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I can definitely ask about how they plan to produce adequate amounts of decorin and where it would come from. 
Thanks for welcoming me here too. I have been having a great deal of problems in dealing with my scars of late so it's been nice to read and now share with others going through the same things.
Later!
SKIN GUN
/\high def it
http://singularityhub.com/2011/06/14/mirac...-without-scars/
In my opinion this seals it. It is here. People with scars could have the tissue debridged or exercised, and this method could be used on the fresh wound to prevent a new scar.
This needs to get FDA clearance here in America ASAP!
Hey Everyone,
So I wrote to Ruoslahti and here's what he had to say:
_____________________________________________________________________________
Thank you for your interest in our work.
We are talking to pharma companies about the targeted decorin to advance it to clinical trials. There has been quite a bit of interest, but to convert that into an actual deal will take time. The difficulty with decorin is that it is quite different from the drugs and biologicals (such as antibodies) the companies are accustomed to dealing with. On the other hand, decorin has the great advantage that it is a physiological substance, apparently meant for the purpose we want to use it for. In the meantime, we have grant funding to further improve the efficacy and pharmacological properties of the molecule; every increment we can add to its efficacy will make it that much more competitive, because it mean that a smaller dose can be used.
An ordinary person can be generally supportive of research - that helps a lot.
We make CAR-decorin in cultured cells. We have not tested CAR-decorin in old scars, mostly because there is no reason to expect that it would work. If the scar is first surgically removed, decorin should prevent the formation of a new scar, but we have no data on that.
Regards, ER
_____________________________________________________________________________
Awesome that he got back to me so fast. Let me know if you guys want to ask anything else.
That's old news man.
ReCell is old news, yeah. Still when you read it you sort of go "Wow" but it doesn't do what is claimed it does in that article as far as I know.
Lapis please explain in more detail. There are images on the site I linked that show a boy with 2nd and 3rd degree burns on his chest with an after treatment image and as far as a I can tell there is no scar, and then when you look at the youtube video in high def you can see the areas on the guy who was burned by the bonfire, and I for the life of me cant see any scars, granted we never saw a before image of the persons real burn damage, but I highly doubt the guy is lying about the extent and location of his burns.
I don't think this is a gimmick. It's already in use in some places like Canada. I did find a website where a woman had an old scar exercised, and treated with the skin gun. It's not in English and there is no follow up images to show or prove this methods effectiveness.
I am very hopeful in regards to this method. Where is the proof that it doesn't work as described?
I blame Renovo for all of this "It must be a lie" effect we all suffer from. Damn them for stringing along the investors and scar victims for 12 years, knowing full well their drug did not work. Those people took everyone for a ride to fatten their bank accounts.
We cant blame the whole lot on one bad apple.
Acell never claimed to treat scars, and it does work as a regenitive treatment for certain parts of the body like hearts and fingers.
Hey Everyone,
So I wrote to Ruoslahti and here's what he had to say:
_____________________________________________________________________________
Thank you for your interest in our work.
We are talking to pharma companies about the targeted decorin to advance it to clinical trials. There has been quite a bit of interest, but to convert that into an actual deal will take time. The difficulty with decorin is that it is quite different from the drugs and biologicals (such as antibodies) the companies are accustomed to dealing with. On the other hand, decorin has the great advantage that it is a physiological substance, apparently meant for the purpose we want to use it for. In the meantime, we have grant funding to further improve the efficacy and pharmacological properties of the molecule; every increment we can add to its efficacy will make it that much more competitive, because it mean that a smaller dose can be used.
An ordinary person can be generally supportive of research - that helps a lot.
We make CAR-decorin in cultured cells. We have not tested CAR-decorin in old scars, mostly because there is no reason to expect that it would work. If the scar is first surgically removed, decorin should prevent the formation of a new scar, but we have no data on that.
Regards, ER
_____________________________________________________________________________
Awesome that he got back to me so fast. Let me know if you guys want to ask anything else.
Wow, he actually said it. That decorin should prevent a new scar from forming after excision. Wow... Interesting reply! It's probably going to take like seven years at least before this thing is realized, though. But hey it's great that it's on its way! I'd be surprised if this thing didn't come into fruition eventually. I mean I don't see it failing like Juvista. But hey, stranger things have happened. Nevertheless it's good knowing that this thing is on track and moving forward! I thought it was just sitting there, waiting for investors to notice it but they're actually out there, trying to make it happen. Very cool!
Lapis please explain in more detail. There are images on the site I linked that show a boy with 2nd and 3rd degree burns on his chest with an after treatment image and as far as a I can tell there is no scar, and then when you look at the youtube video in high def you can see the areas on the guy who was burned by the bonfire, and I for the life of me cant see any scars, granted we never saw a before image of the persons real burn damage, but I highly doubt the guy is lying about the extent and location of his burns.
I don't think this is a gimmick. It's already in use in some places like Canada. I did find a website where a woman had an old scar exercised, and treated with the skin gun. It's not in English and there is no follow up images to show or prove this methods effectiveness.
I am very hopeful in regards to this method. Where is the proof that it doesn't work as described?
I blame Renovo for all of this "It must be a lie" effect we all suffer from. Damn them for stringing along the investors and scar victims for 12 years, knowing full well their drug did not work. Those people took everyone for a ride to fatten their bank accounts.
We cant blame the whole lot on one bad apple.
Acell never claimed to treat scars, and it does work as a regenitive treatment for certain parts of the body like hearts and fingers.
Recell has been around a long time. And renowned doctors have been experimenting with it, not reporting anything anywhere near scarless healing. I remember one institute in Holland saying in an article that they felt Recell had potential but the results they obtained were very disappointing, for instance. It just seems to me that if it did what is claimed, we wouldn't be having scars today. And some videos and photographs are all smoke and mirrors. 
You'd be suprised at just how deceiving things really can be. But hey, I might have it wrong. Seriously.
Lapis please explain in more detail. There are images on the site I linked that show a boy with 2nd and 3rd degree burns on his chest with an after treatment image and as far as a I can tell there is no scar, and then when you look at the youtube video in high def you can see the areas on the guy who was burned by the bonfire, and I for the life of me cant see any scars, granted we never saw a before image of the persons real burn damage, but I highly doubt the guy is lying about the extent and location of his burns.
I don't think this is a gimmick. It's already in use in some places like Canada. I did find a website where a woman had an old scar exercised, and treated with the skin gun. It's not in English and there is no follow up images to show or prove this methods effectiveness.
I am very hopeful in regards to this method. Where is the proof that it doesn't work as described?
I blame Renovo for all of this "It must be a lie" effect we all suffer from. Damn them for stringing along the investors and scar victims for 12 years, knowing full well their drug did not work. Those people took everyone for a ride to fatten their bank accounts.
We cant blame the whole lot on one bad apple.
Acell never claimed to treat scars, and it does work as a regenitive treatment for certain parts of the body like hearts and fingers.
Recell has been around a long time. And renowned doctors have been experimenting with it, not reporting anything anywhere near scarless healing. I remember one institute in Holland saying in an article that they felt Recell had potential but the results they obtained were very disappointing, for instance. It just seems to me that if it did what is claimed, we wouldn't be having scars today. And some videos and photographs are all smoke and mirrors.
I'm not having a go lapiz btw.
You use the labeling term 'renowned Dr's.' BTW who says anyone is a 'renowned Dr?' Why do you want to give one group a free pass and another group no free pass?
What if the group without the free pass has a solution? Do you ignore it?
What if the group you decide is renowned, with the free pass, sells shit? Do you buy it?
Why should one group get the 'renowned' authority card over another? What happened to content?
Can you see the slight of hand you have just fell for by blindly following your perceived authority?
BTW I cant see the youtube link in 2001's post, however if it is the skin spray on thing I can say by myself, without any renowned authority telling me, the spray clearly brought scar free healing.
Also to back up what my eyes seen, it is a known fact that if a wound re-epithelializes within two week there will be no scar. Well I‚„m sure in that case it took 2 or 3 days to re-epithelialize.
Hey Everyone,
So I wrote to Ruoslahti and here's what he had to say:
_____________________________________________________________________________
Thank you for your interest in our work.
We are talking to pharma companies about the targeted decorin to advance it to clinical trials. There has been quite a bit of interest, but to convert that into an actual deal will take time. The difficulty with decorin is that it is quite different from the drugs and biologicals (such as antibodies) the companies are accustomed to dealing with. On the other hand, decorin has the great advantage that it is a physiological substance, apparently meant for the purpose we want to use it for. In the meantime, we have grant funding to further improve the efficacy and pharmacological properties of the molecule; every increment we can add to its efficacy will make it that much more competitive, because it mean that a smaller dose can be used.
An ordinary person can be generally supportive of research - that helps a lot.
We make CAR-decorin in cultured cells. We have not tested CAR-decorin in old scars, mostly because there is no reason to expect that it would work. If the scar is first surgically removed, decorin should prevent the formation of a new scar, but we have no data on that.
Regards, ER
_____________________________________________________________________________
Awesome that he got back to me so fast. Let me know if you guys want to ask anything else.
Wow, he actually said it. That decorin should prevent a new scar from forming after excision. Wow... Interesting reply! It's probably going to take like seven years at least before this thing is realized, though. But hey it's great that it's on its way! I'd be surprised if this thing didn't come into fruition eventually. I mean I don't see it failing like Juvista. But hey, stranger things have happened. Nevertheless it's good knowing that this thing is on track and moving forward! I thought it was just sitting there, waiting for investors to notice it but they're actually out there, trying to make it happen. Very cool!
Agreed.
So, decorin should hinder the proliferation of myofibroblasts, and hence prevent fibrosis. One question that remains, though, even if the delivery system would work, is whether skin appendages are regenerated as well? If closing by primary intention is less than optimal, this will be quite vital imo.
Agreed.
So, decorin should hinder the proliferation of myofibroblasts, and hence prevent fibrosis. One question that remains, though, even if the delivery system would work, is whether skin appendages are regenerated as well? If closing by primary intention is less than optimal, this will be quite vital imo.
Yeah, in particular hair. I was wondering about that. 
But you know, even if there aren't any ones regenerated it would still be something many could benefit from? I'd say so at least... If there were skin appendages regenerated then that would be even more wonderful an achievement.
I'm not having a go lapiz btw.
I'd be surpised if you were (having a go).
You use the labeling term 'renowned Dr's.' BTW who says anyone is a 'renowned Dr?' Why do you want to give one group a free pass and another group no free pass?
I'm not. Bear in mind, English isn't my first language. What I meant with 'renowned' was that these doctors... I'd be surprised if they were hacks. One doctor I was referring to was publically praised a few years ago. I just assume that these people know what they're doing.
What if the group without the free pass has a solution? Do you ignore it?
Of course not.
What if the group you decide is renowned, with the free pass, sells shit? Do you buy it?
No. 
Why should one group get the 'renowned' authority card over another? What happened to content?
Well, see one of the above posts. All I was saying is that I trust the "renowned" doctor's judgements. They've obviously tried things out and found they didn't get the results they hoped for. 
Can you see the slight of hand you have just fell for by blindly following your perceived authority?
I don't blindly follow anyone. If people can prove the "renowned" doctors wrong, then wonderful.
BTW I cant see the youtube link in 2001's post, however if it is the skin spray on thing I can say by myself, without any renowned authority telling me, the spray clearly brought scar free healing.
Also to back up what my eyes seen, it is a known fact that if a wound re-epithelializes within two week there will be no scar. Well I‚„m sure in that case it took 2 or 3 days to re-epithelialize.
But yet, you're not running out to go get treated with it?
Lapis and rimram, if you like I could ask Ruoslahti about whether or not he believes CAR-decorin could regenerate skin appendages as well (and see if that's what he observed with mice). That's something I've been wondering a bout too. It arrests the ability for the body to produce fibrosis but what exactly does the healing look like aesthetically and how far does i go?
As far as the skin gun, I read an article a while back where Gerlach (sp?) said that it currently is only for use on 2nd degree burns where the dermis is relatively undamaged. In a more recent article he said he was investigating ways to treat 3rd degree burns with the gun. With the current technology he said it did not restore things like sweat glands and hair follicles.
ReCell is available just about everywhere but the US 
. Sculpta Clinic in the UK is offering the service right now and the results are pretty damn good. They have two case studies on their site and an article about a woman who recently received treatment was published in the las couple of days and she said it gave her life back. Though, she wasn't suffering exactly from scarring from what I got out of the article.
So many promising things out there (decorin, peptide 15-1, p21 gene etc.) but it seems like we're a bit off from any of it coming to fruition. Though I was very excited with Ruoslahti said he believed scar excision and treatment with CAR-decorin would prevent new scars from forming
Is it officially "come to fruition"? I thought it was "come into fruition". Also, what does "sp" mean? The only sps I know are from the scientology church who Tom Cruise has some kind of problem with!
But yeah, you could ask... But personally, I'd be hesitant to overload someone like Erkki Ruoslahti with questions. I sort of almost did that with Denis Barritault who is working on perfecting this ECM which according to him has the potential to regenerate skin as well (so that's another promising thing, btw) and after the second question he just stopped answering. haha It's sort of tempting to just drain their brains of info but they're so busy... And I guess for all they know the questions will keep coming forever and they just don't have the time. I mean if they were to answer all of them, they'd have a full-time job on their hands just doing that. haha But I may be worrying too much, I dunno.
In any case, he did say that he didn't have any data on excised scars so I guess he can only speculate regarding/give a text book answer to the question if he thinks there will be appendages or not. I personally could do without hair and sweat glands, though. Don't know about y'all but if this thing were only to be able make the skin that would be enough for me.
Haha, I think it's "come to fruition" but I might be wrong. Sp? was me indicating that I wasn't sure I'd spelled his name right.
You're probably right about asking Ruoslahti about hair and sweat glands. It would definitely be just speculation although I would be curious to know if the mice they tested it on saw hair return since excising a scar and creating an incisional wound are pretty much the same thing (creating a new wound bed).
I wish I could find Heber-Katz's e-mail to ask her about how her research into the MRL mice and p21 gene are going.
I'm not having a go lapiz btw.
I'd be surpised if you were (having a go).
You use the labeling term 'renowned Dr's.' BTW who says anyone is a 'renowned Dr?' Why do you want to give one group a free pass and another group no free pass?
I'm not. Bear in mind, English isn't my first language. What I meant with 'renowned' was that these doctors... I'd be surprised if they were hacks. One doctor I was referring to was publically praised a few years ago. I just assume that these people know what they're doing.
What if the group without the free pass has a solution? Do you ignore it?
Of course not.
What if the group you decide is renowned, with the free pass, sells shit? Do you buy it?
No.
Why should one group get the 'renowned' authority card over another? What happened to content?
Well, see one of the above posts. All I was saying is that I trust the "renowned" doctor's judgements. They've obviously tried things out and found they didn't get the results they hoped for.
Can you see the slight of hand you have just fell for by blindly following your perceived authority?
I don't blindly follow anyone. If people can prove the "renowned" doctors wrong, then wonderful.
BTW I cant see the youtube link in 2001's post, however if it is the skin spray on thing I can say by myself, without any renowned authority telling me, the spray clearly brought scar free healing.
Also to back up what my eyes seen, it is a known fact that if a wound re-epithelializes within two week there will be no scar. Well I‚„m sure in that case it took 2 or 3 days to re-epithelialize.
But yet, you're not running out to go get treated with it?
It will not be available were I am yet.
Lapis and rimram, if you like I could ask Ruoslahti about whether or not he believes CAR-decorin could regenerate skin appendages as well (and see if that's what he observed with mice). That's something I've been wondering a bout too. It arrests the ability for the body to produce fibrosis but what exactly does the healing look like aesthetically and how far does i go?
As far as the skin gun, I read an article a while back where Gerlach (sp?) said that it currently is only for use on 2nd degree burns where the dermis is relatively undamaged. In a more recent article he said he was investigating ways to treat 3rd degree burns with the gun. With the current technology he said it did not restore things like sweat glands and hair follicles.
ReCell is available just about everywhere but the US
So many promising things out there (decorin, peptide 15-1, p21 gene etc.) but it seems like we're a bit off from any of it coming to fruition. Though I was very excited with Ruoslahti said he believed scar excision and treatment with CAR-decorin would prevent new scars from forming
Scarring and regeneration are completely related and are completely inversely proportional. Just think of a spectrum, eg. one end is scar the other is regeneration.
E.g. if you have 0% scarring you'll have 100% regeneration. And vice versa. If you have 27% scar you'd have in the same wound 73% regeneration and vice versa, and so on.
The only thing that can interupt the relationship is necrosis (tissue death) like you see in diabetes, but even this is temporary as soon enough the tissue will scar over, unless the wound gets amputated etc.
Lapis and rimram, if you like I could ask Ruoslahti about whether or not he believes CAR-decorin could regenerate skin appendages as well (and see if that's what he observed with mice). That's something I've been wondering a bout too. It arrests the ability for the body to produce fibrosis but what exactly does the healing look like aesthetically and how far does i go?
I'd definitely be interested in this, have a scar in one of my eyebrows that has more or less killed my life so far 
. Considering an HT, but regeneration would surely be preferable.
Lapis' point is well taken though.
Scarring and regeneration are completely related and are completely inversely proportional. Just think of a spectrum, eg. one end is scar the other is regeneration.
E.g. if you have 0% scarring you'll have 100% regeneration. And vice versa. If you have 27% scar you'd have in the same wound 73% regeneration and vice versa, and so on.
The only thing that can interupt the relationship is necrosis (tissue death) like you see in diabetes, but even this is temporary as soon enough the tissue will scar over, unless the wound gets amputated etc.
Hope you're right. Have any studies been conducted on this yet? Personally, I don't necessarily see any correlation between normal fibrotic healing and hair follicle neogenesis. On the other hand, I do think that I've read somewhere that fetuses that heal without scarring also will regenerate the appendages.