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I know what your saying. Its draining to pin your hopes on this with the possibility of a dead end. The thought is actually quite scary to me too.
I wish we could somehow get regular/scheduled updated from Harmon. Not that he is required to do anything for us personally. He has his own priorities. But it would be good for us and it would probably give a real running head start as far as having a following for when/if crowd funding starts.
@chuckstonchew Maybe you could mention this to him. Getting scheduled regular updates. I think it would make a lot of people feel better and get more people interested. Just an idea.
It would definately be helpful for e.g. the Facebook page where it says that people are working on the gel. But if people were to see what progress is being made and if they were to get a realistic timeline indication as far as when people can expect to see any results from further testing is concerned and so on, it would no doubt spark way more interest.
Thanks for the reply, wentworthwhile.
Maybe Dr harmon will know?
It's the manner in which a lot of people post that makes me a tad hesitant to read through the last few pages trying to decipher everything in an effort to draw any conclusions from it all. Don't get me wrong, I'm not speaking negatively about anyone but sometimes the posting isn't very neat.
Typos and chaotic posts... Or dense paragraphs without proper punctuation... I figured I'd just ask a clear question so that someone can give me clear answer.
I keep keeping an eye on this thread and stuff does happen. In the sense that this thing is being pushed forward. But if it's going to take a year before we see the first testing in humans than I might as well check back in a year, you know?
I also know that if it is found out that it works on people it might become available very soon after that. But like I said, if the testing on people doesn't start until after a year...
How likely is it that we will actually be seeing tests this year? Because it seems like a lot of (frustrating) hassle that is going to take aeons to take care of still needs to be taken care of before testing on people can even begin after which we might even get disappointed as we might find out that it doesn't work on people?
I know what your saying. Its draining to pin your hopes on this with the possibility of a dead end. The thought is actually quite scary to me too.
I wish we could somehow get regular/scheduled updated from Harmon. Not that he is required to do anything for us personally. He has his own priorities. But it would be good for us and it would probably give a real running head start as far as having a following for when/if crowd funding starts.
@chuckstonchew Maybe you could mention this to him. Getting scheduled regular updates. I think it would make a lot of people feel better and get more people interested. Just an idea.
He does give me regular updates.
It's just that as of late, his updates are that there are no new updates.
He's waiting for his lawyer to meet with the JHU officials and as soon as that happens, he has said he will let me know the outcome.
Until then, there's really nothing to update on I'm afraid. This is the next step and nothing else can occur until this step is completed.
He said he would let me know as soon as it was completed. And as soon as I know, the first thing I'll do is post it here!
my god this is so sad nothing will happen from here in years!
this is the time where the years pass and nothing will happen, the stagnation phase.
This is pathetic nothing will happen.
Things will happen for those who don't give up.
All the nonsense shit posts in this thread are getting us nowhere.
Let's agree that this will be the last post that doesn't add anything new and constructive to the discussion.
my god this is so sad nothing will happen from here in years!
this is the time where the years pass and nothing will happen, the stagnation phase.
This is pathetic nothing will happen.
Things will happen for those who don't give up.
All the nonsense shit posts in this thread are getting us nowhere.
Let's agree that this will be the last post that doesn't add anything new and constructive to the discussion.
You mean you have to be like those who only speak of facts and do nothing just sit in a chair...
Or you simply be those who say you have to be positive when in fact the years pass and there is no solution....
Or maybe you you become like those that they think they work together with any doctor just because they speak by phone with (when that doctor just by talking to the injured and only want money). and the reality is that it will take a decade at least there is some evidence that people with hydrogel ...
the fuc,ki,n,g reality is that years go by and there's not think there is a solution for mammals bitch on this issue, at least that is the perfect solution I seek.
I'll just say a few things ...
Number one: clone hydrogel is too complicated (not from the professional side they can do), but from the side of the equipment that you need and if you do be done in a place with the minimum requirements and that takes a lot of money as I said this person, this is something you said seabs. Still and all cloned but you could be friends and do some biologist somewhere 'normal' that would be a dirty place and if the hydrogel not work ... so therefore I dismiss it.
Number two: hydrogel is easier to achieve than you think. talk to any biologist to investigate on hydrogel and see ... just the biologist should read a little about the story and find out a little and give them a good tip. So if, like everyone, need some money, shall be joining (if they have not). some good thousands of dollars to go recruit some biologist and then clear your surgeon. I already know how to get it but of course, as I said has enough money. I recommend you not only waste your time with buffoons like chu#y, scar%in#to# or other #d#ot# who promise that hydrogel go on sale ... for that many years will miss ... better talk to biologists to find out about and listen to their recommendations hydrogel , talk to them and say they want to have their hydrogel already, and you will see they are told.
Number three: forget dr hammnd, doing nothing nor cares for us, will happen a decade or more until there is evidence in humans (and probably stay in this nowhere and not work), if they did nothing after 1 year, is that perhaps already tested and does not work.
Remember that this may not work, we are mammals and for over two thousand years that man wants to heal without scarring and can not .. why to do it right now? perhaps we are the lucky ones at the right time? i don't think so...
And yes...reality sucks, learn to live with it.
Maldition, I respect your opinions, but they're just that. Nothing you say is backed up by any sort of evidence or reasoning. I'm sorry that you feel so cheated by the system and that a way to regenerate scars hasn't come about as quickly as you'd like. I think we're all in that same boat.
JHU has never said that the biogel is difficult to create. Quite the opposite actually because in numerous publications they talked about how easy it is to replicate. The problem it seems has been litigation and lack of investment.
Your advice for us is somewhat contradictory. You tell us to seek out biologists but then turnaround and dismiss doctors, researchers, scientists and even biologists that have created the hydrogel. If you think everyone has an agenda and that it's to scam everyone out of their money then why do you trust the specific biologists you've talked to? And are they simply biologists or do they have clinical expertise and experience as well?
Judging by their responses it seems like they are much more likely to be scam artists like the ones you see selling "stem cell cures" all around the globe. You're coming to them in desperation with a problem you've made them feel only they can solve. And what will they say if it doesn't work regardless if they prepared and applied the hydrogel right? Just exactly what you thought to begin with. That it was a failed product from the start. You're putting them in a no-lose situation.
I don't know why you think no one that you might contact wouldn't be able to review and understand the data. We can find it in a matter of seconds and I would imagine something like this, whether or not you believe in the likelihood of its success, would be huge news in the medical community. So of course someone you've contacted could talk about it with relative ease. Even if they hadn't heard of it before, the beauty of the hydrogel is its simplicity so someone with a formal education in the field could easily understand it.
As far as Dr. Harmon wanting to help us or just being out for the money it's just pure speculation and doesn't add anything to the conversation. You don't know him, his motives, his aspirations or anything about the man. So why insinuate that he's a greedy huckster trying to sell scams? And again, you contacted someone just like we did and you seem to have put your faith in them. So I ask, what's the difference?
I guess I don't know what you're advocating. Sitting around doing nothing and proclaiming the sky is falling and accept that your life sucks? I'll admit that no one knows with 100% certainty (and yes seabs, I realize all evidence points to it working) that the hydrogel will work but the facts are that it's the only thing that's gotten these kinds of results. Why not get involved and see what happens? I know the answer; fear. You're afraid of getting burned like I'm sure so many others are. That's fine, I can empathize. But the alternative is doing nothing and being miserable and accepting that as "reality". I'd rather see what I can do to help this along and see where it goes regardless of the outcome.
I'm not trying to offend you by responding in this way. I'm just trying to get you to see the other side of the argument.
Just curious...from what I understand, the scar tissue has to be excised first, right? So would this be practical for someone with extensive scarring? Like people who have rolling scars all over their cheeks, or just widespread scarring in general? Or would the hydrogel be effective in those conditions if say, applied directly after an ablative laser treatment? Or do they just have to keep waiting for the NEXT big thing to come along?
Just curious...from what I understand, the scar tissue has to be excised first, right? So would this be practical for someone with extensive scarring? Like people who have rolling scars all over their cheeks, or just widespread scarring in general? Or would the hydrogel be effective in those conditions if say, applied directly after an ablative laser treatment? Or do they just have to keep waiting for the NEXT big thing to come along?
As far as I understand, there is still contraction. If this is the case, large areas will not be ideal to treat.
It's possible that the contraction could be eliminated though. If the scars aren't too deep, I'd imagine for example that you could do dermabrasion instead of excision, which would help some. Nevertheless, wound contraction is much better understood than scarless healing and should thus be easier to fix. Some agents are already known to block myofibroblast differentiation, like decorin. (Myofibroblasts are responsible for wound contraction.)
Just curious...from what I understand, the scar tissue has to be excised first, right? So would this be practical for someone with extensive scarring? Like people who have rolling scars all over their cheeks, or just widespread scarring in general? Or would the hydrogel be effective in those conditions if say, applied directly after an ablative laser treatment? Or do they just have to keep waiting for the NEXT big thing to come along?
Scarminator the paper mentions nothing about any contraction as far as I can see.
For needed comparisons the hydrogel was compared to a standard state of the art standard control; otherwise if you did not follow that standard procedure that typically happens for the control, you could not compare the hydrogel to the standard control and this would have no standards to compare the hydrogel to. And your paper would not have an objective comparison,... Schmood, for direct comparison between the widely used standard scaffold (the control) and the hydrogel; the experiment had to follow a typical standard procedure that always happens with the control scaffold when you are burned by a 3rd degree burn. Anyway after a 3rd degree burn a full thickness 3rd degree burn tissue was cut out. The 3rd degree burn was fully excised as to what happens in the control standard procedure. They then placed the control scaffold into a wound, the control behaved typically and scarred. The simple degradable digestable hydrogel on the other hand digested rapidly mostly in under 7 days, and got complete scar free healing, complete regeneration. The simple hydrogel degraded rapidly, upon digesting cells were created, (matching data in other studies that shows that cells are created upon digestion). Thats it,the gel degraded rapidly and got complete regeneration. The only way you'd scar is if the hydrogel does not degrade rapidly enough is the logic.
schmood, as I can see from the paper, any area of most sizes will be treatable depending on your immune system (your digestion rate). If you do not produce neutrophils, by logic you will not digest the material no matter the size of the wound, if you do produce neutrophils you will digest the material. All mammals have a tissue response with whiteblood cells when injured. The material is eaten by the whiteblood cells.
As far as I understand, there is still contraction. If this is the case, large areas will not be ideal to treat.
It's possible that the contraction could be eliminated though. If the scars aren't too deep, I'd imagine for example that you could do dermabrasion instead of excision, which would help some. Nevertheless, wound contraction is much better understood than scarless healing and should thus be easier to fix. Some agents are already known to block myofibroblast differentiation, like decorin. (Myofibroblasts are responsible for wound contraction.)
I once spoke to doctors about having my scar cut out and subsequently having it heal with a certain scar reducing dressing. Once I said that it was in a place where there was a certain tension they said that that might make things more difficult but not necessarily impossible. These were doctors from a good hospital.
Wow! Thank you guys for your answers! I really admire how dedicated and knowledgeable you all are (:
Transcript of president Obama's speech:
http://www.foxnews.com/politics/2013/02/12/transcript-obama-state-union-speech/
Today, our scientists are mapping the human brain to unlock the answers to Alzheimer's. We're developing drugs to regenerate damaged organs, devising new materials to make batteries 10 times more powerful. Now is not the time to gut these job-creating investments in science and innovation. Now is the time to reach a level of research and development not seen since the height of the space race. We need to make those investments.
LOLOLOL God people's desire to hope is absolutely astounding. Don't you people think that if this technology showed any real promise the military would just set up an instant fund prove the efficacy of this technology like several months ago!!?? They'd even circumvent any FDA rules, I mean it would have happened. You do realize the power of what this would mean. It's akin to like a cure for AIDS or CANCER --that's the magnitude of this find.
IT'S COMPLETE BULLSHIT.
LOLOLOL God people's desire to hope is absolutely astounding. Don't you people think that if this technology showed any real promise the military would just set up an instant fund prove the efficacy of this technology like several months ago!!?? They'd even circumvent any FDA rules, I mean it would have happened. You do realize the power of what this would mean. It's akin to like a cure for AIDS or CANCER --that's the magnitude of this find.
IT'S COMPLETE BULLSHIT.
Go trolling somewhere else. Seriously. You have obiously no idea how these institutions work (keyword = bureaucracy)
LOLOLOL God people's desire to hope is absolutely astounding. Don't you people think that if this technology showed any real promise the military would just set up an instant fund prove the efficacy of this technology like several months ago!!?? They'd even circumvent any FDA rules, I mean it would have happened. You do realize the power of what this would mean. It's akin to like a cure for AIDS or CANCER --that's the magnitude of this find.
IT'S COMPLETE BULLSHIT.
It is a absolute true fact that complete regeneration happemed (it is retestable) after the hydrogel degraded, and note this is the only permutation. (It is also a fact that scaffolds do not discriminate and that cells are created upon digestion.) There is nothing that can be contested or debated here with regards to any scientific debate. As there is only one permutation proven true. Therefor trying to debate one scienific fact is pointless. An example of how ridicuous it is to debate one fact, John asks jane if she wants ice cream. Jane says its true she does. Do you debate that Jane wants ice cream on a loop when there is only one permutation? Jane wants ice cream, verified. Jane wants ice cream, verified and so on. Any debate when there is only one permutation would only prejudice a fact.
To me as there is only one permutation, to debate the science here is pointless. You'd be more productive talking to a brick wall whilst playing rick astley on loop annoying your neighbours. However there is a debate over funding, there are many permutations that can be discussed here; which have been discussed.
Okay, here's my prediction, and I won't even fucking write another goddamn thing on this thread until Feb. 2014: NOTHING WILL HAPPEN WITH THIS AND SCARRING IN HUMANS FOR ANOTHER 20 YEARS. NOTHING. IF IT WAS GOING TO HAPPEN IT WOULD HAVE ALREADY. IF IT WORKED, THERE WOULD HAVE BEEN A TIDAL WAVE OF FUNDING. HOW'S THAT FOR A FACT!!!??? TILL THEN WE'LL ALL BE A BIT OLDER AND THE COLLAGEN IN OUR SCARS WILL HAVE CONTINUED TO DEGRADE AND LOOK WORSE.
I'm gonna go have an ice cream now, you guys should find another hobby...
Okay, here's my prediction, and I won't even fucking write another goddamn thing on this thread until Feb. 2014: NOTHING WILL HAPPEN WITH THIS AND SCARRING IN HUMANS FOR ANOTHER 20 YEARS. NOTHING. IF IT WAS GOING TO HAPPEN IT WOULD HAVE ALREADY. IF IT WORKED, THERE WOULD HAVE BEEN A TIDAL WAVE OF FUNDING. HOW'S THAT FOR A FACT!!!??? TILL THEN WE'LL ALL BE A BIT OLDER AND THE COLLAGEN IN OUR SCARS WILL HAVE CONTINUED TO DEGRADE AND LOOK WORSE.
I'm gonna go have an ice cream now, you guys should find another hobby...
Anyway, I appreciate your concern. People shouldn't get their hopes up too soon. I agree and people are keeping it mind. 
Hi all - it is a bit disappointing how the hydrogel research has 'moved'
Could these 3 questions be answered by some scientist who has worked on the project:
[1] When they say the skin has 'complete regeneration' does that mean what it sounds like to a person on the street - ie. would the skin return to exactly how it was before scarring, ie look the same - and have the same functionality, ie nerves/sweat etc as before
[2] Some on this thread, including myself, have got/are very hopeful about the fact that this gel resulted in 'complete regeneration' - ie. believe that in the future the discovery might mean a product that can get rid of the scars on our skin - and return it to how it was before we got acne - at this moment is that a mistaken hope - or is there a chance this might happen and more research is needed, or completely unrealistic
[3] We understand the initial trials with hydrogel were in August 2011 - but no follow-up trials have yet been conducted, is there a reason for the delay - are we right/wrong to take this as a sign of what others think of the hydrogel
I understand some of these may have been answered to an extent - but basically - these 3 questions are all that all on here are debating about - and could debate for endlessly - in the end - they need to be answered by someone who carried out research on this project
If someone who is in contact with them could ask these that would be great - I'd email them myself right now - the only thing is I don't want these people to start feeling pestered by our thread.... however, if those in contact say they'd rather I emailed I will
thanks once again to all who've tried to get info 
mars
I asked "1" directly to Sharon Gerecht last year...and received no response.
[1] When they say the skin has 'complete regeneration' does that mean what it sounds like to a person on the street - ie. would the skin return to exactly how it was before scarring, ie look the same - and have the same functionality, ie nerves/sweat etc as before
Hi all - it is a bit disappointing how the hydrogel research has 'moved'
Could these 3 questions be answered by some scientist who has worked on the project:
[1] When they say the skin has 'complete regeneration' does that mean what it sounds like to a person on the street - ie. would the skin return to exactly how it was before scarring, ie look the same - and have the same functionality, ie nerves/sweat etc as before
Complete regeneration means complete regeneration, full tissue with no scarring, like what happens in your non scarred skin. Incomplete regeneration means incomplete regeneration, scarring blocking off complete regeneration, like what happened in the control, and like what happens when anyone scars.
Anyway, I appreciate your concern. People shouldn't get their hopes up too soon.
But people should always have rational expectations built on evidence not perception, one way or another. You should only see what you expect with evidence. It is possible you could break your ankle stepping off a curb, but you do not put a weight of expectation on something that has a probability almost zero. What evidence or logic do you have for hope?
Okay, here's my prediction, and I won't even fucking write another goddamn thing on this thread until Feb. 2014: NOTHING WILL HAPPEN WITH THIS AND SCARRING IN HUMANS FOR ANOTHER 20 YEARS. NOTHING. IF IT WAS GOING TO HAPPEN IT WOULD HAVE ALREADY. IF IT WORKED, THERE WOULD HAVE BEEN A TIDAL WAVE OF FUNDING. HOW'S THAT FOR A FACT!!!??? TILL THEN WE'LL ALL BE A BIT OLDER AND THE COLLAGEN IN OUR SCARS WILL HAVE CONTINUED TO DEGRADE AND LOOK WORSE.
I'm gonna go have an ice cream now, you guys should find another hobby...
There are no facts you have shown here. Your Mother and Father told you there is a santa claus therefor there must be a santa claus, is the logic you are following.
@lapis lazuli - I see.... - did you email any of the others Sun/Harmon?
@seabs135 - I appreciate your enthusiasm - but this really is the crux of the matter - ie. how the skin might look in its everyday appearance - it may be for example that a scientist would describe someone completely regenerated and that they may be just mostly concerned with function - I hope I am wrong! but I think we really need the answer to this question!
@lapis lazuli - I see.... - did you email any of the others Sun/Harmon?
@seabs135 - I appreciate your enthusiasm - but this really is the crux of the matter - ie. how the skin might look in its everyday appearance - it may be for example that a scientist would describe someone completely regenerated and that they may be just mostly concerned with function - I hope I am wrong! but I think we really need the answer to this question!
@Mars btw Mars, I'm not anything about anything in life, sometimes bare facts in life can be brutal. BTW If you look at this thread in general you will see people comparing scars and being enthusiastic with no evidence or logic whatso ever, who then talk about a wide array of approaches with no evidence, they are the ones who go with enthusiasm. Anyway I'm like a broken record here, but if skin is completely regenerated then the skin is completely regenerated, with complete tissue with no scar. If the smallest appendages you can get on the skin (appendages you cant see with your naked eye) are regenerated then anyone, using this evidence and common sense, can make a logical conclusion that this is normal texture.