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Vladislaf if you take the time to investigate like veteran member does...you know that stem cells in wound healing dont work its another scam (like all cains of lasers like fraxel). The only solution is excise the scar, and then apply some product that inhibit scar formation. I really hope hydrogel works...is the only light in the end of the tunel...
Vladislaf if you take the time to investigate like veteran member does...you know that stem cells in wound healing dont work its another scam (like all cains of lasers like fraxel). The only solution is excise the scar, and then apply some product that inhibit scar formation. I really hope hydrogel works...is the only light in the end of the tunel...
than what is this?
http://en.wikipedia.org/wiki/Cytori_Therapeutics#Core_technology:_the_Celution_System
or this?
The only solution is excise the scar, and then apply some product that inhibit scar formation. I really hope hydrogel works...is the only light in the end of the tunel...
Actualy my scar is just under the eye and the plastic surgeon told me honestly that it cannot be excised because it could pull the lower lid of the eye and
to deform the whole face, it's a problem so he told me that the best option for me is the stem cells treatment.
And I have no a genetic predisposition for the creation of excessively large scars (I know it because I have another scar on my forehead from 7 years ago, it is well stiched and it is almost invisible and it is VERY BEAUTIFUL and the scar on my stomach from the surgery is not keloid nor hypetrophic scar, it is not raised, it is in the plane of the skin, it is just relatively wide - somewhere only 1.5mm or 2mm and somewhere 8mm), but the problem with that scar under the eye is that it is poorly stiched, I'm sure that if it could be excised and again precisely and carefully stiched then there will be something like 80% improvement without any product that inhibit scar formation, should I ask my plastic surgeon about the possible insertion of a silicone balloon into the cheek - I guess that if it is possible than the sillicone baloon should create additional skin to prevent cheek to pull the lower eyelid, what do you think?
These are the picturues of that scar under the eye:
Vladislaf if you take the time to investigate like veteran member does...you know that stem cells in wound healing dont work its another scam (like all cains of lasers like fraxel).
Pictures above are photoshop. There have been some great results in the past. These are fake.
ok, but then what is this?
http://en.wikipedia.org/wiki/Cytori_Therapeutics#Core_technology:_the_Celution_System
http://www.cytori.com/Home.aspx
It cannot be a scam, I guess that it is very expensive medical device, if it is a scam then nobody would have bought it, but anyway it is not the device that my plastic surgeon will use on me because this device extract stem cells from adipose tissue and not from the blood and I still don't know exactly what kind of device is that but I'll find it out soon.
Ðhis regenerative medicine is very interesting to me because I have lost my spleen in a stupid accident and then I got the scars, though the spleen is not a vital organ and it is possible to have a perfectly normal life without the spleen, anyway I would like to have my spleen back again, but most of all I would like to see my scars dissapear.
And in a few days I will write something that is even more interesting and promising in the field of regeneration of the skin, very serious thing from a group of very serous people and as I can see it hasn't been mentioned here yet... but the only problem is that I doubt it will be commercially available for us in less than 10 years 
but anyway, I think it is very promising 
Yes and I would like to have wings and a girlfriend that doesn't moan.
Well read about this on an artificial trachea (windpipe):
http://en.wikipedia....Transplantation
In June 2011, a team of surgeons led by Professor Paolo Macchiarini at the Karolinska University Hospital performed the first synthetic windpipe transplant on a 36-year-old Eritrean man, Andemariam Teklesenbet Beyene.
I hope that this is just the beginning of that 'new medicine' that I was talking about because today's medicine is a garbage.
http://www.karolinsk...ered-Windpipe-/
First Successful Transplantation of a Synthetic Tissue Engineered Windpipe
For the first time in history, a patient has been given a new trachea made from a synthetic scaffold seeded with his own stem cells. The patient, a 36-year old man, is well on the way to full recovery and will be discharged from the hospital tomorrow.
The operation was performed on June 9th 2011 at Karolinska University Hospital in Huddinge, Stockholm, by Professor Paolo Macchiarini, of Karolinska University Hospital and Karolinska Institutet, and colleagues.
Professor Macchiarini led an international team including professor Alexander Seifalian from UCL (University College London, UK) who designed and built the nanocomposite tracheal scaffold and Harvard Bioscience (Boston, USA) who produced a specifically designed bioreactor used to seed the scaffold with the patient´s own stem cells. The cells were grown on the scaffold inside the bioreactor for two days before transplantation to the patient. Because the cells used to regenerate the trachea were the patient™s own, there has been no rejection of the transplant and the patient is not taking immunosuppressive drugs.
The patient had been suffering from late stage tracheal cancer. Despite maximum treatment with radiation therapy, the tumor had reached approximately 6 cm in length and was extending to the main bronchus. It was progressing and almost completely blocked the trachea. Since no suitable donor windpipe was available, the transplantation of the synthetic tissue engineered trachea was performed as the last possible option for the patient, referred by Professor Tomas Gudbjartsson of Landspitali University Hospital (Iceland) who was also part of the surgical team.
The successful transplantation of tissue engineered synthetic organs, referred to as regenerative medicine, could open new and very promising therapeutic possibilities for the thousands of patients who suffer from tracheal cancer or other conditions that destroy, block or constrict the airway.
Professor Macchiarini has previously performed successful transplants of tissue engineered tracheas, but on those occasions the tracheas used were taken from organ donors and then reseeded with the patient™s own stem cells.
Transplantations of tissue engineered windpipes with synthetic scaffolds in combination with the patient™s own stem cells as a standard procedure, means that patients will not have to wait for a suitable donor organ. This would be a substantial benefit for patients since they could benefit from earlier surgery and have a greater chance of cure. In addition to treating adult patients; tissue engineered synthetic trachea transplants would, not least, be of great value for children, since the availability of donor tracheas is much lower than for adult patients.
excise the scar, and then apply some product than inhibit scar formation
this is very risky, you would be placing all your trust in the product,
I do not think there any dermatologist (surgeon) willing to practice this, I have consulted with many of them, they have their mind closed
A method more safe is dissolve the scar, and then apply some product(inhibit scar)
Stick to the facts, fact based logic:
Scarring takes longer than regeneration, fact.
Scarring response takes 30days plus to form the white collagen, fact,
The quicker a wound reepithilizes the less scar, fact.
If a wound reepithilizes in under 21 days there will be no scar, clinically observed fact.
Hair follicles and sweat glands do not form in scars, clinically observed fact.
A widget A has been proven to beat a standard widget. This prepared widget A reepithilized a wound in under 21days whilst the standard took longer, fact.
Vlad, in 2012 with these commonsense facts known, why should anyone in 2012 suffer and look at the future from 2007?
Keep to the facts above.
With regards to decorin, it is cited somewhere on this thread that decorin,is absent in wounded tissue and doesnt return to a normal level in the tissue for 12months. It is also cited somewhere in this thread that decorin arrests fibroblast proliferation (fibroblast proliferation is what produces excess collagen).
I'm with anything that can reepithilize a 3rd degree burn wound in under 21days.
Unfortunately you cannot achieve scar-free healing of the skin with decorin, only 40% reduction of the scar is achievable,
you can read about it here:
http://www.purdue.ed... 2010 01 13.pdf
Wounds treated with Pelladerm have shown a 40%reduction in visible scar
Cosmetic appearance results, illustrated in Figure 1 below, showthat a single dose of Pelladerm results in a 40% decrease in visible scar.
Figure 1. Cosmetic Appearance of Wounds. Single dose application of Pelladermresults in a 40% decrease in visible scar. * Denotes statistical significance.
And extraction of natural decorin is very expensive, it could cost $440,000, you can read about it on page 6
I have never talked about the decorin you were pointing to. There is a difference between the decorin your body produces and that decorin.
Your bodies decorin stops scarring 100%, it arrests the fibroblasts.
I have said in this thread that this decorin will not work like your bodies decorin, for two reasons, 1 your body is flooded with decorin 24/7 when not injured. 2 this is artificial decorin that is either injected once or,it is the car decorin stuff that gets transported to injury in some way. And thes actions do not flood your body with decorin.
Is there any scientific study that confirms that natural decorin stops scarring 100%? Can you leave us the link?
There where some nice results from Recell, I wonder if they could perfect the treatment to healing in less then 21 days. Also if hydrogel is coming out this year, I wonder how it will effect combinations of treatment using hydrogel, Acell, recell.
I believe that one of the most important things of scareless healing is the right kind of enviroment for the scar to heal, the moisture on the skin and the task given by the body to heal the scar. Everyone knows the importans of a scab when healing, a scab is a natural scaffold. Maybe a perfect scaffold could be the answer in combination to Recell, Acell or a future stemcell treatment.
Recell promotes healing and cell forming once applied, only thing is that I can't imagine it being enough as there is no scaffold to cultivate the cells in once applied.
The very enviroment might keep results back, and also this might be true about Acell.
I am trying Recell anyway, today I have to contact the surgeon in Leeds. I am already booked for a consultation by Dr. Khan. I have a new goal in life, and that is to be the last person with scars.
Seabs I have great respect that you have sticked to this tread for so long and have been answering questions. You would make a very committed skin biologist.
The other is a naturally occurring protein called decorin, which they previously showed prevents the buildup of fibrous connective tissue that causes scarring. The combination of the peptide and protein turns out to be particularly powerful.
Our original results showing that decorin blocks scarring have been repeated in numerous animal studies and drugs like this are badly needed. However, decorin has never reached the clinic, most likely because decorin is difficult to manufacture in large quantities, says Dr. Ruoslahti.
New Insights into Scar Prevention
http://beaker.sanfordburnham.org/2010/11/new-insights-into-scar-prevention/
Is there any scientific study that confirms that natural decorin stops scarring 100%? Can you leave us the link?
There is the one above that alonso posted which I might have posted myself in a later post.
However IMO all I would need to do with regards to the question is show you the logic:
It has been cited the myofibroblast is responsible for the scar, it nits excess collagen in a process from 4weeks to a year after injury.
After injury decorin is does not reach normal levels till up to 12month following injury. In that time collagen forms.
The myofibroblast in non wounded tissue is arrested by decorin, decorin is flooded in your tissues. When non injured your tissues normally dont scar.
It has been established that decorin at 200nm completely arrests fibroblast proliferation. It has been established fibroblasts create scar tissue.
IMO deduced reason from the above logic shows strongly that decorin stops scarring.
And thVladislav, stop it...we know what you're doing...you only stay here for publish that scam doctor and that scam treatment.
winnietheblue: where you read hydrogels its going to sale on this year? , you wrong, the inventor of this hydrogel says 'we need more experiments on animals, and then on humans'...a couple of years.
Stick to the facts:
Scars take longer than regeneration.
Scars take 30 days+ to form
If a skin reepithilizes in under 21 days there will be no scar
Hair follicles do not grow in scar tissue, sweat glands do not form in scar tissue.
Unfortunately it is not so simple, wound healing is a very complex set of processes, re-epithelialization is just one of the processes of wound healing, there are about 7 or 8 processes of wound healing (I'm not sure for the exact number) - re-epithelialization is just one of them, and each of these processes should be significantly changed if you want to achieve scar free healing of the mammalian skin wound, though it is a true that re-epithelialization should be drastically accelerated but it is not the only thing that should be done if you want to achieve scar free healing, and there are somthing like 10 different proteins that should be changed in its levels (some should be upregulated by 500-fold and the others should be downregulated to 0 or whatsoever) and many other things should be changed, some scientists have some clues how scar free healing works, I will write about it in a few days because I have no enough time right now.
There where some nice results from Recell, I wonder if they could perfect the treatment to healing in less then 21 days. Also if hydrogel is coming out this year, I wonder how it will effect combinations of treatment using hydrogel, Acell, recell.
I believe that one of the most important things of scareless healing is the right kind of enviroment for the scar to heal, the moisture on the skin and the task given by the body to heal the scar. Everyone knows the importans of a scab when healing, a scab is a natural scaffold. Maybe a perfect scaffold could be the answer in combination to Recell, Acell or a future stemcell treatment.
Recell promotes healing and cell forming once applied, only thing is that I can't imagine it being enough as there is no scaffold to cultivate the cells in once applied.
The very enviroment might keep results back, and also this might be true about Acell.
I am trying Recell anyway, today I have to contact the surgeon in Leeds. I am already booked for a consultation by Dr. Khan. I have a new goal in life, and that is to be the last person with scars.
Seabs I have great respect that you have sticked to this tread for so long and have been answering questions. You would make a very committed skin biologist.
Who is doing that recell treatment besides that dr. Khan in the UK? I saw that it is very often mentioned here on this forum and I saw some girl with an ugly scar on her forehead with a pretty good results, is that a stem cells treatment or what is it? Can it help me for this small scar that I have under my eye?
Oooh now is a scientists...this flooder its propaging that scam doctor x treatment.
No, I'm an business school student/MBA undergraduate, I'm not propagating anything and I'm sure that you wouldn't come thousands of miles away for it when you have it somewhere closer to you, and the other plastic surgeon in the same clinic told me that she thinks that I could achieve better results with fat grafting then with that stem cells treatment, I don't know is it true or not, the first thing I need to know is a manufacturer and a model of that device that extract adult stem cells from the blood, then I will find all the information and patient's experiences about it, then I can decide whether I will go for the treatment or not.
there are many processes in wound healing, but re-epithelialization is one of the last processes, if re-epithelialization occurs is because the other processes have already occur
http://en.wikipedia.org/wiki/Wound_healing
The faster re-epithelialization dramatically decreases the incidence of abnormal scarring [2] and gives patients a faster recovery time.
Does anybody know when should we expect results from the fourth Phase II clinical trials of EXC-001? It was a success in three Phase II clinical trials so far.
http://clinicaltrial...=EXC 001&rank=2
