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Again Mr. Ruoslahti replied very fast! Here's what he said:
Thank you for your interest in our work. The primary effect of the wound-targeted decorin (CAR-decorin), which we hope to bring to the clinic, is to prevent the formation of scar tissue after tissue injury (so far in mice and rats). This gives the real skin tissue time to regenerate, so I do think that we can, to an extent, enable the body to cover a wound with tissue that is better than the scar tissue functionally and cosmetically. However, the new would likely not reproduce the full skin structure; sweat glands and hair would likely not be included. That advance, I think, will come from stem cell research. As far as we know, it is necessary to give decorin during the wound healing for it to have an effect, so our treatment would be for preventiing scar formation and thereby enhancing regeneration, rather than us being able to convert scar tissue to normal skin. Regards, ER
Ski, a modulator of wound healing and scar formation in the rat skin and rabbit ear
C a Ski, a novel tissue healing-related gene, not only can it promote wound healing, but also it inhibits scar formation. Doctor Li Ping in Third military medical university DaPing Hospital Institute of Field Surgery, together with his mentor ZhouYuanGuo researcher, found the dual functions of this gene in experiments. Recently, this research paper is published in the journal of international pathology field journal of pathology. It is reported that , this time-consuming research results, which takes nearly 10 years, opens up a new direction thyroidisation for clinical promote wound healing and inhibition. It is with self-owned intellectual property and is expected to promote healing drugs.
Wound healing after speed and the scar of trauma care is always difficult. At present, promote the wound repair many studies, but the effect not ideal, and for the prevention and treatment of thyroidisation drug rarely.
C a Ski is virus cancer gene v a Ski inside the cell homologous content, early in the 1986 found in poultry animals. Li ping and ZhouYuanGuo Ski in the human c a gene experiments that c a Ski may adjust the repair cell biology function influence tissue repair speed, the expression with late may, and further on tissue remodeling Ski has confirmed c a tissue repair function, reveals the c a not only in wound healing Ski plays an important role in put gen composite injury, also has an important effect.
In order to confirm c a Ski can participate in regulating cell proliferation and apoptosis of in vitro cells, they also show that: c a experiment is a new Ski fibroblasts biological actions regulators in wound healing, has accelerated healing effect. Meanwhile, in experiments also found c a Ski with lower collagen secretion role of wound healing, reduce scarring after has an important significance.
They further animal experiments also found that c a Ski restructuring plasmid local subcutaneously in promoting rats after skin wounds heal more at the same time, can make after compared with obvious scar area is reduced, and scar volume significantly reduce scar organization structure, more rules, collagen distribution normalizes; C a Ski restructuring plasmid local subcutaneous injection of rabbit ears hyperplastic scar volume also has significant inhibitory effect. Thus direct proof the c a more and reduce Ski with promoting the dual role of thyroidisation of normal healing, and the scar and hyperplastic scar are effective.
Tissue repair related gene c a can promote Ski as tissue repair function also inhibit healing potential drugs after scarring, has won the national patent of invention, it will become the own property right of projects, and internationally published four papers.
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Article first published online: 21 FEB 2011
DOI: 10.1002/path.2831
Ski, a modulator of wound healing and scar formation in the rat skin and rabbit ear
Ping Li, Ping Liu, Ren-Ping Xiong, Xing-Yun Chen, Yan Zhao, Wei-Ping Lu, Xia Liu, Ya-Lei Ning, Nan Yang, Yuan-Guo Zhou
Abstract
We recently demonstrated that Ski is a novel wound healing-related factor that promotes fibroblast proliferation and inhibits collagen secretion. Here, we show that increasing local Ski expression by gene transfer not only significantly accelerated wound healing by relieving inflammation, accelerating re-epithelialization and increasing formation of granulation tissue, but also reduced scar formation by decreasing collagen production in rat dermal wounds. Similarly, ski gene transfer accelerated wound healing, reduced the protuberant height and volume of scars and increased collagen maturity in a hypertrophic scar model in the rabbit ear. Conversely, reducing Ski expression in the wound by RNA interference resulted in significantly slower wound healing and increased scar area in rat dermal wounds. We demonstrated that these effects of Ski are associated with transforming growth factor-I-mediated signalling pathways through both Smad2/3-dependent and Smad-independent pathways. Together, our results define a dual role for Ski in promoting wound healing and alleviating scar formation, identifying a new target for therapeutic approaches to preventing scar hyperplasia and accelerating wound healing. Copyright A 2011 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Just wanted to let all of you know that I've sent an e-mail Ruoslahti's way in an 'attempt' to get it clarified what he feels his decorin drug will actually do if it ever comes to fruition the way he hopes it will.
If he replies, I'll let you know what he said.
when it goes on sale and with that business name?
Just wanted to let all of you know that I've sent an e-mail Ruoslahti's way in an 'attempt' to get it clarified what he feels his decorin drug will actually do if it ever comes to fruition the way he hopes it will.
If he replies, I'll let you know what he said.
when it goes on sale and with that business name?
It will be a number of years before it will go on sale. If it will go on sale. Right now Erkki Ruoslahti and his team are trying to maximize the efficacy of this approach and they'll keep doing so for another year or so. After that they will enter into clinical trials as soon as they can but there is no deal made yet with any company that will eventually sell it.
Again Mr. Ruoslahti replied very fast! Here's what he said:
Thank you for your interest in our work. The primary effect of the wound-targeted decorin (CAR-decorin), which we hope to bring to the clinic, is to prevent the formation of scar tissue after tissue injury (so far in mice and rats). This gives the real skin tissue time to regenerate, so I do think that we can, to an extent, enable the body to cover a wound with tissue that is better than the scar tissue functionally and cosmetically. However, the new would likely not reproduce the full skin structure; sweat glands and hair would likely not be included. That advance, I think, will come from stem cell research. As far as we know, it is necessary to give decorin during the wound healing for it to have an effect, so our treatment would be for preventiing scar formation and thereby enhancing regeneration, rather than us being able to convert scar tissue to normal skin. Regards, ER
This is not the decorin your body is flooded with 24/7 to stop scarring completely; which then enables your body to continue to regenerate. This is not the decorin that is then absent in fresh wounds.
This is 'cardecorin' that transports a 'proportion' of decorin to a wound.
If you used decorin 24/7 on a wound there would be no scar. As the fibroblasts would be arrested, exactly like they are in your non wounded tissues.
Again Mr. Ruoslahti replied very fast! Here's what he said:
Thank you for your interest in our work. The primary effect of the wound-targeted decorin (CAR-decorin), which we hope to bring to the clinic, is to prevent the formation of scar tissue after tissue injury (so far in mice and rats). This gives the real skin tissue time to regenerate, so I do think that we can, to an extent, enable the body to cover a wound with tissue that is better than the scar tissue functionally and cosmetically. However, the new would likely not reproduce the full skin structure; sweat glands and hair would likely not be included. That advance, I think, will come from stem cell research. As far as we know, it is necessary to give decorin during the wound healing for it to have an effect, so our treatment would be for preventiing scar formation and thereby enhancing regeneration, rather than us being able to convert scar tissue to normal skin. Regards, ER
This is not the decorin your body is flooded with 24/7 to stop scarring completely; which then enables your body to continue to regenerate. This is not the decorin that is then absent in fresh wounds.
This is 'cardecorin' that transports a 'proportion' of decorin to a wound.
If you used decorin 24/7 on a wound there would be no scar. As the fibroblasts would be arrested, exactly like they are in your non wounded tissues.
I think you mentioned something like that earlier but don't you think someone like Erkki Ruoslahti knows how to use this stuff the right way?
He has stated that the "CAR" element actually increases the efficacy of decorin so CAR-decorin is not inferior but superior to a treatment which uses decorin by itself. 
This is not the decorin your body is flooded with 24/7 to stop scarring completely; which then enables your body to continue to regenerate. This is not the decorin that is then absent in fresh wounds.
This is 'cardecorin' that transports a 'proportion' of decorin to a wound.
If you used decorin 24/7 on a wound there would be no scar. As the fibroblasts would be arrested, exactly like they are in your non wounded tissues.
Dr. Ruoslahti and his colleague Dr. Tero JArvinen tested CAR-decorin in mice. Beginning three days after a wound, they administered daily injections of the peptide and then measured the scar size. As they report in the paper, CAR-decorin selectively accumulated in wounds, promoted wound healing and suppressed scar formation.
It says there that they injected daily. So it's not just a single administration.
car-decorin article:
w w w . pnas.org/content/107/50/21671.full
I hope it's not a scam as juvista, seems too science fiction the explanation by the creator of this. in fact the name 'car decorin' seems scam.
What if it is true friends, if you have 20 to 30 years, and years in the research of healing without scarring, the only truth is that we have no time to wait until it goes on sale something that bears much bureaucracy with the FDA.
After years of research, the only conclusion that I have is that I hope a miracle, where a day out news that something so basic as for example 'apply an Apple on a scar', prevents the healing and stimulates the cells behave like stem cells to regenerate without scar '. so in this way i go to buy an Apple and experiment myself, rather than have to wait 30 years that this discovery goes on sale.
20 years ago I read news online 'have discovered this, what mechanisms, solutions' etc, and never get nothing concrete, I can't believe in 2011 humans can not avoid the scar on skin.
This is not the decorin your body is flooded with 24/7 to stop scarring completely; which then enables your body to continue to regenerate. This is not the decorin that is then absent in fresh wounds.
This is 'cardecorin' that transports a 'proportion' of decorin to a wound.
If you used decorin 24/7 on a wound there would be no scar. As the fibroblasts would be arrested, exactly like they are in your non wounded tissues.
Dr. Ruoslahti and his colleague Dr. Tero JArvinen tested CAR-decorin in mice. Beginning three days after a wound, they administered daily injections of the peptide and then measured the scar size. As they report in the paper, CAR-decorin selectively accumulated in wounds, promoted wound healing and suppressed scar formation.
It says there that they injected daily. So it's not just a single administration.
I understand by my research, that when there is a wound immediately come the elements of inflamation and is ordered to generate collagen scar, so that implement a product should be in my opinion before the wound or immediately occur.
when i read the article by the creator of car-decorin, the part where it says 'car decorin applied 3 days after the wound' sounds to me already to scam (another scam like juvista), because I have understood that 3 days later as it is late to generate regeneration.
Yes, them waiting three days before administering the decorin is strange to me too. I have no idea why they wait. 
But I personally don't think this is a scam. I also don't think it will take forever before it becomes available. At least not a few decades. That is if it ends up working.
Yes, them waiting three days before administering the decorin is strange to me too. I have no idea why they wait.
I don't understand this either. It seems like it would make any treatment far less effective. Inflammation is a major part of scarring and instead of trying to stop this inflammation they allow three days for it to happen.
I always presume they know better since they are the experts but I don't get this at all.
Hi Pepo. Nice to see you again. I'm sorry to hear the Kitocell didn't work out. 
I'd ask Ruoslahti about the mysterious three day waiting period but, and I've said this before, I don't want to annoy him as he's a busy man and if he gets bombarded with questions I assume it would annoy him more than anything else.
But yeah, it's weird. I still think Erkki Ruoslahti is no fraud or hack or amateur, though. I really think that if decorin can be used to fix things then he and his team will know/find out how.
Again Mr. Ruoslahti replied very fast! Here's what he said:
Thank you for your interest in our work. The primary effect of the wound-targeted decorin (CAR-decorin), which we hope to bring to the clinic, is to prevent the formation of scar tissue after tissue injury (so far in mice and rats). This gives the real skin tissue time to regenerate, so I do think that we can, to an extent, enable the body to cover a wound with tissue that is better than the scar tissue functionally and cosmetically. However, the new would likely not reproduce the full skin structure; sweat glands and hair would likely not be included. That advance, I think, will come from stem cell research. As far as we know, it is necessary to give decorin during the wound healing for it to have an effect, so our treatment would be for preventiing scar formation and thereby enhancing regeneration, rather than us being able to convert scar tissue to normal skin. Regards, ER
This is not the decorin your body is flooded with 24/7 to stop scarring completely; which then enables your body to continue to regenerate. This is not the decorin that is then absent in fresh wounds.
This is 'cardecorin' that transports a 'proportion' of decorin to a wound.
If you used decorin 24/7 on a wound there would be no scar. As the fibroblasts would be arrested, exactly like they are in your non wounded tissues.
I think you mentioned something like that earlier but don't you think someone like Erkki Ruoslahti knows how to use this stuff the right way?
He has stated that the "CAR" element actually increases the efficacy of decorin so CAR-decorin is not inferior but superior to a treatment which uses decorin by itself.
Mr Erkki Ruoslahti may be a sound person, and he may be an absolute shit for all we know, he may and is probably extremely knowledgable on scarring, I think we can say that at least. But like you and everyone else he is open to biases. Biases he is conscious of and biases he is not conscious of. Also knowledge does not give anyone integrity; you can use knowledge for bad as well as good. You can still be machavillian if you have knowledge. He gets no free pass or divine authority from me if he has knowledge. In fact anyone who has knowledge to me should be held under scrutiny more imo.
Also the same can be said if anyone calls someone an 'expert' because of knowledge. IMO no should be given parental authority when we are all adults.
Also with regards to car-decorin, under no way can something synthetic be better than the protein the human body has evolved with for millions of years, which has evolved for a purpose.
This is the stuff that evolved to arrest fibroblasts, so your tissues can continue to regenerate.
Look at your non wounded tissue & your non scarred tissue that is flooded with the decorin your body produces. This is the stuff that arrests the fibroblasts and allows your tissues from skin, to muscles to regenerate. Tell me this can be bettered. It cant. It is only possible to be matched from my view.
Mr Erkki Ruoslahti may be a sound person, and he may be an absolute shit for all we know, he may and is probably extremely knowledgable on scarring, I think we can say that at least. But like you and everyone else he is open to biases. Biases he is conscious of and biases he is not conscious of. Also knowledge does not give anyone integrity; you can use knowledge for bad as well as good. You can still be machavillian if you have knowledge. He gets no free pass or divine authority from me if he has knowledge. In fact anyone who has knowledge to me should be held under scrutiny more imo.
Also the same can be said if anyone calls someone an 'expert' because of knowledge. IMO no should be given parental authority when we are all adults.
Also with regards to car-decorin, under no way can something synthetic be better than the protein the human body has evolved with for millions of years, which has evolved for a purpose.
This is the stuff that evolved to arrest fibroblasts, so your tissues can continue to regenerate.
Look at your non wounded tissue & your non scarred tissue that is flooded with the decorin your body produces. This is the stuff that arrests the fibroblasts and allows your tissues from skin, to muscles to regenerate. Tell me this can be bettered. It cant. It is only possible to be matched from my view.
The CAR peptide is only there to help bring more of the decorin that is administered to the site of injury. In doing so it makes the treatment more effective not the decorin itself.
I see what you mean about us not knowing enough about Erkki Ruoslahti to be able to say if his intentions are good or not but I still have a good feeling about this. Here's hoping, folks! ![=]](https://static.acne.org/ipb_uploads/emoticons/default_sideways.gif)
I might contact him later on if any more questions pop into my mind that I'd really like to know the answer to. I'm still not going to overload him with questions, though.
2001 said:I see scars on all of the wounds, the best looking one on the mans face next to his eye and ear is a light effect. You ever notice the small size of the images on these sites. There is a reason. I can take 10 mega pixel images with 100 dollar camera. 100% inexcusable...The guy with the arm and neck wounds. Those are second/first degree burns. They heal without scarring if treated properly.
This "Curcumin" is an old hat. Search here, you will see it mentioned before.
Pre existing Scars wont be removed or repaired with a salve from a non mammalian organic origin.
I never meant to suggest that applying topical curcumin to existing scars would help. Obviously the existing scars would have to be excised or extensive needling would have to be done. I honestly wouldn't bother applying any topical to an existing scar as it simply won't do anything (unless keloidal in which case kitoscell might help with prolonged use).
The burns scars on that page I never looked at as they are too small but the other pictures (whilst all showing some scarring) do definitely look better than if nothing was applied. The pictures are very small on the site but they have pictures on facebook which are much much bigger and clearer: [removed]
I also saw another site which showed the pictures much bigger and clearer as well.
I have searched on this website and there is barely anything written about curcumin at all. A few empty threads with people asking about it with no response.
Another thing you have to understand is that the amount of curcumin in that product is tiny. I wasn't for a second saying that we should all go out and buy the product, I think that would be stupid when you could make your own much cheaper and with a much much much larger quantity of curcumin. I posted a link to the site only to show that it has potential as even tiny amounts of curcumin offer some results on FRESH scars. Bear in mind you can needle your skin and then apply curcumin as many times as you want.
Also, there is a lot of research backing curcumin. There is a new paper just published in the International Journal of Dermatology after all. You might say it's "old hat" but that doesn't mean anything when there are facts supporting it. Nobody has ever really tried it and those who have haven't tried it properly (fresh scar/wound). Applying it to an existing scar isn't going to do anything apart from perhaps lighten it at best.
Curcumin isn't like the millions of other things out there that have no scientific backing at all, they are all just scams to make money we know this on this board. Fact of the matter is curcumin does have scientific backing, that's what separates it.
I'm not saying that curcumin is the answer and we should all jump on it. All I'm saying is that it could help based on the dozens of research papers I've read about it. I don't think it should be overlooked so easily. All the talk about the osteopontin gene is to do with inflammation. Curcumin is proven to be a strong anti-inflammatory.
Curcumin causes fibroblast apoptosis: http://www.ncbi.nlm.nih.gov/pubmed/18410527
"curcumin treatment in high doses (>25 microM) may provide a novel way to modulate pathological scar formation through the induction of fibroblast apoptosis"
http://www.ncbi.nlm.nih.gov/pubmed/20214332
"High concentration curcumin can inhibit effectively the fibroblast proliferation and collagen I synthesis in hyperplastic scar"
Very detailed paper on curcumin and it's effects on IPF: http://ajplung.physiology.org/content/298/5/L616.full
"In this study, we show that curcumin effectively inhibits fibroblast proliferation, differentiation to myofibroblasts, and secretion of collagen"
Interested in hearing what you all think.
Pepo the Curcumin was injected into the wounds. Salves and Oral consumption will not work as effectively. I am researching the hell out of it right now using the keywords "Intraperitoneal Curcumin" Intraperitoneal means Injection based. I think I found a PDF doc that describes the formula. Just like th Bee venom- it raises a new issue. Who would we find to mix it and inject it. Took a very long time to find someone trustworthy for the Saline I plan to self inject to treat some of my scars. The Curcumin issue involves precise mix ratios with other medical grade additives. God only knows if the spice needs to be irritated or boiled to remove any infectious hazards.
Pepo the Curcumin was injected into the wounds. Salves and Oral consumption will not work as effectively. I am researching the hell out of it right now using the keywords "Intraperitoneal Curcumin" Intraperitoneal means Injection based. I think I found a PDF doc that describes the formula. Just like th Bee venom- it raises a new issue. Who would we find to mix it and inject it. Took a very long time to find someone trustworthy for the Saline I plan to self inject to treat some of my scars. The Curcumin issue involves precise mix ratios with other medical grade additives. God only knows if the spice needs to be irritated or boiled to remove any infectious hazards.
I'm at work so I can't reply properly.
I've never said anything about oral intake. It has a very poor bioavailability and only a tiny amount reaches the blood stream, though that tiny amount is still said to be very beneficial for certain illnesses. "most of what we swallow goes directly into our gastrointestinal area and is expelled." Topical applicatioin of anything on existing scars is virtually pointless. I am not talking about oral intake and I'm not talking about applying topical curcumin to existing scars.
What I am talking about is applying curcumin to wounds. Fresh wounds/open wounds. There is no need to inject it. As we know curcumin inhibits fibroblast proliferation, that means if you have a fresh wound (where scar tissues hasn't developed yet) and apply curcumin it will help. The problem is existing scar tissue. The new paper in the international journal of dermatology is done on surgical scars as you have the ability to apply a topical immediately after the wound is closed, before any scar tissue has been made. If you excise your scar and apply topical curcumin it will help. How much? I don't know. It inhibits fibroblast proliferation. I'm hoping causing micro wounds with a needle/dermastamp/roller will have a similar effect as I can't excise my scars myself. You have an unlimited amount of times you can repeat this procedure so maybe it could help.
Hey guys,
an article about skin printing. I did not know, that this technique is far enough to produce real healthy skin. A citation from the article : " Atala said the researchers already have been able to make "healthy skin." " Sounds interesting. Hope it will give us results soon. Stay tuned, all together.
Neo