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vladislav, these are poor results,
I don't think so, look at this:
After 4 doses the improvement is obvious. EXC-001 is Excaliard's leading product but there are plans for future drugs - these should target some other proteins besides CTGF, these should additionally improve scar reduction. And that company is actually an Isis Pharmaceuticals spin-off, their financiers were three different venture capital firms and Phizer took over them in November 2011 after three successful Phase II clinical trials. And results from the fourth Phase II clinical trial should be announced this month I guess:
http://clinicaltrial...=EXC 001&rank=2Enrollment:68Study Start Date:May 2011Estimated Study Completion Date:May 2012Estimated Primary Completion Date:May 2012 (Final data collection date for primary outcome measure)
Company comments
We are pleased to reach this significant milestone for Halscion and look forward to making Celotres available to European physicians this year, said Kathleen Beauchamp, President and CEO of Halscion. Celotres will prove an important tool for physicians to consider when managing wound healing and scar outcomes.
Check the site. I have contacted the company when this product will be released and when full results are published.
There where some nice results from Recell, I wonder if they could perfect the treatment to healing in less then 21 days. Also if hydrogel is coming out this year, I wonder how it will effect combinations of treatment using hydrogel, Acell, recell.
I believe that one of the most important things of scareless healing is the right kind of enviroment for the scar to heal, the moisture on the skin and the task given by the body to heal the scar. Everyone knows the importans of a scab when healing, a scab is a natural scaffold. Maybe a perfect scaffold could be the answer in combination to Recell, Acell or a future stemcell treatment.
Recell promotes healing and cell forming once applied, only thing is that I can't imagine it being enough as there is no scaffold to cultivate the cells in once applied.
The very enviroment might keep results back, and also this might be true about Acell.
I am trying Recell anyway, today I have to contact the surgeon in Leeds. I am already booked for a consultation by Dr. Khan. I have a new goal in life, and that is to be the last person with scars.
Seabs I have great respect that you have sticked to this tread for so long and have been answering questions. You would make a very committed skin biologist.
Who is doing that recell treatment besides that dr. Khan in the UK? I saw that it is very often mentioned here on this forum and I saw some girl with an ugly scar on her forehead with a pretty good results, is that a stem cells treatment or what is it? Can it help me for this small scar that I have under my eye?
I have no idea what kind of scar you have or if it will help your skin. There is a skin surgeon in Leeds hospital, he is one of the researchers of Recell. They treat scars at the hospital with stemcell cultivated from you owns skin and sprayed on the treated area. Some impressive improvements have been made in combination with laser and dermabrasion. Although it might not be the best solution there is, for moderate scars and skin texture I am expecting improvement.
Stick to the facts:
Scars take longer than regeneration.
Scars take 30 days+ to form
If a skin reepithilizes in under 21 days there will be no scar
Hair follicles do not grow in scar tissue, sweat glands do not form in scar tissue.
Unfortunately it is not so simple, wound healing is a very complex set of processes, re-epithelialization is just one of the processes of wound healing, there are about 7 or 8 processes of wound healing (I'm not sure for the exact number) - re-epithelialization is just one of them, and each of these processes should be significantly changed if you want to achieve scar free healing of the mammalian skin wound, though it is a true that re-epithelialization should be drastically accelerated but it is not the only thing that should be done if you want to achieve scar free healing, and there are somthing like 10 different proteins that should be changed in its levels (some should be upregulated by 500-fold and the others should be downregulated to 0 or whatsoever) and many other things should be changed, some scientists have some clues how scar free healing works, I will write about it in a few days because I have no enough time right now.
Vlad you have to be trolling imo.
I'm also laughing at the fact, in order to convey this "authority", you are trying to explain the obvious that the microproces of regeneration is complex, which everyone knows as fact. Explaining this does not make what you say special. If you look at anything under a microscope it looks complex, the more you magnify the more complex it looks. Also that fact that something looks more complex the more you magnify has nothing to do with scar free healing, it actually has nothing to do with scar free healing. If you observe something, you just observe that thing. E.g.If I observe a car, I observe a car, if that cars engine is complex its complexity has nothing to do with the fact that I observe that car is parked in the street.
Do you buy a new computer then rip it apart to study all its microproceses, before you use it, or do you just use it? <<<< Can you see your fallacy?
Anyway I'm going to repeat the facts one more time:
Scars take 30+ days to form fact,
Scars form slower than regeneration
If a wound reepithilizes in under 21days there will be no scar.
E.g sweat glands do not grow in scar tissue. If you observe a wound that has sweat glands in it. This means it doesn't scar.
Oooh now is a scientists...this flooder its propaging that scam doctor x treatment.
No, I'm an business school student/MBA undergraduate, I'm not propagating anything and I'm sure that you wouldn't come thousands of miles away for it when you have it somewhere closer to you, and the other plastic surgeon in the same clinic told me that she thinks that I could achieve better results with fat grafting then with that stem cells treatment, I don't know is it true or not, the first thing I need to know is a manufacturer and a model of that device that extract adult stem cells from the blood, then I will find all the information and patient's experiences about it, then I can decide whether I will go for the treatment or not.
so...you re nobody...you only a poor student mba. Go back to school and read more about scarless treatments please.
Hey chill out, do not attack me for no reason, I'm not advertising anything here, you're paranoid and nervous, for a few days I will give you something to read that I expect you will like, it's a research study about scar free healing, I'm surprised that it hasn't been mentioned here yet!?, it was recently published by a group of people that are so long in regenerative medicine, they're beginning to understand a lot about scar free healing, about every process (including re-epithelialization) and much else, they're saying some further, more detailed studies are necessary but they already have a general concept of scar free healing, and it's not about some treatment, it's just an academic article today but tomorrow it could became something that is more tangible, at least if you're young enough, than there could be hope for you and your scars.
Vladislav, when you want advice you should send a picture of your scar and post it in a new topic.
I don't mind you posting, I just wouldn't let a surgery scar obses me in scareless healing.
Just come back in a few years and the cure might be there and in the meanwhile live your life and relax.
You can cover a surgery scar with dermablend of it's close to the surface, you could get a surgical tattoo to blend it in with the surrounding skin.
If you want to swim, just buy a swimming suite for men. If it is for the woman, tell them or have sex with dimmed lights.
Maybe I am wrong, but if your obsessed with one or two scars and exspecially when one is under your shirt. Then maybe you have BDD or something else. It seems like a waste of time when in 4 years you might just read it in the news and can get the scar removed in one go.
If you want to keep posting, sure I don't mind.
Vladislav, when you want advice you should send a picture of your scar and post it in a new topic.
I've already sent it.
Actualy my scar is just under the eye and the plastic surgeon told me honestly that it cannot be excised because it could pull the lower lid of the eye and
to deform the whole face, it's a problem so he told me that the best option for me is the stem cells treatment.
And I have no a genetic predisposition for the creation of excessively large scars (I know it because I have another scar on my forehead from 7 years ago, it is well stitched and it is almost invisible and it is VERY BEAUTIFUL and the scar on my stomach from the surgery is not keloid nor hypetrophic scar, it is not raised, it is in the plane of the skin, it is just relatively wide - somewhere only 1.5mm or 2mm and somewhere 8mm), but the problem with that scar under the eye is that it is poorly stitched, I'm sure that if it could be excised and again precisely and carefully stiched then there will be something like 80% improvement without any product that inhibit scar formation, should I ask my plastic surgeon about the possible insertion of a silicone balloon into the cheek - I guess that if it is possible than the sillicone baloon should create additional skin to prevent cheek to pull the lower eyelid, what do you think?
These are the pictures of that scar under the eye:
So what do you think Is it treatable with recell?
I don't know, I am not a specialist and you should contact Dr. Khan. You could ask a camouflage specialist they are great at concealing a scar and it will save you a lot money.
Please print a picture of a burned person and hang it next to the mirror. (it could really help) Your mind has exaggerated the problem because you focus to much and your seeing it out of perspective. Half of mankind has a scar like that and it fades over time.
Hey people.
I see there are some new people posting here so I thought I'd share my thoughts on "scarless" healing.
I'm sure that in the future one can go and get their scars removed. I'd bet a lot of money on that. That's how certain I am.
However, today is not tomorrow.
Right now it is not possible reverse the damage. To get your scars removed. Maybe in theory it is possible. But not realistically speaking. As there isn't a treatment available that can do the trick. Those are the facts. Now you can read all these things that researchers and companies put up on the internet and that's fine... I mean it's very interesting and it kind of gives you an indication of when "tomorrow" will be here in that you can actually remove your scars.
But the more time you spend reading all of that the less time you have to go out and live your life. What I'm trying to tell you is that you shouldn't obsess over your scars. Ok? Don't put your energy in hoping for a cure. Hoping isn't going to make any treatment come to fruition. It's just going to take time and there isn't a thing we can do to make that time shorter. Unless anyone here is a multi-multi-multi-multi-multi millionnaire, of course. But I highly doubt that.
Put your energy in learning to live with your scars instead. For a large part I think people with physical imperfections who have trouble dealing with it on a daily basis are holding themselves back. It's the psychological trauma that keeps people from feeling secure or peaceful. So deal with that and regardless of your scars still being there or not by the time you have dealt with it the negative impact that having scars will have on your life will be lessened with 90% or more. I really think it is like that. It does depend on the severity of your scarring, I won't deny that. The more you have the more it will have an impact on your life. That's just the way it is. But you'd be surprised by how many people who have physical imperfections are out there living a full life regardless.
This thread is interesting and all and if the news comes out that a genuinely effective treatment is available I'm sure you'll read about it here. But that will probably not be this year. Nor next year. Nor the year after that. Nor the year after that... So try to let go of your insecurities. Give society the benefit of the doubt. The good people in this world won't reject you or treat you differently because of a few scars. Keep moving forward and just make the best of things. And maybe one day you'll be able to even fix your scars. And if that day never comes it doesn't matter either. Because life can be beautiful. Even for people with scarring.
Lapis... read about hydrogel...
I have. I'll bet you 1000 Euros that you'll never hear from that again in the news. It's just going to disappear. Stop. As it won't come to fruition. It won't work on humans. Hydrogels are nothing new. Sure they have achieved an interesting result with the mouse. But they say it will take several years before they will test on humans and I believe that when they will (if they will at all) they will not get the results they hope for. 
False hope is comforting. But letting go of it is liberating. 
Seriously, there have been similar reports in the past. People got their hopes up and have always been disappointed. I don't see that changing any time soon.
the treatments to remove our scars is already here, our work is find a way to access it
right now is possible reverse the damage, YES. no doubt about it
Well what do you suggest we do then? 
Raise millions and millions of Euros? Ask a doctor to treat us with some unproven technology/treatment? There is no way to "access" anything. We, as "normal" people in that we aren't investors or doctors or scientists can't do anything. I'm sorry but there is just nothing you can do. And the treatments are not here. There are things out there that people are working on but they aren't perfected nor even completely proven to work if you ask me. Seabs may disagree though.
the treatments are here, not in clinic form, of course.....
I'll try to do a treatment on my own
and if this works, I will share with you
I actually talked to a doctor one time about having my scar cut out and subsequently treated with an ECM. An ExtraCellular Matrix. This thing was synthetic (I am a vegetarian so animal-derived substances like ACell I stay away from) and was called RGTA made by OTR3. I'd say this is your best bet if you ever want to consider having a doctor treat you. The ECM makes your wound heal faster and (thus) better and there is a (good) possibility that the appearance of your scars are improved, perhaps to a point where you can let things go, mentally.
Other than that lasers can help take out redness of your scars and perhaps make them look smoother. This is what helped me a great deal. I've spent a few hundred Euros or so on treatments and it has made a world of difference. Something to consider perhaps.
I would advise against treating yourself. But it's your life. 
no, I have no intention of cutting my scars, that's crazy
If you are happy with your scars, or if you get over it
It is only because you scars aren´t to bad to the point of going crazy,
I have one scar. Not due to acne but due to an accident. For years it was a huge problem. The laser surgery really helped. It made such a difference... People still notice my scar but it's OK now. 
My scar is pretty big, by the way. It's not small. It's not HUGE either but people see it from a distance. In certain lighting conditions (harsh sunlight for instance) I'm sure it doesn't look very flattering. But what am I going to do? Hide from the world? I've done that to a degree in the past but I have no intention to do so anymore.
My scar used to drive me crazy. Believe me. It was a long road that I had to travel before I got to this point. But now my scar isn't on my mind 90% of the time. Just this weekend I went out and I never once thought of my scar. So the negative psychological impact that it had in the past is now gone. I think everyone can get past their scarring the way I have. Even people with "severe" scarring.
This is a famous football player:
He's on TV all the time and he has a wife and kids... I bet your scarring isn't as bad as his?
the treatments are here, not in clinic form, of course.....
I'll try to do a treatment on my own
and if this works, I will share with you
I actually talked to a doctor one time about having my scar cut out and subsequently treated with an ECM. An ExtraCellular Matrix. This thing was synthetic (I am a vegetarian so animal-derived substances like ACell I stay away from) and was called RGTA made by OTR3. I'd say this is your best bet if you ever want to consider having a doctor treat you. The ECM makes your wound heal faster and (thus) better and there is a (good) possibility that the appearance of your scars are improved, perhaps to a point where you can let things go, mentally.
Other than that lasers can help take out redness of your scars and perhaps make them look smoother. This is what helped me a great deal. I've spent a few hundred Euros or so on treatments and it has made a world of difference. Something to consider perhaps.
I would advise against treating yourself. But it's your life.
This is what I am hoping Recell will do, I am not waiting on scareless healing. Just less scarring so I can cope better. Scare free healing is for the coming years.
Hydrogel has been tested on people, the results are not published yet although they say they where promising. If they are published this year we will know if it's good or bad news. In the meantime everything that helps mentally and physically helps.
Sport and music is helping me a lot lately.
I congratulate you, but you must understand that not all people are equal, there are some people who do not have the capacity to understand that something has changed forever, like me,
Yeah, my life never became 100% the same after the accident. There was before and after. I am a pretty happy person though. But it took a long time before I was at peace with my situation.
This is what I am hoping Recell will do, I am not waiting on scareless healing. Just less scarring so I can cope better. Scare free healing is for the coming years.
Hydrogel has been tested on people, the results are not published yet although they say they where promising. If they are published this year we will know if it's good or bad news. In the meantime everything that helps mentally and physically helps.
Sport and music is helping me a lot lately.
Music helps me too! I actually write music myself. It's awesome. 
I should start exercizing more. 
haha Getting enough physical activity like that does do wonders for one's overall health. ![=]](https://static.acne.org/ipb_uploads/emoticons/default_sideways.gif)
But hey I didn't know they tested the hydrogel on humans. That's cool... I'm certainly curious to see those results when they are published.