20 hours ago, Rez77 said:

I just talked to a famous scientist at MIT who specializes in wound closure and regenerative medicine. He said hydrogels were once a hope for many people but they proved ineffective in humans. He also said that at the earliest we might have some kind of therapy by the 2030s but definitely not by 2020 or before the 2030s --and he said --at the most optimistic there may be something by 2030. Okay, so I'm not going to waste the next 13 years of my life on this site. Checking in every few days to read didly squat except you guys who keep posting stuff about hydrogels when you know none of these companies are doing anything except trying to keep their grant money coming in. Wake me up in a decade and a half.

What is the name of this famous Scientist?

That statement (in in fact any Scientist made it, which I doubt) is not supported by the evidence.

The fact is that there 118 Clinical Trials ongoing (right now) to test potential solutions for scarring. Check out this link for proof:
https://clinicaltrials.gov/search/open/condition ="Cicatrix"

Not all of these will succeed...but not all willfail either. (A solution will be here before 2030!)

^Agreed. We know a fuck ton more about scarring than we did even a few years ago, and no one so far has tried combining every scar reducing method. I don't think it will take more than 10 years, and if it does I think it will be due to bureacracy and not the process of invention.

In regards to the comments about gemstone, everything we're seeing says that it won't work for scarring in humans. Sunogel may have better results.

ask him yourself: https://be.mit.edu/directory/robert-langer

I wish seabs could talk to him directly. So that we can clear this up once and for all. It is tiresome with all this information back and forth: Does it work or doesnt it?

3 hours ago, Frasier said:

I wish seabs could talk to him directly. So that we can clear this up once and for all. It is tiresome with all this information back and forth: Does it work or doesnt it?

No offense Frasier, but I do not want to keep coming to this thread, again and again and again torefutemisinformation...
The hydrogel has proven scar free healing by the fact it has got rete pegs, scar tissue does not get rete pegs... I could go on and on, and on highlighting that and thenotherpeoplecould go on and on obscuring and then misinforming the scientific information from the consensus in a never ending circle.Where time will be wasted and wasted and wasted...

15 hours ago, seabs135 said:

No offense Frasier, but I do not want to keep coming to this thread, again and again and again torefutemisinformation...
The hydrogel has proven scar free healing by the fact it has got rete pegs, scar tissue does not get rete pegs... I could go on and on, and on highlighting that and thenotherpeoplecould go on and on obscuring and then misinforming the scientific information from the consensus in a never ending circle.Where time will be wasted and wasted and wasted...

Why then is Gemstone publicly shifting the focus of the hydrogel to chronic wounds, and not scarless healing, in their response to the paraphrased question "What happened to your plans for scarless healing?"

Success in pigs does not mean it will work in humans, even if the skin had rete pegs. Nothing is proven yet, unless you're solely concerned about wounds in pigs.

What about FS2 any news??

I think mjg's response is as good as we're going to get. Some more details and actual proof would be nice though

6 hours ago, Albaneso said:

What about FS2 any news??

FS2 is promising and I gave all the information already. However, don't count on it being available anytime soon. FS2 would probably take around 3-5 years to reach the public if successful in it's third clinical trial.

^Luckily their trials are pretty short, at least their first one was I think. Basically the the trials only need to last as long as it does for skin to finish remodeling. 3 years sounds reasonable but I'd hope for sooner

FS2 is easily my biggest hope regarding this

1 hour ago, scarred2468 said:

^Luckily their trials are pretty short, at least their first one was I think. Basically the the trials only need to last as long as it does for skin to finish remodeling. 3 years sounds reasonable but I'd hope for sooner

FS2 is easily my biggest hope regarding this

Check out PolarityTE.com and the SkinTE product. It has many strong, accredited doctors and backers behind it. They say the product will be out by early 2018 for clinical use. There just is not a lot of information out on it to judge that timeline.

20 hours ago, mjg713 said:

21 hours ago, scarred2468 said:

^Luckily their trials are pretty short, at least their first one was I think. Basically the the trials only need to last as long as it does for skin to finish remodeling. 3 years sounds reasonable but I'd hope for sooner

FS2 is easily my biggest hope regarding this

Check out PolarityTE.com and the SkinTE product. It has many strong, accredited doctors and backers behind it. They say the product will be out by early 2018 for clinical use. There just is not a lot of information out on it to judge that timeline.

Thanks for sharing, very intesresting! This guys will be more than rich if everything works haha, reading through their website is really promising and i almost want to buy shares from their company haha

The only problem I see is that every scar would be treaten isolated ; from example, patients with multiples acne scars on a area. Each scar would have to be excised to create new wound to induce the regenerative healing process and remove the scarred tissue. But I guess that will be worth it, thanks for the sharing:) For those of you who are sceptical, I was at first, but juste go read this presentation (when there's money and a strong medical personal behind, you can be sure this has to work haha) : http://c.eqcdn.com/_53c4d61041f9d032b30f1347d6381744/polarityte/db/270/1110/pdf/MARCH+2017+POLARITY+SLIDE+DECK.pdf

"....Check out PolarityTE.com and the SkinTE product...."
I dont want to sound negative, but taking a look at the website of this company it does rather look like a cure-all Snake oil

Around two thirds of the website content is PR-bla bla for potential investors, and looking back the "news/press release" section a page until half a year ago this company developed video games, before magically finding the holy grail of the Biomed science.
From animals testing to trials to market in a matter of a few months ?
cant be serious ?

11 hours ago, C h r i s said:

"....Check out PolarityTE.com and the SkinTE product...."
I dont want to sound negative, but taking a look at the website of this company it does rather look like a cure-all Snake oil

Around two thirds of the website content is PR-bla bla for potential investors, and looking back the "news/press release" section a page until half a year ago this company developed video games, before magically finding the holy grail of the Biomed science.
From animals testing to trials to market in a matter of a few months ?
cant be serious ?

You're right in the sense that there is a lot of PR on the website for investors. However, that does not negate the effectiveness of the product. For the record the original company was founded in 2004 and just recently the technology has come to fruition. They did not develop video games, Majesco did but was a failing business so decided to "buy in" last year. That is there right to do so, just as any company has that right. Apple does not have to just sell computers, they got involved with phones and will be getting into self-driving cars soon, etc. Now you may question why would the CEO buy into a bio-tech company? Maybe it's because they know something we don't and truly believe in the product?

If you look at the website, the skin product is the only product close to being clinically used. However, it would not be abnormal to think that cartilage, bone, etc would be next? Why should they stop at just skin? I do agree that their timeline is very ambitious, but it is not impossible. Remember this is a "device" and not a drug, it can be approved very quickly. Regardless of the truth, this company is not any less reputable than Gemstone, which has been smoke and mirrors for around 8 years with an update every 10 months. Or the Sunogel website, which looks like an elementary student put together and the only evidence being the healing of a small abrasion on a finger.

Problem is, acne scarring leads to significant tissue and collagen loss. I doubt. In fact I'm certain that any "scar-free" healing thing will be able to grow back the tissue. For many of us who are older in our late twenties or thirties this means that something like a facelift is actually necessary to re-tighten all this tissue that is severely affected by the collagen and fat loss. Not to mention the actual problem of the scar and skin that is all f'd up as well. Only a multi-modal solution could ever help.

And we are very very far from tissue engineering new skin. That is the holy grail and it wouldn't mean some funding for a hydrogel --it would be as I have always maintained a series of scientific breakthroughs that would mean the fountain of youth. You think that's around the corner? Nope. So I really don't know what to do.... My acne scarring has destroyed parts of my face.

16 hours ago, Rez77 said:

Problem is, acne scarring leads to significant tissue and collagen loss. I doubt. In fact I'm certain that any "scar-free" healing thing will be able to grow back the tissue. For many of us who are older in our late twenties or thirties this means that something like a facelift is actually necessary to re-tighten all this tissue that is severely affected by the collagen and fat loss. Not to mention the actual problem of the scar and skin that is all f'd up as well. Only a multi-modal solution could ever help.

And we are very very far from tissue engineering new skin. That is the holy grail and it wouldn't mean some funding for a hydrogel --it would be as I have always maintained a series of scientific breakthroughs that would mean the fountain of youth. You think that's around the corner? Nope. So I really don't know what to do.... My acne scarring has destroyed parts of my face.

I don't know. You bring up good points. Maybe solutions will regrow the skin to match surrounding skin but not completely tighten the skin like skin of a new born?

21 hours ago, Rez77 said:

Problem is, acne scarring leads to significant tissue and collagen loss. I doubt. In fact I'm certain that any "scar-free" healing thing will be able to grow back the tissue. For many of us who are older in our late twenties or thirties this means that something like a facelift is actually necessary to re-tighten all this tissue that is severely affected by the collagen and fat loss. Not to mention the actual problem of the scar and skin that is all f'd up as well. Only a multi-modal solution could ever help.

And we are very very far from tissue engineering new skin. That is the holy grail and it wouldn't mean some funding for a hydrogel --it would be as I have always maintained a series of scientific breakthroughs that would mean the fountain of youth. You think that's around the corner? Nope. So I really don't know what to do.... My acne scarring has destroyed parts of my face.

Please dont let your emotions define what science can do or cant do. It gets very tiresome. Yes, acne scars sucks, but your negative emotions just clouds what in fact IS possible. And you might bring others here down on the same level that you are emotionally. To be honest I think your are selfish and lack control of your impulses.

5 hours ago, Frasier said:

Please dont let your emotions define what science can do or cant do. It gets very tiresome. Yes, acne scars sucks, but your negative emotions just clouds what in fact IS possible. And you might bring others here down on the same level that you are emotionally. To be honest I think your are selfish and lack control of your impulses.

Okay tell me what science can do.

2 hours ago, Rez77 said:

Okay tell me what science can do.

Seabs has told you zillions of times.

Why is it so hard to believe that regeneration of the skin is near? Look at how great science is, and what is possible to do today. Is skin regeneration more crazy than going to mars (near future) or teleporting (they have already managed to move a particle from a to b)? Dont think so.

i hope i am wrong but i don't see anything getting rid of scars in the next 50 years or ever. Sorry to be a Debbie Downer,

Fraiser......get on with your life....it might happen or it might never happen.......

I used that copper peptides to tighten uo my face to get the look that my scars were better.....did it get rid of them.....no.....but after spending thousands of dollars on scar treatments..it is cheep and helps just as much.

Hi,
i think it won't take 50 years. 10 years ago it was thought to be impossible to regrow hair follicles once lost, however follica is going to be out by next year and it does regrow new hair follicle. The same group (dr cotsarelis and plikus) have identified bmp2 and bmp4 as the key protein which turn myofibroblast (which causes scarring) into fat cells and again both things were considered impossible to turn myofibroblast into another cell and to gegenerate lost fat. You have to understand that our skin regenerates it self every 4 -6 weeks and by eliminating myofibroblast a scar cannot take place, normal regeneration will take place.
Furthermore by the Wnt pathway it is also possible to regrow hair follicle in a wound which will also cause myofibroblast to turn into fat, because the newly created hair follicles express high amount of BMP. In fact PolarityTE is going to use the Wnt pathway to grow complete skin.
On the other hand FS2 will not do much since it cannot completely suppress the myofibroblast. Basically it has been understood in order to prevent scars you need hairfollicles or BMP. science does understand more about regeneration and i think it will take around 10 years not because science but because of regulation on getting new med. on the market.

2 hours ago, nikkigirl said:

i hope i am wrong but i don't see anything getting rid of scars in the next 50 years or ever. Sorry to be a Debbie Downer,

Fraiser......get on with your life....it might happen or it might never happen.......

I used that copper peptides to tighten uo my face to get the look that my scars were better.....did it get rid of them.....no.....but after spending thousands of dollars on scar treatments..it is cheep and helps just as much.

I am getting on with my life, you have no clue how I live my life. If you make statements like: "I dont see anything getting rid of scars in the next 50 years or ever", you have to back it up. Again, it is just emotions speaking. What kind of scientific evidence do you have to make statements like that? It is just annoying to be honest.

1 hour ago, SunnyX said:

Hi,
i think it won't take 50 years. 10 years ago it was thought to be impossible to regrow hair follicles once lost, however follica is going to be out by next year and it does regrow new hair follicle. The same group (dr cotsarelis and plikus) have identified bmp2 and bmp4 as the key protein which turn myofibroblast (which causes scarring) into fat cells and again both things were considered impossible to turn myofibroblast into another cell and to gegenerate lost fat. You have to understand that our skin regenerates it self every 4 -6 weeks and by eliminating myofibroblast a scar cannot take place, normal regeneration will take place.
Furthermore by the Wnt pathway it is also possible to regrow hair follicle in a wound which will also cause myofibroblast to turn into fat, because the newly created hair follicles express high amount of BMP. In fact PolarityTE is going to use the Wnt pathway to grow complete skin.
On the other hand FS2 will not do much since it cannot completely suppress the myofibroblast. Basically it has been understood in order to prevent scars you need hairfollicles or BMP. science does understand more about regeneration and i think it will take around 10 years not because science but because of regulation on getting new med. on the market.

I'm just curious, where did you get that PolarityTE will use the Wnt pathway?

4 hours ago, nikkigirl said:

i hope i am wrong but i don't see anything getting rid of scars in the next 50 years or ever. Sorry to be a Debbie Downer,

Fraiser......get on with your life....it might happen or it might never happen.......

I used that copper peptides to tighten uo my face to get the look that my scars were better.....did it get rid of them.....no.....but after spending thousands of dollars on scar treatments..it is cheep and helps just as much.

what type of scars you have nikki??