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18 minutes ago, JohnRottenSkin said:By the way. I mentioned Quatar because I was in Quatar airport yesterday for 4 hours. And as member of this forum, I checked every persons face skin. I saw arabs (you know those, in all white dresses) buying gold for hundred thousands dollars (really, I saw chain for 12000 $, and they take it in so large amounts like they buying potatoes in market) and more than half of them have really severe scars and it was untreated (not untreatable, but untreated). And i saw that they really don't give a shit about it. Really. (Maybe because they have 30 wives?)
Cmon man. Nobody can. Even CEO best friend. It is huge science project. It is real work. They will not answer somebody. Wait. Just wait. Just 4 month and it will be 2018. They will release results before 2018
yeah and if something go wrong, SkinTE from loading can be ERROR.
sorryformyeng
42 minutes ago, JohnRottenSkin said:By the way. I mentioned Quatar because I was in Quatar airport yesterday for 4 hours. And as member of this forum, I checked every persons face skin. I saw arabs (you know those, in all white dresses) buying gold for hundred thousands dollars (really, I saw chain for 12000 $, and they take it in so large amounts like they buying potatoes in market) and more than half of them have really severe scars and it was untreated (not untreatable, but untreated). And i saw that they really don't give a shit about it. Really. (Maybe because they have 30 wives?)
Cmon man. Nobody can. Even CEO best friend. It is huge science project. It is real work. They will not answer somebody. Wait. Just wait. Just 4 month and it will be 2018. They will release results before 2018
without telling to people how they start human trial ?? who are going to participate in this and how ?
bro i also dont give my scars a shit but i want to tell my sad story first i got chickenpox which gave me 2 scars on my nose and i fell it annoying but i ignored then i got two moles on nose i tried to remove my mole with a razer and endedup cutting large part of skin which now became a hypertrophic scar with a mole under it....after this i got A diseasecalled AMVC which gave me indented lines on my face ...u can google about it and now some acne which giving me some scars and now also 2 large moles on my cheek thats why i am waiting for SkinTe
1 hour ago, Anish004 said:without telling to people how they start human trial ?? who are going to participate in this and how ?bro i also dont give my scars a shit but i want to tell my sad story first i got chickenpox which gave me 2 scars on my nose and i fell it annoying but i ignored then i got two moles on nose i tried to remove my mole with a razer and endedup cutting large part of skin which now became a hypertrophic scar with a mole under it....after this i got A diseasecalled AMVC which gave me indented lines on my face ...u can google about it and now some acne which giving me some scars and now also 2 large moles on my cheek thats why i am waiting for SkinTe
They don't need to tell since they are conducting the trial on real burn patients!
1 hour ago, SunnyX said:3 hours ago, Anish004 said:without telling to people how they start human trial ?? who are going to participate in this and how ?bro i also dont give my scars a shit but i want to tell my sad story first i got chickenpox which gave me 2 scars on my nose and i fell it annoying but i ignored then i got two moles on nose i tried to remove my mole with a razer and endedup cutting large part of skin which now became a hypertrophic scar with a mole under it....after this i got A diseasecalled AMVC which gave me indented lines on my face ...u can google about it and now some acne which giving me some scars and now also 2 large moles on my cheek thats why i am waiting for SkinTe
They don't need to tell since they are conducting the trial on real burn patients!
bro any hope to this
47 minutes ago, Anish004 said:bro any hope to this
Please also do ur own research!!! Anyway no that will not work because -
a- it's a skin graft
b- they are culturing fibroblast etc
c - the Main cells for regeneration are missing
there is also Euroskingraft doing the same but none of them had results like polarity.
its definetly a better approach then most of the other available skin grafts but it does not regenerate complete skin as does polarity. Polarityte skinte is not a skin graft grown in lab, it extracts the cells within healthy skin that are needed for regeneration and they are expanded and the final product is more like a paste. You would know that if you would do more research on you own.
4 hours ago, Anish004 said:without telling to people how they start human trial ?? who are going to participate in this and how ?bro i also dont give my scars a shit but i want to tell my sad story first i got chickenpox which gave me 2 scars on my nose and i fell it annoying but i ignored then i got two moles on nose i tried to remove my mole with a razer and endedup cutting large part of skin which now became a hypertrophic scar with a mole under it....after this i got A diseasecalled AMVC which gave me indented lines on my face ...u can google about it and now some acne which giving me some scars and now also 2 large moles on my cheek thats why i am waiting for SkinTe
We have said several times who will participate in the trials. Go back several pages on this thread and start reading. Nobody is going to do it for you.
Why are you still mentioning all of these other things when I already told you nothing will remove a scar right now? Stop being impatient and accept that. If they had something to remove all of that it would make national news and there would be commercials and ads on the internet etc... Look at Proactiv it was everywhere until ppl realized they couldn't fix the permanent damage with it. When something comes out that works the world will know about it and people will all talk about it.
We aren't here to tell our stories so that people can tell us how to fix our scars. We're here to discuss scarless healing which could be a reality soon. Go to another thread to tell your story if you need to or start reading the information that is provided to you for free from members who research.
Any guesses for why SkinTE might propagate into old scar tissue that wasn't directly treated and cause regeneration? It seems to me that the idea behind the technology is to excise scarred areas and plug in a better-structured replacement, which would then be 'powered up' by the body, and thus become healthy skin. If this caused propagation of healthy tissue into scarred tissue, shouldn't our existing healthy skin do the same thing to scar tissue already? What's the difference between the SkinTE construct and the healthy parts of our existing skin such that the former causes propagation while the latter doesn't? Correct me if I'm wrong in my assumptions - I'm not familiar with cell biology.
28 minutes ago, RickeyDog1989 said:Any guesses for why SkinTE might propagate into old scar tissue that wasn't directly treated and cause regeneration? It seems to me that the idea behind the technology is to excise scarred areas and plug in a better-structured replacement, which would then be 'powered up' by the body, and thus become healthy skin. If this caused propagation of healthy tissue into scarred tissue, shouldn't our existing healthy skin do the same thing to scar tissue already? What's the difference between the SkinTE construct and the healthy parts of our existing skin such that the former causes propagation while the latter doesn't? Correct me if I'm wrong in my assumptions - I'm not familiar with cell biology.
Look at your skin, it gets regenerated everyday, month even your hair grows, falls out and gets regenerated. While your skin regenerates it only created the same skin that was in place and not a new arm or leg is grown out! This is because the existing cells tell the new cells what they have to become and only that is formed. Even scar tissue is regenerated but with the same cells. Now if you add the missing cells the communication can take place and it will regenerate, this is why it can propogate into old scar tissue. Therefore excision will not be required, the cells have only be brought down deep the dermis, that can be done by grafting/transplanting through injections or by micro channels created by lasers / microneedling. However a biopsy will be required to extract and expand the cells. Skinte is more like a paste! All this I and others had posted earlier in the thread, pls read them first.
41 minutes ago, SunnyX said:1 hour ago, RickeyDog1989 said:Any guesses for why SkinTE might propagate into old scar tissue that wasn't directly treated and cause regeneration? It seems to me that the idea behind the technology is to excise scarred areas and plug in a better-structured replacement, which would then be 'powered up' by the body, and thus become healthy skin. If this caused propagation of healthy tissue into scarred tissue, shouldn't our existing healthy skin do the same thing to scar tissue already? What's the difference between the SkinTE construct and the healthy parts of our existing skin such that the former causes propagation while the latter doesn't? Correct me if I'm wrong in my assumptions - I'm not familiar with cell biology.
Look at your skin, it gets regenerated everyday, month even your hair grows, falls out and gets regenerated. While your skin regenerates it only created the same skin that was in place and not a new arm or leg is grown out! This is because the existing cells tell the new cells what they have to become and only that is formed. Even scar tissue is regenerated but with the same cells. Now if you add the missing cells the communication can take place and it will regenerate, this is why it can propogate into old scar tissue. Therefore excision will not be required, the cells have only be brought down deep the dermis, that can be done by grafting/transplanting through injections or by micro channels created by lasers / microneedling. However a biopsy will be required to extract and expand the cells. Skinte is more like a paste! All this I and others had posted earlier in the thread, pls read them first.
Do you think there is a margin after the skin is regenerated or no?
3 hours ago, RickeyDog1989 said:Any guesses for why SkinTE might propagate into old scar tissue that wasn't directly treated and cause regeneration? It seems to me that the idea behind the technology is to excise scarred areas and plug in a better-structured replacement, which would then be 'powered up' by the body, and thus become healthy skin. If this caused propagation of healthy tissue into scarred tissue, shouldn't our existing healthy skin do the same thing to scar tissue already? What's the difference between the SkinTE construct and the healthy parts of our existing skin such that the former causes propagation while the latter doesn't? Correct me if I'm wrong in my assumptions - I'm not familiar with cell biology.
The human body is designed to heal as fast as possible. Evolutionary biologists think this is because we used to be hunter/gatherers and that we became prone to cancer as mammals. Stem cells almost always run the risk of developing into cancer which is why scientists are very careful as to what type of stem cells they use for various therapies. The human body can regenerate the epidermis HOWEVER once the dermis is destroyed your body simply heals via fibrosis. This is true of some organs as well, open heart surgery in part is dangerous because of the troublesome scar tissue that forms. SkinTe takes provides the body with the tools necessary to regenerate the dermis which results in fully formed skin with appednages found in the dermis. i.e. Melanocytes, langhern's cells, hair follicles, sweat glands etc... What is the actual science? Nobody here is even remotely qualified to understand or tell you how it works. You can google the patent but good luck understanding any of it. But to answer your question the body doesn't have the means to regenerate skin on its own when the wound is bad enough.
3 hours ago, CollegeKidd said:So right now everyone's best bet is SkinTE? Correct? And that is being geared toward burn scars initially? And there are trials being conducted as we speak?
Yes are best bet for the near future is SkinTE
It's going for burn wounds then if successful will be expanding to cosmetic/scar revisions for everyone else as well as hair regeneration. They have other projects as well so they are pushing for a bigger goal and they only see scars as a mere stepping stone. These guys dream big.
Trials have either just started or will be starting any day now. We don't have information yet so we have to wait until they post the results.
10 hours ago, SunnyX said:Look at your skin, it gets regenerated everyday, month even your hair grows, falls out and gets regenerated. While your skin regenerates it only created the same skin that was in place and not a new arm or leg is grown out! This is because the existing cells tell the new cells what they have to become and only that is formed. Even scar tissue is regenerated but with the same cells. Now if you add the missing cells the communication can take place and it will regenerate, this is why it can propogate into old scar tissue. Therefore excision will not be required, the cells have only be brought down deep the dermis, that can be done by grafting/transplanting through injections or by micro channels created by lasers / microneedling. However a biopsy will be required to extract and expand the cells. Skinte is more like a paste! All this I and others had posted earlier in the thread, pls read them first.
I did read through the thread before posting. Transplanting through injections seems to be a hypothetical approach. The only real evidence we have involves an excision of the area. I merely posited the most concrete example to form the question.
Anyway this is beside the point. My question was: why would SkinTE cause regeneration of nearby cells and not just be limited to itself? What you said is more or less what the MedCity article said but the mechanism through which old scars that are merely near the 'paste' are improved isn't quite clear. Are there examples of this mechanism being exercised in nature? Since SkinTE allegedly takes a top-down approach, harnessing biological features found in nature instead of trying to cheat it, surely an example of this mechanism is available in nature. I'm not trying to throw shade at the company. Just trying to get my head around the technology out of interest.
1 hour ago, RickeyDog1989 said:I did read through the thread before posting. Transplanting through injections seems to be a hypothetical approach. The only real evidence we have involves an excision of the area. I merely posited the most concrete example to form the question.Anyway this is beside the point. My question was: why would SkinTE cause regeneration of nearby cells and not just be limited to itself? What you said is more or less what the MedCity article said but the mechanism through which old scars that are merely near the 'paste' are improved isn't quite clear. Are there examples of this mechanism being exercised in nature? Since SkinTE allegedly takes a top-down approach, harnessing biological features found in nature instead of trying to cheat it, surely an example of this mechanism is available in nature. I'm not trying to throw shade at the company. Just trying to get my head around the technology out of interest.
http://onlinelibrary.wiley.com/doi/10.1111/exd.13246/full
read this it's the same process observered in nature! Since polarity uses LGR enhanced cells. Well anything at this stage is hypothetical but based on current techniques and what other groups are doing and based on their statement -listen to their Telefon conference you will get infos.
http://news.doccheck.com/en/5846/wound-healing-a-flawless-future/
http://www.follicabio.com/ why I posted this is because they use also micro injury to induce follicle regeneration! Basically it's all about Wnt / FGF9 / LGR etc.
Anyways this is my last post. If I get something new to share I will inform you guys. Wish you all, all the best and a wonderful time ahead and pls do not drag yourself down - world is beautiful and be happy that you are healthy and not blind or sitting in wheelchair.
Bye bye
Sunny
2 hours ago, SunnyX said:http://onlinelibrary.wiley.com/doi/10.1111/exd.13246/fullread this it's the same process observered in nature! Since polarity uses LGR enhanced cells. Well anything at this stage is hypothetical but based on current techniques and what other groups are doing and based on their statement -listen to their Telefon conference you will get infos.
http://news.doccheck.com/en/5846/wound-healing-a-flawless-future/
http://www.follicabio.com/ why I posted this is because they use also micro injury to induce follicle regeneration! Basically it's all about Wnt / FGF9 / LGR etc.
Anyways this is my last post. If I get something new to share I will inform you guys. Wish you all, all the best and a wonderful time ahead and pls do not drag yourself down - world is beautiful and be happy that you are healthy and not blind or sitting in wheelchair.
Bye bye
Sunny
dont leave bro keep checking this thread
15 hours ago, RickeyDog1989 said:I did read through the thread before posting. Transplanting through injections seems to be a hypothetical approach. The only real evidence we have involves an excision of the area. I merely posited the most concrete example to form the question.Anyway this is beside the point. My question was: why would SkinTE cause regeneration of nearby cells and not just be limited to itself? What you said is more or less what the MedCity article said but the mechanism through which old scars that are merely near the 'paste' are improved isn't quite clear. Are there examples of this mechanism being exercised in nature? Since SkinTE allegedly takes a top-down approach, harnessing biological features found in nature instead of trying to cheat it, surely an example of this mechanism is available in nature. I'm not trying to throw shade at the company. Just trying to get my head around the technology out of interest.
I imagine it is somewhat similar to recell in that it allows the wound to heal from the edges. Scars usually heal from the middle, which causes the skin to pucker. By putting correct cell types in areas they otherwise wouldn't be you allow the skin to heal from multiple places.
This is a response to mjg713 because it won't let me reply to your comment.
The truth is not Sunny nor anyone in here except for PolarityTE can answer that.
The margin in that image on their site could be the end result after regeneration or it could've been made by them. What we CAN analyze from that image is that it is under magnification. How zoomed it is; that we don't know either, but it is somewhat close we can conclude.
I'm going to give you my personal perspective.I want you to do a quick experiment. I want you to expose your entire shoulder so that you can see it so it might require you to take your shirt off. Next, put it under any light whether it's from the sun or your house just as long as you can see it clearly. Now look closely at it and you should see multiple little lines intersecting each other forming shapes; It is similar to a basket weave pattern. If you can't quite make them out then put 2 fingers together and push the skin around on your shoulder lightly and they should become more visible.
Now go back to that image on PolarityTE's site and look at that image with the margin again. Do you see the hair follicles in the image below? Well look close and you can tell that the margin is slightly thinner than the follicles. The margin also has a resembling skin tone to the basket weave pattern we have as well. The lines are a little shaded in our pattern and it looks about the same in the margin. That is my perspective of the margin.
The only sure fire way to know if that is an end result or an intentionally made mark to distinguish both skin areas is by seeing the results when they're available.
It's interesting to see that by the margin image they put "Full Defect Epithelialization and Scarless Healing." I wonder how they think those terms are being defined as.
14 minutes ago, Tano1 said:This is a response to mjg713 because it won't let me reply to your comment.
The truth is not Sunny nor anyone in here except for PolarityTE can answer that.
The margin in that image on their site could be the end result after regeneration or it could've been made by them. What we CAN analyze from that image is that it is under magnification. How zoomed it is; that we don't know either, but it is somewhat close we can conclude.
I'm going to give you my personal perspective.I want you to do a quick experiment. I want you to expose your entire shoulder so that you can see it so it might require you to take your shirt off. Next, put it under any light whether it's from the sun or your house just as long as you can see it clearly. Now look closely at it and you should see multiple little lines intersecting each other forming shapes; It is similar to a basket weave pattern. If you can't quite make them out then put 2 fingers together and push the skin around on your shoulder lightly and they should become more visible.
Now go back to that image on PolarityTE's site and look at that image with the margin again. Do you see the hair follicles in the image below? Well look close and you can tell that the margin is slightly thinner than the follicles. The margin also has a resembling skin tone to the basket weave pattern we have as well. The lines are a little shaded in our pattern and it looks about the same in the margin. That is my perspective of the margin.
The only sure fire way to know if that is an end result or an intentionally made mark to distinguish both skin areas is by seeing the results when they're available.
It's interesting to see that by the margin image they put "Full Defect Epithelialization and Scarless Healing." I wonder how they think those terms are being defined as.
What