Acne.org Products
5 hours ago, Rez77 said:9 hours ago, Tano1 said:Fast forward to 1:07:00 and watch just 5-10 minutes from that point. English developmental biologist and professor John Gurdon, presented findings on the potential of turning adult stem cells back into embryonic cells in 2006. Watch just that part of the video because he states "In the far distant future, I'm sure long after my time, it should in principle be possible to take a skin cell and to over-express in that cell those genes which are needed to re-program that cell back into an embryonic condition without even having to go through an egg." In 2007 just a year after, the first induced pluripotent cell (IPS cell) was created. IPS cells are capable of becoming any type of cell. Professor Gurdon thought this wasn't going to be achieved for decades and it was achieved just a year after he gave that speech. By the way, he also has a PhD.PolarityTE has a different ideology than them as well. Everyone is trying to make stuff in a dish with chemical alterations and incubating while Polarity is using all autologous tissue as well as homologous factors. They're two different methodologies.
You also don't know how much Polarity's product will cost so don't say other treatments are more affordable when Polarity has yet to hit the market or establish any pricing for their product. That's if they succeed in human trials.
Here's how this really works: No-one can predict the future.
You know what I agree with this.
I'm not trying to change your opinion by any means, it's just misleading to some if people make a claim. 34er said it's not commercializing in 2018 and who knows it might not, but their timeline was pushed up to a sooner release date than expected so they must be ahead of schedule to they may not don't know yet. The point is no claims can be made until it actually happens. Opinions, now that we're all entitled to.
One thing we do now know is that the margin is indefinitely an end result. I'm sure they used the term "margin" instead of scar because we all know that word is like a bad word in the skin market. Now to wait and see just how visible that margin is to the naked eye.
1 hour ago, rudy1986 said:I still dont get it why people are not botheted by margin..
remember guys? The margin is not a linear scar, it is a circular scar
That's interesting because I've only seen a linear scar. Can you link where you saw that? I actually think a circular scar might even be better than a linear scar. The eye can follow a line very easily and is usually why scars are so easily visible. That's why they've implemented new surgical excisions over the years like Z-Plasty and W-Plasty which can make some scars virtually undetectable due to such complex shapes that were made and then sewed up.
48 minutes ago, Tano1 said:I'm not trying to change your opinion by any means, it's just misleading to some if people make a claim. 34er said it's not commercializing in 2018 and who knows it might not, but their timeline was pushed up to a sooner release date than expected so they must be ahead of schedule to they may not don't know yet. The point is no claims can be made until it actually happens. Opinions, now that we're all entitled to.One thing we do now know is that the margin is indefinitely an end result. I'm sure they used the term "margin" instead of scar because we all know that word is like a bad word in the skin market. Now to wait and see just how visible that margin is to the naked eye. That's interesting because I've only seen a linear scar. Can you link where you saw that? I actually think a circular scar might even be better than a linear scar. The eye can follow a line very easily and is usually why scars are so easily visible. That's why they've implemented new surgical excisions over the years like Z-Plasty and W-Plasty which can make some scars virtually undetectable due to such complex shapes that were made and then sewed up.
Even if there is a margin it seems extremely unnoticeable to me. Don't forget porcine skin is much more complicated than human skin. Who knows, maybe it will be even less noticeable or not there on human skin. This really may not be something that can be seen without a magnifying glass.
On 9/17/2017 at 11:14 AM, Albaneso said:you are totally like me I have scars on face and back from severe cystic acne, like you I refused accutane(this was the biggest mistake of my life). I did not have any good doctor to tell me the consequences of these acne.Now im depressed and suicidal, I do not get out of the house I dont go in pool or beach from my scars in back. Im 21 years old and for me this condition is suicidal.
Don't regret not doing accutane! I was on accutane and it was a horrible experience for me. I broke out worse than ever and that's what 90% of my scars are from- my acne I had while on accutane. Not to mention, years later and I still sometimes break out.
47 minutes ago, mjg713 said:Even if there is a margin it seems extremely unnoticeable to me. Don't forget porcine skin is much more complicated than human skin. Who knows, maybe it will be even less noticeable or not there on human skin. This really may not be something that can be seen without a magnifying glass.
Yes it's a possibility. Don't know if you're in that private group chat with all those other people, but I put out some images and a reference link where they talk about "virtually seamless" results and how they make "scarring a thing of the past." Could just be optimistic choice of words not to discourage us too so don't pop that champagne bottle just yet. Hope they can get the human trial results published soon so we can stop holding our breath in suspense.
On 9/17/2017 at 3:08 PM, 34erer34 said:On 9/17/2017 at 10:39 AM, rudy1986 said:Lets not forget about "margin"
Are you slow? How else would they show the difference between the old and new skin?
What do you mean? Was a margin done on purpose to show the differentiation between the old and new skin? Will there not be a margin when we get to use the product?
Have human trials started yet for SkinTE? Is there any way to become part of them? I'll legit buy my ticket, pack my bags and fly to Utah without even blinking
9 hours ago, CollegeKidd said:What do you mean? Was a margin done on purpose to show the differentiation between the old and new skin? Will there not be a margin when we get to use the product?Have human trials started yet for SkinTE? Is there any way to become part of them? I'll legit buy my ticket, pack my bags and fly to Utah without even blinking
You won't be able to. They will test it at burn centers first. Then for other wounds and facial reconstruction. For people with really bad scars. Then they will try and make it available for cosmetic use.
3 hours ago, 34erer34 said:13 hours ago, CollegeKidd said:What do you mean? Was a margin done on purpose to show the differentiation between the old and new skin? Will there not be a margin when we get to use the product?Have human trials started yet for SkinTE? Is there any way to become part of them? I'll legit buy my ticket, pack my bags and fly to Utah without even blinking
You won't be able to. They will test it at burn centers first. Then for other wounds and facial reconstruction. For people with really bad scars. Then they will try and make it available for cosmetic use.
This doesn't make sense to me. It's great that they're trying to treat burn victims and I think they should keep doing that, but there's no reason why they can't simultaneously test this on other skin problems.
This is just a thought, but for the people unhappy with the margin....maybe you can use this as a bridge for "truly scarless healing". Let's say that takes another 10 years, I'm sure a little margin will be a lot better to deal with than your current scars.
SO my bro has scars too. Quite deep pitted once like a few almost 3mm wide and maybe 3 mm deep. in most lighting you can see it. I have a few that deep too. its awful. I've always thought a full cure here would need to like create new tissue in those areas. Is that how SkinTE works? Could someone explain it to me cause I still don't understand? Simply ablating that surface and then applying something won't work. You need to actually replace lost tissue. Could someone explain to me how SkinTE can do this? The ice pick scars near my temples are the same problem, a lot of lost collagen and tissue/fat from those areas. This is a serious question. Would appreciate an explanation. Thanks.
39 minutes ago, Rez77 said:Guys I'm suffering as much as you are. I want this to work. Please just answer my question to the best of your knowledge.
It's very simple, skinte cannot work with just lasering your acne scars. It will have to basically integrate with all layers of your dermis. In order to do this you will need to excise (fully cut out) the area containing your scars. This will go through all three layers of skins, similar to a third degree burn but much cleaner and uniform. However, given what we currently know there will probably be a margin where the skin was cut. We do not know yet how visible this margin is to the naked eye. I hope this info helps.
1 hour ago, mjg713 said:It's very simple, skinte cannot work with just lasering your acne scars. It will have to basically integrate with all layers of your dermis. In order to do this you will need to excise (fully cut out) the area containing your scars. This will go through all three layers of skins, similar to a third degree burn but much cleaner and uniform. However, given what we currently know there will probably be a margin where the skin was cut. We do not know yet how visible this margin is to the naked eye. I hope this info helps.
Oh man, that sounds like a scary procedure. Also it means I'd have to excise like basically 4 cm squared areas of my face? I still don't kind of understand how it will work. I mean I understand if like you need to laser very deeply and then spray RECELL (i get that technology) this I don't understand so well. Like what is it even? I don't get what it is?
On 9/17/2017 at 11:14 PM, Albaneso said:you are totally like me I have scars on face and back from severe cystic acne, like you I refused accutane(this was the biggest mistake of my life). I did not have any good doctor to tell me the consequences of these acne.Now im depressed and suicidal, I do not get out of the house I dont go in pool or beach from my scars in back. Im 21 years old and for me this condition is suicidal.
Bro, I also felt suicidal but please be strong and stay on. Especially now with so many advancements. If everything goes smoothly, we could have scarless healing very soon. You are still young at 21, you have a long way to go.
17 hours ago, rudy1986 said:Why did i say linear scar?? Simple, it is because margin is coming from excisional margin.. now that excisional wound is circular, it will generate circular marginal scar
No I don't see where you're getting circular scars from. In the images they shared on their site, the margin is linear. I see nothing about circular scarring. If you're talking about excisions, I haven't seen them mention circular excisions either.
9 hours ago, Rez77 said:SO my bro has scars too. Quite deep pitted once like a few almost 3mm wide and maybe 3 mm deep. in most lighting you can see it. I have a few that deep too. its awful. I've always thought a full cure here would need to like create new tissue in those areas. Is that how SkinTE works? Could someone explain it to me cause I still don't understand? Simply ablating that surface and then applying something won't work. You need to actually replace lost tissue. Could someone explain to me how SkinTE can do this? The ice pick scars near my temples are the same problem, a lot of lost collagen and tissue/fat from those areas. This is a serious question. Would appreciate an explanation. Thanks.
The faster they finish trials, the faster it'll be revealed to us. Their view was that a community of cells work together to achieve regeneration. They take a biopsy from a healthy and normal part of your skin and then they imprint the cells using their 3D platform technology. Those cells undergo a process called "polarization" where all 3 layers with appendages begin regenerating. It is then transplanted back to the host and they just let natural healing take its course from there. As for the details of that process well, nobody knows yet. I don't blame them for not telling us either. So many people that can try and steal their idea or compete or take part of the market.
6 minutes ago, Rez77 said:why is no one explaining to me how they think this works? when you say you excise the scar area you mean all the way down to muscle???? Like that would require INTENSIVE surgery on general anesthesia and INCREDIBLE amounts of pain. That sounds ridiculous.
The only painful part would be the pricks of the needle when they're numbing the area. Some soreness after the anesthesia wears off but that's the extent of pain. If you can't handle that then I'd hate to see you step on a lego.
34 minutes ago, Tano1 said:The faster they finish trials, the faster it'll be revealed to us. Their view was that a community of cells work together to achieve regeneration. They take a biopsy from a healthy and normal part of your skin and then they imprint the cells using their 3D platform technology. Those cells undergo a process called "polarization" where all 3 layers with appendages begin regenerating. It is then transplanted back to the host and they just let natural healing take its course from there. As for the details of that process well, nobody knows yet. I don't blame them for not telling us either. So many people that can try and steal their idea or compete or take part of the market. The only painful part would be the pricks of the needle when they're numbing the area. Some soreness after the anesthesia wears off but that's the extent of pain. If you can't handle that then I'd hate to see you step on a lego.
thanks alot this all makes better sense to me know. god i'm praying for this.
If theysuccessful tohealing a burn of the 3eme degree, it will be easier for them to solve the problem of the small margin, in the near future : maybe in 2018 or more... Once again it is necessary to wait for the tests. Maybe that margin is invisible to the naked eyeand everybody will be happy
Maybe that tea margin is there, to indicate US tea difference between tea skinte skin and tea old skin already in good one state. So to US show that there is no difference between both skins (Show where they applied skinte).It is simply has suggestion. We shall gaunt tea answer soon
24 minutes ago, slave of jesus said:If theysuccessful tohealing a burn of the 3eme degree, it will be easier for them to solve the problem of the small margin, in the near future : maybe in 2018 or more... Once again it is necessary to wait for the tests. Maybe that margin is invisible to the naked eyeand everybody will be happy
Maybe that tea margin is there, to indicate US tea difference between tea skinte skin and tea old skin already in good one state. So to US show that there is no difference between both skins (Show where they applied skinte).It is simply has suggestion. We shall gaunt tea answer soon
No the margin was revealed to us already as being an end result of regeneration. Once healing is all finished, that is the end result of regenerated skin. So the margin is definitely not an intentional divider.
16 minutes ago, arte90 said:If you are going to regenerate new skin, then of course, there will be some kind of difference visible. Your normal skinis affected by environmental factors like smoke, air pollution, what you eat (likebeta-carotenes), sun damage etc. Any "new skin" will not have undergone these external influences (yet) and will thus look different.
The regenerated skin itself is actually indistinguishable from native skin. It's the margin where the native skin and the new construct connect that doesn't fully regenerate since it's just connecting the tissue together. The images of the margins that were displayed on their site are all under magnification so the theory everyone has is that it might be invisible to the naked eye. It is definitely small though visible or not.
They take a biopsy from a healthy part of the skin and then re-administer it into the defected area which regenerates just like the skin that the cells were extracted from.
19 minutes ago, Tano1 said:No the margin was revealed to us already as being an end result of regeneration. Once healing is all finished, that is the end result of regenerated skin. So the margin is definitely not an intentional divider.
i hope thatit is invisibleto the naked eye. Should the opposite occur, hope that itfinds a solution to eliminate this margin