one deal with the incredibly huge pain of this procedure and how does one live during those three months when the paste is somehow forming into new skin. I just don't understand how this would work to produce potentially new fresh skin. Maybe I'm not understanding something. I want to believe in this but it doesn't sound kosher to me unless I understand it more. If you were to tell me okay there could be some deriviative product that could be an injectable goo that forms into skin and you just inject that into your scars or something that makes more sense to me --it might make 60 percent improvement even. But something that would do the full deal who knows.
I agree with you. I read Tano1s details about SkinTE but I don't believe it either. Something doesn't add up. No sensible plastic surgeon will excise full thickness portions of skin to have some wacky paste applied on it. This will leave wounds that are not your general type of minor cuts or abrasions open to the environment. The wounds will be deep and prone to infection. We don't know how this paste will help the immune system to fight off infectious agents. Nature has selected scarring to fight off infection fast and efficiently, the faster the lesion is closed, the less risk of infection.
I assume for burn victims this wouldn't matter because the skin is already damaged severely. There's nothing to excise in the first place except for the skin biopsy who one of the founders of SkinTE mentioned must be closed up because you simply can't keep an open wound like that to be vulnerable to bacteria. This creates another scar. We also don't know wether SkinTE can be applied on this scar and why wouldn't it be able to be applied.
Walking around with large pieces of skin excised is also not ideal with some paste on it. Nobody knows how this paste is going to expand to cover wounds and how the body can fight off infections with an open wound while this magical substance does it's thing. Also considering that the body contracts to close the wound and this contraction itself creates new tissue or granulation tissue to fill in wounds, I don't seem to understand how the paste will stop the contraction process and block off granulation tissue from growing. The key is to stop granulation tissue from maturing and thus creating scar tissue. I would assume the simpler way would be to trick the body of stopping granulation tissue to turn into scar tissue and rather become normal looking skin. Scientists already found a way to convert granulation tissue to fat tissue by growing hair on it anyways. I assume 5 years from now, the method will be tested and proven and scars will be history if this works. I believe existing scar tissue will be smeared by special creams that will convert the tissue into healthy skin but we are far away from this now.
Also nobody knows how the regenerated skin will be accepted by the body and wether it's properties function like normal skin.
yeah i gotta tell you guys, I'm starting to lose faith again. this makes sense for burns maybe, but I really don't see how it works for acne scars.
Maybe if you induce severe burns in your own skin with a laser and then apply the paste? I just don't know. I guess no one else does.
Hey guys also thanks to tano wish you can share any email or contact with polarity, now i been following this form for years last big deal things that just was a fail was juvista an European company which had millions invest like this polarity but fail clinical trails found some fraud and false claims, then it was acell which was basically bs, now this, i see alot of money being invested also what seems more interesting is the FDA, it seems they are approving it use limited even thou we it wasnt through any clinical trails like phase 1 2 3 very loooong process years and alots of money, some companys dont have much to even go through this, Now fda is more about managing not curing or processing this that actually helps ppl, there like gas companies and tabacoo they dont give a fuck about the population, just money and how to keep money going is to manage, basically keep the problem there and treating long term, this is medicine today. So i would wait until i see pics before and after before disclaiming but this is an intresting case because of their claims and how its being push right now.Im sure there been discovers of regeneration completely and the FDA THROUGH UP on the shelf, the patent of course or the inventor sold it. just like CAR COMPANY FORD, bought an invention that car can be power by air and hydrogen and the put it on the shelf and keep it from the public because no money can be generated or like TELSA found a way for free energy for the mass and con edision push him out because charging ppl for energy is what USA is about capitalist country, but long story short, we just have to wait but their claims is big and they are doing this in limited clinics but where? anyone knows also pics are prob most important thing we have to wait for
1 hour ago, Rez77 said:yeah i gotta tell you guys, I'm starting to lose faith again. this makes sense for burns maybe, but I really don't see how it works for acne scars.
Maybe if you induce severe burns in your own skin with a laser and then apply the paste? I just don't know. I guess no one else does.
You don't see how it works for acne scars? If it works, it works for all types of scars. It helps regenerate full thickness skin. Acne scars are less than full thickness skin. Replace them with full thickness skin, then you won't have visible scars. What's so hard to understand? If this works, then at least there is a possibility of having cosmetically scarless skin. At least it won't be impossible. It may not be immediately available to everyone, but if it works, it will be possible to eliminate scars on a cosmetic level for those who have the means and the will to undergo the procedure.
Most kinds of surgery have recovery periods. Most kinds of surgery are expensive. Did you expect to be able to get results immediately? What's there to complain about? Nobody is interested in whether anyone has faith in whatever. The only thing of interest is whether a technology is based on plausible assumptions, and whether they produce desired results. None of your complaining will do anything for or against the results of this product, so what is the point of complaining?
4 hours ago, TOPNIKE14 said:Hey guys also thanks to tano wish you can share any email or contact with polarity, now i been following this form for years last big deal things that just was a fail was juvista an European company which had millions invest like this polarity but fail clinical trails found some fraud and false claims, then it was acell which was basically bs, now this, i see alot of money being invested also what seems more interesting is the FDA, it seems they are approving it use limited even thou we it wasnt through any clinical trails like phase 1 2 3 very loooong process years and alots of money, some companys dont have much to even go through this, Now fda is more about managing not curing or processing this that actually helps ppl, there like gas companies and tabacoo they dont give a fuck about the population, just money and how to keep money going is to manage, basically keep the problem there and treating long term, this is medicine today. So i would wait until i see pics before and after before disclaiming but this is an intresting case because of their claims and how its being push right now.Im sure there been discovers of regeneration completely and the FDA THROUGH UP on the shelf, the patent of course or the inventor sold it. just like CAR COMPANY FORD, bought an invention that car can be power by air and hydrogen and the put it on the shelf and keep it from the public because no money can be generated or like TELSA found a way for free energy for the mass and con edision push him out because charging ppl for energy is what USA is about capitalist country, but long story short, we just have to wait but their claims is big and they are doing this in limited clinics but where? anyone knows also pics are prob most important thing we have to wait for
They might be doing testing in Massachusetts General Hospital. Someone by the name of ChatrickClark tweeted about how he used Polarity on a burn on his hand and it grew without a scar. He has since deleted the tweet. It is believed that Massuchusetts General Hospital might be the place where he healed his scarred hand because 1) ChatrickClark is from Massachusetts and 2) Polarityte's Dr Stephen Milner trained in general surgery at Massachusetts General Hospital according to his bio in this link: https://www.polarityte.com/about/management-team
Maybe someone should contact the hospital and ask about Polarity?
On 11/7/2017 at 6:34 PM, Rez77 said:No way! All this speculation is getting out of hand. I don't care about "the margin" and I don't care about the timeline of 3 months.
Like okay, one side of my face, and I have thick skin, is full of deep rolling scars, icepick scars and some really deeply gouged boxcar scars. like i'd say a 3cm by 3 cm portion of my cheek. And because I'm aging the collagen and fat have gone down and made the depressions of these scars even worse.
So you're telling me I "EXCISE" a 9 cm area portion of my skin to full depth thickness. This is the first thing that is BS. No surgeon will do that --okay maybe you find someone trained in Skin TE who does and then what? They smear this past in this area. And you're telling me this will grow to new fresh skin? Will it be as "old" as the surrounding skin or will it be young new skin? What is guiding it to mold into the particular shape of my cheek? Like none of this sounds feasible or even possible and its certainly not explained by any of the questions and answers Tano very kindly posted. What guides the generation? What sort of skin is then created? And I mean how does one deal with the incredibly huge pain of this procedure and how does one live during those three months when the paste is somehow forming into new skin. I just don't understand how this would work to produce potentially new fresh skin. Maybe I'm not understanding something. I want to believe in this but it doesn't sound kosher to me unless I understand it more. If you were to tell me okay there could be some deriviative product that could be an injectable goo that forms into skin and you just inject that into your scars or something that makes more sense to me --it might make 60 percent improvement even. But something that would do the full deal who knows.
These are all good questions. I believe that the skin will grow back as if the wound never happened to begin with. So it won't be like baby skin, but just skin that grows back normally.
For anyone that is having doubts in Polarity or believes that Polarity is better suited for severe burns instead of normal scars, put your focus on Sunogel instead.
Sunogel seems way more simple/effective in my opinion, and the healing process might be better and quicker than Polarity's.
If Sunogel focuses on scarring as opposed to burns, we could potentially see results by the end of the year! Dr. Sun has recently stated that he wants to starts trials ASAP.. they might just need funding and help.
I suggest everyone do whatever they can to help quicken Sunogel's progress... whether by researching, contacting, or donating money to Sunogel for testing. Or volunteering for trials if possible. Anything helps. You can't lose by trying.
1 hour ago, Rez77 said:yeah i gotta tell you guys, I'm starting to lose faith again. this makes sense for burns maybe, but I really don't see how it works for acne scars.
Maybe if you induce severe burns in your own skin with a laser and then apply the paste? I just don't know. I guess no one else does.
rezz chill out I think for acne scars injections with a product like skinte will solve the problem ...
9 hours ago, damnBOY said:11 hours ago, Rez77 said:yeah i gotta tell you guys, I'm starting to lose faith again. this makes sense for burns maybe, but I really don't see how it works for acne scars.
Maybe if you induce severe burns in your own skin with a laser and then apply the paste? I just don't know. I guess no one else does.
rezz chill out I think for acne scars injections with a product like skinte will solve the problem ...
I mean I'm hopeful of course but I don't want this to be wishful thinking. It just sounds suspect.
7 hours ago, Rez77 said:I mean I'm hopeful of course but I don't want this to be wishful thinking. It just sounds suspect.
Rez77, I know how but you feel about your acne scars. I have them too. My face has many indentations from years of severe cystic acne and I still get occasional pimples in my thirties. My back still has lingering acne. My back has been scarred severely. There's a bunch of white scars everywhere, raised and flat. I also had acne on my buttocks/shoulders/thighs. A few small raised scars there as well. Irinically, where the acne did not appear, my skin looks perfect even into my thirties. As I age, the depressions on my face will look worse and I am already starting to notice. It could have been worse. We lucked out in the skin department. We have our health however. There's also thousands out there with acne scarring who lead successful lives.
The solution would just be to find a cure for acne but they just want to make money out of it. Even Accutane is a treatment and not a cure.
As someone mentioned before, SkinTE resembles Recell and Juva. It is very suspect.
I am still hopeful someone will find a way to turn scar tissue into normal skin. Dr. Cotsarelis' discovery looks more promising. I guess we still have to wait a little longer.
13 hours ago, JohnRottenSkin said:https://www.ksat.com/health/new-treatment-could-help-regenerate-skin
Patient sitting in the exact same place where Lough did. Right?SkinTE is registered with the FDA, which means it is available in the U.S. There will be a limited release in 15 centers around the country, and a wider release next year. PolarityTE also hopes to begin a pilot human clinical trial later this year although thats not required by the FDA.
so I do not understand, if it is available to use, why they need pilot human clinical trial?
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http://candlelites.com/search/new+skin+for+7+year+old+boy+marks+advance+in+gene+therapy
how to hide this fckng ad? Not sure that this is about Polarity. But google mentioned Polarity in this link.
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by the way, as I have seen, Polarity hire employes inlinkedinsorry for my eng
A clinical trial has a much more robust system for verifying efficacy. With that comes a greater sense of respect for the product.
For example, for clinical trials an independent committee is formed to inspect and verify a studies findings. While it's true that with something like completely regeneration there isn't much guess work, that verification could go a long way to proving to investors and medical facilities that the product is legit. Plus, it would also get published in medical trade journals, thus increasing visibility that would also lead to more investment.
news of sunogel " Title: tomorrow we shall have all a perfect skin" : https://silex-id.com/newsletters/event-reporter/newsletter-silex-id-2
1 hour ago, CollegeKidd said:^^^^ Can someone translate that article? Why is the year 2020 used?
It is written in french. It basically states that if Sunogel succeeds your scars will be a thing of the past. Their product, a hydrogel, is presently in clinical trials. It will be applied after severe burns in the hopes of eliminating scarring.
Also, there is a french start up company which is trying to replicate what Polarity is trying to do. Fabien Guillemot, CEO of Poietis, basically is explaining that soon they will be able to imprint 3D skin scaffolds of full thickness skin meaning all 3 layers to create a skin sample to graft on a human being. They hope to succesfully use their biotechnology on a human being by 2020.
There's also Carolina Oliveira of OneSkin Technologies who wants to understand how skin functions to reverse aging by reprogramming skin cells.
2 hours ago, Anonymouz1 said:It is written in french. It basically states that if Sunogel succeeds your scars will be a thing of the past. Their product, a hydrogel, is presently in clinical trials. It will be applied after severe burns in the hopes of eliminating scarring.
It's in clinical trials?? on humans?? If so... why is it only for severe burns? Ughhh.. Polarity has that market covered. Sunogel should target less severe injuries/scars
Polarity doesn't have the market on shit covered. From what has been described its basically a souped up version of Recell.
I've thought about it long and hard and if it is indeed a "paste" to be applied to burn scars it doesn't explain anything about how it would be used to treat acne scars or any other type of full thickness scars.
Sorry, I'm not going to swallow my intelligence for wishful thinking. I'm skeptical and 2018 is the year right? We should see at least some concrete before and after photographs of total scar regeneration, hell I'll even settle for pics of burn scars being regenerated. Let's just wait and see.
38 minutes ago, Rez77 said:Polarity doesn't have the market on shit covered. From what has been described its basically a souped up version of Recell.
I've thought about it long and hard and if it is indeed a "paste" to be applied to burn scars it doesn't explain anything about how it would be used to treat acne scars or any other type of full thickness scars.
Sorry, I'm not going to swallow my intelligence for wishful thinking. I'm skeptical and 2018 is the year right? We should see at least some concrete before and after photographs of total scar regeneration, hell I'll even settle for pics of burn scars being regenerated. Let's just wait and see.
they say they create a derivative production for the treatment of small scars be patient if they can treat 3 degree burns scars they will find a way for treatment of acne scars
Recell and SkinTE have nothing in common other than they both take a biopsy. The biopsy itself is different, it's processed different, and it's administered differently. If you claim Recell is similar to SkinTE then you should read more in depth on both products. I even explained in detail all of the differences in an earlier post using Recell's own training video. That information is easily accessible to anyone and they don't come from some wikipedia type sources either. It's fine to disagree with a product, but please have some knowledge on what you're talking about because there's nothing worse than falsifying information or misinterpretation. I suggest just waiting for the results and then downgrading a company if they don't hold up their end of the deal.
Aside from that,
I've been following Follica's research since the beginning of the year and have also found a very excellent source for their information. They were at the World Hair Congress in Japan very recently and I believe I may have an update from there as well. Maksim Plikus is collaborating with Dr. Cotsarelis and is leading a team of researchers studying various cell reprogramming to figure out how to solve scars. I'm in contact with someone who attended the Congress and they'll be sending me some news soon which is great.I may try to reach out to them myself after seabs provided me that source with microcoring awhile back in the private group.
There are some additional studies in microneedling as well (wound regeneration) that might be useful references as I can attest to microneedling myself since I've used with great success. Topicals are twice as effective with wounding so they are trying to figure out a topical that could be used in conjunction with microneedling similar to what Follica is doing.
Tsuji has also made a breakthrough with cultivating Epithelial Cells which could be great news for skin as well. There's a translator I'm in contact with that translates Tsuji's updates for me. They have overcome a major obstacle and are doing quite well with plans to enter clinical trials soon that will actually not last very long since they're in Japan and they are allowed to bypass a phase 3.
I am not very knowledgeable with Sunogel other than they are trying to use a hydrogel as a scaffold similar to 3D Bioprinting. So if anyone has actual knowledge of the process, materials, FDA regulations for their product, or anything else that explains their tech in more detail, I'd appreciate any information. Might see if I can contact them.
I'm a little disappointed with how this thread turned out since it hasn't really progressed with any additional insight on anything else other than PolarityTE which unfortunately still gets over-hyped or degraded despite efforts by others willing to go out of their way to share news with us not including myself. I feel like it's pointless arguing half of the time (not even productive debating) and not really contributing to anything that can be productive. I also received several PMs from a couple of people that when asked, have told me they don't like to comment at all on the main thread. I didn't ask why, but I felt like the constant degrading and arguing were some of the reasons as some hinted. I won't reveal their names as I respect them, but we did exchange some great information privately on SkinTE and other researchers/companies/technology.
I've decided I won't post any updates/interviews in this thread anymore because I don't appreciate when someone falsifies information that I put effort into getting for them.
For those who would like to continue receiving any updates I have from all of these companies/researchers/technologies as well as the contacts and groups I'm associated with, I don't mind providing information on anything that I've mentioned above, but I will probably post, sort and organize all of that on a server off of an app that can be easily accessible any time and anywhere. I am also a part of a health-span server consisting of some amazing and educated individuals that provide information on stem cell research and much more. Feel free to private message me on here or like this post if you would rather me private message you with all of that information.
Take care.
Tano....is micro needling the same as a derma pen? Wonder how the results would be when retin a is used on the face after the procedure. Now as i am getting older....waited years and spent thousands on treatment that didn't work...don't know if i would waste the money even if they came up with scarless healing. My derm told me when i was using a skin bio product to tighten my skin the scars....he didn't know what i was using on my skin but it made my scars much better but it is in appearance only. I hope they find scarless healing but i wouldn't hold my breathe on it as this thread is already 10 years old.
Tano, please don't withhold stuff from this board because of my comments. Certainly, I was mistaken claiming SkinTE is just another Recell. I'll refrain from voicing my skepticism so aggressively on the forum and wait for the science to demonstrate itself. Thanks again for sharing things so openly on this forum and your work.
7 hours ago, Rez77 said:Tano, please don't withhold stuff from this board because of my comments. Certainly, I was mistaken claiming SkinTE is just another Recell. I'll refrain from voicing my skepticism so aggressively on the forum and wait for the science to demonstrate itself. Thanks again for sharing things so openly on this forum and your work.
You have already promised this several times before.. I understand Tano 100%, and have stated many times that people with your attitude ruin this message board with their false statements.