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[Sticky] Scarless Healing

 
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1
(@genetrouble)

Posted : 06/15/2017 7:56 pm

Thank you all guys for keeping this tread live, especially for the optimistick one side. Unfortunatelly, dreadful quality of medicine in my country "cure" me with 40% of acne scars in my face, chest and back and for the last 8 years i've been strugglig with it from stamping and subcision to different kind of lasers. Luckly, i have and improvement without fillers above 50-60%, but the true wish of smooth skin can't be achieved by any kind of lasers or surgical treatment, no matter how much it'll be done. From 2012 year i began to search another "futuristick" alternative of skin repair, and was inspired by iPSC dicsovered and developing by Japanese RIKEN university and, ofc, their report in april 2016 about world first full-thickness skin regrow in mice with all appendages. But from that time there were no any good news about skin, only as i know about eyes IPSC "cure" and hair regrow researching. So i was wondering to reading about Polarity from this thread and even now I can hardly believe they have made such a progress. I was sure, that only bioprinting technologyes will help to "change" skin wounds to a better looking one with a few scars. But this year is very promising, from Penn scarless healing report, SkinGun "fresh" wound healing up to 2nd degree and unbelievable reports from PolarityTE swine tests. We have a huge chance it'll be worked on humans, and i also cross my fingers for their success and believe one more time for a better solution of skin wound, mayhap not scarfree healing, but at least scarless, as it can be seen in facelift technics. If only I had a chance to participate in their trials, I would participate without any doubt and take all the risks, but I'm not from USA. At least to know that there is a treatment that could "repair" my skin will give me a new goals and beliefs :)
Btw, sorry I still have not a very good english level, and there was a broadcast from PolarityTE about ther latest swine tests, and I didn't get all the conversation, but if I'm not mistaken, they gave more information about their product, that it requires skin excision prior and then applying their product for 24 hours to regrow new, full-thickness skin? Could smb make s short summury of their broadcast, plz? Or mayhap even audioscript of that conversation? The link is:  https://78449.themediaframe.com/dataconf/productusers/cool/mediaframe/19885/indexl.html

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1
(@johannan47)

Posted : 06/16/2017 3:15 am

Dermabrasion, combined with fat grafting and mktp transplantation, might give you guys a significant better result, its been observed that stemcells in fat imroves the scars a lot ,though its a slow process, this can be followed up with microneeedling with high needle density to fasten it. more studies is going on, about the role of stemcells in fat on regenerating skin.

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5
(@davrak)

Posted : 06/16/2017 3:51 am

https://www.ncbi.nlm.nih.gov/pubmed/28618059

Cells from subcutaneous tissues contribute to scarless skin regeneration in Xenopus laevis froglets.

Abstract

BACKGROUND:

Mammals cannot regenerate the dermis and other skin structures after an injury and instead form ascar. However, a Xenopus laevis froglet can regenerate scarless skin, including the dermis and secretion glands, on the limbs and trunk after skin excision. Subcutaneous tissues in the limbs and trunk consist mostly of muscles. Although subcutaneous tissues beneath a skin injury appear disorganized, the cellular contribution of these underlying tissues to skin regeneration remains unclear.

RESULTS:

We crossed the inbred J strain with a green fluorescent protein (GFP)-labeled transgenic Xenopus line to obtain chimeric froglets that have GFP-negative skin and GFP-labeled subcutaneous tissues and are not affected by immune rejection after metamorphosis. We found that GFP-positive cells from subcutaneous tissues contributed to regenerating the skin, especially the dermis, after an excision injury. We also showed that the skin on the head, which is over bone rather than muscle, can also completely regenerate skin structures.

CONCLUSIONS:

Cells derived from subcutaneous tissues, at least in the trunk region, contribute to and may be essential for skin regeneration. Characterizing the subcutaneous tissue-derived cells that contribute to skin regeneration in amphibians may lead to the induction of cells that can regenerate complete skin structures without scarring in mammals. Developmental Dynamics, 2017. 2017 Wiley Periodicals, Inc.

2017 Wiley Periodicals, Inc.

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92
(@binga)

Posted : 06/17/2017 7:31 am

Some of the before and afters of this doctor looks seriously good.

http://www.acnespecialists.com.au/before-after/acne-free-rf-program/case-15-acne-and-acne-scars-cheeks-treated-rf

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5
(@davrak)

Posted : 06/17/2017 2:32 pm

6 hours ago, Binga said:

Watch his videos on youtube (Dr Davin Lim), those are really great and informative. There's definitely a great improvement on the post-hyperpigmentstion marks and the scars on this patient, but It's hard to tell specifically about the scars because of the red marks we see on the before picture (some scarred and created intended scars and some did not)

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24
(@nikkigirl)

Posted : 06/18/2017 5:13 pm

Frazier will be 80 years old and still following this thread for anything that works...lol!

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52
(@frasier)

Posted : 06/18/2017 5:53 pm

58 minutes ago, nikkigirl said:

Frazier will be 80 years old and still following this thread for anything that works...lol!

...writes someone that can't even spell my nickname right. Class act as usual. Grow up will you. Your contribution to this message board reflects your intelligence.

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24
(@nikkigirl)

Posted : 06/20/2017 6:56 pm

What's in a name....accept reality.......if you are a guy....just grow a beard and go on with your life. I have not seen anything in the news in the past few years that will get rid of scars. Life is going to pass you by and before you know it you will be old and still waiting for scarless healing. This thread is over 10 years old and we still are not any closer than we were 10 years ago.

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92
(@binga)

Posted : 06/22/2017 4:41 pm

Not scar related but check out the before and after of stem cell fat grafting by this doc. He is one of the guys behind Cytoris celution system.

http://www.facesplus.com/procedure/regenerative/facial-fat-grafting/#results

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0
(@Anonymous)

Posted : 06/23/2017 1:27 am

On 6/20/2017 at 7:56 PM, nikkigirl said:

What's in a name....accept reality.......if you are a guy....just grow a beard and go on with your life. I have not seen anything in the news in the past few years that will get rid of scars. Life is going to pass you by and before you know it you will be old and still waiting for scarless healing. This thread is over 10 years old and we still are not any closer than we were 10 years ago.

I'm sorry but posts like these should be written in the form of an opinion, and not a fact. If we used this board only to post information about scar-free healing we might achieve it faster. If you don't believe in the topic, why are you even posting on this thread? No offense.

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52
(@frasier)

Posted : 06/23/2017 3:28 am

On 21.6.2017 at 1:56 AM, nikkigirl said:

What's in a name....accept reality.......if you are a guy....just grow a beard and go on with your life. I have not seen anything in the news in the past few years that will get rid of scars. Life is going to pass you by and before you know it you will be old and still waiting for scarless healing. This thread is over 10 years old and we still are not any closer than we were 10 years ago.

Yes, why are you even posting?

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378
(@rez77)

Posted : 06/24/2017 9:21 pm

I'm going to become positive on all fronts but there has to be a solution in the next 4 years or my life is over. I'm giving this till 2020. Anyone here can give me the good news it will happen and be available in clinics by then? If so I love you.

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378
(@rez77)

Posted : 06/25/2017 4:18 pm

what no one? I thought we were making so much progress and every day something new and wonderful was happening?

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378
(@rez77)

Posted : 06/25/2017 5:34 pm

you know what makes me so sad. that this thread began in 2007 and is still going strong. with 0 evidence of anything on the market that can help. maybe it's just not possible?

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92
(@binga)

Posted : 06/25/2017 6:00 pm

This new korean treatment for acne scars looks amazing.
http://www.rnmeskin.net/clinic6/clinic6_09.htm?num=1

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92
(@binga)

Posted : 06/25/2017 7:04 pm

Research paper on stem cells and scars.

http://pietrogentile.it/rel_04_2016/wp-content/uploads/2016/04/09-scar.pdf

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92
(@binga)
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378
(@rez77)

Posted : 06/27/2017 10:31 pm

4 hours ago, Binga said:

I'm gonna be honest dude. No point fooling ourselves. The lighting is totally fudged in these pics and so is the cropping. I mark only maybe 20 percent improvement in most patients in these pics calibrating from the lighting effects. That's good, it's standard what is available now. There's promise, but this won't get rid of those really bad boxcar and rolling scars sorry. Next.

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47
(@damnboy)

Posted : 06/28/2017 8:03 am

does anyone know what skinTE exactly is? polarityTE saying: skinTE propagares into old scar tissue and develop full thickness skin. Are they cutting the scar tissues and put the skinTE product like skin grafts? if suppose to work like that its extreme to remove scar tissue and put skinTE product for aesthetic applications........onE photo shows that they have made an incision and then they have put the skinTE which is like a gel and then we see NEW renegenarative skin but other photos showthe progressive regeneratation in scar tissue and is like the renegerative skin replace scar tissue without the sergical remove of the old scar

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92
(@binga)

Posted : 06/28/2017 3:10 pm

8 hours ago, damnBOY said:

does anyone know what skinTE exactly is? polarityTE saying: skinTE propagares into old scar tissue and develop full thickness skin. Are they cutting the scar tissues and put the skinTE product like skin grafts? if suppose to work like that its extreme to remove scar tissue and put skinTE product for aesthetic applications........onE photo shows that they have made an incision and then they have put the skinTE which is like a gel and then we see NEW renegenarative skin but other photos showthe progressive regeneratation in scar tissue and is like the renegerative skin replace scar tissue without the sergical remove of the old scar

Not totally sure but I think they take skin stem cells from a biopsy, 3D prints it into a scaffold and places it in a wound for regeneration. Check out ACELL. They already make similar products.

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47
(@damnboy)

Posted : 06/29/2017 10:30 am

They are saying skinTE propagates into old scar tissue and develop full thickness skin. SO if this statement is not a scam they are saying that they treat scars......Look at the photo its shows how a scar tissue become full thickness skin in pigs which their  skin is similar to image.jpghumans we have a lot of chances polarityte solve our problems

In the second photo you can see how the regenerative skin is connected with the scar tissue and then in the third photo the scar tissue has disappeared so i cant understand how the treatment of scars with skinTE will be but it doesnt seem to be like skin grafting or something similar

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378
(@rez77)

Posted : 06/29/2017 4:16 pm

That looks like a piece of bacon!!! ;D;D

So when is it available? 

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36
(@mjg713)

Posted : 06/29/2017 7:29 pm

3 hours ago, Rez77 said:

That looks like a piece of bacon!!! ;D;D

So when is it available? 

The proposed timeline is first Quarter of 2018 for Clinical use.

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378
(@rez77)

Posted : 07/01/2017 2:37 pm

On 6/29/2017 at 8:29 PM, mjg713 said:
On 6/29/2017 at 5:16 PM, Rez77 said:

That looks like a piece of bacon!!! ;D;D

So when is it available? 

The proposed timeline is first Quarter of 2018 for Clinical use.

That's literally around the corner. 

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47
(@damnboy)

Posted : 07/01/2017 3:40 pm

They say clinical trials start at 3Q 2017 and Market entry by 1H 2018for burn Market.if successful they will explore entry into other markets like chronic wounds scar/COSMETIC revision and hair regeneration

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