In the meantime my hope is on hydrogel.
Hydrogel has only teste in mices, not humans, We do not know if this can work the same way in humans, animals heal better than humans.
By the way, no one has removed their scars and applied ECM, WHY?
If a scar is a result from anything it is the result of denaturing through injury, the tissue reacting to something it perceives as a foreign body or could invade as a foreign body, which then denatures the regeneration response, resulting in the body taking to long to heal, meaning scar etc..
BTW scaffolds work the same in all mammals, they just create and micro manage what is needed and have done for millions of years. To argue that these devices work different in a zebra to a pig and discriminate another tissue is wrong. (Also scaffolds have been shown to work similar in all mammals). The intercellular cells works to promote the tissue needed with the scaffold, i.e pig skin, pig skin, human skin, human skin. Intercellular cells just follow the evolutionary instructions in what ever environment they are in.
In the meantime my hope is on hydrogel.
Hydrogel has only teste in mices, not humans, We do not know if this can work the same way in humans, animals heal better than humans.
By the way, no one has removed their scars and applied ECM, WHY?
If a scar hasn't been removed it is the result of denaturing, the body reacting to something as a foreign body, the body taking longer than a month to degrade the material etc..
BTW scaffolds work the same in all mammals. The intercellular cells works to promote the tissue needed with the scaffold, i.e pig skin, pig skin, human skin, human skin. Stem cells justr follow the evolutionary instructions in what ever environment they are in.
so, osteopontin gene supression showed scar free healing in animal, in humans only showed scarless healing,
acell showed scar free healing in animal, in humans, scarless healing,
the same can happen with hydrogel
scar free healing is here, this is a fact. but........
is very difficult to access this
e.g. you can excise a scar, no matter how deep, and......
inject embryonic stem cells
apply non denatured ECM
inject something that can suppress TGb 1, 2 and increase tgb 3
if you do all this, indoubtedly, you will get perfect regeneration
but, the problem is:
the use of embryonic stem cells is prohibited
ECM completely non denatured is not commercially available
the same whit tgb1,2 and 3
maybe, you could access this technology if you are armed forces member, but is difficult for a civilian
Dear Alonso,
Thanks for your inquiry. I am a colleague of Dr. Stephen Badylak and I am helping him deal with the massive influx of inquiries following the recent publicity on the use of extracellular matrix (ECM) to facilitate the regeneration of tissue.
By way of background, ECM has been used extensively; it is estimated that 2,000,000 patients have been treated with some form of ECM. The predominant form of ECM is sheet material, and some of the most prevalent applications are hernia repair, treatment of pressure ulcers, and orthopaedic procedures, such as rotator cuff, etc. A powdered form has been used in the fingertip regeneration. It should be noted that the success stories to date involved the loss of the fingertip-above the first knuckle, and the nail bed was not destroyed. We have no expectations that the current ECM technology can regenerate joints (knuckles) or nail beds.
Relative to your specific inquiry,
1. Dr. Badylak is not clinically active-his focus is on research and he relies on other physicians to apply his emerging technologies in the clinic. Hence, when scar mitigation via ECM is feasible, you will have to find a plastic surgeon who is using this type of therapy.
the research
2. The research on using ECM for scar mitigation is still in its infancy, and any clinical trials in the next few years will be limited to injured US Military personnel s part of the military funded research project.
3. Assuming that progress in this research continues, it may be possible in 3 to 4 years to refer you to a plastic surgeon somewhere in the world who is applying these emerging technologies.
I hope this introduction helps and thank you for your interest. The best place to follow developments in this area is on our web site at www.mcgowan.pitt.edu.
Other web sites of potential interest to you are:
-Regenerative Medicine: www.regenerativemedicine.net
-McGowan Institute on Facebook: www.facebook.com/McGowanInstitute
John
John N. Murphy
Executive Director-McGowan Institute &
Research Professor-Chemical Engineering
450 Technology Drive, Suite 300
Pittsburgh, PA 15219
Phone: 412-624-5250
Fax: 412-624-5260
Email: @pitt.edu">jmurphy@pitt.edu
as you can see, any clinical trials in the next few years will be limited to injured US Military personnel s part of the military funded research project.
sad but true....METALLICA
In the meantime my hope is on hydrogel.
Hydrogel has only teste in mices, not humans, We do not know if this can work the same way in humans, animals heal better than humans.
By the way, no one has removed their scars and applied ECM, WHY?
If a scar hasn't been removed it is the result of denaturing, the body reacting to something as a foreign body, the body taking longer than a month to degrade the material etc..
BTW scaffolds work the same in all mammals. The intercellular cells works to promote the tissue needed with the scaffold, i.e pig skin, pig skin, human skin, human skin. Stem cells justr follow the evolutionary instructions in what ever environment they are in.
so, osteopontin gene supression showed scar free healing in animal, in humans only showed scarless healing,
acell showed scar free healing in animal, in humans, scarless healing,
the same can happen with hydrogel
scar free healing is here, this is a fact. but........
is very difficult to access this
e.g. you can excise a scar, no matter how deep, and......
inject embryonic stem cells
apply non denatured ECM
inject something that can suppress TGb 1, 2 and increase tgb 3
if you do all this, indoubtedly, you will get perfect regeneration
but, the problem is:
the use of embryonic stem cells is prohibited
ECM completely non denatured is not commercially available
the same whit tgb1,2 and 3
maybe, you could access this technology if you are armed forces member, but is difficult for a civilian
Dear Alonso,
Thanks for your inquiry. I am a colleague of Dr. Stephen Badylak and I am helping him deal with the massive influx of inquiries following the recent publicity on the use of extracellular matrix (ECM) to facilitate the regeneration of tissue.
By way of background, ECM has been used extensively; it is estimated that 2,000,000 patients have been treated with some form of ECM. The predominant form of ECM is sheet material, and some of the most prevalent applications are hernia repair, treatment of pressure ulcers, and orthopaedic procedures, such as rotator cuff, etc. A powdered form has been used in the fingertip regeneration. It should be noted that the success stories to date involved the loss of the fingertip-above the first knuckle, and the nail bed was not destroyed. We have no expectations that the current ECM technology can regenerate joints (knuckles) or nail beds.
Relative to your specific inquiry,
1. Dr. Badylak is not clinically active-his focus is on research and he relies on other physicians to apply his emerging technologies in the clinic. Hence, when scar mitigation via ECM is feasible, you will have to find a plastic surgeon who is using this type of therapy.
the research
2. The research on using ECM for scar mitigation is still in its infancy, and any clinical trials in the next few years will be limited to injured US Military personnel s part of the military funded research project.
3. Assuming that progress in this research continues, it may be possible in 3 to 4 years to refer you to a plastic surgeon somewhere in the world who is applying these emerging technologies.
I hope this introduction helps and thank you for your interest. The best place to follow developments in this area is on our web site at www.mcgowan.pitt.edu.
Other web sites of potential interest to you are:
-Regenerative Medicine: www.regenerativemedicine.net
-McGowan Institute on Facebook: www.facebook.com/McGowanInstitute
John
John N. Murphy
Executive Director-McGowan Institute &
Research Professor-Chemical Engineering
450 Technology Drive, Suite 300
Pittsburgh, PA 15219
Phone: 412-624-5250
Fax: 412-624-5260
Email: @pitt.edu">jmurphy@pitt.edu
as you can see, any clinical trials in the next few years will be limited to injured US Military personnel s part of the military funded research project.
sad but true....METALLICA
Hey alonso, I'm only going to discuss things that reepithilize wounds in under 21days.
my English is understandable?i am doing my best
seabs135, yeah, something that can that reepithilize wounds in under 21days is very cool, I am only sharing my little experience.
i am sorry, but i am very frustrated, I've gone to doctors for help, but only showed indifference
thanks,
my english is understandable?
In the meantime my hope is on hydrogel.
Hydrogel has only teste in mices, not humans, We do not know if this can work the same way in humans, animals heal better than humans.
By the way, no one has removed their scars and applied ECM, WHY?
If a scar hasn't been removed it is the result of denaturing, the body reacting to something as a foreign body, the body taking longer than a month to degrade the material etc..
BTW scaffolds work the same in all mammals. The intercellular cells works to promote the tissue needed with the scaffold, i.e pig skin, pig skin, human skin, human skin. Stem cells justr follow the evolutionary instructions in what ever environment they are in.
so, osteopontin gene supression showed scar free healing in animal, in humans only showed scarless healing,
acell showed scar free healing in animal, in humans, scarless healing,
the same can happen with hydrogel
scar free healing is here, this is a fact. but........
is very difficult to access this
e.g. you can excise a scar, no matter how deep, and......
inject embryonic stem cells
apply non denatured ECM
inject something that can suppress TGb 1, 2 and increase tgb 3
if you do all this, indoubtedly, you will get perfect regeneration
but, the problem is:
the use of embryonic stem cells is prohibited
ECM completely non denatured is not commercially available
the same whit tgb1,2 and 3
maybe, you could access this technology if you are armed forces member, but is difficult for a civilian
Dear Alonso,
Thanks for your inquiry. I am a colleague of Dr. Stephen Badylak and I am helping him deal with the massive influx of inquiries following the recent publicity on the use of extracellular matrix (ECM) to facilitate the regeneration of tissue.
By way of background, ECM has been used extensively; it is estimated that 2,000,000 patients have been treated with some form of ECM. The predominant form of ECM is sheet material, and some of the most prevalent applications are hernia repair, treatment of pressure ulcers, and orthopaedic procedures, such as rotator cuff, etc. A powdered form has been used in the fingertip regeneration. It should be noted that the success stories to date involved the loss of the fingertip-above the first knuckle, and the nail bed was not destroyed. We have no expectations that the current ECM technology can regenerate joints (knuckles) or nail beds.
Relative to your specific inquiry,
1. Dr. Badylak is not clinically active-his focus is on research and he relies on other physicians to apply his emerging technologies in the clinic. Hence, when scar mitigation via ECM is feasible, you will have to find a plastic surgeon who is using this type of therapy.
the research
2. The research on using ECM for scar mitigation is still in its infancy, and any clinical trials in the next few years will be limited to injured US Military personnel s part of the military funded research project.
3. Assuming that progress in this research continues, it may be possible in 3 to 4 years to refer you to a plastic surgeon somewhere in the world who is applying these emerging technologies.
I hope this introduction helps and thank you for your interest. The best place to follow developments in this area is on our web site at www.mcgowan.pitt.edu.
Other web sites of potential interest to you are:
-Regenerative Medicine: www.regenerativemedicine.net
-McGowan Institute on Facebook: www.facebook.com/McGowanInstitute
John
John N. Murphy
Executive Director-McGowan Institute &
Research Professor-Chemical Engineering
450 Technology Drive, Suite 300
Pittsburgh, PA 15219
Phone: 412-624-5250
Fax: 412-624-5260
Email: @pitt.edu">jmurphy@pitt.edu
as you can see, any clinical trials in the next few years will be limited to injured US Military personnel s part of the military funded research project.
sad but true....METALLICA
When did you get this reply?
In the Netherlands there is a new tissue generation lab at the university of Twente. It's an international collabiration and the specialisation is scaffolds. I am just saying this because Acell isn't the only one working with this medicine. There must be hundred's of scientists working on this everyday because of the potential of this becoming a billion dollar industrie.
Here is a exellent explanation of scaffolds and stemcells.
you can comunicate with the stephen badylak lab,
stephen Badylak lab:
Contact Information:
Please contact us with questions about injury/disease
We invite you to have a look around our website to find out more about our laboratory and the research that Dr. Badylak and his colleagues are conducting. If you are interested in being a candidate for one of our clinical trials.
We have a highly experienced and professional staff that will quickly help determine if the regenerative medicine approach at the McGowan Institute may be of benefit to you.
Please direct any inquiries or publications requests to:
Jocelyn Runyon, [email protected]
Include the following information in your email:
- A brief description of your injury or interest.
- Date of the injury or diagnosis.
- A brief description of the medical care that you have received.
- If you have a digital image you would like to include, you are welcome to attach to your email. If not, your description will be enough.
- Dont forget to include your contact information!
You can expect to receive an email response which includes additional information regarding our institute, the use of regenerative medicine for specific problems, and the contact information of one of our physicians or scientists (if treatment is recommended).
Thank you for your interest in the McGowan Institute for Regenerative Medicine!
Stephen Badylak, DVM, PhD, MD
Convert pdf to word. I can't deny I am obsessed myself for a long time now. I can remember the first post about scarless healing.
I am going to Dr.Khan in september for Recell. If I could get my hands on hydrogel, I would order it.
The thing that keeps me going is that this generation is probably going to be the last ever to suffer from scarring. In the meantime I am learning to play studio music and piano, I do some sport. Last year I dropped study in my final year, so I am living isolated and from a social benefit.
I have been letting it influence my whole life on more then one domain. I am scarred over my whole body, although not really bad because the scars are shallow, there are a lot. I have moderate scars on my face. It is stupid because there are people with burnscars who can cope better then me. Maybe it is a form of BDD / or it could be many things in my past had happened that I couldn't handle this.
Anyway my plan is to get rid of the scarring in my face with recell in 5 months, I still have to do one dermaroller. Then probably dermabrasion and tca the scars on my body. Eventually using scareless healing to finish it of. I don't want perfect skin, just a bit normal skin.
So I can't advice otherwise then taking a step back and making a (treatment) plan for yourself. I am kind of hoping that hydrogel is gonna come soon, so that there is a more cheap and better solution. I hope they start testing it on people soon, in stead of the whole animal kingdom.
I forgot, they already have tested in on people:)
http://www.medlatest.com/2012/04/26/can-hydrogel-scaffold-really-improve-a-wounds-appearance/
I would like to see those results, then I'll have to think about going for recell or for hydrogel.
Laser/ dermabrasion and hydrogel might make the best treatment available today. I wonder when the results are published.
hey seabs135, once, you mentioned at ellen heber katz
Studies pioneered in this Wistar Institute laboratory have established the MRL mouse as a gold standard of mammalian regeneration studies with the finding that a single gene, p21, controls the entire process.
Over a decade of research has led to a deep understanding of the genetic, molecular biology, cell biology and physiology of regeneration in this remarkable mouse having profound implications for human application.
http://www.wistar.or...-heber-katz-phd
do you know if actually exist drugs that inhibit gene p21?
I think itis being used,or am I wrong
INHIBITION OF P21 AND USE THEREOF FOR INDUCING TISSUE REGENERATION
http://www.sumobrain...2011112954.html
Unfortunately MRL p21 knock-out mouse can't heal skin without scars, you can read about it here:
Skin wounds in the MRL/MPJ mouse heal with scar.
http://www.ncbi.nlm....pubmed/16476076
Thanks to RNAi gene-silencing technology (discovered by Fire and Mello and for what they received Nobel Prize in 2006) today it is
possible to 'shut down' any human gene locally and for a limited period of time (I guess it is possible with a p21 gene too?)
you can read about that amazing technology here:
http://en.wikipedia.org/wiki/RNAi
But unfortunalely MRL mouse can heal only ear wounds and heart wounds; MRL mouse can completely regenerate multiple tissues in the ear (including skin tissue!!!) but cannot regenerete skin wounds on the other parts of the body, so I'm not sure that p21 gene is the right target for some future drug for scar-free healing; maybe it is (the fact is that the MRL mouse can regenerate skin of the ear completely, 100%, and that it forms blastema that behaves like stem cells on the site of the injury in the ear) but maybe it isn't (the other fact is that the MRL mouse can't regenerate skin on the other body parts and that it forms scars) so I'm not sure.
And as far as I know right now there is no company that is developing or plans to develop an anti-scarring drug based on the discovery of the role of p21 gene in tissue regeneration - it is possible that it is a new discovery and additional examinations are necessery, but it is also possible that scar-free healing of the skin isn't achievable with deactivation of the p21 gene, I really don't know.
Here is an interesting picture (on the left side of the picture is the ear of the 'normal' mouse with the p21 gene in it's DNA and on the right side of the picture is the ear of the MRL mouse without the p21 gene in it's DNA)
Commercially available extracellular matrix (ECM) scaffoldsProduct
1.Product
2.Source
3.Tissue
4.Company
AlloDerm
human
skin
Lifecell
AlloPatch
human
dermis
Musculoskeletal Transplant Foundation
Avaulta, CollaMend
porcine
dermis
BARD
Axis dermis
human
dermis
Mentor
CuffPatch
porcine
SIS
Athrotek
Graft Jacket
human
skin
Wright Medical Tech
Oasis
porcine
SIS
Healthpoint
OrthADAPT, DurADAPT
equine
pericardium
Pegasus Biologicals
Permacol
porcine
skin
Tissue Science Laboratories
Restore
porcine
SIS
DePuy
Surgisis, Durasis, Stratasis
porcine
SIS
Cook SIS
Suspend
human
Fascia lata
Mentor
TissueMend, Durepair, Xenform, SurgiMend, PriMatrix
Fetal bovine
skin
TEI Biosciences
Veritas, Dura-Guard, Vascu-Guard, Peri-Guard
bovine
dermis
Synovis Surgical
Xelma
porcine
Teeth enamel
Molnlycke
but none can give me scar free healing
OASIS WOUND MATRIX, heals faster than acell?
only in two weeks
http://www.burnsurgery.org/Modules/BurnWound/rationale/acute_wounds/traumatic_wounds.htm
With regards to decorin, it is cited somewhere on this thread that decorin,is absent in wounded tissue and doesnt return to a normal level in the tissue for 12months. It is also cited somewhere in this thread that decorin arrests fibroblast proliferation (fibroblast proliferation is what produces excess collagen).
I'm with anything that can reepithilize a 3rd degree burn wound in under 21days.
Unfortunately you cannot achieve scar-free healing of the skin with decorin, only 40% reduction of the scar is achievable,
you can read about it here:
http://www.purdue.ed... 2010 01 13.pdf
Wounds treated with Pelladerm have shown a 40%reduction in visible scar
Cosmetic appearance results, illustrated in Figure 1 below, showthat a single dose of Pelladerm results in a 40% decrease in visible scar.
Figure 1. Cosmetic Appearance of Wounds. Single dose application of Pelladermresults in a 40% decrease in visible scar. * Denotes statistical significance.
And extraction of natural decorin is very expensive, it could cost $440,000, you can read about it on page 6
With regards to decorin, it is cited somewhere on this thread that decorin,is absent in wounded tissue and doesnt return to a normal level in the tissue for 12months. It is also cited somewhere in this thread that decorin arrests fibroblast proliferation (fibroblast proliferation is what produces excess collagen).
I'm with anything that can reepithilize a 3rd degree burn wound in under 21days.
Unfortunately you cannot achieve scar-free healing of the skin with decorin, only 40% reduction of the scar is achievable,
you can read about it here:
http://www.purdue.ed... 2010 01 13.pdf
Wounds treated with Pelladerm have shown a 40%reduction in visible scar
Cosmetic appearance results, illustrated in Figure 1 below, showthat a single dose of Pelladerm results in a 40% decrease in visible scar.
Figure 1. Cosmetic Appearance of Wounds. Single dose application of Pelladermresults in a 40% decrease in visible scar. * Denotes statistical significance.
And extraction of natural decorin is very expensive, it could cost $440,000, you can read about it on page 6
I have never talked about the decorin you were pointing to. There is a difference between the decorin your body produces and that decorin.
Your bodies decorin stops scarring 100%, it arrests the fibroblasts.
I have said in this thread that this decorin will not work like your bodies decorin, for two reasons, 1 your body is flooded with decorin 24/7 when not injured. 2 this is artificial decorin that is either injected once or,it is the car decorin stuff that gets transported to injury in some way. And thes actions do not flood your body with decorin.
the veteran users (like seabs and me), we know that hydrogel its the only serious answer, its the only hope in this life...so please alonso stop flood, stopmake stu.pid question,stop trolling... the only hope here in the group of veteran users is hydrogel, many and many years here in this forum users like me and seabs...searching and waiting...looking scams and craps like juvista,acell,etc...so please alonso if you dont look the hydrogel (what is the only solution perhaps), please go out. i repeat...the veteran users here,we know that hydrogel its the only real and serious answer that we have (at the time).
the veteran users (like seabs and me), we know that hydrogel its the only serious answer, its the only hope in this life...so please alonso stop flood, stopmake stu.pid question,stop trolling... the only hope here in the group of veteran users is hydrogel, many and many years here in this forum users like me and seabs...searching and waiting...looking scams and craps like juvista,acell,etc...so please alonso if you dont look the hydrogel (what is the only solution perhaps), please go out. i repeat...the veteran users here,we know that hydrogel its the only real and serious answer that we have (at the time).
Why are you so pessimistic? The fact is that there is scar free healing in nature, look at salamanders, they have regenerative abilities that go far beyond scar free healing, the only problem is the technology, scientists have to find a way to transfer these abilities from salamanders to humans.
Vladislav...how old are you? Are you a teenager? If you are a young person, i accept you hope...path let me tell you something boy...
people like me and seabs..and others like scar4life,etc in this forum...we searching and investigate for many and many years (more than 14 years), the life pass, we are not youngs now... when you 18years old,you have hope...path the years pass...and nothing happens...the solution is not show... its very difficul find hope when search and investigate more than 14 years and we found nothing...and the veterans users here we know that we need many and many years for a solution (if the solution exist), this is the true...take it or leave it...dream is free...good dreams.
Be happy for generations who might not have to suffer from scars and stop being bitter to people trying to find a cure. Like age or being a veteran is something important. Imagine someone suffering for 30 years talking to you like this, because you only suffered 14 years and are naief for believing in hydrogel.
Who knows if hydrogel is a real answer, it might only give improvement. Maybe eventually the best way will be a combination of drugs, treatment and scaffold. Let Alonso ask and search for himself.
1.- first, I have read the 153 pages of this topic, I have read the pdf SCARLESS HEALING (made by seabs135), I have researched and read a lot.
2.- I have had numerous conversations (via email) with Stephen Badylak Lab, Anthony Atala (research group About skin printer), Juan Carlos Izpisua Belmonte, etc. I have had many disappointments, frustrations, etc.
3.- why hydrogel is the only hope?, only because it heals a 3 burn without scars? (in mices) there are others stuffs than can do the same,
believe me, you can read all you want, you can read hundreds of articles about scar free healing, but These articles are not written by scientists who perform research, there are written by journalists, you can simply deduct the wrong things they write,
I've cried, suffered, I had to leave my studies, I hope that hydrogel isthe solution, but I can not be sure
Vladislav...how old are you? Are you a teenager? If you are a young person, i accept you hope...path let me tell you something boy...
people like me and seabs..and others like scar4life,etc in this forum...we searching and investigate for many and many years (more than 14 years), the life pass, we are not youngs now... when you 18years old,you have hope...path the years pass...and nothing happens...the solution is not show... its very difficul find hope when search and investigate more than 14 years and we found nothing...and the veterans users here we know that we need many and many years for a solution (if the solution exist), this is the true...take it or leave it...dream is free...good dreams.
Ok, I'm very sorry but, anyway, if you want to write what kind of scars you have and where are they located?
I agree that, generally speaking, today's medicine sucks, it does not solve diabetes, cancer, HIV/AIDS, multiple sclerosis and many other terrible diseases, and among others it can not solve scars, but there is some hope that in the not too distant future the medicine will be able to solve some of these diseases far more successfully than how it solves it today, I think that there will be a great revolution in medicine in not so distant future - I'm thinking about stem cells, biotechnology, genetic engineering, the human genome was mapped in the period since 1990. to 2003. - generally speaking, it is a completely new medical approach in the treatment of various diseases, significantly different from all previous medical approaches because it seeks to analyze and manipulate the molecular mechanisms and genes (DNA and RNA) that cause disease, because of all that there is a great hope in the future of medicine.
Otherwise, I'm 25 years old, my scars are maybe not so bad, I have a scar from a surgery on my stomach (it is not visible but it is 12cm or 5 inches long so I'm sure that I will not go to the beach ever again during the summer or at the swimming pool), and the other is on my face but it is small (1.2cm or 0.5 inches long) and I've talked with the best plastic surgeon in my country and he told me that this big scar on my stomach cannot be eliminated or reduced but this small atrophic scar on my face can be reduced by 60-70% by using adult stem cells that can be extracted from my own blood, he told me that the results with that kind of treatment are much better then treatment with fraxel laser where I can expect only about 20% improvement, his clinic where he is an employee has just aquired that equipment for adult stem cells and right now there are ongoing trainings of the staff that will use that adult stem cells equipment and very soon it will be availabe for patients.