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2 hours ago, mjg713 said:4 hours ago, SunnyX said:Hi,
i think it won't take 50 years. 10 years ago it was thought to be impossible to regrow hair follicles once lost, however follica is going to be out by next year and it does regrow new hair follicle. The same group (dr cotsarelis and plikus) have identified bmp2 and bmp4 as the key protein which turn myofibroblast (which causes scarring) into fat cells and again both things were considered impossible to turn myofibroblast into another cell and to gegenerate lost fat. You have to understand that our skin regenerates it self every 4 -6 weeks and by eliminating myofibroblast a scar cannot take place, normal regeneration will take place.
Furthermore by the Wnt pathway it is also possible to regrow hair follicle in a wound which will also cause myofibroblast to turn into fat, because the newly created hair follicles express high amount of BMP. In fact PolarityTE is going to use the Wnt pathway to grow complete skin.
On the other hand FS2 will not do much since it cannot completely suppress the myofibroblast. Basically it has been understood in order to prevent scars you need hairfollicles or BMP. science does understand more about regeneration and i think it will take around 10 years not because science but because of regulation on getting new med. on the market.I'm just curious, where did you get that PolarityTE will use the Wnt pathway?
Hey,
because it uses LGR5 and LGR6 to promote growth of tissue, basically this is one of the ways of implementing Wnt pathway, it's basically all about learning the process and finding the right agonists and antagonists in human tissue. Not everything that works on rats works on humans. This is because our immune system is different and our skin is more tightly woven with thicker collagen fibers. Therefore regeneration in lab mouses has worked but then failed on humans. So all kind of hydrogels etc will not work if the right agonists ne antagonists are not supressed or activated.
15 hours ago, ObservantJeep said:https://www.bostonglobe.com/business/2017/04/14/meet-one-most-important-medical-entrepreneurs-you-never-heard/dfZFRbcdtjLcqyxci9vKlM/story.html#commentsInteresting article, I'm pretty sure this is the same guy who invented fraxel. I'm wondering if anyone knows anything about the "sevenoaks" company he talks about.
Yes, Dr. Anderson and Cotsarelis - combined with Puretech Ventures - these guys really know what they talking about and they have the credentials to make things move. Polarity has also an impressive team - even DARPA is working on scar free healing. I think in the next decade something will be market to regenerate skin.
15 hours ago, SunnyX said:On May 4, 2017 at 4:27 PM, ObservantJeep said:https://www.bostonglobe.com/business/2017/04/14/meet-one-most-important-medical-entrepreneurs-you-never-heard/dfZFRbcdtjLcqyxci9vKlM/story.html#commentsInteresting article, I'm pretty sure this is the same guy who invented fraxel. I'm wondering if anyone knows anything about the "sevenoaks" company he talks about.
Yes, Dr. Anderson and Cotsarelis - combined with Puretech Ventures - these guys really know what they talking about and they have the credentials to make things move. Polarity has also an impressive team - even DARPA is working on scar free healing. I think in the next decade something will be market to regenerate skin.
There is so much research going into scar-free healing/skin regeneration right now, just do a search on Pubmed and see for yourself. As far as regulatory approval, that is only relevant for a drug based therapy as that is a long approval process. Anything that is considered a device (hydrogel etc) or is currently already approved for something else can be approved in 1 year. I would be shocked if it takes a decade.
15 minutes ago, Rez77 said:yeah people were just as optimistic in 2007 when this thread began. What do we got TEN YEARS DOWN THE LINE????
NNNOOOOTHING!!!!!!!!!!!!!!!!
That's is true but science and the medical field take time. 2007, hmm wasn't that right around the time the iPhone came out? A lot of progress has been made since then, it's just not commercialized yet.
5 hours ago, mjg713 said:6 hours ago, Rez77 said:yeah people were just as optimistic in 2007 when this thread began. What do we got TEN YEARS DOWN THE LINE????
NNNOOOOTHING!!!!!!!!!!!!!!!!
That's is true but science and the medical field take time. 2007, hmm wasn't that right around the time the iPhone came out? A lot of progress has been made since then, it's just not commercialized yet.
God I'm praying you're right.
Here's something that could be a very significant part of a scar solution regimen. This device --a new innovation on a recent device. If you had the device inject something like HA fluid or something even more powerful like Sculptura it could fill the entire surface of the skin and plum up depressed scars. Again, I don't know if it is a solution on its own, I doubt it. But lets say you've done it all this could help? It's certainly a very novel delivery system.
https://www.israel21c.org/needle-free-facelift-skin-remodeling-and-scar-repair/
forget above --there's a thread on this device from 2012 --clearly no one is fucking using it.
WHAT DID I FUCKING TELL YOU?
The analogy to the iPhone is FALSE. Biological medicine does NOT contra Ray Kurzweil improve at the same speed as the information sciences or computer transistors thank you very much.
@Rez77
In 2007 it was also thought to be impossible to regrow hair follicles - follica is able to do it and it should be out at the end of this year or starting next year. Till 2016 it was thought impossible to eliminate myofibroblast (the cells which cause scarring) or even make them switch into any other type of cells. Now in 2017 we know that growing hair follicles or adding bmp 2 and bmp4 tells myofibroblast to change into fat cells. Basically a scar has no fat cells or hair follicles it's made of collagen bundles which were caused by myofibroblast. By turning myofibroblast into fat cells you are able to do three things at once A: you are able to regenerate fat B: since myofibroblast are made to become fat, you are also eliminating the thick scar collagen bundles. C: you are not fooling around with the bodies wound repair Management. It is a breakthrough!!!
But till it will be out it will take time although bmp2 is already used in clinics for bone healing but bmp4 is not used yet. But Cotsarelis and dr plikus / dr Anderson they have great credentials in the field of skin / hair regeneration. In 2006 - 7 it was considered a breakthrough that follicle can be regrown and they almost there with the launch www.follicabio.com and in 2017 it's a breakthrough that scar cells can be turned into normal skin. So I guess a very pessimistic outlook would be 10years but it could be sooner out there.
PolarityTE is also working on growing skin in lab it is mainly designed for burn or large wounds and might not be the perfect solution for smaller scars. But it will further push things into the right direction. So I think we will See multiple solutions for wound healing coming up in the next 10years
And checkout this https://renovacareinc.com/
I sincerely think that PolarityTE will be a great solution for scarring. Im entering dental school next year and if you notice, many components to replace teeth have to be ordered and manufactured in labs and each patient is different so, It seems complicated but in fact, It's now s common practice. Why would it be crazier for skin? Dermatology has to progress, as dentistry and ophtalmology did in the last few years (especially with the LASIK)
9 hours ago, SunnyX said:And checkout this https://renovacareinc.com/
Above is just recell --been around for a decade --I talked to one dermatologist who used it after fraxel and said I could expect 30 percent improvement in scars. Which is nothing considering the depth and severity of my scars.
Come on, you're saying a cure for hair loss will be out next year?
I will say though, I'm starting to become a bit more optimistic....
http://www.utsouthwestern.edu/newsroom/news-releases/year-2017/may/gray-hair.html
59 minutes ago, Rez77 said:Above is just recell --been around for a decade --I talked to one dermatologist who used it after fraxel and said I could expect 30 percent improvement in scars. Which is nothing considering the depth and severity of my scars.Come on, you're saying a cure for hair loss will be out next year?
I will say though, I'm starting to become a bit more optimistic....
http://www.utsouthwestern.edu/newsroom/news-releases/year-2017/may/gray-hair.html This article has nothing to do with scars but is related to hair loss, which is kind of related. It seems as though we are discovering more and more each week! No reason not to be optimistic.
11 minutes ago, Rez77 said:I need a cure for balding too
Seems like we are not too far away. They did a study I believe where the amount of money donated for balding research is 10x the amount than cancer. That is pretty crazy, it seems like soon all of the stars will align. Live I've said plenty of times, if most experts agree that bioprinting is the future (bones, organs, etc.) What will be the first thing that has to be conquered? The skin of course!
9 hours ago, Davrak said:I sincerely think that PolarityTE will be a great solution for scarring. Im entering dental school next year and if you notice, many components to replace teeth have to be ordered and manufactured in labs and each patient is different so, It seems complicated but in fact, It's now s common practice. Why would it be crazier for skin? Dermatology has to progress, as dentistry and ophtalmology did in the last few years (especially with the LASIK)
On a tangential note, do you know how far we might be from regenerating or creating biological bioteeth so that we could have living teeth implanted in our jaws instead of metal studded implants? Also, periodontal tissue for receding gums?
2 hours ago, Rez77 said:11 hours ago, Davrak said:I sincerely think that PolarityTE will be a great solution for scarring. Im entering dental school next year and if you notice, many components to replace teeth have to be ordered and manufactured in labs and each patient is different so, It seems complicated but in fact, It's now s common practice. Why would it be crazier for skin? Dermatology has to progress, as dentistry and ophtalmology did in the last few years (especially with the LASIK)
On a tangential note, do you know how far we might be from regenerating or creating biological bioteeth so that we could have living teeth implanted in our jaws instead of metal studded implants? Also, periodontal tissue for receding gums?
http://www.healthline.com/health-news/re-growing-teeth-and-healing-wounds-without-scars
this article answers both of ur questions
ThoughtI would share this article - looks interesting :
'Magic' skin gun sprays stem cells on to burns victims' wounds
17 hours ago, Davrak said:I sincerely think that PolarityTE will be a great solution for scarring. Im entering dental school next year and if you notice, many components to replace teeth have to be ordered and manufactured in labs and each patient is different so, It seems complicated but in fact, It's now s common practice. Why would it be crazier for skin? Dermatology has to progress, as dentistry and ophtalmology did in the last few years (especially with the LASIK)
Dermatology is the most backward of all fields of medicine.
11 hours ago, SunnyX said:http://www.healthline.com/health-news/re-growing-teeth-and-healing-wounds-without-scarsthis article answers both of ur questions
that's really cool. King's college though --I asked the scientist --Paul King of this research project when teeth might be viable and he said he doubts as soon as 2030 but "its possible". So I'm not hugely exepctant this gonna happen "soon"
1 hour ago, Rez77 said:that's really cool. King's college though --I asked the scientist --Paul King of this research project when teeth might be viable and he said he doubts as soon as 2030 but "its possible". So I'm not hugely exepctant this gonna happen "soon"
One step at a time. If we can get scarring under control fairly soon and then teeth by 2030, I'd would be thankfull.
6 hours ago, scarred2468 said:^ Are you looking at teeth regeneration? What are you looking forward to regarding teeth?
Yeah I had teeth taken out by my orthodontist which ruined my bite and some of my teeth are quite scarred from unsightly fillings. If it were possible to have your existing teeth pulled and have a new set of lab grown teeth (with real biological pink gum tissue between the teeth) etc. I would do it in a heartbeat even for a 100 grand (which I don't have lol). Anyone know when having lab-grown teeth will be possible?
9 hours ago, mjg713 said:10 hours ago, Rez77 said:that's really cool. King's college though --I asked the scientist --Paul King of this research project when teeth might be viable and he said he doubts as soon as 2030 but "its possible". So I'm not hugely exepctant this gonna happen "soon"
One step at a time. If we can get scarring under control fairly soon and then teeth by 2030, I'd would be thankfull.
Totally, I'd be the happiest guy in the world.
@Rez77
I think soon there will be multiple solutions for skin and teeth. The reason for my optimism is that in the early days of tissue engineering it was considered that adults cells cannot regenerate, so they concluded that embryonic stem cells can grow organs in the lab and then it can be put into the Patience Body. However, the problem with that approach was that in lab it became difficult to control those cells. For example if u have cut on ur left arm, then only that area will be healing, you will not grow a leg or anything else. In the past 10 years scientists acknowledge that the body is the best bioreactor and they started to look how the existing cells can be manipulated. So by now we understand that embryonic stem cells are not necessarily required, adult stem cells are capable of much more then thought. So basically all the current approaches be it PolarityTE, Follica, dr. Cotsarelis scarfree or skingun, they all use the body as a bioreactor and only try to provide it the information in need to regenerate itself with its own cells.