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they are saying all the time for full thickness regenarative skin (epidermis-dermis-hypodermis). My concern is How they regenarate the veins ? because in some Picture they cut the burn tissue down to the muscle tissue and then with skinTE they regenerate the skin?!? does skinTE work for dermis regneration only? this is abig question
23 minutes ago, damnBOY said:they are saying all the time for full thickness regenarative skin (epidermis-dermis-hypodermis). My concern is How they regenarate the veins ? because in some Picture they cut the burn tissue down to the muscle tissue and then with skinTE they regenerate the skin?!? does skinTE work for dermis regneration only? this is abig question
What veins? You don't need to regenerate veins to regenerate skin. However, to answer your question please visit Polarity's website. Yes, they are hoping to expand this technology to also regenerate: Bone, Capillaries, Muscle, Cartilage, and Peripheral Nerves. What a time to be alive!
2 hours ago, mjg713 said:3 hours ago, damnBOY said:they are saying all the time for full thickness regenarative skin (epidermis-dermis-hypodermis). My concern is How they regenarate the veins ? because in some Picture they cut the burn tissue down to the muscle tissue and then with skinTE they regenerate the skin?!? does skinTE work for dermis regneration only? this is abig question
What veins? You don't need to regenerate veins to regenerate skin. However, to answer your question please visit Polarity's website. Yes, they are hoping to expand this technology to also regenerate: Bone, Capillaries, Muscle, Cartilage, and Peripheral Nerves. What a time to be alive!
I really really need this shit.
I refer to superficial veins. They are on hypodermis. If someone has low body fat he can see their superficial veins under the skin. In their website they show a wound where they have cut the full skin (all the layers: epidermis , dermis , hypodermis ) and then with skinTE they regenerate back all the layers.if skinTE work like this i mean they cut the defective skin incuding hypodermis howwill they restore the superficial veins?
they will propably regenerate veins with angioTE but it will take a lot of time they arentthereyet.I Hope skinTE Works . To understand they are saying that if they bring the skinTE in the Market.First they will target only few burn clinics.The second yearskinTE will be in every burn clinic and if successful with this they willexplore entry into other Market including scar revision.IT will take time even for skinTE
I cant wait more than 4 years to fix my ****** scars
9 hours ago, damnBOY said:I refer to superficial veins. They are on hypodermis. If someone has low body fat he can see their superficial veins under the skin. In their website they show a wound where they have cut the full skin (all the layers: epidermis , dermis , hypodermis ) and then with skinTE they regenerate back all the layers.if skinTE work like this i mean they cut the defective skin incuding hypodermis howwill they restore the superficial veins?
they will propably regenerate veins with angioTE but it will take a lot of time they arentthereyet.I Hope skinTE Works . To understand they are saying that if they bring the skinTE in the Market.First they will target only few burn clinics.The second yearskinTE will be in every burn clinic and if successful with this they willexplore entry into other Market including scar revision.IT will take time even for skinTE
I cant wait more than 4 years to fix my ****** scars
I just talked to a doctor researching this stuff with a huge grant. He's in Australia with a big university. He said we won't have any clinical applications by 2020, he thinks maybe 2025. I think even that's optimistic but possible. Look at it this way. There are companies that made similar promises to roll out clinical apps in a "few years" back in 2007 when this thread started and nothing was intrdouced ieven after a decade. Time to be realistic. When it comes it will come....
12 hours ago, Rez77 said:I just talked to a doctor researching this stuff with a huge grant. He's in Australia with a big university. He said we won't have any clinical applications by 2020, he thinks maybe 2025. I think even that's optimistic but possible. Look at it this way. There are companies that made similar promises to roll out clinical apps in a "few years" back in 2007 when this thread started and nothing was intrdouced ieven after a decade. Time to be realistic. When it comes it will come....
This is only speculation. You can focus on "negative" speculations or positive speculations. Or just observe and read what SkinTE write on their website. Do not make what one doctor says (who isnt even working with SkinTE) a fact.
18 hours ago, Rez77 said:I just talked to a doctor researching this stuff with a huge grant. He's in Australia with a big university. He said we won't have any clinical applications by 2020, he thinks maybe 2025. I think even that's optimistic but possible. Look at it this way. There are companies that made similar promises to roll out clinical apps in a "few years" back in 2007 when this thread started and nothing was intrdouced ieven after a decade. Time to be realistic. When it comes it will come....
You are bringing up a doctor who has no connection to what polarityTE is doing, and that is just his opinion. Also, the companies you are bringing up never actually produced any adequate preclinical results. Polarity is the first company to achieve complete skin regeneration in a Porcine model. You cannot compare and past companies to this one.
Frasier has to learn what a lot of uswent through.....after spending more than 25k on all the latest treatments and getting not much improvement ....until i see real results ....i am not wasting anymore money. I have been all around the world with people that promise the world and don't deliver. Someone may or may not come up with scarless healing in the next 50 years. Right now the world has a lot more pressing issues. There are things you can do to tighten up your skin to help your appearance. If you really get desperate you can wear fake plastic skin......like Tommy Maitlin /Mike Myers on the new Gong Show.....really Myers is wearing fake skin. Rez77.....until you see a lot of improvement in a treatment....save your money......hate to see someone get their hopes up only to get takin' by another snake salesman. I am not going to use fancy terms ect. The main thing is someone has to find a way to improve on years of evolution with the bodies present way to slopply heal a cut that leaves a scar. The best method will probably be somebody thinking outside the box........just sayin'
Frasier and others...if scarring bothers you that bad.......then i suggest you see a psychiatrist to help youdeal with your problems. I understand the problems .....that scarring causes but girls can wear make-up and guys can grow a beard until something suitable comes along..i suggest you see a psychiatrist to help deal with your problems.
I talked to a famous plastic surgeon in Philadelphia a year ago and he told me that he doubts we will see scarless healing in our lifetime. Sure he could be wrong but it is not what i wanted to hear. If someone is hell bent on finding scarless healing get your degree and be a research scientist.....finding something that works is not as easy as you would think or we would have had something by now. The only real thing as far as oral pills in acne prevention
in the last 40 years has been accutane ...and it has mixed results.....didn't last for me.....and you might include spiro.
36 minutes ago, nikkigirl said:Frasier has to learn what a lot of uswent through.....after spending more than 25k on all the latest treatments and getting not much improvement ....until i see real results ....i am not wasting anymore money. I have been all around the world with people that promise the world and don't deliver. Someone may or may not come up with scarless healing in the next 50 years. Right now the world has a lot more pressing issues. There are things you can do to tighten up your skin to help your appearance. If you really get desperate you can wear fake plastic skin......like Tommy Maitlin /Mike Myers on the new Gong Show.....really Myers is wearing fake skin. Rez77.....until you see a lot of improvement in a treatment....save your money......hate to see someone get their hopes up only to get takin' by another snake salesman. I am not going to use fancy terms ect. The main thing is someone has to find a way to improve on years of evolution with the bodies present way to slopply heal a cut that leaves a scar. The best method will probably be somebody thinking outside the box........just sayin'
Frasier and others...if scarring bothers you that bad.......then i suggest you see a psychiatrist to help youdeal with your problems. I understand the problems .....that scarring causes but girls can wear make-up and guys can grow a beard until something suitable comes along..i suggest you see a psychiatrist to help deal with your problems.
I talked to a famous plastic surgeon in Philadelphia a year ago and he told me that he doubts we will see scarless healing in our lifetime. Sure he could be wrong but it is not what i wanted to hear. If someone is hell bent on finding scarless healing get your degree and be a research scientist.....finding something that works is not as easy as you would think or we would have had something by now. The only real thing as far as oral pills in acne prevention
in the last 40 years has been accutane ...and it has mixed results.....didn't last for me.....and you might include spiro.
If you don't believe in scarless healing than why are you here. This thread is suppose to be a discussion on ongoing research.
Looks like PolarityTE is pretty confident about the potential efficacy of SkinTE. They've been recruiting a lot of apparently qualified people, which might be financially disastrous if the idea behind SkinTE proved to be unusable. I would be surprised if this company were just dragging people along in order to get investments, although this doesn't necessarily reflect the product's likely efficacy.
49 minutes ago, RickeyDog1989 said:Looks like PolarityTE is pretty confident about the potential efficacy of SkinTE. They've been recruiting a lot of apparently qualified people, which might be financially disastrous if the idea behind SkinTE proved to be unusable. I would be surprised if this company were just dragging people along in order to get investments, although this doesn't necessarily reflect the product's likely efficacy.
I'm certain its all just marketing hype. As Nikki said I'll see it when I believe it. I would bet 100 grand y'all gonna be here in 2027.
8 hours ago, nikkigirl said:Frasier has to learn what a lot of uswent through.....after spending more than 25k on all the latest treatments and getting not much improvement ....until i see real results ....i am not wasting anymore money. I have been all around the world with people that promise the world and don't deliver. Someone may or may not come up with scarless healing in the next 50 years. Right now the world has a lot more pressing issues. There are things you can do to tighten up your skin to help your appearance. If you really get desperate you can wear fake plastic skin......like Tommy Maitlin /Mike Myers on the new Gong Show.....really Myers is wearing fake skin. Rez77.....until you see a lot of improvement in a treatment....save your money......hate to see someone get their hopes up only to get takin' by another snake salesman. I am not going to use fancy terms ect. The main thing is someone has to find a way to improve on years of evolution with the bodies present way to slopply heal a cut that leaves a scar. The best method will probably be somebody thinking outside the box........just sayin'
Frasier and others...if scarring bothers you that bad.......then i suggest you see a psychiatrist to help youdeal with your problems. I understand the problems .....that scarring causes but girls can wear make-up and guys can grow a beard until something suitable comes along..i suggest you see a psychiatrist to help deal with your problems.
I talked to a famous plastic surgeon in Philadelphia a year ago and he told me that he doubts we will see scarless healing in our lifetime. Sure he could be wrong but it is not what i wanted to hear. If someone is hell bent on finding scarless healing get your degree and be a research scientist.....finding something that works is not as easy as you would think or we would have had something by now. The only real thing as far as oral pills in acne prevention
in the last 40 years has been accutane ...and it has mixed results.....didn't last for me.....and you might include spiro.
You like bringing up my name, dont you? Are you fascinating by me or what? Yet again, what you write make no sense. First you write that "Frasier has to learn what a lot of us went through". Later you write that "Frasier and others...if scarring bother you that bad". You contradict yourself. And honestly, if you spent a lot of money on treatment that doesnt work, well, I know it is frustrating. But let it go and look forward. If we stay positive and look for scientific evidence regarding skin regeneration it will help everybody here. This is the 4th time you bring my name up, remember, I am not the important one here. The shitty past doesnt change what SkinTE can do in the future.
What your famous plastic surgeon in Philadelphia thinks is 100% irrelevant.
4 hours ago, Rez77 said:5 hours ago, RickeyDog1989 said:Looks like PolarityTE is pretty confident about the potential efficacy of SkinTE. They've been recruiting a lot of apparently qualified people, which might be financially disastrous if the idea behind SkinTE proved to be unusable. I would be surprised if this company were just dragging people along in order to get investments, although this doesn't necessarily reflect the product's likely efficacy.
I'm certain its all just marketing hype. As Nikki said I'll see it when I believe it. I would bet 100 grand y'all gonna be here in 2027.
Werent you the one that should be positive? Let me congratulate you with another splendid contribution.
Relax, in 3 months the results from the clinical trial should be available. In fact swine models are very similar to humans, so could be possible that it works even better. Now why do I think it might work is: in previous studies conducted by other researchers, if follicle are created in wounds then the scar forming myofibroblast turn to fat instead of leaving a scar. This has been done by Wnt pathway. What polarity is doing so far as I got it is, it takes out the cells that activate LGR4 -6 which in turn activates the wnt etc pathways. Couple of months ago there was a study that lgr6 is responsible for growing fingertips with Nails.
http://onlinelibrary.wiley.com/doi/10.1111/exd.13246/full fingertip study.
PolarityTe Patent:
https://www.google.com/patents/US20160151540?hl=de&cl=zh
Hair follicle scar free:
http://news.doccheck.com/en/5846/wound-healing-a-flawless-future/
I don't think they are a hype because they also have appointed military high rank personell to provide skinte to wounded soldiers. If they are a scam I don't think they would mess it up with the government.
However, so far we r speaking about burns wounds where all layers of skin have been lost. According to the patent a scaffold is required to mimic the natural matrix of skin, which makes sense, however this sort of application might not be suitable for others such as acne scars or stretch marks. Since in both cases skin is almost intact and it wouldn't be really advisable to remove complete skin from ur body or face! I have written to polarity if they have another approach to heal instead of the scaffold which will require removal of all layers.
I was thinking of combining SkinTE with Microneedling to replace damaged tissue by regenerated one. For that however a gel containing all cells is the better approach.
True Binga.......but don't give people false hopes with something that is not truely scarless healing. The thread has been going on for over 10 years and still nothing in the news about scarless healing.....i am talking mainstream press ....not some local newspaper. All this talk about stem cells still has not brought any cures of any major illnesses. I have yet seen anything that can get rid of scars in humans. Right now all you can do is improve the appearance. If you have any news that actually is scarless healing...by all means post it and tell all of us here where to get rid of our scars. This is nothing more than people stating endless trials on mice and pigs! By the way been to Clinic Estetica in Tijuana twice....i think the guy who created this site went.....got 20k in fillers without much improvement. Untill someone posts something that is scarless healing ...it might be time to finally let this thread die because it is just giving a lot of people false hope.....nite nite!
HA HA.....didn't even read the post above me and it is posted about tests on pigs...yet again!
This company is similar to Polarity TE and have a market ready product.
3 hours ago, Binga said:This company is similar to Polarity TE and have a market ready product.
This is not like Polarity, this acts more like a skin graft. Polarity is not a skin graft.
3 hours ago, nikkigirl said:True Binga.......but don't give people false hopes with something that is not truely scarless healing. The thread has been going on for over 10 years and still nothing in the news about scarless healing.....i am talking mainstream press ....not some local newspaper. All this talk about stem cells still has not brought any cures of any major illnesses. I have yet seen anything that can get rid of scars in humans. Right now all you can do is improve the appearance. If you have any news that actually is scarless healing...by all means post it and tell all of us here where to get rid of our scars. This is nothing more than people stating endless trials on mice and pigs! By the way been to Clinic Estetica in Tijuana twice....i think the guy who created this site went.....got 20k in fillers without much improvement. Untill someone posts something that is scarless healing ...it might be time to finally let this thread die because it is just giving a lot of people false hope.....nite nite!
HA HA.....didn't even read the post above me and it is posted about tests on pigs...yet again!
You are clearly a mentally unstable person. I suggest you see a psyciatrist and stop posting here.
@nikkigirl@Frasier@mjg713 NikkigirlYou are right I have posted about the pig results of polarityte. Please note that pig test are often done before human trials in order to understand if the product will work or not, since pig skin is very similar to ours and in some cases it's even more complex compared to humans. Often studies on mouses work but fail on pigs and consequently on humans. It is so far the first time that complete regeneration in 3rd (loss of all skin layers) has been achieved. So I think it will work on humans with 3rd as well maybe even better due to lower complexity. We will see their results in couple of months.
However, what has to be considered is that polarityte creates a 3D matrix with all the cells, growthfactors required to kickstart the lgr and Wnt pathway. So as far I understood it, they will require to remove all layers of skin to make it mimic natural regeneration. However this approach might not suitable for acne scars or stretchmarks. Also it's unclear how they want to regrow hair on bold men. Will they remove the scalp skin and apply their Matrix scaffold? This sound way to aggressive, I wouldn't be thrilled to remove skin on my face etc. What about 2nd degree burns? Again not all layers are damaged and it would be to aggressive to remove them! I have written to polarity if their approach can be combined with less aggressive non invasive techniques such as medical needling to damage scared tissue and then make it regenerate? This approach is infact also planned by follica to regrow new hair follicles, micro injury combined with their compound. So far I did not get any response from them! We might see more infos in couple of month.
14 hours ago, SunnyX said:@nikkigirl@Frasier@mjg713 NikkigirlYou are right I have posted about the pig results of polarityte. Please note that pig test are often done before human trials in order to understand if the product will work or not, since pig skin is very similar to ours and in some cases it's even more complex compared to humans. Often studies on mouses work but fail on pigs and consequently on humans. It is so far the first time that complete regeneration in 3rd (loss of all skin layers) has been achieved. So I think it will work on humans with 3rd as well maybe even better due to lower complexity. We will see their results in couple of months.However, what has to be considered is that polarityte creates a 3D matrix with all the cells, growthfactors required to kickstart the lgr and Wnt pathway. So as far I understood it, they will require to remove all layers of skin to make it mimic natural regeneration. However this approach might not suitable for acne scars or stretchmarks. Also it's unclear how they want to regrow hair on bold men. Will they remove the scalp skin and apply their Matrix scaffold? This sound way to aggressive, I wouldn't be thrilled to remove skin on my face etc. What about 2nd degree burns? Again not all layers are damaged and it would be to aggressive to remove them! I have written to polarity if their approach can be combined with less aggressive non invasive techniques such as medical needling to damage scared tissue and then make it regenerate? This approach is infact also planned by follica to regrow new hair follicles, micro injury combined with their compound. So far I did not get any response from them! We might see more infos in couple of month.
About hair, there is a technique called HFE (Hair follicul extraction, the most modern I guess) when from nape (or even body) hair follicles "transphere" on your head, or beard or mustache if you want so. It seems their SinTE isn't a some kind of grown in lab skin for using it like grafts (as btw in Japanese RIKEN was grown in lab full-thickness Skin in april 2016, but only in mice, and then no news from them, only about iPSC and hair restoration) but probably they could grow it not in human body and extract only a hair folliculs for transplantation.
And about the skin, it sounds mayhap scary, but for me, after i've done a couple of CO2, Profractional procedures and for ppl after dermabrasion, it should be not so horrible. But yes, all this lasers and dermabrasion can reach only a smallest part of derma and not make a total skin "wound", and what is the PolarityTE suggest, if you are right, it would be bloody to remove whole skin. But in the other way, mayhap it'll get us some kind of a "baby skin" about so many dream of: without scars, excessive redness, pigmentation, large pores, dark spots, birth marks, wrinkles and other skin desease. In this way it'll be the most popular anti-aging procedure (and this market is far mor valuable compare to acne and skincare). But it's really sounds miracle. As was mentioned, we do not know still about how scarless will be the result, as it's not mentioned about "scarfree". If it'll be like after facelift scars, it's ok, but the cost of such procedure will be very high, and Polarity team said that it should not to be so. It's may sound like a face transplantation procedures that for the last decade was improved a lot (the last news was about a man and he looked I could say pretty good comparing to the first woman, who overcame this kind of procedure). But it's ofc much more complex procedure, cuz there are a lot of works with bones, muscles etc. Within 3 mounths we should get the results and after succesfull pig tests we have more than 90% it'll be work on humans, compare to 30% after mice tests. Hope It'll be as good as in "Face/OFF" film (20 years already passed from that movie btw :P).
On 7/7/2017 at 4:14 AM, SunnyX said:@nikkigirl@Frasier@mjg713 NikkigirlYou are right I have posted about the pig results of polarityte. Please note that pig test are often done before human trials in order to understand if the product will work or not, since pig skin is very similar to ours and in some cases it's even more complex compared to humans. Often studies on mouses work but fail on pigs and consequently on humans. It is so far the first time that complete regeneration in 3rd (loss of all skin layers) has been achieved. So I think it will work on humans with 3rd as well maybe even better due to lower complexity. We will see their results in couple of months.However, what has to be considered is that polarityte creates a 3D matrix with all the cells, growthfactors required to kickstart the lgr and Wnt pathway. So as far I understood it, they will require to remove all layers of skin to make it mimic natural regeneration. However this approach might not suitable for acne scars or stretchmarks. Also it's unclear how they want to regrow hair on bold men. Will they remove the scalp skin and apply their Matrix scaffold? This sound way to aggressive, I wouldn't be thrilled to remove skin on my face etc. What about 2nd degree burns? Again not all layers are damaged and it would be to aggressive to remove them! I have written to polarity if their approach can be combined with less aggressive non invasive techniques such as medical needling to damage scared tissue and then make it regenerate? This approach is infact also planned by follica to regrow new hair follicles, micro injury combined with their compound. So far I did not get any response from them! We might see more infos in couple of month.
ACell make similar products but from pig bladder. Pretty sure plastic surgeons will find a way to treat acne scars using it. You can read more about it here http://www.rejuvemedical.com/acell-prp-injection-therapy/
6 hours ago, mjg713 said:Has anyone been able to get into contact with Polarity? I sent 2 emails and haven't heard back from them.
yes I ask them if skinTE Works for scars on Facebook and they answer this:Hi George, thank you for your note. Our launch product, SkinTE, is currently in development for application in the wound and burn market to regenerate full-thickness, fully-functional skin. We are planning for clinical application in Q3 2017 and market entry by 1H 2018. If successful, we plan to explore entry into other markets such as acute and chronic wounds, cosmetic/scar revisions, and hair regeneration. If youd like to keep updated on our progress, please feel free to sign up for email alerts to receive PolarityTEs latest news announcements ( http://www.polarityte.com/email-alerts ).
I think some doctors are already using Epicel, lab grown skin graft from biopsy, to treat burns. Wonder if it can be used for scars as well.
http://vcel.com/product-portfolio/
http://www.doctoralizadeh.com/cosmoplastic-surgery/reconstructive-surgery/regenerative-medicine.html