Acne.org Products
14 hours ago, Rez77 said:No I'm serious please just explain the mechanics of how this would work on deeply atrophic scars. Obviously you can't just burn off that 4mm deep layers of flesh and have this stuff somehow magically grow back your tissue. So I'm actually very curious.
There is no evidence it will. You all just need to be patient.
Investing in skinte and buying stock would be a smart business move for anyone who believes skinte could be huge. I suggest doing it.
Also, I would rather have my scars/skin lasered than cut out.. I would imagine you could do both? I also don't understand the margin and how/why the new skin wouldn't perfectly connect to the old skin- to me, this is a huge setback. Maybe in human skin there won't be a margin. The picture that everyone is looking at with the margin is pig skin?
2 hours ago, CollegeKidd said:Investing in skinte and buying stock would be a smart business move for anyone who believes skinte could be huge. I suggest doing it.
Also, I would rather have my scars/skin lasered than cut out.. I would imagine you could do both? I also don't understand the margin and how/why the new skin wouldn't perfectly connect to the old skin- to me, this is a huge setback. Maybe in human skin there won't be a margin. The picture that everyone is looking at with the margin is pig skin?
Yes, pictureis that of the pig. i does not understand the margin. If the marginat for cause the excision. why the margin does notthe shape of a stamp? Because polarityextract the skin under the shape of a stampit seems to me not? The margin should make all the outline of the place to whichthey have excised the skin
10 minutes ago, slave of jesus said:Yes, pictureis that of the pig. i does not understand the margin. If the marginat for cause the excision. why the margin does notthe shape of a stamp? Because polarityextract the skin under the shape of a stampit seems to me not? The margin should make all the outline of the place to whichthey have excised the skin
that, gentlemen, is why i said thay it wouldnt be a linear margin.. it would instead be a circular stamp margin
55 minutes ago, Rez77 said:I don't even give a shit about a margin. I mean ANYTHING is better than the condition I have now. If this works I can start having a life again.
I agree! But I wanted to have explanation on the margin. I remain positive, becausepolarity could certainlyeliminate the margin inadaptive their techniquefor acne scarin the near future
This is so old and I posted this years ago when I thought this would be the miracle I was looking for.
For anyone who might enjoy this bit of information or wants to do some research here you go.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4078877/
Update two years ago:
http://www.massgeneral.org/News/pressrelease.aspx?id=1974
_________________________________________________________________________
These are both within the past month:
https://mdibl.org/press-release/mdi-biological-laboratory-study-finds-immune-system-is-critical-to-regeneration/
1 hour ago, CollegeKidd said:This is so old and I posted this years ago when I thought this would be the miracle I was looking for.
For anyone who might enjoy this bit of information or do some bit of research here you go.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4078877/
Update two years ago:
http://www.massgeneral.org/News/pressrelease.aspx?id=1974_________________________________________________________________________
These are both within the past month:
https://mdibl.org/press-release/mdi-biological-laboratory-study-finds-immune-system-is-critical-to-regeneration/
Thanks for posting that stuff. I looked at a lot of the other links there as well as the military sites. I think its cool that the scientist said what we thought was 50 years away wtih regeneration may be only 10 years away. I think that's right. I actually think clinical application of this stuff will be relatively fast and we are engaging in new asymptotic curves for the development of these technologies. But there are some biological realities posing some significant challenges and those will take another 10 years to resolve. I mean even if I get this stuff done in my late 40s or 50s I still have a lot of life left. Sometimes i wonder if major progress is really being made or if its just that now people talk about this stuff alot cause of the internet. The number of times I've heard of Wake Forest and the number of advances they supposedly have with the 3D printer blah blah I looked it up and the only time a 3D printed espohageous was printed and implanted in a child it failed a few weeks later and the child died. And they haven't done a single bloody thing since then. Sometimes I look at "Futuretimeline" to see what their predictions are and they predicted stem cell regeneration of teeth by 2017 and it didn't happen nor do i think it will happen soon. I'm not trying to be negative I just need to manage my expectations. I think it's great this shit might happen in 10 years. Those of you still in your twenties. You're babies. You're lucky this stuff will be able to help you in your prime.
5 hours ago, rudy1986 said:6 hours ago, slave of jesus said:Yes, pictureis that of the pig. i does not understand the margin. If the marginat for cause the excision. why the margin does notthe shape of a stamp? Because polarityextract the skin under the shape of a stampit seems to me not? The margin should make all the outline of the place to whichthey have excised the skinthat, gentlemen, is why i said thay it wouldnt be a linear margin.. it would instead be a circular stamp margin
You realize the excision was made on a pig and for an unpredictable burn wound right?
I didn't understand where you were getting circular excisions from but I see now.
Not all burn wounds are going to look identical. If they have to do excisions then they will do them in such a manner that will give the most minimal scarring. That's common sense.
the scarring is still linear though. 4 lines come together to form the "stamp" you call it.
If it didn't need to cover such a big area then it looks like it could be just 1 linear scar. If it's small enough to be invisible then I could care less if I have 10 linear "margins"
1 hour ago, Rez77 said:Thanks for posting that stuff. I looked at a lot of the other links there as well as the military sites. I think its cool that the scientist said what we thought was 50 years away wtih regeneration may be only 10 years away. I think that's right. I actually think clinical application of this stuff will be relatively fast and we are engaging in new asymptotic curves for the development of these technologies. But there are some biological realities posing some significant challenges and those will take another 10 years to resolve. I mean even if I get this stuff done in my late 40s or 50s I still have a lot of life left. Sometimes i wonder if major progress is really being made or if its just that now people talk about this stuff alot cause of the internet. The number of times I've heard of Wake Forest and the number of advances they supposedly have with the 3D printer blah blah I looked it up and the only time a 3D printed espohageous was printed and implanted in a child it failed a few weeks later and the child died. And they haven't done a single bloody thing since then. Sometimes I look at "Futuretimeline" to see what their predictions are and they predicted stem cell regeneration of teeth by 2017 and it didn't happen nor do i think it will happen soon. I'm not trying to be negative I just need to manage my expectations. I think it's great this shit might happen in 10 years. Those of you still in your twenties. You're babies. You're lucky this stuff will be able to help you in your prime.
Well thank you for making me feel like I still have my whole life ahead of me. But I don't want to wait 10 years to be in my prime with clear skin, I want my prime to be each and every day of my life. And I know this isn't the place to post emotional things, but very simply, I'll never be happy with these insecurities on my face. And there's no way I could endure this for another 10 years. I've waited long enough. I hope I'm not naive for believing this journey of pure hell will very soon come to an end and I will finally get to live my life and do the things I've always wanted to do.
3 minutes ago, slave of jesus said:Yes well on, a big stepis realized. I am very optimistic!
Yes, this is a big step, and I am optimistic. I hope the process SkinTE is making will kick all the other scar regeneration companies into full gear. By the end of the year, I am hopeful that scarring will be a thing of the past.
You guys need to stop freaking out about the margin. They haven't even finished human trials yet and everyone is panicking. I don't understand why people keep asking the same questions over and over as if they're going to get answered the more they ask. This is the real world and instant gratification isn't compatible with every aspect of life here. First off not me nor anybody in this forum can tell you that this is or isn't going to work especially without citing sources and evidence. They don't have all the results yet for us to draw a conclusion. You have to do some research on your own and draw your own opinions, ideas, etc... don't discard something simply because you want to wait until someone has something optimistic to say. You have to think for yourself too.
The only thing everyone can have is opinions of the margin. The only fact we have about the margin as of recently is that it is an end result and not some divider to distinguish between native skin and SkinTE.
My OPINION is that if these guys are able to make the entirety of the integumentary system regenerate in skin that was completely roasted 3 layers deep, then they could possibly find a way to deal with a small margin. They might be able to expand on their tech or augment something or even just administer through a repeat injection into a margin to achieve true full regeneration. They said they wanted to branch out into cosmetic/scar revision already which means they're well aware that a noticeable margin would be undesirable.
You guys also need to take into account that they want to get this out as fast as possible to start treating (saving) these people. Burn victims DIE due to some of these wounds. They don't give a fuck about a margin if their life is on the line. Later on they might figure out how to deal with the margins once they reach the point to begin trialing for scar revisions. Though if the margins are invisible to the naked eye, I can't see why they would need to even improve it any further. We don't have pictures for humans yet either so who knows how the margin will look in humans. I'm sure at the end of the day nobody is going to complain about having some invisible margins over a bunch of craters that make us look like we were hit by a meteor shower.
2 hours ago, Tano1 said:You realize the excision was made on a pig and for an unpredictable burn wound right?I didn't understand where you were getting circular excisions from but I see now.
Not all burn wounds are going to look identical. If they have to do excisions then they will do them in such a manner that will give the most minimal scarring. That's common sense.
the scarring is still linear though. 4 lines come together to form the "stamp" you call it.
If it didn't need to cover such a big area then it looks like it could be just 1 linear scar. If it's small enough to be invisible then I could care less if I have 10 linear "margins"
1
This isn't true. They were recreating a full thickness burn. In the cases of most full thickness burns they debride all of the burned tissue. That means they remove all of the burned flesh in order to seal the wound via graft, dressing etc... They do this to stop infections etc...
5 hours ago, CollegeKidd said:I don't expect anyone to know the answer to this, but I might as well ask anyway. Would you need to remove all three layers of skin to get regeneration? Could you just remove two layers and still get regeneration?
Once the dermis is compromised epidermal regeneration isn't possible anymore.
2 hours ago, Tano1 said:You guys need to stop freaking out about the margin. They haven't even finished human trials yet and everyone is panicking. I don't understand why people keep asking the same questions over and over as if they're going to get answered the more they ask. This is the real world and instant gratification isn't compatible with every aspect of life here. First off not me nor anybody in this forum can tell you that this is or isn't going to work especially without citing sources and evidence. They don't have all the results yet for us to draw a conclusion. You have to do some research on your own and draw your own opinions, ideas, etc... don't discard something simply because you want to wait until someone has something optimistic to say. You have to think for yourself too.
The only thing everyone can have is opinions of the margin. The only fact we have about the margin as of recently is that it is an end result and not some divider to distinguish between native skin and SkinTE.
My OPINION is that if these guys are able to make the entirety of the integumentary system regenerate in skin that was completely roasted 3 layers deep, then they could possibly find a way to deal with a small margin. They might be able to expand on their tech or augment something or even just administer through a repeat injection into a margin to achieve true full regeneration. They said they wanted to branch out into cosmetic/scar revision already which means they're well aware that a noticeable margin would be undesirable.
You guys also need to take into account that they want to get this out as fast as possible to start treating (saving) these people. Burn victims DIE due to some of these wounds. They don't give a fuck about a margin if their life is on the line. Later on they might figure out how to deal with the margins once they reach the point to begin trialing for scar revisions. Though if the margins are invisible to the naked eye, I can't see why they would need to even improve it any further. We don't have pictures for humans yet either so who knows how the margin will look in humans. I'm sure at the end of the day nobody is going to complain about having some invisible margins over a bunch of craters that make us look like we were hit by a meteor shower.
I am 100 % all right! Moreover, we should speak about the margin Until the moment of the results
Great article on upcoming treatments for scars
http://www.ozy.com/fast-forward/can-sea-creature-slime-and-stem-cells-put-an-end-to-scars/80628
5 hours ago, 34erer34 said:This isn't true. They were recreating a full thickness burn. In the cases of most full thickness burns they debride all of the burned tissue. That means they remove all of the burned flesh in order to seal the wound via graft, dressing etc... They do this to stop infections etc... Once the dermis is compromised epidermal regeneration isn't possible anymore.
You're right they weren't unpredictable burn wounds; they were actually recreated and controlled. I was wrong, but more so the reason for the "stamp" margin as these guys call it. In a real world setting the burns will be unpredictable though so that's something to make note of. Still unclear if they would proceed with the same excision in the case of an unusual shaped burn.
Plus they're worried about their acne scars so they could end up doing something entirely different for those regarding excisions. If they reach that point that is.
As for epidermal regeneration not being possible anymore, cite a source or evidence for that. I haven't read that yet and don't see how I would believe you without a credible source for the claims you're making once again.
You still dont get it do you? None of you do..things needs to be done and we do it..
You , you just plan there and plan and hesitate
You pretend like you know when you don't. You wish things weren't what they are. Things don't get better because you - You want them to. Starting right now, we have to live in the real world
2 hours ago, Tano1 said:You're right they weren't unpredictable burn wounds; they were actually recreated and controlled. I was wrong, but more so the reason for the "stamp" margin as these guys call it. In a real world setting the burns will be unpredictable though so that's something to make note of. Still unclear if they would proceed with the same excision in the case of an unusual shaped burn.Plus they're worried about their acne scars so they could end up doing something entirely different for those regarding excisions. If they reach that point that is.
As for epidermal regeneration not being possible anymore, cite a source or evidence for that. I haven't read that yet and don't see how I would believe you without a credible source for the claims you're making once again.
Look up scar. The only reason you get a scar is because the dermis was damaged. That's why first degree burns don't scar. It's kind of common sense although you have two hands and can google it yourself.
33 minutes ago, rudy1986 said:You still dont get it do you? None of you do..things needs to be done and we do it..
You , you just plan there and plan and hesitate
You pretend like you know when you don't. You wish things weren't what they are. Things don't get better because you - You want them to. Starting right now, we have to live in the real world
Who are you talking to?
2 hours ago, Tano1 said:You're right they weren't unpredictable burn wounds; they were actually recreated and controlled. I was wrong, but more so the reason for the "stamp" margin as these guys call it. In a real world setting the burns will be unpredictable though so that's something to make note of. Still unclear if they would proceed with the same excision in the case of an unusual shaped burn.Plus they're worried about their acne scars so they could end up doing something entirely different for those regarding excisions. If they reach that point that is.
As for epidermal regeneration not being possible anymore, cite a source or evidence for that. I haven't read that yet and don't see how I would believe you without a credible source for the claims you're making once again.
No, they would, they always scrape.cut off the dead flesh and clean the raw tissue to kill bacteria and prevent infection. Many people used to die due to infection. This is part of the reason they graft, to prevent infection and to prevent too much water loss. There are some areas where grafting is simply too difficult initially, certain parts of the face etc... Or they simply don't have enough healthy skin to graft on. That's when things like skin substitutes come into play. They used to think that these created non functional skin and in a way they were right. In reality, they basically just provided the skin a cover and allowed better scars to heal vs the scars that would be created without the skin substitute.
Hopefully all of the SkinTE updates will influence Sunogel, John Hopkins, and other companies to target human scar treatments ASAP. Maybe even delve into a different market instead of third degree burns. (acne scarring, surgical scar, etc..)
The first person to prove scar-free healing will change the world forever. I would imagine everyone should be racing to prove it?
Regarding the margin in SKinTE- there might not even be a margin for regeneration that's not full thickness all 3 layers. If SkinTE had any sense, they would test on all different skin types at all different depths on all different skin conditions. Also, even if there was a margin in pig skin, human skin might heal without one no matter what. I would like to think a human's skin is more intelligent than that of a pig's.
24 minutes ago, CollegeKidd said:Regarding the margin in SKinTE- there might not even be a margin for regeneration that's not full thickness all 3 layers. If SkinTE had any sense, they would test on all different skin types at all different depths on all different skin conditions. Also, even if there was a margin in pig skin, human skin might heal without one no matter what. I would like to think a human's skin is more intelligent than that of a pig's.
You forget? Scarring occurs when dermal appendages are compromised
when we have acne scars, the dermal appendages are destroyed.
of course they inevitably have to excise full thickness skin, which is the same method for 3rd degree burn
11 hours ago, CollegeKidd said:Hopefully all of the SkinTE updates will influence Sunogel, John Hopkins, and other companies to target human scar treatments ASAP. Maybe even delve into a different market instead of third degree burns. (acne scarring, surgical scar, etc..)
The first person to prove scar-free healing will change the world forever. I would imagine everyone should be racing to prove it?
It's doubtful unless they have something to add that is different. SkinTe will have a patent.
On 9/22/2017 at 10:44 AM, 34erer34 said:Look up scar. The only reason you get a scar is because the dermis was damaged. That's why first degree burns don't scar. It's kind of common sense although you have two hands and can google it yourself. Who are you talking to? No, they would, they always scrape.cut off the dead flesh and clean the raw tissue to kill bacteria and prevent infection. Many people used to die due to infection. This is part of the reason they graft, to prevent infection and to prevent too much water loss. There are some areas where grafting is simply too difficult initially, certain parts of the face etc... Or they simply don't have enough healthy skin to graft on. That's when things like skin substitutes come into play. They used to think that these created non functional skin and in a way they were right. In reality, they basically just provided the skin a cover and allowed better scars to heal vs the scars that would be created without the skin substitute.
Wow... We're talking about the potential near future for scarless healing and you reference me to present time scarring? You're not even on the same topic. Nobody here is talking about present time injury because it's irrelevant to the thread's subject, cause, and is considered off topic. People who discover new things and help the world progress and advance don't settle for conformity.
I don't understand what you're doing here if you think dermal damage is permanent. That means you obviously don't believe in this tech. It looks Iike you're just here to argue for reasons unknown.
So what do you believe can potentially branch out to scarless healing since this is what this thread is about? If the answer is nothing and dermal damage will always be permanent to you, then you're on the wrong thread my friend. There is always the belief that it's impossible, but that'd have to be for another thread that shares your beliefs.