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[Sticky] Scarless Healing

 
MemberMember
33
(@chuckstonchew)

Posted : 01/18/2013 3:57 pm

More good news.

I'm in contact with writers from the popular technology websites PopSci and Gizmag.

PopSci has agreed to do an article on it when the Indiegogo campaign is launched.

Gizmag hasn't agreed yet, but I think they will.

 

Does anyone else have any websites like this that you think I should contact?

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MemberMember
16
(@maldition)

Posted : 01/18/2013 4:58 pm

More good news.

I'm in contact with writers from the popular technology websites PopSci and Gizmag.

PopSci has agreed to do an article on it when the Indiegogo campaign is launched.

Gizmag hasn't agreed yet, but I think they will.

 

Does anyone else have any websites like this that you think I should contact?

 

 

 

the sun

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MemberMember
73
(@seabs135)

Posted : 01/18/2013 5:17 pm

More good news.

I'm in contact with writers from the popular technology websites PopSci and Gizmag.

PopSci has agreed to do an article on it when the Indiegogo campaign is launched.

Gizmag hasn't agreed yet, but I think they will.

 

Does anyone else have any websites like this that you think I should contact?

 

 

Heres some websites I've just found off an internet search

 

 

http://www.ebizmba.c...cience-websites

 

www.wired.com

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0
(@Anonymous)

Posted : 01/18/2013 6:23 pm

chuckstonchew awesome awesome work!

With Dr Harmon starting a small company and contacting his lawyer, does this mean hes doing this himself?

or still through JHU?

maybe there are some specific online mags like for cosmetic surgery, scars etc...

i will have a look

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MemberMember
16
(@maldition)

Posted : 01/18/2013 6:53 pm

hydrogel

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MemberMember
8
(@mars123)

Posted : 01/18/2013 9:13 pm

wow - how great all this is happening!

 

As regards media - if Dr Harmon does go through with this of course contact magazines/sites that this would directly apply to - but also I would contact big publications as I think you'd easily get some to print a story on this!

 

After all - it is a great story, it involves something anyone can understand and millions can directly relate to [ie. scars] - it has the interesting angle of crowdfunding as a potential new way of the new way of funding projects whilst cutting down on the institutional process of money-raising - and also a potential breakthrough discovery... I honestly think it would be quite easy to get majors to print something about this... which would obviously help it to be funded !

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MemberMember
16
(@maldition)

Posted : 01/18/2013 10:01 pm

wow - how great all this is happening!

 

As regards media - if Dr Harmon does go through with this of course contact magazines/sites that this would directly apply to - but also I would contact big publications as I think you'd easily get some to print a story on this!

 

After all - it is a great story, it involves something anyone can understand and millions can directly relate to [ie. scars] - it has the interesting angle of crowdfunding as a potential new way of the new way of funding projects whilst cutting down on the institutional process of money-raising - and also a potential breakthrough discovery... I honestly think it would be quite easy to get majors to print something about this... which would obviously help it to be funded !

 

 

 

i told you before...reality sucks, many years for hydrogel. is not negative...it's reality

 

 

be realistic...

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MemberMember
8
(@mars123)

Posted : 01/19/2013 8:05 am

@Maldition

 

you're opinion is as valid as anyone elses - and you're welcome to it - but if the hydrogel does what we want it to do in larger animal/human skin and it's just the bureaucratic process holding it up then the process can be changed - which is exactly what Dr Harmon is attempting to do by considering using crowd-funding

 

Of course when transferred to larger animal/human testing it may not do what we want - but as far as I can see this is the only thing in existence at the moment that at least has a chance [of promoting scarfree healing] so I for one at least want to see what the next level testing will do - and as quickly as possible

 

If it doesn't live up to expectations, it doesn't - but if nothing is done then method for scarfree healing certainly wont drop out of the sky and land on some scientist's lap

 

And it seems that a common theme around this hydrogel is that scientists who developed it and have specialist knowledge in this area believe in it

 

Also

 

@chuckstonchew

 

please inform Dr Harmon of this site if he doesn't already know it! - this foundation specifically funds scientists who are independent

 

http://www.breakoutlabs.org/home.html

 

 

BREAKOUT LABS

 

Breakout Labs is the Thiel Foundations newest program. Through Breakout Labs, were reshaping the way early-stage science is funded, so that early-stage companies can advance their most radical ideas. Venture capital firms want research that can be quickly brought to market, and federal funding offers little room for risky, unproven ideas. We are jumping into this funding gap to energize innovative research. Breakout Labs is not a typical foundation grantwe are a revolutionary, revolving funding model where successful projects fund the next generation of audacious scientific exploration.

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MemberMember
41
(@vladislav)

Posted : 01/19/2013 9:14 am

More good news.

I'm in contact with writers from the popular technology websites PopSci and Gizmag.

PopSci has agreed to do an article on it when the Indiegogo campaign is launched.

Gizmag hasn't agreed yet, but I think they will.

 

Does anyone else have any websites like this that you think I should contact?

 

 

This one is interesting, I find a lot of interesting things in this magazine:

http://www.scientificamerican.com/

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MemberMember
7
(@nightlilly89)

Posted : 01/19/2013 9:37 am

I'm new to this info on hydrogel. Can someone explain how or if this can help indented or white scars?

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MemberMember
16
(@maldition)

Posted : 01/19/2013 11:45 am

I'm new to this info on hydrogel. Can someone explain how or if this can help indented or white scars?

 

 

 

if you want help, you should donate money to the creators of hydrogel so that they can start testing phase (you must be a millionaire of course). or if you can not do as chuck and do positive things, like making contact Facebook and foundations and magazines for them to put money

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MemberMember
7
(@nightlilly89)

Posted : 01/19/2013 11:49 am

 

I'm new to this info on hydrogel. Can someone explain how or if this can help indented or white scars?

 

 

 

if you want help, you should donate money to the creators of hydrogel so that they can start testing phase (you must be a millionaire of course). or if you can not do as chuck and do positive things, like making contact Facebook and foundations and magazines for them to put money

 

 

how many years have you gone through this

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MemberMember
16
(@maldition)

Posted : 01/19/2013 11:58 am

 

 

I'm new to this info on hydrogel. Can someone explain how or if this can help indented or white scars?

 

 

 

if you want help, you should donate money to the creators of hydrogel so that they can start testing phase (you must be a millionaire of course). or if you can not do as chuck and do positive things, like making contact Facebook and foundations and magazines for them to put money

 

 

how many years have you gone through this

 

 

 

1

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MemberMember
33
(@chuckstonchew)

Posted : 01/19/2013 12:27 pm

I'm new to this info on hydrogel. Can someone explain how or if this can help indented or white scars?

 

 

The scar could be excised and covered with the hydrogel just like in the trials with mice.

 

 

if you want help, you should donate money to the creators of hydrogel so that they can start testing phase (you must be a millionaire of course). or if you can not do as chuck and do positive things, like making contact Facebook and foundations and magazines for them to put money

 

 

You mustn't be a millionaire. That's the beauty of crowd funding. Everyone donates a little and it adds up. Strength in numbers.

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MemberMember
16
(@maldition)

Posted : 01/19/2013 1:44 pm

 

I'm new to this info on hydrogel. Can someone explain how or if this can help indented or white scars?

 

 

The scar could be excised and covered with the hydrogel just like in the trials with mice.

 

 

if you want help, you should donate money to the creators of hydrogel so that they can start testing phase (you must be a millionaire of course). or if you can not do as chuck and do positive things, like making contact Facebook and foundations and magazines for them to put money

 

 

You mustn't be a millionaire. That's the beauty of crowd funding. Everyone donates a little and it adds up. Strength in numbers.

 

 

 

is good to know this

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MemberMember
157
(@golfpanther)

Posted : 01/19/2013 3:06 pm

chuckstonchew, I'm amazed by the progress you've made and definitely want to help any way I can with crowdfunding or anything else. Also, to whoever created the FB page, good work!

 

indiegogo, kickstarter and sites like them typically want a video made promoting/explaining whatever is being funded. As I've said before, I can help with that should the need arise.

 

I think it's a great move to get in touch with publications like Wired, Scientific American and the like. We might also want to try for more broad magazines that reach a lot of people such as Newsweek, Time etc. I realize those might be a bit of a longshot but if we're working with a researcher or team at JHU on a crowdfunding project there is definitely a story there. I haven't heard of any other community such as ours working with the scientific community to help something get funded.

 

Anyway, good work all around and chuckstonchew keep us posted on the progress. I'm curious to know if Harmon has discussed a funding goal yet.

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MemberMember
16
(@maldition)

Posted : 01/19/2013 10:33 pm

chuckstonchew, I'm amazed by the progress you've made and definitely want to help any way I can with crowdfunding or anything else. Also, to whoever created the FB page, good work!

 

indiegogo, kickstarter and sites like them typically want a video made promoting/explaining whatever is being funded. As I've said before, I can help with that should the need arise.

 

I think it's a great move to get in touch with publications like Wired, Scientific American and the like. We might also want to try for more broad magazines that reach a lot of people such as Newsweek, Time etc. I realize those might be a bit of a longshot but if we're working with a researcher or team at JHU on a crowdfunding project there is definitely a story there. I haven't heard of any other community such as ours working with the scientific community to help something get funded.

 

Anyway, good work all around and chuckstonchew keep us posted on the progress. I'm curious to know if Harmon has discussed a funding goal yet.

 

 

users on here not yet put a coin in the Foundation created. something we can put all this money to accelerate not you think?

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MemberMember
16
(@maldition)

Posted : 01/19/2013 11:40 pm

@seabs135

 

if you read the news for months the first amphibious discovered regenerative capacity of the world (the mouse Africa), this mouse has the ability to create blasphemous known as the salamander, but the scientists said that the key is that tissue regeneration is which makes it slow and not fast as scientists believe it should be for no scar ... here I hit a piece you can find in the notes to the web:

 

 

It could represent a new model of skin wound healing and tissue regeneration in humans, "he said.

Another difference to the researcher, was observed in the protein network that holds the cell in place, called extracellular matrix.

"These mice seem to deposit extracellular matrix in their wounds more slowly than other rodents, pigs and humans," says Dr. Seifert.

"While many scientists are trying to accelerate the healing process, our studies spiny mouse and salamanders show the right path to regeneration is slow things."

 

 

 

Who believes that being more rapid healing will have less scar ... will hit a wall.

 

 

Indeed in a hydrogel note I found this snippet:

The project was funded by Maryland Stem Cell Research Fund Exploratory Grant and Postdoctoral Fellowship and the National Institutes of Health.

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MemberMember
73
(@seabs135)

Posted : 01/20/2013 5:17 am

Malditon, the results are not the property of your opinion, my opinion or anyone elses. The results come from a paper...

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MemberMember
16
(@maldition)

Posted : 01/20/2013 11:39 am

and in the end that's just what we are going to serve us the results. therefore seek explanations and no good, as some say that healing is a form and then others say it is another.

 

 

I still do not trust anything regenerate by the fact that 'digest' a hydrogel ... probably if a component is regenerated VEGF but maybe they do not want to say. if hydrogel fails we're screwed for life because the next step is to wait a cure African mouse. so work should pray that hydrogel

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MemberMember
49
(@panos)

Posted : 01/20/2013 12:08 pm

and in the end that's just what we are going to serve us the results. therefore seek explanations and no good, as some say that healing is a form and then others say it is another.

 

 

I still do not trust anything regenerate by the fact that 'digest' a hydrogel ... probably if a component is regenerated VEGF but maybe they do not want to say. if hydrogel fails we're screwed for life because the next step is to wait a cure African mouse. so work should pray that hydrogel

 

 

 

from the pantent:

 

 

 

[0089] In exemplary embodiments, the delivery of VEGF promotes tissue ingrowth and functional vascularization. In the examples that follow, five- week-long study first revealed significantly more tissue ingrowth, primarily by macrophages, into the VEGF-encapsulated hydrogel than into blank hydrogel. This result may suggest that VEGF attracts circulating cells into the hydrogel, thus promoting tissue penetration. Phelps et al. also found that matrices lacking VEGF showed less tissue invasion than VEGF-incorporating matrices (Phelps et al., Proc Natl Acad Sci U S A, vol. 107, no. 8, pp. 3323-8, 2010). The tissue ingrowth might further expedite scaffold biodegradation, which in return could facilitate further ingrowth. This result was further confirmed by a three-week-long multiple GF delivery study; without the VEGF encapsulation, in which neither the blank hydrogel nor the hydrogel loaded with SDF-1 and IGF showed any significant tissue ingrowth. Although Cohen et al. (Dvir et al., Proc Natl Acad Sci U S A vol. 106, no. 35, pp. 14990-5, 2009) demonstrated that a scaffold encapsulated with SDF-1 and IGF promoted prevascularization when implanted onto a rat omentum, these hydrogels revealed neither significant tissue ingrowth nor vascular structures with the encapsulation of SDF-1 and IGF. Overall, these results suggest that VEGF delivery is required to initiate sufficient tissue ingrowth, which eventually leads to functional vascular development within the hydrogel implants.

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MemberMember
73
(@seabs135)

Posted : 01/20/2013 1:08 pm

Malditon, with regards to digestion and cell creation. Why do you not trust something that has been proven?. It is cited in the paper that the loose in architecture hydrogel digested rapidly and got complete regeneration, the control did not digest rapidly. Also the paper also cites another study which highlights that digestable gels create cells and non digestable gels scar.

 

Additionally, recent studies demonstrated that a degradable hydrogel allowed and directed cell growth in vitro (31, 32) compared to nondegradable hydrogels.

With regards to VEGF, and vascular networks. The hydrogel had no problems with the angiogenic response. By day 5 vascular networks were established in the hydrogel, unlike the control. That is another thing that stands out and is shown in the paper. it soaked up blood and created vascular networks early.

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MemberMember
16
(@maldition)

Posted : 01/20/2013 3:15 pm

Malditon, with regards to digestion and cell creation. Why do you not trust something that has been proven?. It is cited in the paper that the loose in architecture hydrogel digested rapidly and got complete regeneration, the control did not digest rapidly. Also the paper also cites another study which highlights that digestable gels create cells and non digestable gels scar.

 

Additionally, recent studies demonstrated that a degradable hydrogel allowed and directed cell growth in vitro (31, 32) compared to nondegradable hydrogels.

With regards to VEGF, and vascular networks. The hydrogel had no problems with the angiogenic response. By day 5 vascular networks were established in the hydrogel, unlike the control. That is another thing that stands out and is shown in the paper. it soaked up blood and created vascular networks early.

 

 

 

just hope it works ... the best of it is that it can regenerate hole wide as the mouse so it is not necessary to suture wounds would open perhaps.

 

perhaps by not using sutures takes longer but better. though maybe stay motionless in bed for a few weeks to not move the skin to heal well

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MemberMember
73
(@seabs135)

Posted : 01/22/2013 12:58 pm

chuckstonchew, I'm amazed by the progress you've made and definitely want to help any way I can with crowdfunding or anything else. Also, to whoever created the FB page, good work!

 

indiegogo, kickstarter and sites like them typically want a video made promoting/explaining whatever is being funded. As I've said before, I can help with that should the need arise.

 

I think it's a great move to get in touch with publications like Wired, Scientific American and the like. We might also want to try for more broad magazines that reach a lot of people such as Newsweek, Time etc. I realize those might be a bit of a longshot but if we're working with a researcher or team at JHU on a crowdfunding project there is definitely a story there. I haven't heard of any other community such as ours working with the scientific community to help something get funded.

 

Anyway, good work all around and chuckstonchew keep us posted on the progress. I'm curious to know if Harmon has discussed a funding goal yet.

 

 

This has massive appeal, this should not stop at anything.

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MemberMember
8
(@mars123)

Posted : 01/22/2013 8:28 pm

thought this might interest some - just shows scientists are working towards some pretty radical things...

http://www.dailymail.co.uk/sciencetech/article-2266689/Cancer-victim-growing-new-nose-arm-Businessman-lost-organ-disease-hopes-new-sewn-face.html

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