Acne.org Products
4 hours ago, CoconutRough said:thanks for some very interesting insights.
my prognosis: in 2027 acne scarring will still be treated with lasers, fillers and all that inadequate stuff that is known by today. and this thread will still be there and ppl there will see the next big thing coming..it's only human to react in that way: the miracle has to be at hand.. within reach. then we can believe in it. bc we want to believe in it.
serious, fat deficient acne scarring is not curable with current or proposed methods. learning to accept ourrselves with flaws, that's the real challenge we must go through.
don't let it fck u up.
It's so depressing when someone expresses doubts like this. Of courrse I want to believe the Skin TE scientists and not the doubt or skepticism. But at the same time its this kind of skepticism that governs a proper scientific method. Explaining how SkinTE works is not the same as demonstrating it does. And we need that demonstration soon in humans. I'm going to choose to live with hope that Skin TE will show us such a demonstration within the next 2 years.
1 hour ago, Rez77 said:It's so depressing when someone expresses doubts like this. Of courrse I want to believe the Skin TE scientists and not the doubt or skepticism. But at the same time its this kind of skepticism that governs a proper scientific method. Explaining how SkinTE works is not the same as demonstrating it does. And we need that demonstration soon in humans. I'm going to choose to live with hope that Skin TE will show us such a demonstration within the next 2 years.
Yes, and therefore it should not be posted here. Because they have absolutely NO EVIDENCE - it is just their emotional feeling. And this will keep going forever. Now and then a new person shows up and pretends to now how the future will be. Like this coconut guy, whoever he/she is. They should be removed from this thread.
My advice is to always have a 'B plan', and do not expect a 100% , but I am very optimistic. Maybe we are seeing something that can change the world. At this point we should just learn more about SkinTE and always look for other options like Sunogel ..... (I watch the forum for two years, I do not participate because my English is very bad use googleo translator, sorry 
)
3 hours ago, rudy1986 said:Why are you attacking people like that? You have problem with discussion here? You are newbie here...
The definition of discussion:
These people have absolutely no intention of that. They use this thread to express their emotional stress on others. Nothing more, nothing less.
48 minutes ago, Frasier said:The definition of discussion:the action or process of talking about something in order to reach a decision or to exchange ideas.
These people have absolutely no intention of that. They use this thread to express their emotional stress on others. Nothing more, nothing less.
You must've been wrong on me...
i didnt meant it was you Frasier
What we can confirm from the interview is that SkinTE is released in select burn centers already. So this is being utilized right now. Their human trials are being conducted simultaneously with their product's release instead of being conducted first before a release.
This could be used for scars as it stands now but it is going to be a bit extreme for areas like the face. However, Dr. Swanson did say that if the provider and patient both agreed that it could provide great results, then it could technically be used for smaller skin defects. I wouldn't jump right into it though and would instead wait to see some actual human results before deciding on this. For big surgical scars this can be used as it stands, for smaller scars like acne scars it may be possible too but like he said, they're developing a specific treatment for thoseso that it's not so invasive and extreme.
It's a great advancement, but as for improvement, I would really like to see them do this without trading one scar for another. He didn't want to admit it to me, but he knew it's basically trading one scar for another because the skin biopsy will be sutured and it will end up healing to form a scar. The good news is that you can choose where you will have that scar whether under your armpit or your back or behind a thigh. The other good news is that if you go to a surgeon who is experienced with Z-plasty and/or W-plasty closures then that scar from the biopsy will be almost invisible or at least less distinguishable than a normal scar. Look up some of those closures if you all have time because there's some pretty good results out there.
Is this fully scarless healing? Absolutely not.
is it an advancement from any current treatments we have? I would say it's 2 steps above if those results in humans come out as expected.
Knowing they're working to improve upon this for smaller defects is already good enough for me. Now to await results.
1 hour ago, Tano1 said:What we can confirm from the interview is that SkinTE is released in select burn centers already. So this is being utilized right now. Their human trials are being conducted simultaneously with their product's release instead of being conducted first before a release.
This could be used for scars as it stands now but it is going to be a bit extreme for areas like the face. However, Dr. Swanson did say that if the provider and patient both agreed that it could provide great results, then it could technically be used for smaller skin defects. I wouldn't jump right into it though and would instead wait to see some actual human results before deciding on this. For big surgical scars this can be used as it stands, for smaller scars like acne scars it may be possible too but like he said, they're developing a specific treatment for thoseso that it's not so invasive and extreme.
It's a great advancement, but as for improvement, I would really like to see them do this without trading one scar for another. He didn't want to admit it to me, but he knew it's basically trading one scar for another because the skin biopsy will be sutured and it will end up healing to form a scar. The good news is that you can choose where you will have that scar whether under your armpit or your back or behind a thigh. The other good news is that if you go to a surgeon who is experienced with Z-plasty and/or W-plasty closures then that scar from the biopsy will be almost invisible or at least less distinguishable than a normal scar. Look up some of those closures if you all have time because there's some pretty good results out there.
Is this fully scarless healing? Absolutely not.
is it an advancement from any current treatments we have? I would say it's 2 steps above if those results in humans come out as expected.Knowing they're working to improve upon this for smaller defects is already good enough for me. Now to await results.
I don't see the biopsy being a big deal. Who cares about a small piece of skin being taken from their armpit? lol
I wouldn't care about the 'margin' or the scar from the biopsy, since the margin is only visible under a microscope, allegedly. I don't look at my face with a microscope. What can only be seen under the microscope is cosmetically irrelevant - there are a ton of irregularities in the skin outside of acne scarring that are invisible without extreme magnification. If they can really produce so much skin for a couple square centimeters, unless you have visible scars all over your body, the biopsy scar wouldn't be a big deal cosmetically, especially if they can take the skin from any area of the body.
If this technology works as they hope it would, effectively the treated scars will be invisible. The issue of whether it's true scarless healing or not becomes more of an academic question, which is beyond what most of us are concerned with.
Would the new skin conform to the contours of the bones - that is, would it look natural, not just in terms of the skin's structure under the microscope, but also in terms of how it shapes the facewhen seen with the naked eye? I also wonder if the new skin will be similar to the skin before scarring, or if the new skin will make new interpretations of how it would look. For example, if someone had cheeks that were significantly fatterthan other ares(like skinny people with round cheeks) before being scarred, would the new skin have a similar composition as the skin before being scarred, or would it becomposed similar to the surrounding areas and create skin that conforms to the 'norm,' with less fat than the original skin?
Also, perhaps this is implied by the information already provided, but I don't have a medical background - could the technology be used for anti-aging purposes, where wrinkled skin is replaced with newskin with fat layers as thick as the skin before being damaged, and therefore with less or no wrinkling?
one thing I'll say is I don't think the initial SkinTE makes sense for acne scars. You're not going to get an excision of a full skin thickness on your cheek. I mean that's pretty extreme and then have a skin paste applied. I bet some of their more second tier derivative products will make sense for cosmetic use. I dunno, just guessing. Still positive.
3 hours ago, JohnRottenSkin said:6 hours ago, RickeyDog1989 said:Would the new skin conform to the contours of the bones - that is, would it look natural, not just in terms of the skin's structure under the microscope, but also in terms of how it shapes the facewhen seen with the naked eye? I also wonder if the new skin will be similar to the skin before scarring, or if the new skin will make new interpretations of how it would look. For example, if someone had cheeks that were significantly fatterthan other ares(like skinny people with round cheeks) before being scarred, would the new skin have a similar composition as the skin before being scarred, or would it becomposed similar to the surrounding areas and create skin that conforms to the 'norm,' with less fat than the original skin?
that is the main question everybody forgot to ask
We didnt because he said seamless...
9 hours ago, ermete55 said:when you said it's not fully scarless healing you mean that because of the biopsy scar or for the margin?
Both. The biopsy is a definite scar especially because they'll be taking full thickness skin which means they'll utilize at least down to the dermal part as well and that inevitably causes a scar at least for now anyway. The margin is the end result of the SkinTE application. It's said to be very very small, but it's not absolute full scarless healing because the margin is considered an abnormality in the skin. Your natural skin, when never injured, does not contain a margin so it's not completely scarless, but it is probably the closest and most impressive thing to scarless that we've ever had.
The term "margin" is used correctly and strategically here as it is basically less scarier than using the term "scar" because well, nobody in the skin market wants to hear the word scar for obvious reasons. It is essentially a scar, but of a tiny proportion so "margin" can be used as an appropriate name to refer to a tiny scar.
10 hours ago, mjg713 said:I don't see the biopsy being a big deal. Who cares about a small piece of skin being taken from their armpit? lol
To me it's not. The area being treated is what matters the most. That still is something that could be improved though and people will still try to achieve full scarless healing. Some researchers are actually trying to accomplish this with methods such as: Bioprinting, Multipotent cells and wounding.
For some it will still be a big deal, but I do know that it wouldn't matter because everyone can easily weigh out what they think would be the best solution if it means they can change a scar's location and switch out a bigger skin defect for a smaller one. Even with this advancement they've made, something better than this will still come out eventually whether from PolarityTE themselves or from others because it's already in the works.
1 hour ago, Tano1 said:Both. The biopsy is a definite scar especially because they'll be taking full thickness skin which means they'll utilize at least down to the dermal part as well and that inevitably causes a scar at least for now anyway. The margin is the end result of the SkinTE application. It's said to be very very small, but it's not absolute full scarless healing because the margin is considered an abnormality in the skin. Your natural skin, when never injured, does not contain a margin so it's not completely scarless, but it is probably the closest and most impressive thing to scarless that we've ever had.The term "margin" is used correctly and strategically here as it is basically less scarier than using the term "scar" because well, nobody in the skin market wants to hear the word scar for obvious reasons. It is essentially a scar, but of a tiny proportion so "margin" can be used as an appropriate name to refer to a tiny scar.
If they could take certain square cm as sample to generate pastelike substance to our scar, then the same pastelike could be applied to where the sample was taken
13 hours ago, Tano1 said:What we can confirm from the interview is that SkinTE is released in select burn centers already. So this is being utilized right now. Their human trials are being conducted simultaneously with their product's release instead of being conducted first before a release.
This could be used for scars as it stands now but it is going to be a bit extreme for areas like the face. However, Dr. Swanson did say that if the provider and patient both agreed that it could provide great results, then it could technically be used for smaller skin defects. I wouldn't jump right into it though and would instead wait to see some actual human results before deciding on this. For big surgical scars this can be used as it stands, for smaller scars like acne scars it may be possible too but like he said, they're developing a specific treatment for thoseso that it's not so invasive and extreme.
It's a great advancement, but as for improvement, I would really like to see them do this without trading one scar for another. He didn't want to admit it to me, but he knew it's basically trading one scar for another because the skin biopsy will be sutured and it will end up healing to form a scar. The good news is that you can choose where you will have that scar whether under your armpit or your back or behind a thigh. The other good news is that if you go to a surgeon who is experienced with Z-plasty and/or W-plasty closures then that scar from the biopsy will be almost invisible or at least less distinguishable than a normal scar. Look up some of those closures if you all have time because there's some pretty good results out there.
Is this fully scarless healing? Absolutely not.
is it an advancement from any current treatments we have? I would say it's 2 steps above if those results in humans come out as expected.Knowing they're working to improve upon this for smaller defects is already good enough for me. Now to await results.
U said the biopsy will end as a scar u can treat the biopsy scar with skinTE so the biopsy scar will not exist what do you mean it is not scarless healing no it is scarless healing the margins is not a scar it's just a line between a regerated skin and the native skin and u can't even look it with naked eye so where is the problem ?
55 minutes ago, damnBOY said:14 hours ago, Tano1 said:What we can confirm from the interview is that SkinTE is released in select burn centers already. So this is being utilized right now. Their human trials are being conducted simultaneously with their product's release instead of being conducted first before a release.
This could be used for scars as it stands now but it is going to be a bit extreme for areas like the face. However, Dr. Swanson did say that if the provider and patient both agreed that it could provide great results, then it could technically be used for smaller skin defects. I wouldn't jump right into it though and would instead wait to see some actual human results before deciding on this. For big surgical scars this can be used as it stands, for smaller scars like acne scars it may be possible too but like he said, they're developing a specific treatment for thoseso that it's not so invasive and extreme.
It's a great advancement, but as for improvement, I would really like to see them do this without trading one scar for another. He didn't want to admit it to me, but he knew it's basically trading one scar for another because the skin biopsy will be sutured and it will end up healing to form a scar. The good news is that you can choose where you will have that scar whether under your armpit or your back or behind a thigh. The other good news is that if you go to a surgeon who is experienced with Z-plasty and/or W-plasty closures then that scar from the biopsy will be almost invisible or at least less distinguishable than a normal scar. Look up some of those closures if you all have time because there's some pretty good results out there.
Is this fully scarless healing? Absolutely not.
is it an advancement from any current treatments we have? I would say it's 2 steps above if those results in humans come out as expected.Knowing they're working to improve upon this for smaller defects is already good enough for me. Now to await results.
U said the biopsy will end as a scar u can treat the biopsy scar with skinTE so the biopsy scar will not exist what do you mean it is not scarless healing no it is scarless healing the margins is not a scar it's just a line between a regerated skin and the native skin and u can't even look it with naked eye so where is the problem ?
I agree with everything you said except the margin is bothersome
7 hours ago, rudy1986 said:If they could take certain square cm as sample to generate pastelike substance to our scar, then the same pastelike could be applied to where the sample was taken
6 hours ago, damnBOY said:U said the biopsy will end as a scar u can treat the biopsy scar with skinTE so the biopsy scar will not exist what do you mean it is not scarless healing no it is scarless healing the margins is not a scar it's just a line between a regerated skin and the native skin and u can't even look it with naked eye so where is the problem ?
I thought the same about applying SkinTE to the biopsied area as well of course assuming you re-open the area because it would take a day or two mailing the biopsy and receiving the product in return. So it would definitely have to be closed at least while you wait. That was answered in the interview though and he said it will be closed with sutures and SkinTE wouldn't be applied for reasons unknown still. Maybe it all has to be localized to one area for appropriate regeneration to occur. So no they won't treat the biopsied area with the product for reasons still unknown and you can find those answers in the interview.
The margin can be as tiny as it wants to be to where it's only detectable in microscopes, but if it's there, then that's still a skin abnormality. you don't have to call it a scar if you don't want, but skin in an uninjured and natural setting does not contain any margins. It's not 100% full regeneration, but rather fully functional regeneration. Nearly scarless healing is the most accurate term.
The margin doesn't matter to me because it's too small. What does matter to me is having correct and accurate information whether good or bad.
I don't know how to feel about PolarityTE. It's an amazing improvement, but it doesn't seem like an easy/convenient process.
1) It would take 2-3 months for the wound to heal and then the following year to finally settle into place? That's such a long period of time.
2) There is most likely a margin for humans, which isn't a big deal I guess. I just don't understand how your skin can regenerate and heal without a scar, yet the new skin isn't connecting to the old skin in one cohesive thing.
3) There will be a biopsy scar, which isn't a big deal either... but it's still not ideal. Why can't you use the same method on the biopsy scar to heal without scar?
What I do like is that you wouldn't have to excise all 3 layers of skin for it to work.
Anyway, thank you Tano for conducting the interview.
35 minutes ago, CollegeKidd said:I don't know how to feel about PolarityTE. It's an amazing improvement, but it doesn't seem like an easy/convenient process.
1) It would take 2-3 months for the wound to heal and then the following year to finally settle into place? That's such a long period of time.Th
2) There is most likely a margin for humans, which isn't a big deal I guess. I just don't understand how your skin can regenerate and heal without a scar, yet the new skin isn't connecting to the old skin in one cohesive thing.
3) There will be a biopsy scar, which isn't a big deal either... but it's still not ideal. Why can't you use the same method on the biopsy scar to heal without scar?What I do like is that you wouldn't have to excise all 3 layers of skin for it to work.
Anyway, thank you Tano for conducting the interview.
5
The biopsy scar would likely be small and on an inconspicuous part of the body.
Skin regeneration will always take that long.
Normal skinte will NOT be applied to acne scars etc...From the interview, Lough seemed to indicate that only specific scars will be treated with Skinte, but they are working on different products for scars, which includes acne scars.
Does skin regeneration really always take that long? Even on wounds that aren't full thickness? I mean, a year??
Best case scenario, if something like Sunogel works, which has healing properties in it, it might fasten the healing process. Whereas, Polarity just uses your own skin as opposed to healing, regenerative substances.
12 hours ago, CollegeKidd said:Does skin regeneration really always take that long? Even on wounds that aren't full thickness? I mean, a year??
Best case scenario, if something like Sunogel works, which has healing properties in it, it might fasten the healing process. Whereas, Polarity just uses your own skin as opposed to healing, regenerative substances.
Most of the regeneration is complete within the 1st 3 months. Yes skin regeneration and many types of healing take months. Within 2 weeks though you can see in the swine images of all that's left which is a red surface in the skin that continues to heal. This was also stated in the interview responses I posted. Around 80% of regeneration is complete within the first 3 months and then the last 20% is a slower process over the course of the remaining months leading up to a full year depending on you of course.
Sunogel would be more desirable, but it looks like they have to enter clinical trials. If they have to go through all 3 phase trials then that could take at least a couple of years based on the FDA's regulations of the criteria required for each trial; one being time. It does state that it "attenuates" scar formation which is a tricky word. That would just mean a reduction but not elimination of scarring. If they can produce a margin similar or better than PolarityTE's, then sunogel is yet a step above them.
Hopefully Trump does something about the FDA's regulations like he said he was going to do so that we can get through these processes quicker and get effective treatments out to the market.
14 hours ago, CollegeKidd said:Does skin regeneration really always take that long? Even on wounds that aren't full thickness? I mean, a year??
Best case scenario, if something like Sunogel works, which has healing properties in it, it might fasten the healing process. Whereas, Polarity just uses your own skin as opposed to healing, regenerative substances.
think the healing time is for third degree burns. For scar treatments could be way less.