Acne.org Products
1 minute ago, damnBOY said:http://ammrf.org.au/news-and-media/innovation-in-action/fast-tracking-elastin-to-market/
Prof. Tony Weiss from the University of Sydney in conjunction with Elastagen Pty Ltd has been awarded a $1million Translation Award from the Wellcome Trust to fast track their elastin-based synthetic skin to clinical trials. They will refine and optimise its physical and biological properties so this innovative material can be tested for its safety and efficacy in repairing full thickness skin wounds. They aim to use the mesh to help wounds like those that arise from injury, surgery or disease heal faster and without scarring.Elastin is the bodys naturally occurring elastic protein and Prof. Weiss and his research group have depended on confocal and scanning electron microscopy in the AMMRF at the University of Sydney to develop and improve their elastin products. Its from 2015 but they already do clinical trials.....
what you want to say bro
i want to say that tropoelastin may contributes to scarless healing they are going to finish clinical trials with strech marks and acne scars and if it really Works and erase atrophic scars it will beon the Market soon so if anyone has atrophic scars tropoelastin may solve him problems. I dont say that skinTE will not work .... but for aesthetic applications it may be too far away....
24 minutes ago, damnBOY said:i want to say that tropoelastin may contributes to scarless healing they are going to finish clinical trials with strech marks and acne scars and if it really Works and erase atrophic scars it will beon the Market soon so if anyone has atrophic scars tropoelastin may solve him problems. I dont say that skinTE will not work .... but for aesthetic applications it may be too far away....
can a normal scar not ateophic scar just a flat scar tissue from any accident can removed by tropoelastin
1 minute ago, Anish004 said:26 minutes ago, damnBOY said:i want to say that tropoelastin may contributes to scarless healing they are going to finish clinical trials with strech marks and acne scars and if it really Works and erase atrophic scars it will beon the Market soon so if anyone has atrophic scars tropoelastin may solve him problems. I dont say that skinTE will not work .... but for aesthetic applications it may be too far away....
can a normal scar not ateophic scar just a flat scar tissue from any accident can removed by tropoelastin
they do clinical trials for atrophic scars now......
4 hours ago, Anish004 said:which scar you are seeing i am talking about that on up my nose below my eyebrow
Lol, you have smooth ass skin and are worried about a tiny dimple? As someone who has burns albeit small burn scars I have to laugh. Your best bet is just gaining some self confidence my friend. I guarantee nobody but you sees your extremely small scars.
22 minutes ago, Anish004 said:47 minutes ago, damnBOY said:i want to say that tropoelastin may contributes to scarless healing they are going to finish clinical trials with strech marks and acne scars and if it really Works and erase atrophic scars it will be on the Market soon so if anyone has atrophic scars tropoelastin may solve him problems. I dont say that skinTE will not work .... but for aesthetic applications it may be too far away....
can a normal scar not ateophic scar just a flat scar tissue from any accident can removed by tropoelastin
This is what I've wondered. I know Fiona Wood work with these people so maybe they'll use it in combination with recell. Her lab has a ton of stuff on scars and burns. Nanochemistry etc... Would be interested in seeing what she thinks of SkinTe.
4 minutes ago, 34erer34 said:Lol, you have smooth ass skin and are worried about a tiny dimple? As someone who has burns albeit small burn scars I have to laugh. Your best bet is just gaining some self confidence my friend. I guarantee nobody but you sees your extremely small scars. This is what I've wondered. I know Fiona Wood work with these people so maybe they'll use it in combination with recell. Her lab has a ton of stuff on scars and burns. Nanochemistry etc... Would be interested in seeing what she thinks of SkinTe.
bro thats not only scar u seeing in pic aside those i have many AMVC scars scarred pores and moles thats why i am waiting for SkinTe
5 hours ago, AI3forever said:I can tell you that once PolarityTE has proven that it can successfully regenerate third degree wounds its wouldn't be a problem for a surgeon to cut up the skin for treatment. May I ask you,what is the dilemma here since it CAN regenerate the skin fully? You could say it is too aggressive or whatever but the end result the skin would be fully regenerated so it doesn't even matter. Like has any mother who went through C-section would say it is too aggressive (Literally cutting up the belly area) over natural birth?You are having the dilemma because you are not sure whether this product works. If you are living in the era before the Wright Brothers invented the airplane and if someone from the future told you you can travel by air on a machine that weighs tens of thousands of kg, you would also think said person is insane and no way in hell would such a thing ever exist. Too risky to ever workandthe machine would fall off the sky, no one would risk their life travelling on airwould be your initial thoughts.
Point in case, there are way more controversial surgeries being done. There are several successful face transplants, literally taking someone's else face and implanting to another person. Recently, there was even a head transplant being planned. Now slicing up some skin (That would have regenerated anyway applying PolarityTE)sounds like child's play ain't it?
You cannot just remove the facial skin like that. You run the risk of infection, fluid loss etc... There isn't a dilemma over if it works, we'll see if it does. It's called being practical, I've seen so many posts acting like surgeons will just cut off the skin and rub some stuff on it and you'll be good as new. A surgeon won't do that for acne scars unless they are horrific and causing you functional issues. Burns scars and surgical scars are a different ball game that cause the body dysfunction. Acne scars don't.
Hmm polarityte's patent says that it can be grafted, transplanted and injected! So skinte can be injected the way fat grafting or filler are transplanted. Even Elastagen wants to inject Tropoelastin. Below is a section from the PolarityTe patent in which it says so. The point is that the cells have to reach the dermis plus inflammatory reaction of wounding is required. With injecting it to achieve both, even micro needling plus skinte is a possibility. In one interview they said that skinte is like a paste. Skinte will be quickest on the market because once it shows it works, there won't be much changes required for further application. Even in the interview they are speaking about cosmetical application. I had posted the link earlier.
From the patent:
The invention relates to methods for making and methods for using constructs of micro-aggregate multicellular grafts containing isolated Leucine-rich repeat-containing G-protein coupled Receptor (LGR) expressing cells for the delivery, application, transplantation, implantation, directed seeding, directed migration, directed tracking, in setting, laminating and/or injection of the cellular element generating, regenerating, enhancing and/or healing epithelial systems, glands, hair, nerves, bone, muscle, fat, tendons, blood vessels, fascia, ocular tissues and peptide secreting cellular elements for use in wound therapy applications, tissue engineering, cell therapy applications, regenerative medicine applications, medical/therapeutic applications, tissue healing applications, immune therapy applications, and tissue transplant therapy applications.
10 hours ago, SunnyX said:Yeah sort of but it would not make any sense to remove such a small scar, because they need a sample of your skin first. For your scar I would suggest you go and see a dermatologist to get it microneeded! So it make Sense for people with large areas covered with scars such as acne / burn / surgical scars and stretchmarks.
Skinte could be injected on small scars asin ice pick scars? Skinte can regenerate completement the skin. Why we could not use him for small zones as that of anish004 ? In this case there, only those who have big scars will be favored by skinte
7 minutes ago, slave of jesus said:Skinte could be injected on small scars asin ice pick? Skinte can regenerate completement the skin. Why we could not use him for small zones as that of anish004 ? In this case there, only those who have big scars will be favored by skinte
Because the part of the skin that is responsible for scars is the dermis. You have to recreate the dermis in order to get skin regeneration. In terms of acne scarring imo, injections will work once they figure out a way to convert scar tissue into fat. That's why I don't think SkinTe is a good option for acne scars. I mean, I'm sure Polarity will work on something for acne scars, but the initial tech doesn't seem so applicable. It would work to reduce acne scars though.
1 hour ago, 34erer34 said:6 hours ago, AI3forever said:I can tell you that once PolarityTE has proven that it can successfully regenerate third degree wounds its wouldn't be a problem for a surgeon to cut up the skin for treatment. May I ask you,what is the dilemma here since it CAN regenerate the skin fully? You could say it is too aggressive or whatever but the end result the skin would be fully regenerated so it doesn't even matter. Like has any mother who went through C-section would say it is too aggressive (Literally cutting up the belly area) over natural birth?You are having the dilemma because you are not sure whether this product works. If you are living in the era before the Wright Brothers invented the airplane and if someone from the future told you you can travel by air on a machine that weighs tens of thousands of kg, you would also think said person is insane and no way in hell would such a thing ever exist. Too risky to ever workandthe machine would fall off the sky, no one would risk their life travelling on airwould be your initial thoughts.
Point in case, there are way more controversial surgeries being done. There are several successful face transplants, literally taking someone's else face and implanting to another person. Recently, there was even a head transplant being planned. Now slicing up some skin (That would have regenerated anyway applying PolarityTE)sounds like child's play ain't it?
You cannot just remove the facial skin like that. You run the risk of infection, fluid loss etc... There isn't a dilemma over if it works, we'll see if it does. It's called being practical, I've seen so many posts acting like surgeons will just cut off the skin and rub some stuff on it and you'll be good as new. A surgeon won't do that for acne scars unless they are horrific and causing you functional issues. Burns scars and surgical scars are a different ball game that cause the body dysfunction. Acne scars don't.
They will have make incisions somehow. The key to regeneration is wounding. They will have to slice up your skin to remove the cosmetic or problematic defect. They may be able to do it in a less aggressive way though.
They can use varying size punches to punch out the skin which literally just jabs into your scar/acne. and is then excised leaving a small hole. Or they can go for some dermarolling method with longer needles and then apply their product.
Either which way the skin will be penetrated and must be wounded. They would numb the area of course so I wouldn't see a problem even if they did decide to slice and dice done through a trained professional.
I guess for those worried they could always just wait for others to get the procedure done first.
11 hours ago, SunnyX said:Why can't u guys read the patent that I sent u? Anyways it says the following;
The invention relates to methods for making and methods for using constructs of micro-aggregate multicellular grafts containing isolated Leucine-rich repeat-containing G-protein coupled Receptor (LGR) expressing cells for the delivery, application, transplantation, implantation, directed seeding, directed migration, directed tracking, in setting, laminating and/or injection of the cellular element generating, regenerating, enhancing and/or healing epithelial systems, glands, hair, nerves, bone, muscle, fat, tendons, blood vessels, fascia, ocular tissues and peptide secreting cellular elements for use in wound therapy applications, tissue engineering, cell therapy applications, regenerative medicine applications, medical/therapeutic applications, tissue healing applications, immune therapy applications, and tissue transplant therapy applications.
I think with other scar types apart from burns it can be injected and the cells can be transplanted within the scar. Basically same way as fat grafting or fillers are used currently to improve appearance of scars/stretchmarks. @damnBOY@mjg713
The skin MUST be wounded. What they talk about with transplantation is their reference to the autologous cells which are acquired from our own body. They take our own cells and then transplant them into the scar/acne/skin condition only after the skin is wounded.
Anesthesia or numbing cream would be applied so people wouldn't feel a thing.
Myofibroblasts in scar tissue have to be converted into adipocytes to produce adipose fat. They do this through wounding though. If they can make it work by just microneedling then that's fantastic, but I'll still be excited if they make skin regeneration work period regardless of the method so long as it is safe and painless.
Transplanting can be done in Multiple ways. Even micro- Transplantation is done today such as micro fat grafting. There are different types of scar Keloids, hypertrophic and athropic scars. Stretch marks and acne scars often are Atrophic scar which means layers are missing. Stretchmarks are kind of a hole in the dermis which is connected by a few new collagen and elastin fibers. A micro transplanting would be enough. Even for hair regeneration this technique can be used. In terms of stretchmarks the hypodermis, epidermisis still intact only the dermis is thinned out. Anyways I spoke to a very famous surgeon about possible applications and he promised me to look into the matter
read this line:
transplantation, implantation, directed seeding, directed migration, directed tracking, in setting, laminating and/or injection
even here injection is mentioned as one form. In the patent there are more detailed applications mentioned...
57 minutes ago, slave of jesus said:Skinte could be injected on small scars asin ice pick scars? Skinte can regenerate completement the skin. Why we could not use him for small zones as that of anish004 ? In this case there, only those who have big scars will be favored by skinte
They will branch out if they're successful with burns and move into cosmetic/scar revision and even hair regeneration as stated by them.
It may also be a simpler procedure as well when it comes to wounding and regeneration for acne and anything else pertaining to the Epidermis.
Everyone will be favored by SkinTE because it's a huge market. If they can apply their method 3 layers deep in skin, then they will apply their method 1 layer deep in its epidermis because they have addressed all 3 layers with burns anyway. So technically in swine, the epidermis was already regenerated as healthy.
Don't try to over-think it too much. It will be possible to address acne and ice pick scars if they're starting off by addressing the most serious stuff regarding skin.
4 minutes ago, Tano1 said:They will branch out if they're successful with burns and move into cosmetic/scar revision and even hair regeneration as stated by them.It may also be a simpler procedure as well when it comes to wounding and regeneration for acne and anything else pertaining to the Epidermis.
Everyone will be favored by SkinTE because it's a huge market. If they can apply their method 3 layers deep in skin, then they will apply their method 1 layer deep in its epidermis because they have addressed all 3 layers with burns anyway. So technically in swine, the epidermis was already regenerated as healthy.
Don't try to over-think it too much. It will be possible to address acne and ice pick scars if they're starting off by addressing the most serious stuff regarding skin.
I agree! There are multiple ways to apply it. We should wait and see the results, once regeneration is possible surgeons will find hundreds of ways of treatment...
23 minutes ago, SunnyX said:Transplanting can be done in Multiple ways. Even micro- Transplantation is done today such as micro fat grafting. There are different types of scar Keloids, hypertrophic and athropic scars. Stretch marks and acne scars often are Atrophic scar which means layers are missing. Stretchmarks are kind of a hole in the dermis which is connected by a few new collagen and elastin fibers. A micro transplanting would be enough. Even for hair regeneration this technique can be used. In terms of stretchmarks the hypodermis, epidermisis still intact only the dermis is thinned out. Anyways I spoke to a very famous surgeon about possible applications and he promised me to look into the matter
read this line:
transplantation, implantation, directed seeding, directed migration, directed tracking, in setting, laminating and/or injection
even here injection is mentioned as one form. In the patent there are more detailed applications mentioned...
Yes I did see injection on there, but I don't see that being the case for scars. I would think since scars are filled with Myofibroblasts that they would need to be converted through wounding which is the case with SkinTE. I think what you're suggesting and correct me if I'm wrong, but just by injecting with the needle into small acne and scars would create a big enough wounding setting from the needle's penetration to provide opportunity for regeneration once the cells are injected.
I could see that being possible for acne if it's in a small area, but to address the entire face for example: might require a more aggressive approach. It would depend on how far the wound setting is able to expand. And if it's not all localized to the entire area then it would require multiple treatments where-as if you excise the area then you just have to worry about the incision line and I would see it working for acne as well. Of course I'd rather it be done your way if possible. Both methods are very real possibilities.
I am very interested in what the surgeon will have to say since a simple injection as opposed to excising would probably be more cost affordable and much less time consuming. Skin regeneration done with a simple in office injection during your lunch break sounds very appealing to me. Please fill us in on their response.
Its exciting to read about the science regarding skin regeneation. But the waiting time is also hard. Sometimes it just wonderful to dream about the day when the treatment is here - and the treatment is done. That you look in the mirror. And see a face without scars. And think that all the frustration is over. No more worries. No more reading about needling, dermabrasion, peeling.... I really do hope - and believe - that the day will come soon.
1 hour ago, Tano1 said:Yes I did see injection on there, but I don't see that being the case for scars. I would think since scars are filled with Myofibroblasts that they would need to be converted through wounding which is the case with SkinTE. I think what you're suggesting and correct me if I'm wrong, but just by injecting with the needle into small acne and scars would create a big enough wounding setting from the needle's penetration to provide opportunity for regeneration once the cells are injected.I could see that being possible for acne if it's in a small area, but to address the entire face for example: might require a more aggressive approach. It would depend on how far the wound setting is able to expand. And if it's not all localized to the entire area then it would require multiple treatments where-as if you excise the area then you just have to worry about the incision line and I would see it working for acne as well. Of course I'd rather it be done your way if possible. Both methods are very real possibilities.
I am very interested in what the surgeon will have to say since a simple injection as opposed to excising would probably be more cost affordable and much less time consuming. Skin regeneration done with a simple in office injection during your lunch break sounds very appealing to me. Please fill us in on their response.
Hey,
not all scars are filled by myofibroblast, this is the case with hypertrophic and keloid or contractual scars. Whereas athropic scars are different, they are indented, for example stretch marks, they are not full of fibrotic material which is collagen filled in by myofibroblast. Instead the dermis is lacking the other appendixes and has infact few collagen bundles of hold the skin together. This is also why stretchmarks and athropic are filled in with healthy organized collagen bundle by laser or microneedling. Basically what I wanted to say is that depending on the type of scar a different approach will be required and used. In Stretchmarks and in athropic scar it would be sufficient to inject it or by microneedling it and apply skinte. This approach is also used by Elastagen to apply Tropoelastin. In fact currently also micro fat grafting is used to inject fat within the scar tissue, to break down the collagen bundles and allow the stemcells in fat to sort of regenerate the skin to some extend. This approach will be most probably used to apply it for hair regeneration in bold men and in nerve regenerate which is the next product of polarity. Since they want to apply their approach to multiple tissues for large variety of injuries or cosmetic application, therefore multiple ways of administering will or has to be used... 3rd degree burns all layers have to be removed as done currently as well, in 2degree burns however only the epidermis has to be removed since most of the dermis is intact. So even in burns it won't be applied the same way, so why assume that it can only be applied in a single way. well it won't be done during lunch break since they need a biopsy of the size of a poststamp and that wound has to be treated. Yeah I will let you know as soon I get a feedback.
Huge technological breakthrough came out today from Ohio University. Probably the mother of all scar treatments.
http://www.genengnews.com/gen-articles/chip-reprograms-skin-into-any-cell-type/6115
18 minutes ago, Binga said:Huge technological breakthrough came out today from Ohio University. Probably the mother of all scar treatments.
http://www.genengnews.com/gen-articles/chip-reprograms-skin-into-any-cell-type/6115
this thing is totally going to fail from my view
I agree. Dont overthink too much. If SkinTE can regenerate skin - it can! If it can heal burn wounds scar free how on earth can it be a problem to heal acne scars?? Why shouldnt the doctors want to cut out acne scars if it possible to regenerate the wounds? Too aggressive you say? Well, doctors have been treating acne sufferers with too aggressive lasers for years.
I dont even care about how they will do it. If they need to cut my face, well so be it. I dont even think about going in on a lunch break to regenerate my skin - I could be hospitalized for a week after such treatment. I dont care! I only want SkinTE to work. To me it is kind of "snobby" to be asking for a lunch break treatment to get my skin regenerated.
20 minutes ago, Anish004 said:39 minutes ago, Binga said:Huge technological breakthrough came out today from Ohio University. Probably the mother of all scar treatments.
http://www.genengnews.com/gen-articles/chip-reprograms-skin-into-any-cell-type/6115
this thing is totally going to fail from my view
And your background for saying that is?
1 hour ago, Frasier said:I agree. Dont overthink too much. If SkinTE can regenerate skin - it can! If it can heal burn wounds scar free how on earth can it be a problem to heal acne scars?? Why shouldnt the doctors want to cut out acne scars if it possible to regenerate the wounds? Too aggressive you say? Well, doctors have been treating acne sufferers with too aggressive lasers for years.
I dont even care about how they will do it. If they need to cut my face, well so be it. I dont even think about going in on a lunch break to regenerate my skin - I could be hospitalized for a week after such treatment. I dont care! I only want SkinTE to work. To me it is kind of "snobby" to be asking for a lunch break treatment to get my skin regenerated.
And your background for saying that is?
bro a skin cant be healed scarless by chip...from my view anyways they researchers know better than me.