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1 hour ago, mjg713 said:I just don't like that he says "Almost Scarless". Don't know what that means.
Hey in my earlier reply I was exactly explaining why polarityTe will be only useful for large wounds such as for third degree burns where all layers of skin are lost and wound closure would not take place. Currently skin from unaffected area is taken and it tried to cover up the wound so it can close (with scarred skin). In case of polarity the scaring would be limited so compared to current methods it's almost scarless. For real Scarfree healing the way of the Cotsarelis lab is useful.@Davrakhe mentioned it but he didn't get the point that the only difference between a scar and normal skin is that scar tissue has more collagen bundles and no follicle and fat. As shown in research if follicle are regenerated in Skin it leads to regeneration of fat by turning myofibroblast which are scar forming cells into fat. Basically by their approach you truly get a regenerated skin. Basically both approaches will help in future to heal skin without scars
1 hour ago, SunnyX said:Hey in my earlier reply I was exactly explaining why polarityTe will be only useful for large wounds such as for third degree burns where all layers of skin are lost and wound closure would not take place. Currently skin from unaffected area is taken and it tried to cover up the wound so it can close (with scarred skin). In case of polarity the scaring would be limited so compared to current methods it's almost scarless. For real Scarfree healing the way of the Cotsarelis lab is useful.@Davrakhe mentioned it but he didn't get the point that the only difference between a scar and normal skin is that scar tissue has more collagen bundles and no follicle and fat. As shown in research if follicle are regenerated in Skin it leads to regeneration of fat by turning myofibroblast which are scar forming cells into fat. Basically by their approach you truly get a regenerated skin. Basically both approaches will help in future to heal skin without scars
I don't see what would be the difference between a third degree burn and an excised area of scar tissue?
Recent Economist article. I dunno some of the stuff cited here is from 2005!!!! Seems to me there isn't much happening.
http://www.economist.com/news/science-and-technology/21715638-how-build-organs-scratch
God I'm so depressed since talking to that skin scientist at university of arizona who told me he doubts there will be anything as far as
regenerative technology for skin even by 2030. I think I'm just going to accept my fate. There will be cures one day. But too late for me.
It's sure that PolarityTE will target burn market first as there's a crucial unmet medical need in that area and than will proceed with cosmetic applications such as injury, acne scars .. but especially scar revision I think It would be pretty useful, because many times a scar revision isn't really useful because when you excise the scar tissue and than suture the skin, in many ways there will be a lot of tension around the wound that will contribute to a similar scar that was there before the revision. If you excise it and than fill in will normal skin, the scar tissue fan only develop in the limits between the ex-scarred area and the normal skin with a minimum of tension around the wound which minimizes scarring. So large surgery scars will probably be a thing of the past, which is a huge step for those who had facial injuries in the past. And like i said, a few years ago, researchers were thinking that only stem cells of the embryo could have medical applications ; now we know that were not limited to the stem cells of the embryo only. Adult stem cells have potential too. And by the way, for those who want valuable information on the subject, the best way to do so is trough Pubmed data base! (But you need an access through a university or something, otherwise you can only read the abstracts )
Well there was a few years ago the idea of taking out micro full thickness skin graft from normal skin side and add them into the wounded area. This would mean that at the donor site no scaring would take place and at the wounded area scaring could be limited. Now to make you guys understand why polarity won't have much effect on small wounds is the following example: when a plastic surgeon makes a cut, he/she then Stiches the boundaries of the wound super close to each other. Even by virtually leaving no gap between the wound, you still end up with a scar. So even with polarity you will end up with a scar between the old and new skin. However for large wounds this would mean a far better outcome compared to current techniques. For smaller wounds or better said for Scarfree healing we need to manipulate the wounding response in human body. Now we know that scars formation can inhibited if either follicle are regenerated or if bmp2/4 is applied to the wound. Nevertheless Polarity will be able to improve life's of millions and it would certainly kickstart the industry for scar free healing, and more stuff will be funded by investors. http://mentalfloss.com/article/90943/hair-follicles-may-help-wounds-heal-without-scars in this article Cotsarelis actually said that trial could be in place within a year since bmp is already used in clinic. Unfortunately there is not much follow up to this and it's not clear if it's going to happen. I have in fact written cotsarelis and even to mentalfloss to have a follow up on this research. But didn't get a response yet. I think the bmp approach combined with laser or microneedling could be the most effective way of breaking down scartissue and regenerate normal skin.
This company have released a product to diminish acne scars through physicians. Their main ingredient is umbilical cord stem cells. For those pessimistic people check out the before and after of radio frequency micro needling. That is a good place to start instead of waiting for scarless healing.
14 hours ago, SunnyX said:Well there was a few years ago the idea of taking out micro full thickness skin graft from normal skin side and add them into the wounded area. This would mean that at the donor site no scaring would take place and at the wounded area scaring could be limited. Now to make you guys understand why polarity won't have much effect on small wounds is the following example: when a plastic surgeon makes a cut, he/she then Stiches the boundaries of the wound super close to each other. Even by virtually leaving no gap between the wound, you still end up with a scar. So even with polarity you will end up with a scar between the old and new skin. However for large wounds this would mean a far better outcome compared to current techniques. For smaller wounds or better said for Scarfree healing we need to manipulate the wounding response in human body. Now we know that scars formation can inhibited if either follicle are regenerated or if bmp2/4 is applied to the wound. Nevertheless Polarity will be able to improve life's of millions and it would certainly kickstart the industry for scar free healing, and more stuff will be funded by investors. http://mentalfloss.com/article/90943/hair-follicles-may-help-wounds-heal-without-scars in this article Cotsarelis actually said that trial could be in place within a year since bmp is already used in clinic. Unfortunately there is not much follow up to this and it's not clear if it's going to happen. I have in fact written cotsarelis and even to mentalfloss to have a follow up on this research. But didn't get a response yet. I think the bmp approach combined with laser or microneedling could be the most effective way of breaking down scartissue and regenerate normal skin.
Where did you see that Polarity was stitching skin? That would just be another form of a skin graft. Polarity says it will be regenerating skin, this is different. I read nowhere that they plan on grafting anything.
yeah i think i'll leave the forum for a while, it's always about the "next thing" first hydroel, now you guys are bringing up polarity stuff, then it'll be another thing. I'm not being antagonistic, I just want this thread to be realistic. sure people are working on all sots of things including flying to mars. Will it happen for you and me? No. The type of total regeneration we're looking for or assume would be the holy grail, the fountain of youth. And we're not hundreds but thousands of years from that. If this world still continues.
23 minutes ago, Rez77 said:yeah i think i'll leave the forum for a while, it's always about the "next thing" first hydroel, now you guys are bringing up polarity stuff, then it'll be another thing. I'm not being antagonistic, I just want this thread to be realistic. sure people are working on all sots of things including flying to mars. Will it happen for you and me? No. The type of total regeneration we're looking for or assume would be the holy grail, the fountain of youth. And we're not hundreds but thousands of years from that. If this world still continues.
Yes, do leave. Posts like that are so negative, so discouraging and so misleading. And based solely on how you feel, not on what science tells us. Again, there are sub-forums here if you feel down, are depressed, whatever. Be a man and dont bring others down in your misery.
16 hours ago, SunnyX said:Well there was a few years ago the idea of taking out micro full thickness skin graft from normal skin side and add them into the wounded area. This would mean that at the donor site no scaring would take place and at the wounded area scaring could be limited. Now to make you guys understand why polarity won't have much effect on small wounds is the following example: when a plastic surgeon makes a cut, he/she then Stiches the boundaries of the wound super close to each other. Even by virtually leaving no gap between the wound, you still end up with a scar. So even with polarity you will end up with a scar between the old and new skin. However for large wounds this would mean a far better outcome compared to current techniques. For smaller wounds or better said for Scarfree healing we need to manipulate the wounding response in human body. Now we know that scars formation can inhibited if either follicle are regenerated or if bmp2/4 is applied to the wound. Nevertheless Polarity will be able to improve life's of millions and it would certainly kickstart the industry for scar free healing, and more stuff will be funded by investors. http://mentalfloss.com/article/90943/hair-follicles-may-help-wounds-heal-without-scars in this article Cotsarelis actually said that trial could be in place within a year since bmp is already used in clinic. Unfortunately there is not much follow up to this and it's not clear if it's going to happen. I have in fact written cotsarelis and even to mentalfloss to have a follow up on this research. But didn't get a response yet. I think the bmp approach combined with laser or microneedling could be the most effective way of breaking down scartissue and regenerate normal skin.
I dont know why you compare Polarity TE with stitching?! Of course wounds that need stitching can make you scar. Thats old school and old news. You write "...we need to manipulate the wounding response in human body". Isnt that what Polarity TE will do?
53 minutes ago, Frasier said:Yes, do leave. Posts like that are so negative, so discouraging and so misleading. And based solely on how you feel, not on what science tells us. Again, there are sub-forums here if you feel down, are depressed, whatever. Be a man and dont bring others down in your misery. I dont know why you compare Polarity TE with stitching?! Of course wounds that need stitching can make you scar. Thats old school and old news. You write "...we need to manipulate the wounding response in human body". Isnt that what Polarity TE will do?
it's all a bullshit, polarityte is nothing.
@AlbanesoThe concept of polarity te is nothing new. Its already being done at various labs in the world. Polarity te is trying to commercialize it. Please go to a doctor and start treating your scars. You will feel better once you see improvement.
Check out figure 1 and 2 from this article.
7 hours ago, mjg713 said:21 hours ago, SunnyX said:Well there was a few years ago the idea of taking out micro full thickness skin graft from normal skin side and add them into the wounded area. This would mean that at the donor site no scaring would take place and at the wounded area scaring could be limited. Now to make you guys understand why polarity won't have much effect on small wounds is the following example: when a plastic surgeon makes a cut, he/she then Stiches the boundaries of the wound super close to each other. Even by virtually leaving no gap between the wound, you still end up with a scar. So even with polarity you will end up with a scar between the old and new skin. However for large wounds this would mean a far better outcome compared to current techniques. For smaller wounds or better said for Scarfree healing we need to manipulate the wounding response in human body. Now we know that scars formation can inhibited if either follicle are regenerated or if bmp2/4 is applied to the wound. Nevertheless Polarity will be able to improve life's of millions and it would certainly kickstart the industry for scar free healing, and more stuff will be funded by investors. http://mentalfloss.com/article/90943/hair-follicles-may-help-wounds-heal-without-scars in this article Cotsarelis actually said that trial could be in place within a year since bmp is already used in clinic. Unfortunately there is not much follow up to this and it's not clear if it's going to happen. I have in fact written cotsarelis and even to mentalfloss to have a follow up on this research. But didn't get a response yet. I think the bmp approach combined with laser or microneedling could be the most effective way of breaking down scartissue and regenerate normal skin.
Where did you see that Polarity was stitching skin? That would just be another form of a skin graft. Polarity says it will be regenerating skin, this is different. I read nowhere that they plan on grafting anything.
Uff again, Polarity takes your skin via biopsy and grows that in the lab to larger area and after growing it, it is then grafted onto the wound site. This has been done in Germany couple of years back! They do not regenerate anything in your body, it's a skin graft basically with your own skin. In Europe they had the problem so far that they had to make sure that blood rushes quickly through the new skin otherwise scarring would take place. Overall this approach is still better for large wound compared to what is currently available.
Read this: https://www.euroskingraft.eu/
This approach does not manipulate the wound healing processes. So basically do not get confused, it's only full thickness skin graft.
However what the Cotsarelis group is doing is more relevant since their approach manipulates wound healing directly in humans, through turning scar creating cells into fat cells. So this approach is more suitable for surgery scars, acne scars, stretch marks etc. So if u get a wound then it will be closed by the body without scar tissue.
http://news.doccheck.com/en/5846/wound-healing-a-flawless-future/
6 hours ago, Rez77 said:yeah i think i'll leave the forum for a while, it's always about the "next thing" first hydroel, now you guys are bringing up polarity stuff, then it'll be another thing. I'm not being antagonistic, I just want this thread to be realistic. sure people are working on all sots of things including flying to mars. Will it happen for you and me? No. The type of total regeneration we're looking for or assume would be the holy grail, the fountain of youth. And we're not hundreds but thousands of years from that. If this world still continues.
Relax, we have just recently discovered that the scarforming cells can be turned into fatcells. Till date it was considered impossible and therefore all science was trying to eliminate TGF-s, but now we now that ironically BMP which is a protein from TGF-s superfamily that inhibits scar formation. This is a remarkable breakthrough because we do not need to manipulate to much of our wound healing processes. Apart from that bmp is already used in clinic for bone fractures, where it has shown to regenerate bone quicker and better. So i think once they figure out how and when to apply bmp, it could be out in the next 5+ years. Furthermore since they now know how to turn scarcells into fat, they are also looking at other signaling proteins that could be easier applied. So I think if it also works out in humans it could change dermatology in the next 5 - 10 years
9 hours ago, SunnyX said:Uff again, Polarity takes your skin via biopsy and grows that in the lab to larger area and after growing it, it is then grafted onto the wound site. This has been done in Germany couple of years back! They do not regenerate anything in your body, it's a skin graft basically with your own skin. In Europe they had the problem so far that they had to make sure that blood rushes quickly through the new skin otherwise scarring would take place. Overall this approach is still better for large wound compared to what is currently available.
Read this: https://www.euroskingraft.eu/This approach does not manipulate the wound healing processes. So basically do not get confused, it's only full thickness skin graft.
However what the Cotsarelis group is doing is more relevant since their approach manipulates wound healing directly in humans, through turning scar creating cells into fat cells. So this approach is more suitable for surgery scars, acne scars, stretch marks etc. So if u get a wound then it will be closed by the body without scar tissue.
http://news.doccheck.com/en/5846/wound-healing-a-flawless-future/
Please read this interview with the founder of polarity, he mentions regeneration multiple times: https://www.bioinformant.com/polarityte/ . I am not saying i'm right and your wrong but where is a source that proves Polarity is using skin grafts? Because I have not read anything about that.
9 hours ago, mjg713 said:Please read this interview with the founder of polarity, he mentions regeneration multiple times: https://www.bioinformant.com/polarityte/ . I am not saying i'm right and your wrong but where is a source that proves Polarity is using skin grafts? Because I have not read anything about that.
Hmm okay one more time, check their Website dude! http://c.eqcdn.com/_d6bae27b94f978a9a34b9362be63e37a/polarityte/db/270/1110/pdf/APRIL+2017+POLARITY+SLIDE+DECK_WEB.pdf
They take your skin - expand it in lab - and try to bring it back to the wound site within 24 - 48 hrs!
1 hour ago, SunnyX said:Hmm okay one more time, check their Website dude! http://c.eqcdn.com/_d6bae27b94f978a9a34b9362be63e37a/polarityte/db/270/1110/pdf/APRIL+2017+POLARITY+SLIDE+DECK_WEB.pdfThey take your skin - expand it in lab - and try to bring it back to the wound site within 24 - 48 hrs!
Then check this statement, dude:
"Dr. Swanson (chief operating officer) noted that because the product uses patients' own skin, the results can be virtually seamless, making scarring a thing of the past."
1 hour ago, SunnyX said:Hmm okay one more time, check their Website dude! http://c.eqcdn.com/_d6bae27b94f978a9a34b9362be63e37a/polarityte/db/270/1110/pdf/APRIL+2017+POLARITY+SLIDE+DECK_WEB.pdfThey take your skin - expand it in lab - and try to bring it back to the wound site within 24 - 48 hrs!
Look at the pictures in the link you posted, looks like they use a tissue matrix/scaffold to REGENERATE skin on the old wound. Where do you see a skin graft sutured anywhere in those pictures? Again, I could be wrong but there's absolutely no solid evidence to what you keep repeating.
On 6/4/2017 at 9:11 PM, Rez77 said:Recent Economist article. I dunno some of the stuff cited here is from 2005!!!! Seems to me there isn't much happening.
http://www.economist.com/news/science-and-technology/21715638-how-build-organs-scratch
God I'm so depressed since talking to that skin scientist at university of arizona who told me he doubts there will be anything as far as
regenerative technology for skin even by 2030. I think I'm just going to accept my fate. There will be cures one day. But too late for me.
Look, any scientist or doctor can state their opinion that they don't believe scar-free healing will be a reality for x amount of years. That doesn't mean it's a fact. They might be unaware of the advances happening with sunogel, microcoring, hydrogels, etc.. There's no point in believing the words of one person who could easily be completely wrong. For every scientist that says scar-free healing won't happen soon, I'm sure there's one that says it will. Only time will tell.
In the meantime, we can't have this message board turn into a place where everyone doubts everything and writes how long they believe it will take to achieve scar-free healing. By doing this, we are only blocking important information for people to read, which then prolongs the chances for scar-free healing to happen asap by not helping spread the information in an accessible manner. The more positive and proficient people are in their posts here, the quicker we will see progress.
On 6/5/2017 at 8:14 PM, Albaneso said:On 6/5/2017 at 7:19 PM, Frasier said:Yes, do leave. Posts like that are so negative, so discouraging and so misleading. And based solely on how you feel, not on what science tells us. Again, there are sub-forums here if you feel down, are depressed, whatever. Be a man and dont bring others down in your misery. I dont know why you compare Polarity TE with stitching?! Of course wounds that need stitching can make you scar. Thats old school and old news. You write "...we need to manipulate the wounding response in human body". Isnt that what Polarity TE will do?it's all a bullshit, polarityte is nothing.
Posts like these block important information from being seen by the public, which can prolong scar-free healing from becoming a reality as soon as possible. I suggest you keep posts like these off of this message board if you want people to see the facts.