Acne.org Products
@Frasier
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC299367/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3904096/
Pdgf was already identified in 1987. 2010 also by the Cotsarelis lab and more. By now the focus has shifted away since for regeneration it is part but not the most important signal to kickstart regenerative pathways. I agree with science is quickly moving ahead and i am sure more signaling proteins will be found to better control the pathway in the next 5 - 10 years. And after this is it will take another 5+ years to get thing into clinic. Apart from that , in 1957 it was discovered that hair regenerate under certain case in large animal wounds. In 2005 it then taken up by the Upenn to find out that it's was possible. In 2013 they first briefly understood how hair follicles grow. In 2017 they understood how fat regenerates. So now they are trying to find more signaling proteins, this will take time. We do understand now far more than compared to 20years and we ruled out a lot of cells, proteins etc so that we have now few left to do research on. In lab I have seen a lot of new tec getting developed and tested, but it will take time till they can be safely applied to humans. I don't want to hurt anyone's sentiments. We are getting closer to crack the code, nature has a lot of secrets. And yes I cannot rule out that we will see a breakthrough in the next 5 years but even then it would have to go through all trials etc and that will be time consuming. As of now according to my research we are getting closer but aren't there yet, this is for sure, I think you agree on this. And I never said that scarfree healing will not take place ever, otherwise I wouldn't be in this field. I am just saying that to the current standpoint of our knowledge and then getting things into clinic passed by regulation for wide public use a more realistic timeframe would be of 10 - 15 years.
6 hours ago, SunnyX said:@Frasier
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC299367/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3904096/
Pdgf was already identified in 1987. 2010 also by the Cotsarelis lab and more. By now the focus has shifted away since for regeneration it is part but not the most important signal to kickstart regenerative pathways. I agree with science is quickly moving ahead and i am sure more signaling proteins will be found to better control the pathway in the next 5 - 10 years. And after this is it will take another 5+ years to get thing into clinic. Apart from that , in 1957 it was discovered that hair regenerate under certain case in large animal wounds. In 2005 it then taken up by the Upenn to find out that it's was possible. In 2013 they first briefly understood how hair follicles grow. In 2017 they understood how fat regenerates. So now they are trying to find more signaling proteins, this will take time. We do understand now far more than compared to 20years and we ruled out a lot of cells, proteins etc so that we have now few left to do research on. In lab I have seen a lot of new tec getting developed and tested, but it will take time till they can be safely applied to humans. I don't want to hurt anyone's sentiments. We are getting closer to crack the code, nature has a lot of secrets. And yes I cannot rule out that we will see a breakthrough in the next 5 years but even then it would have to go through all trials etc and that will be time consuming. As of now according to my research we are getting closer but aren't there yet, this is for sure, I think you agree on this. And I never said that scarfree healing will not take place ever, otherwise I wouldn't be in this field. I am just saying that to the current standpoint of our knowledge and then getting things into clinic passed by regulation for wide public use a more realistic timeframe would be of 10 - 15 years.
Thanks for the information. I appreciate it. But still, we do not know how it will look in 5 years time. And people almost depend their lives on this. Another thing to consider; we dont need complete regeneration to be satisfied. I will say that nowadays the treatment for acne scars are very unpredictable and very bad. What if we get something that is about 80% close to scar free skin? Many here would be very happy with such results.
These before and after pics looks incredible
https://renovacareinc.com/before-after-photos/
This company is about to release a scar reduction gel
2 hours ago, Binga said:These before and after pics looks incredible
https://renovacareinc.com/before-after-photos/
This company is about to release a scar reduction gel
God don't you people read. Yeah the indication is for cutaneous radiation injury. LolOLOLOL
Twenty years????? God I am so depressed now.
16 hours ago, SunnyX said:@Frasier
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC299367/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3904096/
Pdgf was already identified in 1987. 2010 also by the Cotsarelis lab and more. By now the focus has shifted away since for regeneration it is part but not the most important signal to kickstart regenerative pathways. I agree with science is quickly moving ahead and i am sure more signaling proteins will be found to better control the pathway in the next 5 - 10 years. And after this is it will take another 5+ years to get thing into clinic. Apart from that , in 1957 it was discovered that hair regenerate under certain case in large animal wounds. In 2005 it then taken up by the Upenn to find out that it's was possible. In 2013 they first briefly understood how hair follicles grow. In 2017 they understood how fat regenerates. So now they are trying to find more signaling proteins, this will take time. We do understand now far more than compared to 20years and we ruled out a lot of cells, proteins etc so that we have now few left to do research on. In lab I have seen a lot of new tec getting developed and tested, but it will take time till they can be safely applied to humans. I don't want to hurt anyone's sentiments. We are getting closer to crack the code, nature has a lot of secrets. And yes I cannot rule out that we will see a breakthrough in the next 5 years but even then it would have to go through all trials etc and that will be time consuming. As of now according to my research we are getting closer but aren't there yet, this is for sure, I think you agree on this. And I never said that scarfree healing will not take place ever, otherwise I wouldn't be in this field. I am just saying that to the current standpoint of our knowledge and then getting things into clinic passed by regulation for wide public use a more realistic timeframe would be of 10 - 15 years.
Fuck I think Sunny is right 10-15 years.
9 hours ago, Frasier said:16 hours ago, SunnyX said:@Frasier
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC299367/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3904096/
Pdgf was already identified in 1987. 2010 also by the Cotsarelis lab and more. By now the focus has shifted away since for regeneration it is part but not the most important signal to kickstart regenerative pathways. I agree with science is quickly moving ahead and i am sure more signaling proteins will be found to better control the pathway in the next 5 - 10 years. And after this is it will take another 5+ years to get thing into clinic. Apart from that , in 1957 it was discovered that hair regenerate under certain case in large animal wounds. In 2005 it then taken up by the Upenn to find out that it's was possible. In 2013 they first briefly understood how hair follicles grow. In 2017 they understood how fat regenerates. So now they are trying to find more signaling proteins, this will take time. We do understand now far more than compared to 20years and we ruled out a lot of cells, proteins etc so that we have now few left to do research on. In lab I have seen a lot of new tec getting developed and tested, but it will take time till they can be safely applied to humans. I don't want to hurt anyone's sentiments. We are getting closer to crack the code, nature has a lot of secrets. And yes I cannot rule out that we will see a breakthrough in the next 5 years but even then it would have to go through all trials etc and that will be time consuming. As of now according to my research we are getting closer but aren't there yet, this is for sure, I think you agree on this. And I never said that scarfree healing will not take place ever, otherwise I wouldn't be in this field. I am just saying that to the current standpoint of our knowledge and then getting things into clinic passed by regulation for wide public use a more realistic timeframe would be of 10 - 15 years.
Thanks for the information. I appreciate it. But still, we do not know how it will look in 5 years time. And people almost depend their lives on this. Another thing to consider; we dont need complete regeneration to be satisfied. I will say that nowadays the treatment for acne scars are very unpredictable and very bad. What if we get something that is about 80% close to scar free skin? Many here would be very happy with such results.
Well currently all treatments are bad for all types of scars. So far I never got the point of these percentages. First of all, scars are not made of different cells! They are made of collagen 1 & 3, elastin fibers like the rest of the skin as well. So why do scars look different - because after wounding the collagen fibers do not rearrange the way they used to be, the main intention is to fill the gab left by lost appendages. So the lost appendages are follicles, sweatglands, fat and melanocytes. As long these appendages are not regenerated the skin will always look different. After restoring the lost tissue the skin looks as if never anything happened. We know now that BMP2/4 can regenerate fat. We know that under certain circumstances fgf9 can regenerate follicles. However the problem with fgf9 was that it did not always work out, so other pathways are currently studied. Furthermore, inflammatory response has to be brought under control. So I am very sure that in the next 5 - 10years we will find other more reliable pathways and combination of different proteins will be required to up&down regulate signals. So for clinical use, again we are talking about 10 - 15 years.
https://www.sciencedaily.com/releases/2013/06/130602144327.htm
this was discovered in 1956 then in 2007 and proven in 2013. based on this in 2016
this was proven further down the research
basically it took us first 50 years to prove this then another 10years to find further signals, so another 10years we will be sorted.
They have a similar product like gemstone and is currently used on animals by vets.
http://cresilon.com/
https://cresilon.com/index.php/traumagel/
"A preliminary pilot study in patients suffering from acne scars treated with SP-DERM Acne demonstrated improvement in both doctor assessed and self-assessed results after 4 weeks and 8 weeks of treatment with SP-DERM Acne"
17 hours ago, Binga said:"A preliminary pilot study in patients suffering from acne scars treated with SP-DERM Acne demonstrated improvement in both doctor assessed and self-assessed results after 4 weeks and 8 weeks of treatment with SP-DERM Acne"
this is all shit. we need something far more powerful.
2 hours ago, Binga said:
Don't post shit like this you ass. It's clearly a make-up type thing that is synthetic and doesn't "live". And its certainly not a solution for acne scars. Stop filling this thread with dead-ends.
3 hours ago, Rez77 said:6 hours ago, Binga said:Don't post shit like this you ass. It's clearly a make-up type thing that is synthetic and doesn't "live". And its certainly not a solution for acne scars. Stop filling this thread with dead-ends.
Are you really that stupid? He's trying to provide a middle way. But I guess you rather sit in your own misery than try to find what may make life bearable for now. Be my guest, but don't drag others into it.
This is similar to what polarity TE is trying to do I think
2 hours ago, Binga said:This is similar to what polarity TE is trying to do I think
Only the methodology which means the harvest phase of your skin (Biopsy)
PolarityTE will regenerate the entire dernal layer of the skin with Its appendages resulting in normal looking skin.
5 minutes ago, Albaneso said:stevenringlermd.com/in-the-news/is-scarless-healing-possible-for-humans/
What's the purpose of this link ? Yes, most mammals scar when a wound occurs except those mice species .. the goal is to solve this problem by manipulating the molecular mechanisms behind scarring. If you go back in the thread, you'll see that major progress have been made to understand this mechanism and the simpliest way to achieve normal looking skin would be through hair folicles ( in this case you don't have a 100% regenerated skin but you do have a normal looking skin because of fat and this clinical result would be satisfying for scars victims)
For full skin regeneration researchers have identify the key signaling proteins implicated in the scarring mechanism and that's the challenge i think.
Once this defined, there would be multiple ways to manipulate the process i think and one of the biggest advances that you're going to see in the media is the CRISPR-Cas9 system, a genome editing tool to add genes, turn off genes expression ... (to be synthetized, a protein needs to be coded by a gene) It will be powerful once the ethic questions will be solved concerning genetics, because you can also use this tool to repair DNA mutations (aging, cancer ...)
@Davrak
The question is how long will it take until complete scar regeneration.
1 hour ago, Albaneso said:@Davrak
The question is how long will it take until complete scar regeneration.
I don't think somebody will be able to answer this question honestly because It's subjective and It depends on many factors : for my personal opinion, there's a huge market associated with skin regeneration ; burns, acne scars, injury scars, plastic surgery ... Regenerative medicine will be progressing a lot I think in the upcoming years so There will introduce the next advances in wound healing and dermatology because since 2000, there haven't been such progress in that field ... But now the researches come out, regenerative medicine is slowly taking its place so there's clearly hope.
When the scar foundation says "by 2045", I think they're extremely conservative haha because skin regeneration "in vitro" will take place in the end of this year (according to polarityTE) so why "in vivo" It would take so long I don't think so
6 hours ago, Davrak said:I don't think somebody will be able to answer this question honestly because It's subjective and It depends on many factors : for my personal opinion, there's a huge market associated with skin regeneration ; burns, acne scars, injury scars, plastic surgery ... Regenerative medicine will be progressing a lot I think in the upcoming years so There will introduce the next advances in wound healing and dermatology because since 2000, there haven't been such progress in that field ... But now the researches come out, regenerative medicine is slowly taking its place so there's clearly hope.When the scar foundation says "by 2045", I think they're extremely conservative haha because skin regeneration "in vitro" will take place in the end of this year (according to polarityTE) so why "in vivo" It would take so long I don't think so
when I hear "until 2045", im totally hopeless.
2 hours ago, Albaneso said:9 hours ago, Davrak said:I don't think somebody will be able to answer this question honestly because It's subjective and It depends on many factors : for my personal opinion, there's a huge market associated with skin regeneration ; burns, acne scars, injury scars, plastic surgery ... Regenerative medicine will be progressing a lot I think in the upcoming years so There will introduce the next advances in wound healing and dermatology because since 2000, there haven't been such progress in that field ... But now the researches come out, regenerative medicine is slowly taking its place so there's clearly hope.When the scar foundation says "by 2045", I think they're extremely conservative haha because skin regeneration "in vitro" will take place in the end of this year (according to polarityTE) so why "in vivo" It would take so long I don't think so
when I hear "until 2045", im totally hopeless.
If you have the money there are already treatments out there that gives 90% improvement. No point being hopeless.
For people in Singapore
http://www.cambridgetherapeutics.com.sg/services-fusion-stem-cell-regeneration
4 hours ago, Binga said:
Was going to post this. I like how they give you an actual timeline compared to the smoke and mirrors with Gemstone!