Acne.org Products
as I said 4 years ago on this thread, scarless healing is of course the treatment for acne scars that will be the best and definitive solution. The problem is, how long will it be before you can walk into a plastic surgeon's office and get this treatment for acne scars? i.e scarred tissue removed and new uninjured skin replaces it, without scars? Not for a long, long time. But I'll check back in another 4 years to see how the thread is going 
I dont want to sound arrogant here, [cue arrogance] but if you read the 2 or 3 pages before this one you will see something that repeithilizes a full thickness burn wound in a mammal in under 21 days. In that time frame hair follicles are restored, sweat glands are restored.
It is a fact that when a wound reepithilizes in under 21 days no scar occurs (scar free healing) which is cited here, it is a fact that hair and sweat glands do not grow in scar tissue which is cited here.
Well I have no acne scars, I have a scar from a surgery on my stomach, and as far as I know acne scar are quite different from hypertrophic scars or wide scars or keloids, they are 'deep' atrophic scars and they are treatable with fraxel laser or the newest possibility is adult stem cells treatment.
Well I have no acne scars, I have a scar from a surgery on my stomach, and as far as I know acne scar are quite different from hypertrophic scars or wide scars or keloids, they are 'deep' atrophic scars and they are treatable with fraxel laser or the newest possibility is adult stem cells treatment.
All scarring is the same, an over production of collagen.
Hi, I'm new to the forum, I speak Spanish, I speak basic English.
I have been following this topic a few months ago, I read from beginning to end.
I live in Peru, I have acne scars, I am 17 years old,
All scarring is the same, an over production of collagen. Many people think that the term "over production of collagen" is exclusive of hypertrophic scars and keloids.
There are several different kinds of scarring, each caused by differing amounts of collagen over expression. One of the most common types is hypertrophic and keloid scarring,[6] both of which experience excessive stiff collagen bundled growth over extending the tissue, blocking off regeneration of tissues. Another form is atrophic scarring (sunken scarring), which also has an over expression of collagen blocking of regeneration, this scar type is sunken, the collagen bundles do not over extend the tissue. Stretch marks (striae) are regarded as scars to some.
Here is a quote from a cite from the article. As you can see the belief that scarring is different is bs.
6.^ a b c d e f Roseborough IE, Grevious MA, Lee RC (January 2004). "Prevention and treatment of excessive dermal scarring". J Natl Med Assoc 96 (1): 10816. PMC 2594768. PMID 14746360.
However, advances in scar management have been hampered by the confusing or ambiguous terminology. There is no consensus on what amount of post-traumatic skin scar formation is "normal" and what should be considered "hypertrophic".
Again what is a scar?
Answer: a bundled overgrowth of disorganised collagen. Acne a bundled overgrowth of disorganised collagen like any other scar...
hey seabs135, once, you mentioned at ellen heber katz
Studies pioneered in this Wistar Institute laboratory have established the MRL mouse as a gold standard of mammalian regeneration studies with the finding that a single gene, p21, controls the entire process.
Over a decade of research has led to a deep understanding of the genetic, molecular biology, cell biology and physiology of regeneration in this remarkable mouse having profound implications for human application.
http://www.wistar.org/our-science/scientists/ellen-heber-katz-phd
do you know if actually exist drugs that inhibit gene p21?
I think it is being used, or am I wrong
INHIBITION OF P21 AND USE THEREOF FOR INDUCING TISSUE REGENERATION
http://www.sumobrain.com/patents/wipo/Inhibition-p21-use-thereof-inducing/WO2011112954.html
hey seabs135, once, you mentioned at ellen heber katz
Studies pioneered in this Wistar Institute laboratory have established the MRL mouse as a gold standard of mammalian regeneration studies with the finding that a single gene, p21, controls the entire process.
Over a decade of research has led to a deep understanding of the genetic, molecular biology, cell biology and physiology of regeneration in this remarkable mouse having profound implications for human application.
http://www.wistar.or...-heber-katz-phd
do you know if actually exist drugs that inhibit gene p21?
I think itis being used,or am I wrong
INHIBITION OF P21 AND USE THEREOF FOR INDUCING TISSUE REGENERATION
http://www.sumobrain...2011112954.html
We discussed this about three or four year ago. It looks like it could lead to the regeneration of limbs etc.
BTW I've seen nothing of this being used.
[0008] The present invention features a method for inducing tissue regeneration by administering to the tissue of a subject in need of treatment an effective amount of a p21 inhibitor. In one embodiment, the p21 inhibitor directly inhibits p21 activity. In another embodiment, the p21 inhibitor inhibits expression of p21.
[00011] According to the present invention, a sufficient dose of a p21 inhibitor is administered to the tissue of a subject (e.g., a patient) in need of such treatment. A subject "in need of such treatment" can be, e.g., a subject with a wound; damaged/ injured organ or tissue (e.g., skin or muscle) ; and/or tissue or organ defect, wherein administration of a p21 inhibitor induces or facilitates repair and/or regeneration of said tissue or organ. Tissue regeneration in the context of the present invention includes in vivo, in vitro or ex vivo applications of tissues, with particular embodiments embracing regeneration of tissues which do not normally regenerate. Desirably, tissue regeneration is induced locally at the site of administration. In this respect, a p21 inhibitor can be administered locally to a wound site of a subject to induce tissue regeneration by biological interaction with surrounding tissues. As used herein, "induce", as well as the correlated terms "induction" and "inducing" , refer to the action of generating, promoting, forming, regulating, activating, enhancing or accelerating a biological phenomenon. Subjects benefiting from treatment in accordance with the method of this invention include mammals such as rats, mice, rabbits, dogs, cats, goats, sheep, cows, pigs, primates and humans.
http://www.sumobrain.com/patents/wipo/Inhibition-p21-use-thereof-inducing/WO2011112954.html
Anyone live in Baltimore?
One of the people involved in the scar free hydrogel has a presentation there today.
is what this doctor saying in the 1st post that he's used acell and regrown normal tissue without scarring ?
there is a new laser....
this laser allows plastic surgeons to go deeper than ever before
The UltraPulse SCAAR FX (Synergistic Coagulation and Ablation for Advanced Resurfacing), manufactured by Lumenis, uses up to 150 mJ per pulse and allows penetration into the scar tissue up to 4.0 mm, which is up to 4 times deeper than any other CO2 laser currently on the market.
maybe, this would be a good option to dissolve scar tissue
there is a new laser....
this laser allows plastic surgeons to go deeper than ever before
The UltraPulse SCAAR FX (Synergistic Coagulation and Ablation for Advanced Resurfacing), manufactured by Lumenis, uses up to 150 mJ per pulse and allows penetration into the scar tissue up to 4.0 mm, which is up to 4 times deeper than any other CO2 laser currently on the market.
maybe, this would be a good option to dissolve scar tissue
http://www.medscape....warticle/762631
Maybe it will be better than previous lasers for treatment of acne scars and other atrophic scars, but I doubt that it will be better than stem cells treatments.
No one haven't mention Renovo's other drug (besides Juvista) failure - Prevascar, the results were announced on 16th April, Prevascar is a failure just like Juvista:
http://uk.finance.ya...-101535984.html
Renovo Group Plc - Prevascar Trial 0110 results
AFX CNF Mon, Apr 16, 2012 11:15 BST
Prevascar Trial:
Exploratory clinical trial of Prevascar on scarring in subjects of African Ancestral Origin
Renovo Group plc (LSE: RNVO), today announces the outcome of its clinical trial designed to explore safety and efficacy of Prevascar on scarring in subjects of African Ancestral Origin. Volunteer subjects were randomised to receive Prevascar and placebo to two small incisions on each inner upper arm, and scar appearance and size was evaluated over 13 months. At month 1, one scar from each pair was excised for histological evaluation. Four different dose regimens of Prevascar were employed.
Fifty-six subjects were enrolled in the study and all completed except one who was lost to follow-up. The most common adverse events reported in the trial were nasopharyngitis (32%) and headache (25%). Local effects at the scar site were infrequent and similar between Prevascar and placebo-treated scars.
At month 1 there was a small but significant reduction in scar width following administration of 100ng Prevascar compared to placebo, as assessed histologically. However, by month 13 there was a small but significant improvement in the placebo scar width compared to 100ng Prevascar. Most other assessments, including the Global Scar Comparison Scale, showed no difference between treatments
The Board of Renovo has decided that it will not perform any further work on Prevascar and will continue to focus on its previously announced merger and acquisition plans and its Share Buy Back programme in order to enhance shareholder value.
Although it is not exactly scareless healing, here is some news of hydrogel coming this year.
hey seabs135, along this topic you say that scar free healing (not scarless healing) is here. I am with you, I have researched and read a lot.
You always mentioned the term "non denatured" to refer to ECM, also, You mentioned decorin at 200 nM,
You say that ECM "non denatured" or decorin 200 nM can achieve scar free healing, but I cant find the article or the document.
I write in google ECM non denatured and nothing appears, only appears links to this forum.
Can you show me where you find this? Ecm non denatured heals without scar, or similar.
scar free healing is here, but, I sent emails to Stephen Badylak lab, to Ellen Heber katz, they say that their work is only basic research, they dont listen patients, etc, I am very frustated.
There are images, showing scar free healing with ECM (visually):
1.The Use of Acellular Dermal Matrix for Coverage of Exposed Joint and Extensor Mechanism in
Thermally Injured Patients With Few Options (scar free healing with Alloderm)
2.Healing acute excisional wounds from Mohs Micrographic Surgery: (scar free healing with Apligraft)
but, no one has cut their scars and applied ECM (Alloderm or Apligraft) WHY? we are in 2012, this topic began in june 2007.
I think that enough is enough, WE HAVE TO MOVE.
Otherwise, years will continue going, and people will continue suffering for this.
Forgive If I am wrong, but, I think that all in this forum want have the skin we had before,
Personally, I am tired, I am going to purchase Alloderm. I have a distributor in my city, and the friend of my father is a doctor, he can prescribe me this ECM.
hey seabs135, along this topic you say that scar free healing (not scarless healing) is here. I am with you, I have researched and read a lot.
You always mentioned the term "non denatured" to refer to ECM, also, You mentioned decorin at 200 nM,
You say that ECM "non denatured" or decorin 200 nM can achieve scar free healing, but I cant find the article or the document.
I write in google ECM non denatured and nothing appears, only appears links to this forum.
Can you show me where you find this? Ecm non denatured heals without scar, or similar.
scar free healing is here, but, I sent emails to Stephen Badylak lab, to Ellen Heber katz, they say that their work is only basic research, they dont listen patients, etc, I am very frustated.
There are images, showing scar free healing with ECM (visually):
1.The Use of Acellular Dermal Matrix for Coverage of Exposed Joint and Extensor Mechanism in
Thermally Injured Patients With Few Options (scar free healing with Alloderm)
2.Healing acute excisional wounds from Mohs Micrographic Surgery: (scar free healing with Apligraft)
but, no one has cut their scars and applied ECM (Alloderm or Apligraft) WHY? we are in 2012, this topic began in june 2007.
I think that enough is enough, WE HAVE TO MOVE.
Otherwise, years will continue going, and people will continue suffering for this.
Forgive If I am wrong, but, I think that all in this forum want have the skin we had before,
Personally, I am tired, I am going to purchase Alloderm. I have a distributor in my city, and the friend of my father is a doctor, he can prescribe me this ECM.
I can understand your frustration.
You could try contacting Acell. Stephen Badylak is director of Acell. You can order scaffolds there on the site.
I myself believe they are stuck or delayed somehow, because the results are very few and the promise is huge. If the cure was there and easy available, it would make a biljon dollar industry. They are still working on it.
I would like to see more results, statistics, pictures and smilling scarefree people. Stephen Badylak says results aren't published because scaffolds might be applied wrong by surgeons as done in the past and FDA approval is needed. Maybe I am sceptical, but I think they are still recruiting investors for their research. It is probably coming within years, even if FDA approval is needed there are always surgeons who are going to try and apply this without approval. Stephen Babylak is at singularity summit in October 2012.
hey seabs135, along this topic you say that scar free healing (not scarless healing) is here. I am with you, I have researched and read a lot.
You always mentioned the term "non denatured" to refer to ECM, also, You mentioned decorin at 200 nM
Well there was a biotech company that was called Glytrix and their plan was to develop drug called Pellagen based on Decorin that should reduce dermal scarring, they were looking for $4,7 million for Pellagen development but no one was willing to finance them, if there were no venture capital funds that were interested in financing their anti-scarring drug development than something is wrong with it (and I don't know what?), they have won 100.000 dollars for their business plan from some university and that's their greatest success so far. 
Glytrix official web site:
and their business plan: (back in 2010 the plan was to start selling Pellagen anti-scarring drug in Q2 2012 and to earn $60 millions by 2014)
hey seabs135, once, you mentioned at ellen heber katz
Studies pioneered in this Wistar Institute laboratory have established the MRL mouse as a gold standard of mammalian regeneration studies with the finding that a single gene, p21, controls the entire process.
Over a decade of research has led to a deep understanding of the genetic, molecular biology, cell biology and physiology of regeneration in this remarkable mouse having profound implications for human application.
http://www.wistar.or...-heber-katz-phd
do you know if actually exist drugs that inhibit gene p21?
I think itis being used,or am I wrong
INHIBITION OF P21 AND USE THEREOF FOR INDUCING TISSUE REGENERATION
http://www.sumobrain...2011112954.html
We discussed this about three or four year ago. It looks like it could lead to the regeneration of limbs etc.
BTW I've seen nothing of this being used.
Discovery of the rule of P21 gene in regeneration of the ear and the heart wound in MRL mouse was announced in march 2010 by Wistar Institute, it was two years ago so you couldn't discuss it three or four years ago. 
hey seabs135, along this topic you say that scar free healing (not scarless healing) is here. I am with you, I have researched and read a lot.
You always mentioned the term "non denatured" to refer to ECM, also, You mentioned decorin at 200 nM,
You say that ECM "non denatured" or decorin 200 nM can achieve scar free healing, but I cant find the article or the document.
I write in google ECM non denatured and nothing appears, only appears links to this forum.
Can you show me where you find this? Ecm non denatured heals without scar, or similar.
scar free healing is here, but, I sent emails to Stephen Badylak lab, to Ellen Heber katz, they say that their work is only basic research, they dont listen patients, etc, I am very frustated.
There are images, showing scar free healing with ECM (visually):
1.The Use of Acellular Dermal Matrix for Coverage of Exposed Joint and Extensor Mechanism in
Thermally Injured Patients With Few Options (scar free healing with Alloderm)
2.Healing acute excisional wounds from Mohs Micrographic Surgery: (scar free healing with Apligraft)
but, no one has cut their scars and applied ECM (Alloderm or Apligraft) WHY? we are in 2012, this topic began in june 2007.
I think that enough is enough, WE HAVE TO MOVE.
Otherwise, years will continue going, and people will continue suffering for this.
Forgive If I am wrong, but, I think that all in this forum want have the skin we had before,
Personally, I am tired, I am going to purchase Alloderm. I have a distributor in my city, and the friend of my father is a doctor, he can prescribe me this ECM.
Regarding denaturing of ECM. Here is my quick fire response.
My understanding comes from the patent by Alan Speviak I read a few years ago.
This is off the top of my head as I currently cant find the patent.
In the Alan Speivack patent for ecm, he mentions what sterilization processes and chemicals denature the product to varying degrees. (<<< He gives out information that the ecm can be spoiled or denatured by sterilization.)
In explaining the denaturing he explains what happens with regards to the degrees of denaturing. E.g. the new tissue will either have tissue rejection or a white texture with fibrotic encapsulation (i.e. he described scar tissue in other words.)
He explains the behaviour of a strongly denatured product e.g. if denatured the ECM takes longer to resorb and be degraded, or it doesn't resorb at all or get rejected by the host
He explained that the scale of denaturing can affect the ecm in varying ways.
Basically that is where I got my logic about denatured ECM.
With regards to decorin, it is cited somewhere on this thread that decorin,is absent in wounded tissue and doesnt return to a normal level in the tissue for 12months. It is also cited somewhere in this thread that decorin arrests fibroblast proliferation (fibroblast proliferation is what produces excess collagen).
In the meantime my hope is on hydrogel.
I'm with anything that can reepithilize a 3rd degree burn wound in under 21days.
where I can find the patent?
and, no one has excise their scars and applied ECM, WHY?
Here is the patent, the term crosslink is interchangeable with denature...
http://www.pharmcast...issue061703.htm
Regarding ecm, people have used it.
E.g look on the acell site. also look for a Dr called Hitzig, he done a talk were he explained how another Dr regenerated an ear. See the Dr Jones case, or the Cooley papers...