Acne.org Products
8 hours ago, Davrak said:The famous facebook page of science (Hashem Al-Ghaili) shared an interesting article yesterday ; "Scientifists found a way to Radically Reduce scarring, thanks to sea creatures"
This is the article and video.
Not scar related but this is exactly what I am looking for to treat my scars right now. Its available in Europe and Asia.
http://kerastem.com/
https://clinicaltrials.gov/ct2/show/NCT02503852?term=cell+enriched+fat+grafting&rank=6
http://onlinelibrary.wiley.com/doi/10.1111/exd.13246/full
good article about how Wnt pathway can regenerate skin - basically the plikus lab had found out in 2013 that FGF6 can switch on the Wnt pathway which would lead hair follicle growth and thus to scarfree healing. Another way of switching on Wnt is LGR6 which as far I Understand is the way PolarityTE wants to achieve cell polarity.
" "I think it will be exponential," he said. "It will be the same thing (we saw) with deciphering the human genome. The knowledge will go up exponentially, and the cost will go exponentially down."
Thanks for sharing this article ! We must not be far from skin complete regeneration after all these articles and researches, there's definitely an evidence that there's hope for scarring issues in the next few years.
2 hours ago, Davrak said:" "I think it will be exponential," he said. "It will be the same thing (we saw) with deciphering the human genome. The knowledge will go up exponentially, and the cost will go exponentially down."Thanks for sharing this article ! We must not be far from skin complete regeneration after all these articles and researches, there's definitely an evidence that there's hope for scarring issues in the next few years.
hope but im very skeptic.
https://horizon-magazine.eu/article/complete-human-skin-grown-lab_en.html
@BingaFull thickness skin has been created in the lab and is currently under trial for burns in Germany, Holland and Swiss. Now in the article one of the scientists says as well that they are far more capable doing things in the lab but are not allowed by regulation to test on humans - so even crowdfunding won't help since getting approved by the authorities is time and money consuming, so for that u need a lot of money - I believe we would require atleast 100million dollars or even more to get things moving fast. With far less amounts u will be stuck and play it only safe. Anyways we are still far of achieving scarfree healing that would be required for acne scars, surgical scars, stretchmarks - i think till we see a treatment for them to be completely gone will take atleast 20 - 30 years. Maybe we will see in between new research etc but till something actually will be available to the public will take tons of time. So our kids would be the one who would benefit from all this and we will tell them that wounding always resulted in a scar.
1 hour ago, SunnyX said:https://horizon-magazine.eu/article/complete-human-skin-grown-lab_en.html@BingaFull thickness skin has been created in the lab and is currently under trial for burns in Germany, Holland and Swiss. Now in the article one of the scientists says as well that they are far more capable doing things in the lab but are not allowed by regulation to test on humans - so even crowdfunding won't help since getting approved by the authorities is time and money consuming, so for that u need a lot of money - I believe we would require atleast 100million dollars or even more to get things moving fast. With far less amounts u will be stuck and play it only safe. Anyways we are still far of achieving scarfree healing that would be required for acne scars, surgical scars, stretchmarks - i think till we see a treatment for them to be completely gone will take atleast 20 - 30 years. Maybe we will see in between new research etc but till something actually will be available to the public will take tons of time. So our kids would be the one who would benefit from all this and we will tell them that wounding always resulted in a scar.
Yes but your article is dated 2015 ; science is moving fast
nowadays.
This is what has been achieved in 2017 till now ;
- PolarityTE plans to release SkinTE in early 2018 on the market which will move things even faster (theres so much money to do with regenerative medicine so there will be competition indeed)
- Penn medicine has figured out how to achieve scarfree healing by switching myofibroblasts into adipocytes
4 minutes ago, Davrak said:Yes but your article is dated 2015 ; science is moving fast
nowadays.This is what has been achieved in 2017 till now ;
- PolarityTE plans to release SkinTE in early 2018 on the market which will move things even faster (theres so much money to do with regenerative medicine so there will be competition indeed)
- Penn medicine has figured out how to achieve scarfree healing by switching myofibroblasts into adipocytes
Hmm -
Polarity: well there is a company called stratatech doing the same stuff and being stuck for the last 6 or so years. And the article which I have send you is from European scientist. Now the problem with lab grown skin is that it matter how quickly and cleanly it can attach itself to the surrounding skin. The biggest problem is that if it is not quickly adopted by the body, scaring will take place. Furthermore it's designed more for larger wound than small wounds.
Penn medicine: dr Cotsarelis and Plikus team had discovered back in 2013 how follicle can be grown in wounds which he would also create fat. Now by only turning myofibroblast into fatcells you will not achieve a complete scarfree healing since the skin will still miss hairfollicles and sweatglands and also the collagen and elastin fibers do not arrange perfectly as before the wounding took place.
Even with follica inc which was formed in 2007 by Cotsarelis to grow hair, they are stuck for the past 10years.
So far there is not one single research that has created full proof scarfree healing in humans. Where the scientist say "here we go, no matter how u injure the skin, if you apply our therapy your skin will get to original shape 100% guaranteed" , so far it all about it could possibly or it will decrease significantly but noo 100% scarfree.
So Yeah i am an optimist but I guess the scarfree foundation is right about scarfree healing being available by around 2045. could be bit faster but will take 20years or so... I know technology is moving fast and will help us with research etc. but still it will take that long because most of the new tec that could help us has come out recently so it is used in research but all of it will take time till we will see some results. Or maybe we need Elon Musk to start a new company - like Neuralink 😉
anyways hope never dies
6 hours ago, SunnyX said:Hmm -
Polarity: well there is a company called stratatech doing the same stuff and being stuck for the last 6 or so years. And the article which I have send you is from European scientist. Now the problem with lab grown skin is that it matter how quickly and cleanly it can attach itself to the surrounding skin. The biggest problem is that if it is not quickly adopted by the body, scaring will take place. Furthermore it's designed more for larger wound than small wounds.Penn medicine: dr Cotsarelis and Plikus team had discovered back in 2013 how follicle can be grown in wounds which he would also create fat. Now by only turning myofibroblast into fatcells you will not achieve a complete scarfree healing since the skin will still miss hairfollicles and sweatglands and also the collagen and elastin fibers do not arrange perfectly as before the wounding took place.
Even with follica inc which was formed in 2007 by Cotsarelis to grow hair, they are stuck for the past 10years.So far there is not one single research that has created full proof scarfree healing in humans. Where the scientist say "here we go, no matter how u injure the skin, if you apply our therapy your skin will get to original shape 100% guaranteed" , so far it all about it could possibly or it will decrease significantly but noo 100% scarfree.
So Yeah i am an optimist but I guess the scarfree foundation is right about scarfree healing being available by around 2045. could be bit faster but will take 20years or so... I know technology is moving fast and will help us with research etc. but still it will take that long because most of the new tec that could help us has come out recently so it is used in research but all of it will take time till we will see some results. Or maybe we need Elon Musk to start a new company - like Neuralink 😉
anyways hope never dies
So you mean scar free healing will be able 28 years from now? Of course this is just speculation from your side. I believe it will be here in 5-10 years time. So lets agree about disagreeing.
7 hours ago, SunnyX said:Hmm -
Polarity: well there is a company called stratatech doing the same stuff and being stuck for the last 6 or so years. And the article which I have send you is from European scientist. Now the problem with lab grown skin is that it matter how quickly and cleanly it can attach itself to the surrounding skin. The biggest problem is that if it is not quickly adopted by the body, scaring will take place. Furthermore it's designed more for larger wound than small wounds.Penn medicine: dr Cotsarelis and Plikus team had discovered back in 2013 how follicle can be grown in wounds which he would also create fat. Now by only turning myofibroblast into fatcells you will not achieve a complete scarfree healing since the skin will still miss hairfollicles and sweatglands and also the collagen and elastin fibers do not arrange perfectly as before the wounding took place.
Even with follica inc which was formed in 2007 by Cotsarelis to grow hair, they are stuck for the past 10years.So far there is not one single research that has created full proof scarfree healing in humans. Where the scientist say "here we go, no matter how u injure the skin, if you apply our therapy your skin will get to original shape 100% guaranteed" , so far it all about it could possibly or it will decrease significantly but noo 100% scarfree.
So Yeah i am an optimist but I guess the scarfree foundation is right about scarfree healing being available by around 2045. could be bit faster but will take 20years or so... I know technology is moving fast and will help us with research etc. but still it will take that long because most of the new tec that could help us has come out recently so it is used in research but all of it will take time till we will see some results. Or maybe we need Elon Musk to start a new company - like Neuralink 😉
anyways hope never dies
if take 28 years until 2045, we are hopeless.
54 minutes ago, Frasier said:7 hours ago, SunnyX said:Hmm -
Polarity: well there is a company called stratatech doing the same stuff and being stuck for the last 6 or so years. And the article which I have send you is from European scientist. Now the problem with lab grown skin is that it matter how quickly and cleanly it can attach itself to the surrounding skin. The biggest problem is that if it is not quickly adopted by the body, scaring will take place. Furthermore it's designed more for larger wound than small wounds.Penn medicine: dr Cotsarelis and Plikus team had discovered back in 2013 how follicle can be grown in wounds which he would also create fat. Now by only turning myofibroblast into fatcells you will not achieve a complete scarfree healing since the skin will still miss hairfollicles and sweatglands and also the collagen and elastin fibers do not arrange perfectly as before the wounding took place.
Even with follica inc which was formed in 2007 by Cotsarelis to grow hair, they are stuck for the past 10years.So far there is not one single research that has created full proof scarfree healing in humans. Where the scientist say "here we go, no matter how u injure the skin, if you apply our therapy your skin will get to original shape 100% guaranteed" , so far it all about it could possibly or it will decrease significantly but noo 100% scarfree.
So Yeah i am an optimist but I guess the scarfree foundation is right about scarfree healing being available by around 2045. could be bit faster but will take 20years or so... I know technology is moving fast and will help us with research etc. but still it will take that long because most of the new tec that could help us has come out recently so it is used in research but all of it will take time till we will see some results. Or maybe we need Elon Musk to start a new company - like Neuralink 😉
anyways hope never dies
So you mean scar free healing will be able 28 years from now? Of course this is just speculation from your side. I believe it will be here in 5-10 years time. So lets agree about disagreeing.
Well, I would be the one who would love to have the stuff out 2moro but let's face it, even if they exactly find out something against scars tomorrow morning even then it would take 5+years till it would be available in clinic. And before someone says otherwise the new treatment would have to go through clinical trial phase 1, phase 2, phase3 etc. So yeah 5 - 10 years won't happen, i agree fully on disagreeing with you. Sorry
13 minutes ago, Albaneso said:7 hours ago, SunnyX said:Hmm -
Polarity: well there is a company called stratatech doing the same stuff and being stuck for the last 6 or so years. And the article which I have send you is from European scientist. Now the problem with lab grown skin is that it matter how quickly and cleanly it can attach itself to the surrounding skin. The biggest problem is that if it is not quickly adopted by the body, scaring will take place. Furthermore it's designed more for larger wound than small wounds.Penn medicine: dr Cotsarelis and Plikus team had discovered back in 2013 how follicle can be grown in wounds which he would also create fat. Now by only turning myofibroblast into fatcells you will not achieve a complete scarfree healing since the skin will still miss hairfollicles and sweatglands and also the collagen and elastin fibers do not arrange perfectly as before the wounding took place.
Even with follica inc which was formed in 2007 by Cotsarelis to grow hair, they are stuck for the past 10years.So far there is not one single research that has created full proof scarfree healing in humans. Where the scientist say "here we go, no matter how u injure the skin, if you apply our therapy your skin will get to original shape 100% guaranteed" , so far it all about it could possibly or it will decrease significantly but noo 100% scarfree.
So Yeah i am an optimist but I guess the scarfree foundation is right about scarfree healing being available by around 2045. could be bit faster but will take 20years or so... I know technology is moving fast and will help us with research etc. but still it will take that long because most of the new tec that could help us has come out recently so it is used in research but all of it will take time till we will see some results. Or maybe we need Elon Musk to start a new company - like Neuralink 😉
anyways hope never dies
if take 28 years until 2045, we are hopeless.
Sorry dude there is nothing out there yet. I wish truly I could tell u otherwise. But to cheer you up they now know that you need to regenerate first follicles be it through Wnt, Fgf, lgr5, LGR6 pathways. So they looking at other molecules which could be safe for humans and would trigger on those pathways. Maybe we need a visionary who is willing to spend a billion dollars to quickly get things moving. If you are young then study hard and become a scientist and workout a way
We demonstrated that adult mice have the capacity to regenerate hair follicles, sebaceous glands and fat following a full thickness wound. We have evidence that Wnt, Fgf, Hh pathways and gamma/delta T cells are vital players controlling this wound induced hair follicle neogenesis (WIHN). We hypothesize that manipulation of these molecular pathways at the right time and place will convert non-regenerative tissue into regenerative tissue with the ability to form hair follicles, sebaceous glands and fat in response to wounding. To test this hypothesis, we will determine: 1. The role of dermal Wnt/ss-catenin signaling in hair follicle neogenesis using transgenic and conditional knockout mice, 2. The cellular origin of nascent hair follicles in the wound using promoters targeting fibroblasts, myofibroblasts, hair follicle dermal papilla and other dermal subpopulations for lineage analysis, 3. The role of sonic hedgehog signaling in the ability to coax healing wounds to regenerate rather than scar. Human skin xenografted to immunodeficient mice will be studied for its ability to respond with follicular neogenesis to Wnt and/or Shh activation. Ultimately, our findings will yield insights into scarless wound healing tht have implications for understanding skin biology and developing future treatments for wounds, alopecia and other degenerative skin disorders.
Public Health Relevance
Scars typically lack hair follicles. We are developing ways to regenerate hair follicles after wounding by taking advantage of genetically manipulated mice that heal with little scarring. These studies will ultimately benefit people with wounds, scars, alopecias and other degenerative skin disorders.
8 hours ago, SunnyX said:Hmm -
Polarity: well there is a company called stratatech doing the same stuff and being stuck for the last 6 or so years. And the article which I have send you is from European scientist. Now the problem with lab grown skin is that it matter how quickly and cleanly it can attach itself to the surrounding skin. The biggest problem is that if it is not quickly adopted by the body, scaring will take place. Furthermore it's designed more for larger wound than small wounds.Penn medicine: dr Cotsarelis and Plikus team had discovered back in 2013 how follicle can be grown in wounds which he would also create fat. Now by only turning myofibroblast into fatcells you will not achieve a complete scarfree healing since the skin will still miss hairfollicles and sweatglands and also the collagen and elastin fibers do not arrange perfectly as before the wounding took place.
Even with follica inc which was formed in 2007 by Cotsarelis to grow hair, they are stuck for the past 10years.So far there is not one single research that has created full proof scarfree healing in humans. Where the scientist say "here we go, no matter how u injure the skin, if you apply our therapy your skin will get to original shape 100% guaranteed" , so far it all about it could possibly or it will decrease significantly but noo 100% scarfree.
So Yeah i am an optimist but I guess the scarfree foundation is right about scarfree healing being available by around 2045. could be bit faster but will take 20years or so... I know technology is moving fast and will help us with research etc. but still it will take that long because most of the new tec that could help us has come out recently so it is used in research but all of it will take time till we will see some results. Or maybe we need Elon Musk to start a new company - like Neuralink 😉
anyways hope never dies
Stratatechs approach is NOT the same as Polaritys approach. Stratatech uses a skin substitute, whereas Polarity deals with an Lgr pathway.
Euroskingraft uses full thickness lab grown skin. They are already applying it in Germany and I spoke to them and they said it suitable only for large wounds since they are still left with scars at the border between the old and new skin, furthermore it still depends how quickly the body can rush blood into the new tissue, in order to keep scaring at bay. If lgr pathway signaling can be applied onto human body it would be more suitable for small wounds since the body will close the wound itself whereas if it's only used in the lab to expand the skin they will experience the same issues as euroskingraft.
In Seabs we trust. What hes telling makes most sense. I have absolutely no believe in that it will take 30 years to get scar free healing. I think that we, in no more than 5 years time, will have methods that are good enough for us.
I know you disagree...but in Seabs we trust!
@FrasierWell here is why dextran hydrogel will not work in humans. First of all a scar is made of overproduced collagen bundles which are also part of normal skin. Furthermore when skin is damaged we lose hairfollicle/sweatglands/ fat cells which do not regenerate in humans, therefore our body creates excessive collagen to fill in the gap. When a new compound is tested on animals they often heal without scars by regenerating all the above mentioned appendages. In humans however they often fail, because we are not able to regenerate follicle, fat, sweatglands. Just look at a oldaged persons skin, it will have wrinkles because fatcells are lost and the otherwise healthy skin is unable to promote regeneration. Now recently scientists have found out that humans do not havegamma/delta T cells which most animals have and these cells promote fgf/Wnt pathways to recreate hairfollicles, which leads to regenerating sweatglands which results in fat and no overproduction of collagen = healed skin. This is why the tests work in animal models but fail in human trials. Furthermore because we do not have those cells/proteins, we are the only species which can get Hypertrophic and keloid scaring. As long any hydrogel is not able to promote regeration of follicles etc in dermis, scarfree healing will not take place!
Still I know u won't believe me, which is fine. Let's have a look at this thread in 24.05.2027. I hope I will be wrong.
21 minutes ago, SunnyX said:@FrasierWell here is why dextran hydrogel will not work in humans. First of all a scar is made of overproduced collagen bundles which are also part of normal skin. Furthermore when skin is damaged we lose hairfollicle/sweatglands/ fat cells which do not regenerate in humans, therefore our body creates excessive collagen to fill in the gap. When a new compound is tested on animals they often heal without scars by regenerating all the above mentioned appendages. In humans however they often fail, because we are not able to regenerate follicle, fat, sweatglands. Just look at a oldaged persons skin, it will have wrinkles because fatcells are lost and the otherwise healthy skin is unable to promote regeneration. Now recently scientists have found out that humans do not havegamma/delta T cells which most animals have and these cells promote fgf/Wnt pathways to recreate hairfollicles, which leads to regenerating sweatglands which results in fat and no overproduction of collagen = healed skin. This is why the tests work in animal models but fail in human trials. Furthermore because we do not have those cells/proteins, we are the only species which can get Hypertrophic and keloid scaring. As long any hydrogel is not able to promote regeration of follicles etc in dermis, scarfree healing will not take place!Still I know u won't believe me, which is fine. Let's have a look at this thread in 24.05.2027. I hope I will be wrong.
First of all, complete skin regeneration has been proven on pigs. There is a difference between mice and pigs. Second of all, SkinTE has a very impressive list of people that are involved and their website clearly state human skin regeneration. Soon. Third of all, you have absolutely no idea how this whole skin regeneration will look only a couple of years a head of us. Things are moving fast these days. So by stating here that it will take28 years before skin regeneration takes placeis just bullshit, to be honest. Dont be bombastic in your opinions, it will only make you look less informative.
@FrasierWell pigs are not humans. Pig skin is similar to ours but in studies it has been shown that pigs do not form keloidal scars which is because they have less of the key cells and proteins to kickstart fgf/lgr/Wnt pathways compared to mice but they have more than us. We do now know that one of these pathway is required and currently they are looking into which proteins can be used to activate those pathways safely in humans. But again it will still take time since there are so many cells, signaling proteins that we need to look into. So I guess there is no point of fighting or abusing, you have ur opinion (i respect that) and I have mine. In 2027 we will know who is right and who is wrong.
7 hours ago, SunnyX said:@FrasierWell pigs are not humans. Pig skin is similar to ours but in studies it has been shown that pigs do not form keloidal scars which is because they have less of the key cells and proteins to kickstart fgf/lgr/Wnt pathways compared to mice but they have more than us. We do now know that one of these pathway is required and currently they are looking into which proteins can be used to activate those pathways safely in humans. But again it will still take time since there are so many cells, signaling proteins that we need to look into. So I guess there is no point of fighting or abusing, you have ur opinion (i respect that) and I have mine. In 2027 we will know who is right and who is wrong.
Pigs are not humans, but when you write animalsit is misleading. It is well known that pigs are very close to human in biology. Which mean we are getting pretty close. I dont abuse anybody here, but when people here come with statements like yours (skin regeneration will not be here in 28 years, some write 50 years, others write never), it can bring people down. People here are sensitive after what they have been going through. And science is moving fast these days and a lot is happening regarding skin regeneration. Look back 28 years and you will be in the 80s. Big change isnt it? And life will change at a faster rate the next 28 years. Like I wrote, I dont know, you dont know, nobody here knows.
Like an example, did you expect that this would happen today? 😉 https://www.technologynetworks.com/tn/news/signal-crucial-to-stem-cell-function-in-hair-follicles-identified-289052