Acne.org Products
This thread has been going on 10 years with nothing new or they still won't be still using lasers. It has been about 37 years since the advent of accutane. Almost nothing new for the treatment of acne since accutane. Nothing new for 40 or 50 years in the treatment of cancer...it is still cut it out and treat the rest with chemo and radiation. Frazier doesn't have anything to prove scarless healing. Just a bunch of high tech gobble de gook. Back in the day the next big thing was Isologen and what happened to that and RECELL? Blaaa blaaaa blaaa.....seeing is believing.....so far i have not seen or read anything in the news about anything making acne scars going away.......it is just endless hope.
This company is valued at a massive $12 billion and some of their products are undergoing phase II clinical trials.
http://www.businessinsider.com/samumed-wants-to-regenerate-hair-bone-cartilage-2017-3
Basically what has been said in the conferences ; we're assisting to the growth of two massive fields in medicine, genome editing and emergence of stem cells therapies. Genome editing consists of modifying the genes to remove a mutation associated to an illness for example but many ethical questions adress this concern. For stem cells, what has been mostly said has confirmed precedent posts in this topic ; adult stem cells will lead to regenerative medicine and not necesseraly those from the embryo so yes, things will be simplier and MDs were confident that regeneration of neurones will become reality ; obviously, the first organ who will be adressed is skin, which is good news! (Didn't learn many things from the conference, but it pretty much confirmed what I learned through pubmed and biotech companies)
On 5/8/2017 at 4:42 AM, SunnyX said:http://www.healthline.com/health-news/re-growing-teeth-and-healing-wounds-without-scarsthis article answers both of ur questions
This sounds amazing if it will be a scar-free solution for skin regeneration. My only confusion is that this article claims that the cells found in wounded skin were transformed into fat, which, I assume, regenerated into normal skin? But then the article claims, That fat will not form without the new hairs, but once it does, the new cells are indistinguishable from the preexisting fat cells, giving the healed wound a natural look instead of leaving a scar. Does natural look mean regenerated skin? Or will it still leave a slight scar that just looks natural?
38 minutes ago, CollegeKidd said:This sounds amazing if it will be a scar-free solution for skin regeneration. My only confusion is that this article claims that the cells found in wounded skin were transformed into fat, which, I assume, regenerated into normal skin? But then the article claims, That fat will not form without the new hairs, but once it does, the new cells are indistinguishable from the preexisting fat cells, giving the healed wound a natural look instead of leaving a scar. Does natural look mean regenerated skin? Or will it still leave a slight scar that just looks natural?
Well they actually saw after hair got created in wounds that even fat cells got created instead of scartissue. You have to understand that scartissue is basically collagen overproduced by the so called myofibroblast. So why does a scar look different is because the collagen bundles created are not aligned in basket woven form instead a formed into one direction, second it does not contain any hair follicles and fat cells. Now as we know follicles and fat were considered impossible to be regrown in adults once lost. Now what happend in experiment is that they tried to create hair in wounds and also fat got created and the myofibroblast did not create the scar tissues, instead they changed to fat cells. They also found out that the hair follicle sends a signal in form of the BMP protein which tells the myofibroblast in wounds to change into fat instead of forming a scar. They also tried applying only bmp to a wound and it did also work out the same way. Since the scar cells are changed into fat, your skin will heal without a scar and looking like the surrounding skin
On 2017-05-08 at 2:37 AM, Rez77 said:On 2017-05-07 at 5:28 PM, Davrak said:I sincerely think that PolarityTE will be a great solution for scarring. Im entering dental school next year and if you notice, many components to replace teeth have to be ordered and manufactured in labs and each patient is different so, It seems complicated but in fact, It's now s common practice. Why would it be crazier for skin? Dermatology has to progress, as dentistry and ophtalmology did in the last few years (especially with the LASIK)
On a tangential note, do you know how far we might be from regenerating or creating biological bioteeth so that we could have living teeth implanted in our jaws instead of metal studded implants? Also, periodontal tissue for receding gums?
I think 3D printing could be useful in that field, I actually know colleagues in fourth year that did a presentation on 3D printing and reconstructive maxillo facial surgeries. But yes "bioteeth" are conceavable according to me because of the upcoming clinical applications of stem cells ; you can regenerate anything once you know the recipe for the differenciation!
2 hours ago, SunnyX said:3 hours ago, CollegeKidd said:This sounds amazing if it will be a scar-free solution for skin regeneration. My only confusion is that this article claims that the cells found in wounded skin were transformed into fat, which, I assume, regenerated into normal skin? But then the article claims, That fat will not form without the new hairs, but once it does, the new cells are indistinguishable from the preexisting fat cells, giving the healed wound a natural look instead of leaving a scar. Does natural look mean regenerated skin? Or will it still leave a slight scar that just looks natural?Well they actually saw after hair got created in wounds that even fat cells got created instead of scartissue. You have to understand that scartissue is basically collagen overproduced by the so called myofibroblast. So why does a scar look different is because the collagen bundles created are not aligned in basket woven form instead a formed into one direction, second it does not contain any hair follicles and fat cells. Now as we know follicles and fat were considered impossible to be regrown in adults once lost. Now what happend in experiment is that they tried to create hair in wounds and also fat got created and the myofibroblast did not create the scar tissues, instead they changed to fat cells. They also found out that the hair follicle sends a signal in form of the BMP protein which tells the myofibroblast in wounds to change into fat instead of forming a scar. They also tried applying only bmp to a wound and it did also work out the same way. Since the scar cells are changed into fat, your skin will heal without a scar and looking like the surrounding skin
Amazing! But now my other question is this... We looked at isolated molecules from keloids, which are very big benign tumors that form on pierced ears, and are sometimes the size of golf balls, Cotsarelis said. If we can convert those cells to fat, it will be easier to treat scarring, including cancer surgery scars." So do they plan on 1) converting already scarred tissue into scar-free skin, 2) preventing scarring from taking place after a wound occurs, or 3) removing scars to regrow new skin through their method??
10 hours ago, nikkigirl said:This thread has been going on 10 years with nothing new or they still won't be still using lasers. It has been about 37 years since the advent of accutane. Almost nothing new for the treatment of acne since accutane. Nothing new for 40 or 50 years in the treatment of cancer...it is still cut it out and treat the rest with chemo and radiation. Frazier doesn't have anything to prove scarless healing. Just a bunch of high tech gobble de gook. Back in the day the next big thing was Isologen and what happened to that and RECELL? Blaaa blaaaa blaaa.....seeing is believing.....so far i have not seen or read anything in the news about anything making acne scars going away.......it is just endless hope.
I agree, very little has happenened in 40-50 years. But that fact is telling me that we finally get some clear signs that something positive is happening. Just read the facts that others are telling you here. There have been breakthroughs, and I am very positive that something will happen within 10 years time, maybe even 5 years. It may sound like a very long time (in a way it is), but time goes by so fast. Look back 10 years and you will understand. Build your life in other areas; get some education, get a good job, work out, spend time on your family/friends/hobbies. At the same time we will get closer day by day.
And you know what, the feeling we all will get the day we can get rid of our scars is a feeling most people never will be able to feel. I will be so happy. That is something.
6 hours ago, CollegeKidd said:Amazing! But now my other question is this... We looked at isolated molecules from keloids, which are very big benign tumors that form on pierced ears, and are sometimes the size of golf balls, Cotsarelis said. If we can convert those cells to fat, it will be easier to treat scarring, including cancer surgery scars." So do they plan on 1) converting already scarred tissue into scar-free skin, 2) preventing scarring from taking place after a wound occurs, or 3) removing scars to regrow new skin through their method??
Hi,
keloids are scars which can form anywhere on ur body after trauma and they go beyond the actual wound area. So if u get keloids then even a small ear piercing can become a size of golf ball. The problem so far if they remove them surgically they still get back and get worse. So this is what he meant! Existing Scars cannot be changed you would still require surgical removal, so that scar tissue can be replaced with complete skin.
i believe PolarityTE and Dr. Cotsarelis Research out of both one will crack the code of scarfree healing.
PolarityTE wants to enter the market for burn patients by next year with completely grown full thickness skin (epidermis, dermis, hair follicle, fat cells). Once it proves itself in the burn injury market it should be quickly available for the cosmetic surgery market. Let's hope they make it - their team is impressive, most of them are former surgeons from John Hopkins.
17 hours ago, nikkigirl said:This thread has been going on 10 years with nothing new or they still won't be still using lasers. It has been about 37 years since the advent of accutane. Almost nothing new for the treatment of acne since accutane. Nothing new for 40 or 50 years in the treatment of cancer...it is still cut it out and treat the rest with chemo and radiation. Frazier doesn't have anything to prove scarless healing. Just a bunch of high tech gobble de gook. Back in the day the next big thing was Isologen and what happened to that and RECELL? Blaaa blaaaa blaaa.....seeing is believing.....so far i have not seen or read anything in the news about anything making acne scars going away.......it is just endless hope.
Hey,
i agree but always think about that before 1928 for thousands of years people often died of simple infection and in 1928 Fleming cracked code for antibiotics. For the first time humans where able to tackle bacteria. Now skin is not just one cell it is made of different cells and there are millions of genes and proteins and signals that have to be understood. I wish there could be one single cream and all woud be fixed but our skin is a very complex organ. But in the last couple of years a lot of secrets of our human body has been cracked by scientist. For example only in 2001 we managed to crack the human genome - we have around 30000 genes with 3,4 billion DNA base pairs and the cost was around 3 billion dollars. Steve jobs had spent 100,000 dollars to learn the DNA sequence of his genome and that of the cancer tumor killing him. Now u can get ur DNA sequenced for only couple of thousand dollars and it getting faster and cheaper daily.
What I want to say is that people are working on regeneration and the breakthrough will come soon or later.
200 years ago nobody could think of planes flying.
150 years ago we couldn't think of electricity
100 years ago killing bacteria
80 years ago flying to the moon
30 years ago of the internet
15 years ago about smartphones
10 years ago about electric cars and drones
5 years ago about automated cars and 3D printing
Now artificial intelligence, robotic, flying to mars, scar free healing, regrowing body parts or even not dieing at all! Science will not stop to progress! In fact in the last 100years specially after the Second World War, humanity has made great progress never seen before in history.
2 hours ago, SunnyX said:Hey,
i agree but always think about that before 1928 for thousands of years people often died of simple infection and in 1928 Fleming cracked code for antibiotics. For the first time humans where able to tackle bacteria. Now skin is not just one cell it is made of different cells and there are millions of genes and proteins and signals that have to be understood. I wish there could be one single cream and all woud be fixed but our skin is a very complex organ. But in the last couple of years a lot of secrets of our human body has been cracked by scientist. For example only in 2001 we managed to crack the human genome - we have around 30000 genes with 3,4 billion DNA base pairs and the cost was around 3 billion dollars. Steve jobs had spent 100,000 dollars to learn the DNA sequence of his genome and that of the cancer tumor killing him. Now u can get ur DNA sequenced for only couple of thousand dollars and it getting faster and cheaper daily.
What I want to say is that people are working on regeneration and the breakthrough will come soon or later.
200 years ago nobody could think of planes flying.
150 years ago we couldn't think of electricity
100 years ago killing bacteria
80 years ago flying to the moon
30 years ago of the internet
15 years ago about smartphones
10 years ago about electric cars and drones
5 years ago about automated cars and 3D printing
Now artificial intelligence, robotic, flying to mars, scar free healing, regrowing body parts or even not dieing at all! Science will not stop to progress! In fact in the last 100years specially after the Second World War, humanity has made great progress never seen before in history.
medicine is more difficult, discoveries in electro engineering are easy against medicine.
sorry for my english
45 minutes ago, Albaneso said:medicine is more difficult, discoveries in electro engineering are easy against medicine.sorry for my english
Yes it is but look at what has been all invented in the last 100years in medicine, we can fight cancer, bacteria and viruses. We can create artificial hormones to help ppl with diabetes, many medical conditions can be treated today from which u would have died 100years ago. besides medical discoveries are linked to electrical engineering because supercomputer, artificial intelligence and other devices can help us to understand cell communication and movement. For example just recently the largest X-ray has been built in Germany, it is multiple kilometers large and has a price tag of almost 2 billion dollars. The aim of this device is to further understand communication between cells. Many of the discoveries that are coming out now are only because the technology to find them has just improved/invented recently
http://www.sciencetimes.com/articles/13399/20170425/largest-x-ray-laser-world-now-operational.htm
SunnyX wrote:"Besides medical discoveries are linked to electrical engineering because supercomputer, artificial intelligence and other devices can help us to understand cell communication and movement."
Exactly. You cant think of medical discoveries without thinking of other scientific discoveries. Thats why it will go faster and faster. Artificial intelligence will help humans in this work. Medicine progress is today in the same stroke as working with computers. Its no longer about "blood & needles". This is important to understand.
By the way, how is PolarityTE going to produce the skin? Will they produce it in a labratory and put in back on the body? Will that be precise enough for cosmetic procedures?
2 hours ago, Frasier said:SunnyX wrote:"Besides medical discoveries are linked to electrical engineering because supercomputer, artificial intelligence and other devices can help us to understand cell communication and movement."
Exactly. You cant think of medical discoveries without thinking of other scientific discoveries. Thats why it will go faster and faster. Artificial intelligence will help humans in this work. Medicine progress is today in the same stroke as working with computers. Its no longer about "blood & needles". This is important to understand.
By the way, how is PolarityTE going to produce the skin? Will they produce it in a labratory and put in back on the body? Will that be precise enough for cosmetic procedures?
They are going to produce the matrix outside ur body and then put it back to let ur body heal. As i explained in my past post, the body is the best incubator for any cell. But how exactly it will be applied we will see that at the end of this year. As they r looking into creating complete skin not only parts of it, it could be possible to remove small areas or even large area defects and get replaced with new skin. Since it's ur own skin cells, the new skin will resemble the surrounding. but again we will later this year how successful this approach will be. But remember Cotsarelis lab has also a possible cure with turning scar tissue into fat, regenerating complete skin. So by next year we will see more on both approaches
11 hours ago, SunnyX said:14 hours ago, Frasier said:SunnyX wrote:"Besides medical discoveries are linked to electrical engineering because supercomputer, artificial intelligence and other devices can help us to understand cell communication and movement."
Exactly. You cant think of medical discoveries without thinking of other scientific discoveries. Thats why it will go faster and faster. Artificial intelligence will help humans in this work. Medicine progress is today in the same stroke as working with computers. Its no longer about "blood & needles". This is important to understand.
By the way, how is PolarityTE going to produce the skin? Will they produce it in a labratory and put in back on the body? Will that be precise enough for cosmetic procedures?
They are going to produce the matrix outside ur body and then put it back to let ur body heal. As i explained in my past post, the body is the best incubator for any cell. But how exactly it will be applied we will see that at the end of this year. As they r looking into creating complete skin not only parts of it, it could be possible to remove small areas or even large area defects and get replaced with new skin. Since it's ur own skin cells, the new skin will resemble the surrounding. but again we will later this year how successful this approach will be. But remember Cotsarelis lab has also a possible cure with turning scar tissue into fat, regenerating complete skin. So by next year we will see more on both approaches
Thanks for the reply! So the healing itself will be on your own body?
@FrasierHmmm very good question. I will look into their research and let u know more. as soon as possible. I was more into the Cotsarelis groups research, but also the PolarityTE approach might work as well but here there more questions.
http://www.sciencedirect.com/science/article/pii/S0142961217302788
and one more group working on scar free healing
This product looks quite promising
http://regeneus.com.au/product-pipeline/cell-secretions
19 hours ago, CollegeKidd said:Wow, it's so incredible to see the tons of organizations working on scar-free healing.
BARDA and US Army is pouring millions into skin regeneration and burn treatments. We will have something soon.
http://www.timesofisrael.com/israeli-researchers-rub-it-in-with-new-anti-wrinkle-cream/ not scar related but they claim to have invented a cream that basically cures wrinkles, similar to botox in a cream. Interesting nonetheless.