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Hey Guys,
Errki got back to me again. A somewhat curious response in my opinion.
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We can't make the skin appendices to come back because we use a full-thickness model (even the deep layers of the skin are removed). However, the scars are only half as wide as in the controls, which leaves a much smaller area without the appendices. Regards, ER
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I'm a little perplexed about this because in his previous e-mail he said that scar excision followed by a treatment of CAR-Decorin should (in theory) prevent the return of the scar tissue. The part about the appendices not returning does make some sense since it's a full-thickness wound. I guess for wounds like this CAR-Decorin might need something else (wnt signalling, gene suppression, who knows) to work in tandem to promote regeneration of not only the layers of skin but appendices as well.
The last thing that doesn't seem to make sense in the e-mail is that while the scars are half as wide (good, not great) he goes on to state that it means a smaller area without appendices. I'm not sure whether he's saying that the CAR-Decorin is minimizing the spreading of the scar by tension forces (hence a smaller scar) or that it's regenerating twice the area of the control group and that area does see a return of appendices. Anyone else care to take a stab at that?
Anyway, not the best of news but maybe with more research they can improve the efficacy and lower the dose so it has clinical and commercial viability.
Hey Guys,
Errki got back to me again. A somewhat curious response in my opinion.
________________________________________________________________
We can't make the skin appendices to come back because we use a full-thickness model (even the deep layers of the skin are removed). However, the scars are only half as wide as in the controls, which leaves a much smaller area without the appendices. Regards, ER
________________________________________________________________
I'm a little perplexed about this because in his previous e-mail he said that scar excision followed by a treatment of CAR-Decorin should (in theory) prevent the return of the scar tissue. The part about the appendices not returning does make some sense since it's a full-thickness wound. I guess for wounds like this CAR-Decorin might need something else (wnt signalling, gene suppression, who knows) to work in tandem to promote regeneration of not only the layers of skin but appendices as well.
The only thing I can think of here is:
Only a proportion of this synthetic CARdecorin is getting carried to the wound by the CAR and therefor the wound is not flooded enough with decorin 24/7 like the way your non wounded tissues are flooded with your bodies decorin 24/7.
(An explanation its like cooking sausages (vegetarian ones btw), you need to cook it on a certain heat level for 12minutes or the sausages can not be cooked to a crisp. And the sausages can never be cooked fully if you flash a light on the pan.)
I wouldn't say all hope. More like a signal that more work needs to be done to either improve the homing action of CAR (as seabs was saying) or that the treatment needs to be used in tandem with something else for the time being (like Gurtner's new shield dressings that reduce tension across a wound after sutures have been removed).
All in all I think it's good news that it's getting grants for more research and actively looking for commercial partners. I'd love to know the status of research into suppressing the p21 gene but I can't find Heber-Katz e-mail.
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We can't make the skin appendices to come back because we use a full-thickness model (even the deep layers of the skin are removed). However, the scars are only half as wide as in the controls, which leaves a much smaller area without the appendices. Regards, ER
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That is confusing to me as he's saying the appendices can't come back just before saying that in the portion that is regenerated they do come back? 
Or maybe I read it wrongly, I dunno.
But I wouldn't draw the conclusion that it's not going to work, people. It's the right approach, seemingly, to achieving SH and right now they're tweaking it. Even if it regenerates a portion, you can just get treated as many times as needed until everything is back. 
http://news.scotsman.com/health/Scifi-brou...e-as.6757797.jp
Hey guys, click this link. It shows an article which has a scarless healing treatment.
exact quote,""Thanks to the technology involved, patients suffering from debilitating burns, horrific scarring, vitiligo, pigmentation and aged appearance are now able to heal properly, leaving them with no traces of the previous affliction."
Quote again, "The clinic says results of a one-off treatment are seen within weeks, with scars "virtually" gone within a year."
Let me re-emphasize this few sentences..."no traces of the previous affliction"..."scars virtually gone within a year". All this points to scarless healing.
Let what seabs said, scarless healing has been done. But it is not widely known enough like how the chinese invented paper/gunpowder and the rest of the world took years to catch up.
http://news.scotsman.com/health/Scifi-brou...e-as.6757797.jp
Hey guys, click this link. It shows an article which has a scarless healing treatment.
exact quote,""Thanks to the technology involved, patients suffering from debilitating burns, horrific scarring, vitiligo, pigmentation and aged appearance are now able to heal properly, leaving them with no traces of the previous affliction."
Quote again, "The clinic says results of a one-off treatment are seen within weeks, with scars "virtually" gone within a year."
Let me re-emphasize this few sentences..."no traces of the previous affliction"..."scars virtually gone within a year". All this points to scarless healing.
Let what seabs said, scarless healing has been done. But it is not widely known enough like how the chinese invented paper/gunpowder and the rest of the world took years to catch up.
Someone else posted that link too. I call 
It's just the skin spray thing. And 3500 Pounds? Could they just be trying to rob people? I think so. 
Hey Guys,
Errki got back to me again. A somewhat curious response in my opinion.
________________________________________________________________
We can't make the skin appendices to come back because we use a full-thickness model (even the deep layers of the skin are removed). However, the scars are only half as wide as in the controls, which leaves a much smaller area without the appendices. Regards, ER
________________________________________________________________
I'm a little perplexed about this because in his previous e-mail he said that scar excision followed by a treatment of CAR-Decorin should (in theory) prevent the return of the scar tissue. The part about the appendices not returning does make some sense since it's a full-thickness wound. I guess for wounds like this CAR-Decorin might need something else (wnt signalling, gene suppression, who knows) to work in tandem to promote regeneration of not only the layers of skin but appendices as well.
The last thing that doesn't seem to make sense in the e-mail is that while the scars are half as wide (good, not great) he goes on to state that it means a smaller area without appendices. I'm not sure whether he's saying that the CAR-Decorin is minimizing the spreading of the scar by tension forces (hence a smaller scar) or that it's regenerating twice the area of the control group and that area does see a return of appendices. Anyone else care to take a stab at that?
Curious indeed. It would be weird if the scars were smaller because of greater tensile forces, since that would be the job of the myofibroblasts. I'm not sure what to make out of his answer, really. Perhaps, if the wounds in the study were let heal by primary intention (and hence reapproximated without any help from the myofibroblasts), normal fibrous proliferation would expand the scarred area?
Thanks for asking him btw! If the new scar only lacks appendages (?), I'd still say we're half way there 
Hey Guys,
Errki got back to me again. A somewhat curious response in my opinion.
________________________________________________________________
We can't make the skin appendices to come back because we use a full-thickness model (even the deep layers of the skin are removed). However, the scars are only half as wide as in the controls, which leaves a much smaller area without the appendices. Regards, ER
________________________________________________________________
I'm a little perplexed about this because in his previous e-mail he said that scar excision followed by a treatment of CAR-Decorin should (in theory) prevent the return of the scar tissue. The part about the appendices not returning does make some sense since it's a full-thickness wound. I guess for wounds like this CAR-Decorin might need something else (wnt signalling, gene suppression, who knows) to work in tandem to promote regeneration of not only the layers of skin but appendices as well.
The last thing that doesn't seem to make sense in the e-mail is that while the scars are half as wide (good, not great) he goes on to state that it means a smaller area without appendices. I'm not sure whether he's saying that the CAR-Decorin is minimizing the spreading of the scar by tension forces (hence a smaller scar) or that it's regenerating twice the area of the control group and that area does see a return of appendices. Anyone else care to take a stab at that?
Curious indeed. It would be weird if the scars were smaller because of greater tensile forces, since that would be the job of the myofibroblasts. I'm not sure what to make out of his answer, really. Perhaps, if the wounds in the study were let heal by primary intention (and hence reapproximated without any help from the myofibroblasts), normal fibrous proliferation would expand the scarred area?
Thanks for asking him btw! If the new scar only lacks appendages (?), I'd still say we're half way there
Myofibroblast proliferate more, and create more scar when the two sides of a wound can move polar away from each other (mechanical creep), they create less scar when they are more secure. As the job of the myfibroblast is to contract the tissue with scar to stop the wound moving apart.
If you contract the tissue in effect you are taking away the job of the myofibroblast and therefor you'd get less scar.
I can see why it has worked.
Read this:
http://www.bbc.co.uk/news/health-14047670
A cancer patient was saved in the world's first synthetic organ transplant when he received a windpipe grown purely from his stem cells.
So they can make new windpipes already, I forsee skin next..
Nice story.
i found an interesting new study with before and after pics....i can see absolutely no scarring in the later pic 
.... its ski..anyhoo the link links it up to a page describing it, with links to the research article. they say it may take up to 10 years to release, but still interesting as. lets raid their lab and steal the test samples of it
http://www.2n2u.com/2011/04/ski-a-modulato...d-rabbit-ear-2/
Think you might be right, unfortunately. The creases don't match. The only other place that google can find that picture is from some kind of chinese plastic surgery clinic (I guess? - http://www.xsdmrzx.com/Special/xfbh/ ), although its size is smaller there .
Good find though. I've read the study that the article refers to. They only seem to have conducted testing in murine and rabbit so far. Although healing seems to have been improved, its not scarless. They do conclude, however, that the response seems dose dependent, so it could very well be possible to improve the delivery.
I think it's the same person. The creases looking a bit different is due to the angle and the lighting. However if it's true they never actually tested on people then it's just a fake photo. And if it is a real photo and it's due to Ski that this has been achieved then that is really, really, really, really promising!
Btw, I also might shoot an e-mail Histogen's way, asking politely about how what's in the pipeline may be of benefit to us. No stalker. haha As they said anyone can contact them anytime.
A few days ago I received a reply from Histogen. In a nutshell, they said that they do not intend to market any anti-scarring product in the near future. Oh well.
I think it's the same person. The creases looking a bit different is due to the angle and the lighting. However if it's true they never actually tested on people then it's just a fake photo. And if it is a real photo and it's due to Ski that this has been achieved then that is really, really, really, really promising!
the best way to know if the picture is real or not is to ask the person who read the study, whether that picture was a part of it or not...?
the hands definitely looked human and not like rabbits paws *lol*, so maybe it isnt attached to the study?
I think we are really looking over the potential of matristem powder. Not 1 person in this thread has completely excised their scar tissue and then applied the powder. That's probably because excising the tissue is a painful and bloody process. I truly believe all we need to find is a substance or product that dissolves/eats-away the scar tissue. Search for serrapeptase and you'll see all these rave reviews but that is really designed for internal scarring. Let's all get to work and try to find an enzyme specifically designed to eat away external scar tissue.
Then we can, for the first time, properly use acell's matristem.
no the problem is that the powder isnt available anywhere
btw i just cut myself on my pinky. i doubt therell be a scar. lets see how it goes.
or does anyone have scars on their palm or on the sole of the foot? i tell you, i stepped into glass and it bled a lot, yet healed scarless. they should study the palms and soles and find out why it works there.
The powder is available for sale on [removed]. The guy who runs the site has a medical license so he is allowed to purchase it and do as he pleases. And he is selling it off his site to anyone. I bought some last year but it was the smallest amount(probably half of what's needed for an excised scar). But the excising part was impossible. We need to find a scar eating enzyme specifically for external scars.